基于磁共振肠成像模式的克罗恩病患者管理的变化

表1

基于磁共振小肠造影的患者特征及疾病分层。


基线特征	所有患者( ）	炎症性模式( ）	穿透模式( ）	Fibrostenosing模式( ）	混合模式( ）	没有异常( ）	价值

年龄、中值(年)	45.5 (33.7 -58)	45.5 (38.2 - -59.3)	56 (16)	51 (45)	51 (-58 - 30.2)	41 (23-55)	0.154
疾病持续时间(年)	7.5 (4.7 - -15.3)	5.0 (3.7 -15)	6.0 (0 -)	14.5 (12)	9.5 (5.2 - -21.5)	6.0 (3 - 10)	0.091
女性	41 (55.4%)	7 (50.0%)	1 (33.3%)	2 (100.0%)	21 (58.3%)	10 (52.6%)	0.781
诊断年龄(岁)
A1 (< 17)	6 (8.1%)	0 (0.0%)	1 (33.3%)	0 (0.0%)	1 (2.8%)	4 (21.1%)	0.350
A2 (17-40)	42 (56.8%)	9 (64.3%)	0 (0.0%)	2 (100.0%)	23 (63.9%)	8 (42.1%)
A3 (> 40)	26 (35.1%)	5 (35.7%)	2 (66.7%)	0 (0.0%)	12 (33.3%)	7 (36.8%)
行为
B1(炎症)	22 (29.7%)	7 (50.0%)	0 (0.0%)	0 (0.0%)	6 (16.7%)	9 (47.4%)	0.109
B2(狭窄)	22 (29.7%)	4 (28.6%)	0 (0.0%)	2 (100.0%)	12 (33.3%)	4 (21.1%)
B3(渗透)	30 (40.5%)	3 (21.4%)	3 (100.0%)	0 (0.0%)	18 (50.0%)	6 (31.6%)
位置
L1(回肠)	18 (24.3%)	4 (28.6%)	0 (0.0%)	1 (50.0%)	9 (25.0%)	4 (21.1%)	0.452
L2(结肠)	13 (17.6%)	1 (7.1%)	1 (33.3%)	0 (0.0%)	4 (11.1%)	7 (36.8%)
L3 (ileocolonic)	43 (58.1%)	9 (64.3%)	2 (66.7%)	1 (50.0%)	23 (63.9%)	8 (42.1%)
肛周疾病	16 (21.6%)	3 (21.4%)	3 (100.0%)	0 (0.0%)	7 (19.4%)	3 (15.8%)	0.481
近端疾病	6 (8.1%)	1 (7.1%)	0 (0.0%)	0 (0.0%)	4 (11.1%)	1 (5.3%)	0.604
以前的手术	27 (36.5%)	4 (28.6%)	0 (0.0%)	0 (0.0%)	13 (36.1%)	10 (52.6%)	0.092
EIM	14 (18.9%)	1 (7.1%)	2 (66.7%)	1 (50.0%)	9 (25.0%)	1 (5.3%)	0.080
吸烟史	13 (17.6%)	2 (14.2%)	0 (0.0%)	0 (0.0%)	6 (16.7%)	5 (26.3%)	0.251
HBI
活动	28 (37.8%)	6 (42.9%)	1 (33.3%)	1 (50.0%)	16 (44.4%)	4 (21.1%)	0.082
缓解	46 (62.2%)	8 (57.1%)	2 (66.7%)	1 (50.0%)	20 (55.6%)	15 (78.9%)
CRP(毫克/升)	2.8 (1.4 - -5.5)	2.6 (1.3 - -3.0)	1.1 (1.0 -)	4.3 (4.3 -)	3.6 (2.1 - -6.0)	2.3 (0.5 - -16.3)	0.772
ESR(毫米/小时)	28 (16-41)	37 (20-56)	(17 - 25日)	41 (41)	28日(15 - 40)	19日(10 - 35)	0.467
血红蛋白(g / dL)	13.0 (11.5 - -13.7)	12.1 (9.8 - -13.3)	12.5(11岁)	13.0 (13.0 -)	12.9 (11.5 - -13.8)	13.3 (12.8 - -13.8)	0.205
Calprotectin (μg / g)	177年(83 - 492)	201年(110 - 299)	55 (30)	72 (72 -)	299年(98 - 997)	100 (20 - 180)	0.238
结肠镜检查成绩
SES-CD ( ）	4 (1 - 10)	3.5 (1 - 11.3)	9 (2 -)	5 (4 -)	6.5 (1.0 - -12.3)	3.5 (0 - 7.8)	0.297
Rutgeerts评分( ）	1 (0 - 3)	2 (0.25 - -3.0)	- - - - - -	- - - - - -	2 (0 - 3.0)	0 (0 - 2.5)	0.390
治疗
IMM只	47 (63.5%)	10 (71.4%)	3 (100.0%)	2 (100.0%)	21 (58.3%)	11 (57.9%)	0.561
生物制剂(±IMM)	27 (36.5%)	4 (28.6%)	0 (0.0%)	0 (0.0%)	15 (41.7%)	8 (42.1%)
变更的管理	31 (41.9%)	6 (42.9%)	3 (100.0%)	0 (0.0%)	21 (58.3%)	1 (5.3%)	< 0.001

值以四分位区间或as的中位数表示百分比;EIM: extraintestinal表现;HBI:哈维和布拉德肖指数;CRP: c反应蛋白;ESR:红细胞沉降率;SES-CD:克罗恩病的内镜评分系统;方法:免疫调制剂。

胃肠病学研究与实践

基于磁共振肠成像模式的克罗恩病患者管理的变化

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