表3
的等位优势比和95% CI的比较IL-12B具有IBD表型的小等位基因的变异携带。
| (一) |
|
|
IL-12Brs1363670 |
IL-12Brs6887695 |
|
或(95%置信区间) |
价值 |
或(95%置信区间) |
价值 |
|
| 性别 |
|
|
|
|
| 女 |
1.54 (0.96 - -2.46) |
0.086 |
0.79 (0.57 - -1.10) |
.178 |
| 男性 |
0.85 (0.51 - -1.42) |
0.608 |
0.93 (0.66 - -1.32) |
.725 |
|
| 初诊年龄 |
|
|
|
|
| 约年 |
1.41 (0.69 - -2.89) |
0.317 |
0.76 (0.42 - -1.37) |
.394 |
| 17-40年 |
1.28 (0.90 - -1.81) |
0.175 |
0.92 (0.71 - -1.19) |
.513 |
| > 40年 |
0.84 (0.43 - -1.63) |
0.747 |
0.73 (0.46 - -1.15) |
.184 |
|
| CD位置 |
|
|
|
|
| 结肠 |
1.16 (0.71 - -1.89) |
0.523 |
0.94 (0.66 - -1.34) |
.790 |
| 肠阻塞的 |
1.39 (0.89 - -2.16) |
0.153 |
0.55 (0.38 - -0.80) |
.002 |
| Ileocolonic |
1.11 (0.68 - -1.80) |
0.703 |
1.26 (0.89 - -1.79) |
.206 |
|
| CD的行为 |
|
|
|
|
| 炎症 |
1.23 (0.84 - -1.81) |
0.313 |
0.83 (0.62 - -1.11) |
.220 |
| 穿透 |
0.46 (0.16 - -1.30) |
0.161 |
1.06 (0.61 - -1.83) |
.888 |
| 狭窄 |
1.60 (1.01 - -2.53) |
0.055 |
0.85 (0.59 - -1.23) |
.408 |
| 结肠/炎症 |
1.16 (0.69 - -1.96) |
0.580 |
0.82 (0.56 - -1.21) |
.332 |
| 回肠/狭窄 |
1.86 (1.08 - -3.20) |
0.036 |
0.58 (0.35 - -0.96) |
.035 |
| 有没有亲属患有炎症性肠病 |
1.43 (0.91 - -2.25) |
0.137 |
0.96 (0.68 - -1.36) |
.859 |
| 肠切除 |
1.22 (0.77 - -1.92) |
0.401 |
0.91 (0.65 - -1.28) |
.609 |
| 吸烟者在诊断 |
1.47 (0.79 - -2.74) |
0.282 |
0.91 (0.60 - -1.39) |
.668 |
| 任何eim |
1.33 (0.73 - -2.42) |
0.327 |
1.1 (0.70 - -1.74) |
.724 |
|
|
| (b) |
|
|
IL23Rrs10889677 |
IL23Rrs11209026 |
IL23Rrs11805303 |
IL23Rrs1343151 |
IL23Rrs7517847 |
|
或(95%置信区间) |
|
或(95%置信区间) |
|
或(95%置信区间) |
|
或(95%置信区间) |
|
或(95%置信区间) |
|
|
| 性别 |
|
|
|
|
|
|
|
|
|
|
| 女 |
0.93 (0.67 - -1.29) |
0.739 |
0.57 (0.31 - -1.05) |
0.086 |
1.24 (0.89 - -1.73) |
0.210 |
0.67 (0.48 - -0.94) |
0.024 * |
0.79 (0.57 - -1.09) |
.144 |
| 男性 |
0.75 (0.53 - -1.05) |
0.113 |
0.51 (0.23 - -1.16) |
0.119 |
1.32 (0.93 - -1.86) |
0.129 |
0.67 (0.47 - -0.96) |
0.028 * |
0.69 (0.49 - -0.97) |
.041 * |
| 初诊年龄 |
|
|
|
|
|
|
|
|
|
|
| 约年 |
0.60 (0.35 - -1.02) |
0.064 |
0.24 (0.03 - -1.75) |
0.175 |
1.56 (0.90 - -2.69) |
0.110 |
0.41 (0.21 - -0.80) |
0.007 * |
0.63 (0.36 - -1.10) |
.105 |
| 17-40年 |
0.81 (0.63 - -1.05) |
0.116 |
0.61 (0.36 - -1.04) |
0.073 |
1.32 (1.02 - -1.70) |
0.041 |
0.62 (0.47 - -0.81) |
0.0006 * |
0.65 (0.50 - -0.84) |
.0008 * |
| > 40年 |
0.76 (0.49 - -1.17) |
0.216 |
0.73 (0.29 - -1.84) |
0.675 |
1.34 (0.87 - -2.08) |
0.205 |
0.84 (0.54 - -1.31) |
0.506 |
0.91 (0.60 - -1.38) |
.750 |
|
| CD位置 |
|
|
|
|
|
|
|
|
|
|
| 结肠 |
0.80 (0.57 - -1.13) |
0.211 |
0.69 (0.33 - -1.45) |
0.406 |
1.27 (0.90 - -1.80) |
0.202 |
0.79 (0.55 - -1.13) |
0.210 |
1.04 (0.74 - -1.45) |
.864 |
| 肠阻塞的 |
0.77 (0.55 - -1.07) |
0.140 |
0.68 (0.34 - -1.38) |
0.346 |
1.40 (1.00 - -1.95) |
0.055 |
0.68 (0.48 - -0.97) |
0.037 * |
0.62 (0.44 - -0.87) |
.005 * |
| Ileocolonic |
0.76 (0.54 - -1.08) |
0.123 |
0.34 (0.12 - -0.94) |
0.026 |
1.38 (0.97 - -1.96) |
0.080 |
0.43 (0.28 - -0.65) |
0.00004 * |
0.52 (0.36 - -0.75) |
.0003 * |
|
| CD的行为 |
|
|
|
|
|
|
|
|
|
|
| 炎症 |
0.78 (0.59 - -1.03) |
0.096 |
0.73 (0.42 - -1.28) |
0.296 |
1.31 (0.99 - -1.74) |
0.067 |
0.69 (0.51 - -0.93) |
0.013 * |
0.82 (0.62 - -1.08) |
.165 |
| 穿透 |
0.76 (0.45 - -1.29) |
0.333 |
0.23 (0.03 - -1.68) |
0.179 |
1.40 (0.82 - -2.39) |
0.255 |
0.38 (0.20 - -0.74) |
0.003 * |
0.53 (0.30 - -0.92) |
.025 * |
| 狭窄 |
0.76 (0.53 - -1.09) |
0.136 |
0.35 (0.13 - -0.97) |
0.037 |
1.47 (1.03 - -2.10) |
0.040 |
0.60 (0.40 - -0.89) |
0.014 * |
0.56 (0.39 - -0.81) |
.002 * |
结肠/ 炎症 |
0.80 (0.55 - -1.16) |
0.243 |
0.63 (0.27 - -1.47) |
0.363 |
1.26 (0.86 - -1.84) |
0.274 |
0.76 (0.51 - -1.13) |
0.206 |
1.05 (0.73 - -1.51) |
.852 |
| 回肠/狭窄 |
0.80 (0.51 - -1.26) |
0.345 |
0.30 (0.07 - -1.24) |
0.082 |
1.54 (0.98 - -2.41) |
0.072 |
0.69 (0.42 - -1.13) |
0.155 |
0.59 (0.37 - -0.94) |
.032 * |
| 有没有亲属患有炎症性肠病 |
0.89 (0.63 - -1.26) |
0.529 |
0.49 (0.21 - -1.14) |
0.099 |
1.22 (0.86 - -1.73) |
0.278 |
0.62 (0.43 - -0.90) |
0.015 * |
0.64 (0.45 - -0.90) |
.013 * |
| 肠切除 |
0.78 (0.56 - -1.08) |
0.145 |
0.36 (0.14 - -0.90) |
0.024 * |
1.33 (0.96 - -1.85) |
0.101 |
0.61 (0.43 - -0.87) |
0.008 * |
0.54 (0.38 - -0.76) |
.0004 * |
| 吸烟者在诊断 |
0.88 (0.57 - -1.37) |
0.578 |
0.60 (0.28 - -1.29) |
0.192 |
0.96 (0.62 - -1.49) |
0.911 |
0.75 (0.48 - -1.16) |
0.219 |
0.98 (0.65 - -1.48) |
1.00 |
| 任何eim |
0.64 (0.41 - -1.00) |
0.057 |
0.32 (0.08 - -1.32) |
0.116 |
1.46 (0.93 - -2.30) |
0.116 |
0.52 (0.31 - -0.88) |
0.016 * |
0.65 (0.41 - -1.03) |
.069 |
|
|
*使用FDR进行多次测试校正后仍然具有重要意义。
|