表2
基因型和等位基因计数IL-12B和IL-23R在CD患者和白人控制的变体。
|
|
|
控制(%) |
案件(%) |
OR(95%CI) |
|
|
| IL-12B |
C / C |
10(2.9) |
11(3.6) |
1.30(0.54-3.12) |
0.638 |
| rs1363670 |
C / G |
71(20.8) |
70(23.3) |
1.17(0.80-1.70) |
|
|
G / G |
260(76.3) |
220(73.1) |
1.00 |
|
|
HWE |
0.10 |
0.08 |
|
|
|
科克伦 - Armitage趋势对于G |
, |
0.172 |
|
|
|
C |
91(13.3) |
92(15.3) |
1.17(0.86-1.60) |
0.338 |
|
G |
591(86.7) |
510(84.7) |
1.00 |
|
|
| IL-12B |
C / C |
39(10.8) |
29(9.2) |
0.79(0.47-1.35) |
.625 |
| rs6887695 |
C / G |
177(48.9) |
148(47.1) |
0.89(0.65-1.23) |
|
|
G / G |
146(40.3) |
137(43.6) |
1.00 |
|
|
HWE |
0.21 |
0.25 |
|
|
|
C |
255(35.2) |
206(32.8) |
0.90(0.72-1.13) |
0.358 |
|
G |
469(64.8) |
422(67.2) |
1.00 |
|
|
| IL-23R |
A / A |
45(12.5) |
37(11.8) |
1.18(0.72-1.93) |
0.030 |
| rs10889677 |
的A / C |
146(40.6) |
158(50.5) |
1.55(1.12-2.15) |
|
|
C / C |
169(46.9) |
118(37.7) |
1.00 |
|
|
HWE |
0.15 |
0.18 |
|
|
|
一个 |
236(32.8) |
232(37.1) |
1.21(0.96-1.52) |
.100 |
|
C |
484(67.2) |
394(62.9) |
1.00 |
|
|
| IL-23R |
A / A |
5(0.8) |
0(0) |
- |
|
| rs11209026 |
A / G |
75(11.9) |
28(8.0) |
0.64(0.41-1.01) |
0.164 |
|
G / G |
553(87.4) |
321(92.0) |
1.00 |
|
|
HWE |
0.19 |
1.00 |
|
|
|
科克伦 - Armitage趋势对于G |
, |
0.008 |
|
|
|
一个 |
85(6.7) |
28(4.0) |
0.58(0.37-0.90) |
0.015 |
|
G |
1181(93.3) |
670(96.0) |
1.00 |
|
|
| IL-23R |
C / C |
173(47.3) |
123(39.3) |
1.00 |
0.108 |
| rs11805303 |
C / T |
158(43.2) |
153(48.9) |
1.36(0.99-1.88) |
|
|
T / T |
35(9.6) |
37(11.8) |
1.49(0.89-2.49) |
|
|
HWE |
1.00 |
0.33 |
|
|
|
Ť |
228(31.1) |
227(36.3) |
1.26(1.01-1.58) |
.049 |
|
C |
504(68.9) |
399(63.7) |
1.00 |
|
|
| IL-23R |
A / A |
56(15.2) |
16(5.1) |
0.29(0.16-0.53) |
0.0002 |
| rs1343151 |
A / G |
154(41.7) |
142(45.4) |
0.95(0.69-1.30) |
|
|
G / G |
159(43.1) |
155(49.5) |
1.00 |
|
|
HWE |
0.07 |
0.02 |
|
|
|
科克伦 - Armitage趋势对于G |
, |
0.0006 |
|
|
|
一个 |
266(36.0) |
174(27.8) |
0.68(0.54-0.86) |
0.001 |
|
G |
472(64.0) |
452(72.2) |
1.00 |
|
|
| IL-23R |
G / G |
72(19.6) |
29(9.4) |
0.42(0.25-0.70) |
0.001 |
| rs7517847 |
G / T |
183(49.7) |
172(55.7) |
0.98(0.70-1.38) |
|
|
T / T |
113(30.7) |
108(34.9) |
1.00 |
|
|
HWE |
0.92 |
0.001 |
|
|
|
G |
327(44.4) |
230(37.2) |
0.74(0.59-0.92) |
0.007 |
|
Ť |
409(55.6) |
388(62.8) |
1.00 |
|
|
|