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结核分枝杆菌新一代全基因组测序:机遇和挑战
|
| 药物 |
轨迹 |
阻力所占百分比突变 |
引用 |
|
| 利福平 |
rpoB |
96% |
(28] |
| 异烟肼 |
韩国仁荷,katG ahpC-oxyR |
84% |
(29日] |
| 乙胺丁醇 |
embB |
70% |
(30.] |
| 链霉素 |
rrs, rpsL |
60% - -70% |
(28] |
| 吡嗪酰胺 |
pncA |
72% - -99% |
(31日] |
| 氟喹诺酮类原料药 |
gyrA |
|
(32] |
|
|
87%(莫西沙星) |
|
|
|
83%(氧氟沙星) |
|
| 氨基糖甙类 |
rrs |
|
(33] |
|
|
70% - -80%(卷曲霉素和阿米卡星) |
|
|
|
60%(卡那霉素) |
|
|
|
