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Stem Cells International
Stem Cells International/2020/Article/Fig 8

Research Article

Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in ProtectingβCells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice

Figure 8

Schematic diagram of the effect of human umbilical cord-derived- (UC-) mesenchymal stem cells (MSCs) combined with decitabine (DAC) on T2D mice. The accumulation of proinflammatory M1 macrophages resulted inβ-cell dysfunction and impaired glucose homeostasis in T2D. UC-MSCs combined with DAC induced sustained macrophage polarization towards M2 via the PI3K/AKT signaling pathway, leading to prolongedβ-cell restoration and improvement of glucose homeostasis.

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