研究文章
肝脏葡糖激酶A456V引发的低血糖没有血脂异常通过矛盾归纳Glucose-6-Phosphatase催化亚基的
表1
STZ-diabetic老鼠的肝脏代谢产物与pControl转染,pGK pGKA456V。
|
|
美联储 |
5 h-Fasted |
| pControl |
pGK |
pGKA456V |
pControl |
pGK |
pGKA456V |
|
| 相关(μ摩尔/ g肝脏) |
40.70±5.921 |
32.72±1.475 |
47.68±7.328 |
52.29±9.524 |
32.23±12.18 |
6.35±4.043 * |
|
|
|
|
|
|
|
| G6P (μ摩尔/ g肝脏) |
0.16±0.021 |
0.14±0.018 |
0.15±0.021 |
0.06±0.024 |
0.20±0.068§ |
0.04±0.017 |
|
|
|
|
|
|
|
| F2 6 bp (nmol / g肝脏) |
1.19±0.215 |
2.84±0.625 * |
1.90±0.517 |
0.71±0.173 |
9.86±1.812§ |
4.14±1.607 |
|
|
|
|
|
|
|
| 乳酸(μ摩尔/ g肝脏) |
1.31±0.275 |
1.78±0.424 |
2.27±0.951 |
1.16±0.239 |
1.28±0.322 |
1.32±0.222 |
|
|
|
|
|
|
|
| 标签(毫克/克肝) |
6.25±0.26 |
6.08±0.36 |
6.26±0.17 |
9.18±1.48 |
12.56±0.50 |
11.84±2.13 |
|
|
|
|
|
|
|
| 谷胱甘肽(GSSG比率 |
11.73±0.87 |
11.81±0.93 |
11.37±0.87 |
5.372±0.49 |
9.479±1.38 |
9.926±1.84 * |
|
|
|
|
|
|
|
|
|
数据意味着±SE。(-12)。*而其pControl,§
与pGK快速pControl和快A456V。
|
