研究文章
特定的氧化还原生物标志物和年龄之间的联系欧洲大型队列:MARK-AGE项目
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() |
RASIG () |
() |
SGO () |
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| 抗氧化剂 |
| 抗坏血酸(毫克/升) |
4.41 (4.26;4.58) |
4.13 (3.91;4.36) |
4.73 (4.44;5.02)‡ |
4.70 (4.33;5.08)‡ |
0.002 |
| 调整后的漠视2 |
|
4.32 (4.13;4.52) |
4.17 (3.87;4.49) |
3.85 (3.32;4.41) |
0.258 |
| 尿酸(毫克/升) |
45.9 (45.3;46.5) |
45.7 (44.9;46.5) |
45.3 (44.2;46.3) |
47.4 (46.0;48.8)◊ |
0.047 |
| 调整后的漠视2 |
|
45.4 (44.6;46.1) |
46.0 (44.7;47.2) |
47.0 (44.7;49.3) |
0.341 |
| 总半胱氨酸(μ摩尔/升) |
148.2 (146.6;149.8) |
144.8 (142.5;147.1) |
150.8 (147.9;153.6)‡ |
153.3 (149.3;157.3)‡ |
< 0.001 |
| 调整后的漠视2 |
|
144.2 (141.8;146.6) |
149.6 (145.7;153.4)‡ |
145.5 (138.4;152.6) |
0.072 |
| 总谷胱甘肽(μ摩尔/升) |
1100 (1091;1110) |
1088 (1074;1102) |
1110 (1093;1127) |
1120 (1099;1141)‡ |
0.024 |
| 调整后的漠视2 |
|
1092 (1077;1106) |
1112 (1089;1135) |
1149 (1106;1193)‡ |
0.025 |
| 番茄红素(μ摩尔/升) |
0.574 (0.556;0.592) |
0.631 (0.604;0.659) |
0.525 (0.497;0.554)‡ |
0.503 (0.464;0.543)‡ |
< 0.001 |
| 调整后的漠视2 |
|
0.608 (0.583;0.635) |
0.566 (0.526;0.606) |
0.539 (0.470;0.613) |
0.069 |
| α生育酚(μ摩尔/升) |
28.8 (28.4;29.2) |
27.8 (27.3;28.3) |
30.1 (29.4;30.8)‡ |
29.6 (28.6;30.5)‡ |
< 0.001 |
| 调整后的漠视2 |
|
27.9 (27.4;28.5) |
29.3 (28.4;30.3)‡ |
29.9 (28.2;31.7)‡ |
0.005 |
| 氧化应激生物标志物 |
| 蛋白质羰基(nmol /毫克) |
0.577 (0.573;0.582) |
0.595 (0.590;0.601) |
0.558 (0.551;0.566)‡ |
0.561 (0.552;0.571)‡ |
< 0.001 |
| 调整后的漠视2 |
|
0.591 (0.585;0.597) |
0.566 (0.557;0.575)‡ |
0.564 (0.547;0.581)‡ |
< 0.001 |
| 3-Nitrotyrosine (pmol /毫克) |
4.11 (3.97;4.25) |
3.94 (3.75;4.13) |
4.40 (4.14;4.67)‡ |
4.10 (3.77;4.44) |
0.018 |
| 调整后的漠视2 |
|
3.90 (3.70;4.11) |
4.38 (4.03;4.74)‡ |
3.76 (3.18;4.38) |
0.048 |
| 丙二醛(μ摩尔/升) |
0.316 (0.306;0.326) |
0.336 (0.322;0.350) |
0.284 (0.266;0.302)‡ |
0.317 (0.290;0.346) |
< 0.001 |
| 调整后的漠视2 |
|
0.334 (0.319;0.348) |
0.288 (0.267;0.311)‡ |
0.314 (0.274;0.357) |
0.004 |
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1几何平均数(95% CI)。2调整一般线性模型(GLM):单变量一般线性模型调整年龄、体重指数、吸烟状况、性别、和国家(中心)。‡RASIG统计上的显著差异。◊统计上的显著差异。价值观:统计上显著的差异是由单向方差分析与图基的事后考验和费舍尔的最小显著差事后考验的漠视。
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