透射电镜(TEM)分析线粒体重塑inMSCs挑战与有限合伙人。(一)控制MSC的形象。线粒体是用黄色箭头指示。((b) - (f))的图像与LPS msc的挑战。(b)受损的线粒体进行重构和mitophagy与红色箭头所示。双层膜的自溶酶体用白色箭头指示。太,线粒体。((c) - (d))受损的线粒体的融合(Mt)和自噬体(ATG)用红色箭头指示。ATG膜有白色的箭头表示。(d)分泌自吞噬泡的形成包含multilamellar结构(红色箭头)辐照MSC。 (e) Fusion of mitochondria (Mt) is indicated with yellow arrow. (f) Formation of elongated mitochondria is indicated with white arrow. Mitophagy is indicated with red arrow. Conditions: MSCs were incubated with 500 ng/mL LPS for 3 h. The cells were analyzed 24 h after challenge with LPS.