生物标志物的诊断和预测结果的对比感应肾病

表2

生物标志物特征在CIN +和CIN−参与者在不同的时间点。


变量	CIN + (n= 30)	CIN−(n= 60)	价值

sNGAL_p (ng / ml)	100.31 (64.28 - -142.01)	74.33 (43.97 - -127.99)	0.34
sNGAL_24 (ng / ml)	99.61 (72.26 - -135.98)	78.42 (51.12 - -107.00)	0.07
sNGAL_48 (ng / ml)	83.81 (57.90 - -109.05)	60.91 (37.36 - -100.71)	0.13
sNGAL_5 (ng / ml)	96.20 (74.48 - -156.66)	65.77 (51.94 - -72.44)	0.06
uNGAL_p (ng / ml)	88.4 (39.3 - -366.2)	34.1 (17.2 - -62.2)	0.02
uNGAL_24 (ng / ml)	40.1 (33.1 - -96.9)	46.5 (28.5 - -100.6)	0.72
uNGAL_48 (ng / ml)	39.4 (22.1 - -100.9)	49.5 (14.2 - -98.3)	0.96
sCystatin C_ p (ng / ml)	711.45 (550.08 - -934.10)	687.41 (566.61 - -769.76)	0.25
sCystatin C_24 (ng / ml)	856.59 (620.75 - -1002.96)	617.42 (533.11 - -805.20)	< 0.01
sCystatin C_48 (ng / ml)	764.32 (560.28 - -1010.71)	572.13 (461.67 - -708.11)	0.01
sCystatin C_5 (ng / ml)	811.52 (708.54 - -986.12)	596.14 (534.56 - -684.38)	0.01
uCystatin C_p (ng / ml)	53.7 (32.0 - -412.1)	49.4 (13.6 - -170.0)	0.38
uCystatin C_24 (ng / ml)	107.8 (64.3 - -157.7)	95.9 (27.0 - -193.9)	0.82
uCystatin C_48 (ng / ml)	47.8 (16.6 - -166.8)	43.5 (17.7 - -132.5)	0.87
sIL18_p (pg / ml)	170.41 (105.19 - -327.4)	123.73 (65.87 - -178.2)	0.13
sIL18_24 (pg / ml)	152.32 (92.905 - -279.62)	122.36 (82.45 - -256.6)	0.40
sIL18_48 (pg / ml)	137.62 (100.965 - -285.14)	95.75 (73 - 165.59)	0.06
sIL18_5 (pg / ml)	133.385 (122.36 - -395.75)	131.93 (70.82 - -294.91)	0.64
uIL18_p (pg / ml)	102.8 (55.3 - -185.6)	76.8 (33.2 - -189.0)	0.38
uIL18_24 (pg / ml)	145.1 (22.6 - -326.2)	131.0 (50.7 - -262.4)	0.97
uIL18_48 (pg / ml)	125.1 (50.2 - -348.7)	124.6 (57.0 - -372.6)	0.92
年代β2 m_p (μg / ml)	4.4 (3.8 - -7.8)	3.8 (3.2 - -4.9)	0.04
年代β2 m_24 (μg / ml)	4.55 (3.9 - -7.55)	3.7 (2.9 - -4.8)	0.01
年代β2 m_48 (μg / ml)	5.1 (3.8 - -6.9)	3.3 (2.7 - -4.5)	< 0.001
年代β2 m_5 (μg / ml)	12.1 (4.4 - -16.4)	3.7 (3.1 - -4.9)	0.01
sTNFα_p (pg / ml)	4.87 (4.15 - -9.12)	4.6 (2.65 - -5.95)	0.12
sTNFα大于(pg / ml)	5.3 (4.15 - -6.7)	5.23 (3.43 - -7.39)	0.94
sTNFα_48 (pg / ml)	5.9 (4.6 - -6.7)	4.29 (2.6 - -7.04)	0.06
sTNFα_5 (pg / ml)	4.3 (3.43 - -5.23)	6.315 (4.26 - -8.26)	0.22
sIL10_p (pg / ml)	4.94 (4.5 - -11.3)	4.1 (2.59 - -5.4)	0.19
sIL10_24 (pg / ml)	4 (3.4 - -5.5)	3.9 (2.6 - 5)	0.45
sIL10_48 (pg / ml)	4.6 (3.7 - -9.2)	3.4 (2 - 4.5)	0.10
sIL10_5 (pg / ml)	9.5 (9.5 - -9.5)	4.2 (3.24 - -19.4)	0.51
uKIM_p (pg / ml)	108.1 (39.9 - -1593.2)	39.9 (12.2 - -274.6)	0.21
uKIM_24 (pg / ml)	144.0 (39.9 - -1343.0)	91.6 (12.2 - -196.8)	0.26
uKIM_48 (pg / ml)	160.2 (45.8 - -303.5)	91.6 (12.2 - -274.5)	0.34

CIN−, CIN缺席;CIN +, CIN礼物;sNGAL uNGAL,血清和尿中性粒细胞gelatinase-associated lipocalin;sIL18 uIL18,血清尿白介素18;年代β2 m,血清β2微球蛋白;sTNFα血清肿瘤坏死因子α;uKIM1,尿肾损伤分子1在不同的时间点。

国际肾脏病学会杂志

生物标志物的诊断和预测结果的对比感应肾病

表2