研究文章
90天口服Methylurate嘌呤生物碱Theacrine的毒理学评价
|
| 集团(毫克/公斤体重/天) |
|
|
器官重量和体重相对于脑重量(%) |
| 体重 |
肝 |
肾脏 |
心 |
胸腺 |
脾 |
睾丸或子宫 |
附睾或卵巢 |
肾上腺 |
甲状腺 |
|
| 男性 |
|
| 控制() |
的意思是 |
19608.6 |
465.49 |
105.54 |
52.99 |
19.90 |
32.71 |
161.64 |
75.55 |
3.58 |
1.29 |
| SD |
1278.39 |
59.62 |
8.82 |
3.84 |
4.61 |
4.51 |
12.20 |
9.17 |
0.51 |
0.23 |
| 180 () |
的意思是 |
19285.0 |
492.44 |
108.86 |
52.07 |
18.44 |
35.34 |
160.22 |
75.51 |
3.39 |
1.03 |
| SD |
759.63 |
40.09 |
8.86 |
8.62 |
3.60 |
3.05 |
11.73 |
7.23 |
0.64 |
0.22 |
| ±% |
−1.7 |
6 |
3 |
−2 |
−7 |
8 |
−1 |
0 |
−5 |
−20 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 300 () |
的意思是 |
18700.4 |
467.55 |
110.87 |
56.86 |
15.45 |
37.96 |
127.31 |
64.29 |
4.04 |
0.97 |
| SD |
1910.29 |
48.08 |
13.13 |
7.56 |
3.34 |
6.61 |
32.03 |
6.09 |
0.64 |
0.23 |
| ±% |
−5 |
0 |
5 |
7 |
−22 |
16 |
−21 |
−15 |
13 |
−25 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 375 () |
的意思是 |
18314.2 |
460.80 |
107.34 |
60.39 |
14.59 |
34.75 |
68.41 |
55.41 |
4.52 |
1.14 |
| SD |
1352.12 |
35.16 |
7.32 |
10.94 |
2.47 |
5.35 |
31.26 |
5.53 |
0.45 |
0.18 |
| ±% |
−7 |
−1 |
2 |
14 |
−27 |
6 |
−58 |
−27 |
26 |
−12 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
|
| 女性 |
|
| 控制() |
的意思是 |
12466.2 |
341.455 |
82.693 |
42.583 |
21.197 |
28.267 |
34.109 |
8.473 |
4.554 |
1.056 |
| SD |
957.28 |
37.492 |
10.797 |
3.797 |
2.917 |
5.757 |
5.119 |
1.847 |
0.652 |
0.183 |
| 180 () |
的意思是 |
12062.5 |
368.27 |
78.98 |
38.14 |
18.71 |
31.46 |
43.10 |
7.66 |
4.20 |
1.10 |
| SD |
591.84 |
25.74 |
4.94 |
3.23 |
2.17 |
4.83 |
12.09 |
1.39 |
0.78 |
0.23 |
| ±% |
−3 |
8 |
−4 |
−10 |
−12 |
11 |
26 |
−10 |
−8 |
4 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 300 () |
的意思是 |
12642.0 |
356.58 |
78.94 |
46.31 |
16.71 |
30.83 |
29.21 |
7.48 |
4.63 |
1.10 |
| SD |
863.82 |
20.88 |
4.51 |
4.30 |
2.80 |
3.60 |
8.44 |
1.66 |
0.77 |
0.23 |
| ±% |
1 |
4 |
−5 |
9 |
−21 |
9 |
−14 |
−12 |
2 |
4 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 375 () |
的意思是 |
12643.1 |
365.80 |
79.19 |
48.41 |
15.81 |
31.17 |
29.31 |
7.69 |
4.84 |
1.13 |
| SD |
1076.51 |
40.84 |
6.37 |
6.57 |
3.62 |
5.39 |
9.33 |
1.45 |
0.85 |
0.25 |
| ±% |
1 |
7 |
−4 |
14 |
−25 |
10 |
−14 |
−9 |
6 |
7 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
|
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±%,百分比偏差与控制、毫克/公斤体重/天,毫克每千克体重每天;SD,标准偏差;党卫军,统计学意义;动物的数量。
< 0.05;< 0.01。
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