实验的时间表(a)环丙甲羟二羟吗啡酮拮抗U50,488-induced复职。大鼠()被训练服用乙醇,然后按压杆被扑灭。灭绝后,老鼠使用环丙甲羟二羟吗啡酮(3.0毫克/公斤,南卡罗来纳州。)或生理盐水测试前30分钟。老鼠被注射U50,488(0.1 - -1.0毫克/公斤,i.p)或生理盐水测试前10分钟。测试会话进行每3 - 4天,老鼠经历灭绝会话之间的日常测试的日子。(b)实验的时间表nor-BNI U50,488-induced拮抗复职。稳定的自治水平恢复后(a)中所描述的实验,然后熄灭。灭绝后,老鼠使用单一注射生理盐水。24 h后老鼠注射U50,488(0.1 - -1.0毫克/公斤,i.p)或生理盐水测试前10分钟。测试会话重复每3 - 4天与老鼠经历灭绝会话之间的日常测试的日子。毕竟剂量的U50,488测试、老鼠都被赋予了一项单一的注入nor-BNI(20毫克/公斤,i.p)。 24 h later, rats were injected with U50,488 (0.1–1.0 mg/kg, i.p.) or saline 10 minutes prior to testing. Test sessions were repeated every 3-4 days with rats experiencing extinction sessions daily between test days.