|
|
南非 |
塞内加尔 |
| 基因型 |
白色 |
混合 |
黑色的 |
结合 |
塞内加尔 |
| 基因 |
控制
（4） |
情况下
（） |
控制(） |
情况下
（） |
控制(） |
情况下
（） |
控制(） |
情况下
（） |
‡控制(） |
‡情况下
（） |
|
| CYP3A4(rs2740574) |
|
|
|
|
|
|
|
|
|
|
| AA |
122
(91.0%) |
84
(70.0%) |
117例(70.1%) |
82例(39.6%) |
2
(10.0%) |
9
(36.0%) |
241例(75.1%) |
175例(49.7%) |
21
(7.5%) |
6
(7.1%) |
| AG) |
12
(9.0%) |
34 (28.3%) |
49 (29.3%) |
111例(53.6%) |
15 (75.0%) |
16 (64.0%) |
76例(23.7%) |
161例(45.7%) |
91例(32.3%) |
40 (47.6%) |
| GG |
0
(0%) |
2
(1.7%) |
1
(0.6%) |
14
(6.8%) |
3.
(15.0%) |
0
(0%) |
4
(1.2%) |
16
(4.6%) |
170例(60.3%) |
38 (45.2%) |
|
| CYP3A5(rs776746) |
|
|
|
|
|
|
|
|
|
|
| GG |
113例(84.3%) |
95例(79.2%) |
58 (34.7%) |
58 (28.0%) |
1
(5.0%) |
1
(4.0%) |
172例(53.6%) |
154例(43.8%) |
14
(5.3%) |
4
(5.1%) |
| AG) |
18 (13.4%) |
22 (18.3%) |
72例(43.1%) |
106例(51.2%) |
5
(25.0%) |
5
(20.0%) |
95例(29.6%) |
133例(37.8%) |
66例(25.1%) |
20 (25.3%) |
| AA |
3.
(2.3%) |
3.
(2.5%) |
37 (22.2%) |
43 (20.8%) |
14 (70.0%) |
19 (76.0%) |
54 (16.8%) |
65例(18.4%) |
183例(69.6%) |
55 (69.6%) |
|
| SRD5A2V89L (rs523349) |
|
|
|
|
|
|
|
|
|
|
| GG |
56 (41.8%) |
61例(50.8%) |
96例(57.5%) |
131例(63.3%) |
5
(25.0%) |
16 (64.0%) |
157例(48.9%) |
208例(59.1%) |
26 (12.2%) |
10 (14.1%) |
| CG |
70例(52.2%) |
51 (42.5%) |
65例(38.9%) |
71例(34.3%) |
7
(35.0%) |
7
(28.0%) |
142例(44.2%) |
129例(36.6%) |
61例(28.5%) |
10 (14.1%) |
| CC |
8
(6.0%) |
8
(6.7%) |
6
(3.6%) |
5
(2.4%) |
8
(40.0%) |
2
(8.0%) |
22
(6.9%) |
15
(4.3%) |
127例(59.4%) |
51 (71.8%) |
|
| SRD5A2A49T (rs9282858) |
|
|
|
|
|
|
|
|
|
|
| GG |
107例(79.8%) |
90例(75.0%) |
127例(76.0%) |
120例(58.0%) |
10 (50.0%) |
17 (68.0%) |
244例(76.0%) |
227例(64.5%) |
278例(100.0%) |
75例(100.0%) |
| 遗传算法 |
27 (20.2%) |
30 (25.0%) |
40 (24.0%) |
87例(42.0%) |
10 (50.0%) |
8
(32.0%) |
77例(24.0%) |
125例(35.5%) |
0
(0%) |
0
(0.0%) |
|
|
