BMDMSC or an equal volume of saline solution. Control mice received intraperitoneal endotoxin followed by 5×105 lung fibroblasts given intravenously. Cys, cystine (CySS), GSH, and glutathione disulfide (GSSG) concentrations were determined by HPLC. Results showed sequential preservation of plasma Cys and GSH levels in response to BMDMSC infusion. The data show that BMDMSC infusion leads to a more reducing Cys and GSH redox state. The findings are the first to demonstrate that BMDMSC have antioxidant effects in vivo, and add to our understanding of the systemic effects of BMDMSC in lung injury.">
骨髓来源的影响间充质干小鼠血浆半胱氨酸的内毒素诱导的氧化和谷胱甘肽细胞</GÿdF4y2Batitle>
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<p class="sc-ipZHIp hDKZCZ article_type">研究论文|<GÿdF4y2Ba!-- -->开放存取</GÿdF4y2Bap>
<div class="sc-iGrrsa eZlme article_citation">
卷<GÿdF4y2Ba!-- -->
<!-- -->2010<GÿdF4y2Ba!-- -->
<span class="sc-dEoRIm gusDuS">|</小号pan>文章编号<GÿdF4y2Ba!-- -->
<!-- -->868076<GÿdF4y2Ba!-- -->
<span class="sc-dEoRIm gusDuS">|</小号pan>
<!-- -->9<GÿdF4y2Ba!-- -->
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<span class="sc-dEoRIm gusDuS">|</小号pan>
<a class="sc-htpNat bUhGXt link sc-jtggT iUDBGe" href="https://doi.org/10.4061/2010/868076" aria-label="Doi-link">https://doi.org/10.4061/2010/868076</一个>
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<h1 class="sc-jAaTju cxkaTM sc-bmyXtO lmNMHJ article_title">骨髓来源的影响间充质干小鼠血浆半胱氨酸的内毒素诱导的氧化和谷胱甘肽细胞</H1GÿdF4y2Ba>
</div>
<div class="sc-jeCdPy bpzNtR article_authors">
<hr class="sc-likbZx PHYWq hr__author">
<span class="">史密塔S.艾耶<GÿdF4y2Ba!-- -->，<小号up>1<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->2<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->3<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4</小号up></span>
<span class="">埃迪尔森托雷斯冈萨雷斯<GÿdF4y2Ba!-- -->，<小号up>2<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
<span class="">大卫C. Neujahr<GÿdF4y2Ba!-- -->，<小号up>4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
<span class="">迈克权<GÿdF4y2Ba!-- -->，<小号up>4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
<span class="">肯尼斯·布里格姆<GÿdF4y2Ba!-- -->，<小号up>2<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
<span class="">院长P.琼斯<GÿdF4y2Ba!-- -->，<小号up>1<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->3<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
<span class="">安娜L.莫拉<GÿdF4y2Ba!-- -->，<小号up>2<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up>
<!-- -->和</小号pan>
<span class=""><b>毛里西奥·罗哈斯</bGÿdF4y2Ba><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail to Author Option"><img alt="" class="sc-EHOje cPuqxU sc-jtRlXQ jIaDFG" title="" role="presentation" src="data:image/svg+xml;base64,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" height="16"></a><sup>2<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->4<GÿdF4y2Ba!-- -->，<GÿdF4y2Ba!-- -->五</小号up></span>
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<p><sup>1</小号up><span>营养和健康科学计划，埃默里大学，亚特兰大，GA 30322，USA</小号pan></p>
<p><sup>2</小号up><span>中心埃默里大学转化医学研究在肺，亚特兰大，GA 30322，USA</小号pan></p>
<p><sup>3</小号up><span>临床生物标志物实验室，埃默里大学，亚特兰大，GA 30322，USA</小号pan></p>
<p><sup>4</小号up><span>肺，过敏和危重病急救医学，埃默里大学，亚特兰大，GA 30322，USA的分部</小号pan></p>
<p><sup>五</小号up><span>麦凯维中心肺移植和肺血管疾病，埃默里大学，亚特兰大，GA 30322，USA</小号pan></p>
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<b>学术编辑：</bGÿdF4y2Ba>杰拉尔德·a·科尔文</GÿdF4y2Badiv>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到</小号pan>
<span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2009年8月12日</小号pan>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">修订</小号pan>
<span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2009年12月02日</小号pan>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">公认</小号pan>
<span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2009年12月10日</小号pan>
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<span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发布时间</小号pan>
<span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年03月08</小号pan>
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<article class="sc-kZmsYB iukjRu article_body ">
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<h4 class="header" id="abstract">摘要</H4GÿdF4y2Ba>
<p>骨髓间充质干细胞(BMDMSC)正在成为各种炎症状态下的一种治疗方式，包括急性肺损伤(ALI)。炎症的一个标志，以及对ALI患者的一致观察，是系统氧化还原环境的紊乱。然而，BMDMSC对系统氧化还原状态的影响知之甚少。本研究的目的是确定外源注入BMDMSC是否能保护内毒素诱导的血浆半胱氨酸(Cys)氧化和谷胱甘肽(GSH)氧化状态。为了确定BMDMSC对氧化还原状态的影响，小鼠腹腔注射内毒素(1 mg/kg)，然后静脉注射其中任何一种<小号vg height="14.5" id="M1" style="vertical-align:-0.3135pt;width:46.612499px;" version="1.1" viewbox="0 0 46.612499 14.5" width="46.612499" xmlns="http://www.w3.org/2000/svg">
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</svg>BMDMSC或生理盐水等体积。对照小鼠接受腹腔内毒素，随后<小号vg height="14.5" id="M2" style="vertical-align:-0.3135pt;width:46.612499px;" version="1.1" viewbox="0 0 46.612499 14.5" width="46.612499" xmlns="http://www.w3.org/2000/svg">
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</svg>肺成纤维细胞静脉注射。采用高效液相色谱法测定Cys、CySS、GSH和GSSG的浓度。结果显示，血浆Cys和GSH水平序贯保存响应BMDMSC输注。数据显示，BMDMSC输注导致Cys和GSH氧化还原状态更低。该发现首次证明了BMDMSC在体内具有抗氧化作用，并增加了我们对BMDMSC在肺损伤中的系统性作用的理解。</GÿdF4y2Bap>
<span class="end-abs"></span>
<h4 id="introduction">1.介绍</H4GÿdF4y2Ba>
<p>到病原体，物理创伤，或毒性刺激的炎症反应是在宿主防御的关键，但过度的和未发炎可能伤害肺部[<一个Href="#B1">1</一个>]。在患有革兰氏阴性脓毒症，细菌内毒素的失调的炎症反应增加了急性肺损伤（ALI）的风险，这可导致严重的呼吸衰竭称为急性呼吸窘迫综合征（ARDS）[<一个Href="#B1">1</一个>]。急性呼吸窘迫综合征和急性呼吸窘迫综合征的发病率和死亡率很高[<一个Href="#B2">2</一个>]。因此，减轻急性呼吸窘迫综合征和急性呼吸窘迫综合征炎症反应的策略是非常值得关注的。</GÿdF4y2Bap>
<p>在各种炎性疾病的新兴的治疗方式是采用骨髓来源的间充质干细胞/骨髓间充质基质细胞（BMDMSCs）<一个Href="#B3">3</一个>]。BMDMSCs是可以从骨髓相对容易地分离并扩增在培养多能细胞。几项研究，包括我们自己，都显示出外生注入BMDMSCs对内毒素诱导的炎症，保护和ALI小鼠[<一个Href="#B4">4</一个>-<一个Href="#B6">6</一个>]。在这些研究中，BMDMSCs的保护作用是由循环中促炎细胞水平的降低介导的，并且似乎独立于BMDMSCs移植入肺。炎症的一个标志是细胞外硫醇/二硫化物氧化还原环境的紊乱，这在ALI患者中得到了一致的观察。然而，关于BMDMSCs对系统硫醇/二硫化物氧化还原环境的影响知之甚少。</GÿdF4y2Bap>
<p>半胱氨酸（Cys）和它的二硫化物胱氨酸（CySS），与谷胱甘肽（GSH）和谷胱甘肽二硫化物（GSSG）一起，包括主要细胞外硫醇/二硫化物氧化还原控制系统。Cys和GSH是细胞因子表达的重要决定因素，和变更在Cys和GSH代谢是炎症的一个主要特点[<一个Href="#B7">7</一个>]。由于硫醇/二硫化物氧化还原环境与炎症和组织损伤密切相关，本研究旨在研究外源性BMDMSC输注对血浆Cys和GSH水平的影响。越来越多的证据表明，Cys和GSH的氧化还原状态是独立调控的[<一个Href="#B8">8</一个>]。因此辅助目的是要确定在两个氧化还原对是否BMDMSC输注不同的响应。小鼠接受腹膜内内毒素，随后静脉输注<小号vg height="14.5" id="M3" style="vertical-align:-0.3135pt;width:46.612499px;" version="1.1" viewbox="0 0 46.612499 14.5" width="46.612499" xmlns="http://www.w3.org/2000/svg">
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</svg>，CD 45免疫亲BMDMSCs。结果显示血浆Cys和GSH氧化还原态的顺序保存响应于BMDMSC输注。该数据提供了新颖的观察，即BMDMSC输注调制硫醇/二硫化物氧化还原状态的体内。</GÿdF4y2Bap>
<h4 id="materials-and-methods">2。材料和方法</H4GÿdF4y2Ba>
<h5 id="sec2.1">2.1。物料</H五>
<p>除特别说明外，所有的化学品均购自Sigma化学公司（Sigma公司，圣路易斯，MO）购买。蒸馏中，使用去离子水用于分析目的。HPLC质量的溶剂用于HPLC。</GÿdF4y2Bap>
<h5 id="sec2.2">2.2。实验动物</H五>
<p>实验用10-14周龄，雌性C57BL / 6J小鼠（杰克逊实验室，巴港，ME）进行。小鼠饲养在笼子里，并维持在动物资源的埃默里大学司12小时光照，12小时黑暗周期。全部动物喂沉淀啮齿动物食物（测试膳食5015，实验室饮食公司，里士满，IN），并有自由饮水。所有的实验在光周期期间启动。所有动物方案进行了审查，并通过机构的动物护理和使用委员会的批准。因为雌激素可以发挥抗炎作用，发情周期的影响不能完全在当前实验[排除<一个Href="#B9">9</一个>]。</GÿdF4y2Bap>
<h5 id="sec2.3">2.3。有限合伙人管理</H五>
<p>将O55: B5大肠杆菌溶解于无菌PBS中，以1 mg LPS/kg体重腹腔注射。小鼠随后吸入异氟烷麻醉(百特制药、鹿田、IL)，给予<小号vg height="14.5" id="M4" style="vertical-align:-0.3135pt;width:46.612499px;" version="1.1" viewbox="0 0 46.612499 14.5" width="46.612499" xmlns="http://www.w3.org/2000/svg">
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</svg>在0.1 mL PBS中，<小号vg height="14.5" id="M5" style="vertical-align:-0.3135pt;width:46.612499px;" version="1.1" viewbox="0 0 46.612499 14.5" width="46.612499" xmlns="http://www.w3.org/2000/svg">
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</svg>primary lung fibroblasts in 0.1 mL PBS, or 0.1 mL PBS. The retro-orbital vein was used for intravenous administration. Studies by group have shown that BMDMSCs at this dose exert anti-inflammatory effects in vivo [<一个Href="#B10">10</一个>]。因此，该剂量用于确定是否BMDMSCs也施加氧化应激的保护作用。Animals were sacrificed at 2, 6, and 24 hours postLPS administration. No mortality was associated with LPS administration.</p>
<h5 id="sec2.4">2.4。样品采集和半胱氨酸的分析，CySS，GSH和GSSG</H五>
<p>使用经优化的方法，以最小化由于收集和处理[错误收集样品<一个Href="#B11">11</一个>]。Mice were anesthetized by isofluorane inhalation and blood was collected by submandibular bleeding using a 4 mm mouse-bleeding lancet (Medipoint, Inc. Mineola, NY). To minimize artificial overestimation of GSH due to hemolysis, blood was collected into a heparin-coated eppendorf tube to inhibit coagulation. Samples that showed evidence of hemolysis were not included in the analysis.</p>
<p>收集的血液(0.18 mL)立即转移到含有0.02 mL保存溶液的eppdendorf管中。保存液中加入肝素、丝氨酸硼酸盐，以抑制谷胱甘肽的降解<小号vg height="9.9375" id="M6" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>-glutamyltranspeptidase，红菲绕啉二磺酸盐到GSH和Cys和碘乙酸的抑制氧化烷基化GSH和Cys。为了方便硫醇和二硫化物的量化，<小号vg height="9.9375" id="M7" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>谷酰基谷氨酸(<小号vg height="9.9375" id="M8" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>-Glu-GLU）用作内标[<一个Href="#B12">12</一个>]。小号一个米ples were centrifuged at 16000 g for 60 seconds to remove precipitated protein, and 0.1 mL of the supernatant was immediately transferred to an equal volume of ice-cold 10% (w/v) perchloric acid. Samples were immediately stored at<小号vg height="11.0375" id="M9" style="vertical-align:-0.17555pt;width:30.9125px;" version="1.1" viewbox="0 0 30.9125 11.0375" width="30.9125" xmlns="http://www.w3.org/2000/svg">
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</svg>C和用1个月内丹磺酰氯衍生化。稳定性测试表明，非衍生样品在至少稳定2个月<小号vg height="11.0375" id="M10" style="vertical-align:-0.17555pt;width:30.9125px;" version="1.1" viewbox="0 0 30.9125 11.0375" width="30.9125" xmlns="http://www.w3.org/2000/svg">
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<h5 id="sec2.5">2.5。细胞培养</H五>
<p>细胞维持在加湿的5% CO中<小号ub>2</小号ub>在孵化器<小号vg height="11.0375" id="M16" style="vertical-align:-0.17555pt;width:20.200001px;" version="1.1" viewbox="0 0 20.200001 11.0375" width="20.200001" xmlns="http://www.w3.org/2000/svg">
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<p>初级成纤维细胞是从8-10周龄的野生型C57BL / 6J小鼠的肺中分离，如先前描述的<一个Href="#B15">15</一个>]。细胞保持在DMEM补充有10个％FBS和1％青霉素 - 链霉素（Mediatech公司，马纳萨斯，VA）多达10次传代。对于体内输注，收获细胞，并如上述进行处理。BMDMSC和初级成纤维细胞传代次数是所有动物每个实验重复内的所有时间点相似。</GÿdF4y2Bap>
<h5 id="sec2.6">2.6。细胞因子分析</H五>
<p>IL-1的水平<小号vg height="13.425" id="M19" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
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<h5 id="sec2.7">2.7。流式细胞术</H五>
<p>物上使用标准技术在FACScan流式细胞仪（Becton Dickinson公司）上进行流式细胞术表面标志物组的表达。BMDMSCs were harvested by trypsinization, washed in PBS, and stained with the following antibodies : Fluorescein isothiocyanate- (FITC-) anti-CD45, PE-anti-CD11b, and PerCP-Cy5.5-anti-Sca-1 (Pharmigen San Jose, CA). Acquired data were analyzed using FlowJo software (Tree Star, San Carlos, CA).</p>
<h5 id="sec2.8">2.8。分化测定</H五>
<p>使用间充质干细胞中有功能鉴定试剂盒（R＆d系统明尼阿波利斯，MN USA）测定BMDMSC的分化成多种间充质谱系的能力。成脂分化为14天诱导种子细胞<小号vg height="7.1750002" id="M20" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>有10％FBS，1％青霉素 - 链霉素，和含有氢化可的松，异丁基甲基黄嘌呤生脂补充剂，和消炎痛-MEM介质。在文化油滴通过染色细胞与油红O.成骨细胞分化的诱导培养细胞21天确定<小号vg height="7.1750002" id="M21" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>-MEM培养基，含10%胎牛血清，1%青霉素-链霉素，以及含有地塞米松、抗坏血酸-磷酸盐和<小号vg height="13.425" id="M22" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
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</GÿdF4y2Batspan>
</text>
</g>
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</svg>3.沉淀的细胞14天进行培养，并与阿尔新蓝染色以显现酸mucopolysachharides。</GÿdF4y2Bap>
<h5 id="sec2.9">2.9。统计方法</H五>
<p>数据表示为平均值<小号vg height="9.3125" id="M24" style="vertical-align:-0.51414pt;width:10.825px;" version="1.1" viewbox="0 0 10.825 9.3125" width="10.825" xmlns="http://www.w3.org/2000/svg">
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</svg>SEM 4-6动物。统计分析使用Graph垫棱镜v 4.01进行。单尾，不成对的<小号vg height="9.125" id="M25" style="vertical-align:-0.11285pt;width:5.0124998px;" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg">
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</svg>-test被用于将LPS / BMDMSC组在每个给定的时间点进行比较，以LPS /盐水和LPS /成纤维细胞组。显着性设定在<小号vg height="10.325" id="M26" style="vertical-align:-0.0pt;width:11.75px;" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg">
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。</GÿdF4y2Batspan>
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</svg>。</GÿdF4y2Bap>
<h4 id="results">3.结果</H4GÿdF4y2Ba>
<h5 id="sec3.1">3.1。骨髓间充质干细胞的表征</H五>
<p>通过选择既不表达造血细胞也不表达内皮细胞表面标记，但对粘附和基质标记表达阳性的塑贴人群，从原始骨髓悬浮液中富集骨髓源间充质干细胞[<一个Href="#B3">3</一个>]。然而，由于缺乏一组明确的、明确的标记来区分间充质干细胞，建立间充质干细胞表型的金标准标准是三联分化试验，其中间充质干细胞的可塑性通过其在刺激下分化为脂肪细胞、骨细胞和软骨细胞的能力来确认[<一个Href="#B16">16</一个>]。</GÿdF4y2Bap>
<p>在本研究中，我们通过流式细胞术分析和通过分化测定证实MSC表型。通过流式细胞仪分析显示，细胞均匀阴性造血标志物，CD11b和CD45（蓝色，BMDMSC）。细胞染色呈阳性干细胞抗原（SCA）-1（图<一个Href="//www.newsama.com/journals/sci/2010/868076/fig1/" target="_blank">图1（a）</一个>-<一个Href="//www.newsama.com/journals/sci/2010/868076/fig1/" target="_blank">图1（c）</一个>)。分化测定表明BMDMSCs保留其分化成脂肪细胞，骨细胞，软骨细胞和多达10次传代（图能力<一个Href="//www.newsama.com/journals/sci/2010/868076/fig1/" target="_blank">1（d）</一个>-<一个Href="//www.newsama.com/journals/sci/2010/868076/fig1/" target="_blank">1（e）中</一个>)。因此，在本研究中使用的细胞群代表的表型，其与MSC一致。</GÿdF4y2Bap>
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<span class="caption-text">图1</小号pan>
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<i>通过流式细胞术和分化能力BMDMSC表征。</GÿdF4y2Bai>
<table>
BMDMSC的流式细胞术证实细胞不表达造血标志物，CD11b和CD45（（A） - （B）;蓝色; BMDMSC;灰色;同种型对照，红色;肺泡巨噬细胞）。BMDMSC对的Sca-1（;蓝色; BMDMSC;灰色;同种型对照（c））的染色呈阳性。在（d） - （f）中，进行了检查分化能力的细胞。在脂肪形成培养基中培养14天的细胞制备脂肪滴用油红O（d）进行染色。与成骨培养基中培养21天的细胞进行染色，茜素红检测钙（e）所示。软骨沉淀用阿尔新蓝染色以检测mucopolysachharides，之后在软骨形成培养基（F）14天。</GÿdF4y2Batable>
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<h5 id="sec3.2">3.2。BMDMSC输液对内毒素诱导的炎症反应的影响</H五>
<p>之前我们已经报道了BMDMSC输液衰减到内毒素的全身炎症反应[<一个Href="#B4">4</一个>]。在本研究中，我们确定了BMDMSC输注对一组选择的促炎细胞因子的影响，以证实BMDMSC输注的抗炎作用不依赖于LPS血清型的输注(本研究中O55: B5 vs O111: B6 [<一个Href="#B18">17</一个>]）。在LPS / BMDMSC组响应进行比较，以LPS /生理盐水组。</GÿdF4y2Bap>
<p>血浆TNF-α的<小号vg height="7.1750002" id="M28" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>（数字<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（a）</一个>），IFN-γ<小号vg height="9.9375" id="M29" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>（数字<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（b）</一个>），和IL-1<小号vg height="13.425" id="M30" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
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</svg>（数字<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（c）</一个>)分别在内毒素处理后2小时、6小时和24小时进行。细胞因子水平在生理盐水/BMDMSC组从无法检测到<小号vg height="11.0625" id="M31" style="vertical-align:-0.30096pt;width:30.799999px;" version="1.1" viewbox="0 0 30.799999 11.0625" width="30.799999" xmlns="http://www.w3.org/2000/svg">
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</svg> pg/mL at all time points and are not shown for clarity.</p>
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<i>BMDMSC输注对内毒素诱导的炎症反应。</GÿdF4y2Bai>
<math id="M32" xmlns="http://www.w3.org/1998/Math/MathML">
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<table>
C五7BL/6J mice were treated with 1 mg/kg i.p LPS followed by i.v infusion of either 500,000 BMDMSC (LPS/BMDMSC), or 0.1 mL Saline (LPS/Saline) alone. At 2 hours, 6 hours, and 24 hours mice were sacrificed and plasma was collected for analysis of TNF-（a）中，IFN-（b）中和il - 1（C）。数据表示为means + SEM。GÿdF4y2Ba值在LPS / BMDMSC组从时间匹配的LPS /生理盐水组显著不同。</GÿdF4y2Batable>
</div>
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<p>与先前的观察结果一致，结果显示BMDMSC输注减弱了内毒素的急性炎症反应。血浆TNF-显著降低<小号vg height="7.1750002" id="M34" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>升evels was observed at 2 hours (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（a）</一个>（皮克/毫升）;LPS /盐水，<小号vg height="12.2375" id="M35" style="vertical-align:-1.09097pt;width:62.0625px;" version="1.1" viewbox="0 0 62.0625 12.2375" width="62.0625" xmlns="http://www.w3.org/2000/svg">
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</g>
</g>
</svg>）和6 hours (LPS/Saline,<小号vg height="12.2375" id="M38" style="vertical-align:-1.09097pt;width:65.962502px;" version="1.1" viewbox="0 0 65.962502 12.2375" width="65.962502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
7</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
五</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="43.285385" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
2</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.2375" id="M39" style="vertical-align:-1.09097pt;width:46.424999px;" version="1.1" viewbox="0 0 46.424999 12.2375" width="46.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M40" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。血浆IFN-的评价<小号vg height="9.9375" id="M41" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.9375)">
<g transform="translate(72,-64.05)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>升evels revealed a 5-fold decrease with BMDMSC infusion at 6 h (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（b）</一个>（皮克/毫升）;LPS /盐水，<小号vg height="12.175" id="M42" style="vertical-align:-1.09097pt;width:85.5px;" version="1.1" viewbox="0 0 85.5 12.175" width="85.5" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="18.754499" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">
7</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.982914" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="52.662636" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="58.914135" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="62.039886" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.05" id="M43" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.05" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
3</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.0625" id="M44" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.0625" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
<g transform="translate(72,-63.15)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。</GÿdF4y2Bap>
<p>测定il - 1<小号vg height="13.425" id="M45" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>升evels demonstrated a 1.7-fold decrease in response to BMDMSC infusion at 2 hours (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig2/" target="_blank">图2（c）</一个>（微克/毫升）;LPS /盐水，<小号vg height="12.175" id="M46" style="vertical-align:-1.09097pt;width:71.175003px;" version="1.1" viewbox="0 0 71.175003 12.175" width="71.175003" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
7</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="19.79225" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.907415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="44.335636" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="50.587139" y="0">
0</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.05" id="M47" style="vertical-align:-1.09097pt;width:65.962502px;" version="1.1" viewbox="0 0 65.962502 12.05" width="65.962502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="43.285385" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
2</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M48" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)， 6小时时减少2倍(脂多糖/生理盐水，<小号vg height="12.175" id="M49" style="vertical-align:-1.09097pt;width:77.6875px;" version="1.1" viewbox="0 0 77.6875 12.175" width="77.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="52.662636" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="55.788387" y="0">
3</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.175" id="M50" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.175" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
6</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.0625" id="M51" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.0625" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
<g transform="translate(72,-63.15)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。在TNF-α减少<小号vg height="7.1750002" id="M52" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>，IFN-γ<小号vg height="9.9375" id="M53" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.9375)">
<g transform="translate(72,-64.05)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>和IL-1<小号vg height="13.425" id="M54" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>LPS/BMDMSC组的水平证实了BMDMSC在体内的抗炎作用。</GÿdF4y2Bap>
<h5 id="sec3.3">3.3。BMDMSC输注血浆GSH和GSH的氧化/谷胱甘肽氧化还原状态的内毒素引起的耗尽效应</H五>
<p>在确定了BMDMSC输液引起的体内抗炎作用，我们接下来确定是否BMDMSC输液也与血浆谷胱甘肽氧化还原状态免受干扰有关。因为肺成纤维细胞选自间充质前体代表伯，间质细胞群始发，动物注射了充当第二指令集，用于这些分析对照LPS /肺成纤维细胞。</GÿdF4y2Bap>
<p>在以前的研究中，我们发现，内毒素引起的体重减轻的发生是由于食物摄入减少[<一个Href="#B7">7</一个>]，和食物摄入减少是血浆GSH和Cys水平的一个重要决定因素[<一个Href="#B17">18</一个>]。在本研究中，我们测定了LPS/生理盐水组与LPS/BMDMSC组治疗24小时后的体重损失。小鼠腹腔注射生理盐水，然后静脉注射BMDMSC作为对照组。如图所示<一个Href="//www.newsama.com/journals/sci/2010/868076/fig3/" target="_blank">3</一个>，米ice treated with Saline/BMDMSC did not show a significant decline in body weight (body weight (g); 0 hours,<小号vg height="12.2375" id="M55" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.2375" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
五</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
6</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;24 hours,<小号vg height="12.175" id="M56" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.175" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
6</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。As expected, LPS/Saline-treated animals lost a significant amount of body weight (0 hours,<小号vg height="12.2375" id="M57" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.2375" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;24 hours,<小号vg height="12.175" id="M58" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.175" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
6</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M59" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。HØwever, body weight did not significantly decrease in mice treated with LPS/BMDMSC (0 hours,<小号vg height="12.05" id="M60" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.05" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
9</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;24 hours,<小号vg height="12.05" id="M61" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.05" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
7</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.1" id="M62" style="vertical-align:-0.17555pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.1" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.1)">
<g transform="translate(72,-63.12)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
=</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>），表明保护由于BMDMSC输注。但是，必须指出的是，BMDMSCs对体重的影响是不太可能的临床显著。</GÿdF4y2Bap>
<div class="floats-partial-section partial-carousel-wrapper" data-section="fig3">
<div class="floats-partial-content fig-content-fig3">
<div class="partial-carousel--single-image">
<img alt="" name="868076.fig.003" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.003.jpg">
<br>
<strong></strong>
</div>
</div>
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">图3</小号pan>
<a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/sci/2010/868076/fig3/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<i>BMDMSC输液对内毒素引起的体重减轻。</GÿdF4y2Bai>
<table>
C五7BL/6J mice were treated with 1 mg/kg i.p LPS or with saline. LPS-treated animals were either given intravenous Saline (LPS/Saline) or BMDMSC (LPS/BMDMSC). Saline treated mice were given intravenous BMDMSC. Body weight was measured at 0 hours and 24 hours post treatment.</table>
</div>
</div>
</div>
<p>血浆GSH和Cys的响应内毒素的动力学预先由我们的组描述<一个Href="#B18">17</一个>]。In contrast to the sustained oxidation of GSH and Cys redox states until 24–48 hours that we previously reported; the present experiments show recovery of these thiol/disulfide couples by 24 hours. These differences can be ascribed to serotype differences in LPS. However, we cannot exclude the possibility that these differences may have also resulted, in part, from variations in the dose of endotoxic LPS delivered.</p>
<p>如图所见<一个Href="//www.newsama.com/journals/sci/2010/868076/fig4/" target="_blank">图4（a）</一个>，BMDMSC infusion had no effect on the acute decline in plasma GSH at 2 hours (plasma GSH (<小号vg height="9.6750002" id="M63" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>M），控制<小号vg height="12.05" id="M64" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.05" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
2</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS /盐水，<小号vg height="12.05" id="M65" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
9</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>（<小号vg height="11.0625" id="M66" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.0625" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
<g transform="translate(72,-63.15)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>）;LPS / BMDMSC，<小号vg height="12.05" id="M67" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
8</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>），but protected against decline in GSH levels at 6 h (LPS/Saline,<小号vg height="12.05" id="M68" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
7</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.175" id="M69" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.175" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="17.354164" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="30.782387" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="37.033886" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
7</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M70" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>），和24 hours (LPS/Saline,<小号vg height="12.05" id="M71" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
4</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="46.411137" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="49.536884" y="0">
4</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.175" id="M72" style="vertical-align:-1.09097pt;width:75.087502px;" version="1.1" viewbox="0 0 75.087502 12.175" width="75.087502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.175)">
<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
8</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="28.819414" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="44.335636" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="50.587139" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="53.712887" y="0">
8</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M73" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。LPS/肺成纤维细胞组GSH水平在6小时和24小时显著低于LPS/BMDMSC组(LPS/肺成纤维细胞;6小时,<小号vg height="12.05" id="M74" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
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<div class="floats-partial-section partial-carousel-wrapper" data-section="fig4">
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<img alt="（一个）GÿdF4y2Ba" name="868076.fig.004a" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004a.jpg">
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<strong>（一个）</小号trong>
</div>
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<img alt="（b）中GÿdF4y2Ba" name="868076.fig.004b" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004b.jpg">
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<strong>（b）中</小号trong>
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<img alt="（C）GÿdF4y2Ba" name="868076.fig.004c" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004c.jpg">
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<button class="partial-carousel-dot" aria-label="(a)"><img alt="（一个）GÿdF4y2Ba" name="868076.fig.004a" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004a.jpg"><br><strong>（一个）</小号trong></button>
<button class="partial-carousel-dot" aria-label="(b)"><img alt="（b）中GÿdF4y2Ba" name="868076.fig.004b" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004b.jpg"><br><strong>（b）中</小号trong></button>
<button class="partial-carousel-dot" aria-label="(c)"><img alt="（C）GÿdF4y2Ba" name="868076.fig.004c" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.004c.jpg"><br><strong>（C）</小号trong></button>
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<span class="caption-text">图4</小号pan>
<a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/sci/2010/868076/fig4/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<i>BMDMSC输注对血浆GSH的内毒素引起的耗尽和氧化GSH / GSSG氧化还原状态的。</GÿdF4y2Bai>
<math id="M77" xmlns="http://www.w3.org/1998/Math/MathML">
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<sup>一个</小号up>
<sup>b</小号up>
<table>
C五7BL/6J mice were treated with 1mg/kg i.p LPS followed by i.v infusion of either 500,000 BMDMSC (LPS/BMDMSC), Lung fibroblasts (LPS/Lung fibroblast), or 0.1 mL Saline (LPS/Saline) alone. At 2 hours, 6 hours, and 24 hours mice were sacrificed and plasma was collected for HPLC analysis of GSH (a) and GSSG (b).G小号H/G小号小号G（C）由GSH和GSSG浓度使用Nernst方程计算。数据表示为means + SEM。GÿdF4y2Ba值在LPS / BMDMSC组从时间匹配的LPS /生理盐水组显著不同。GÿdF4y2BaLPS/BMDMSC组与时间匹配的LPS/肺成纤维细胞组差异显著。</GÿdF4y2Batable>
</div>
</div>
</div>
<p>等离子GSSG没有表现出与处理显著的变化（图<一个Href="//www.newsama.com/journals/sci/2010/868076/fig4/" target="_blank">图4（b）</一个>)。使用GSH和GSSG的浓度GSH氧化还原状态的计算表明，<小号vg height="14.35" id="M78" style="vertical-align:-3.22282pt;width:18.2125px;" version="1.1" viewbox="0 0 18.2125 14.35" width="18.2125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.35)">
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</g>
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</svg>G小号H/G小号小号G一个t 24 hours was, on average, 8 mV more reduced in LPS/BMDMSC group compared to LPS/Saline and LPS/Lung fibroblast group (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig4/" target="_blank">图4（c）</一个>;Ë<小号ub>H</小号ub>GSH / GSSG（毫伏），LPS /盐水，<小号vg height="12.05" id="M79" style="vertical-align:-1.09097pt;width:88.387497px;" version="1.1" viewbox="0 0 88.387497 12.05" width="88.387497" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.36)">
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</svg>;有限合伙人/肺成纤维细胞,<小号vg height="12.2375" id="M80" style="vertical-align:-1.09097pt;width:76.675003px;" version="1.1" viewbox="0 0 76.675003 12.2375" width="76.675003" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.21)">
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</svg>;<小号vg height="11.0625" id="M82" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.0625" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
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0</GÿdF4y2Batspan>
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</text>
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</svg>)。数据显示，在24小时内，BMDMSC通过改善GSH的稳态保护其免受内毒素诱导的GSH/GSSG氧化还原状态。</GÿdF4y2Bap>
<h5 id="sec3.4">3.4。BMDMSC输注血浆Cys和半胱氨酸氧化/ CySS氧化还原状态的内毒素引起的耗尽效应</H五>
<p>降低血浆中的Cys水平和Cys / CySS氧化还原状态的氧化是内毒素诱导的ALI [中的早期事件<一个Href="#B7">7</一个>]。结果小号HØwed that BMDMSC infusion did not protect against the acute decline in plasma Cys levels at 2 hours (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig5/" target="_blank">图5（a）</一个>;血浆半胱氨酸（<小号vg height="9.6750002" id="M83" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
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</svg>M），控制<小号vg height="12.175" id="M84" style="vertical-align:-1.09097pt;width:77.6875px;" version="1.1" viewbox="0 0 77.6875 12.175" width="77.6875" xmlns="http://www.w3.org/2000/svg">
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2</GÿdF4y2Batspan>
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6</GÿdF4y2Batspan>
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</text>
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</svg>;LPS /盐水，<小号vg height="12.05" id="M85" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
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4</GÿdF4y2Batspan>
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</g>
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</svg>;有限合伙人/肺成纤维细胞,<小号vg height="12.05" id="M86" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.05" width="69.875" xmlns="http://www.w3.org/2000/svg">
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</svg>;LPS / BMDMSC，<小号vg height="12.05" id="M87" style="vertical-align:-1.09097pt;width:62.0625px;" version="1.1" viewbox="0 0 62.0625 12.05" width="62.0625" xmlns="http://www.w3.org/2000/svg">
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</g>
</g>
</svg>而控制)。事实上，LPS/BMDMSC组2小时时Cys水平明显低于LPS/生理盐水组(<小号vg height="11.25" id="M89" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">
<</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。Despite this early decline, plasma Cys levels started to recover in LPS/BMDMSC treated group compared to LPS/Saline group at 6 hours (LPS/Saline,<小号vg height="12.05" id="M90" style="vertical-align:-1.09097pt;width:62.0625px;" version="1.1" viewbox="0 0 62.0625 12.05" width="62.0625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
9</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="9.3772497" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="20.479914" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="33.908134" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="43.285385" y="0">
8</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS / BMDMSC，<小号vg height="12.05" id="M91" style="vertical-align:-1.09097pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 12.05" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.05)">
<g transform="translate(72,-62.36)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">
3</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.731415" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="40.159637" y="0">
1</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M92" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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<tspan style="font-size: 12.50px; " x="10.890113" y="0">
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<tspan style="font-size: 12.50px; " x="22.930502" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>)。LPS/肺成纤维细胞组Cys水平也升高(<小号vg height="12.2375" id="M93" style="vertical-align:-1.09097pt;width:75.087502px;" version="1.1" viewbox="0 0 75.087502 12.2375" width="75.087502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
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1</GÿdF4y2Batspan>
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五</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
。</GÿdF4y2Batspan>
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2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="28.819414" y="0">
±</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="44.335636" y="0">
0</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="50.587139" y="0">
。</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="53.712887" y="0">
3</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;<小号vg height="11.25" id="M94" style="vertical-align:-0.30096pt;width:68.912498px;" version="1.1" viewbox="0 0 68.912498 11.25" width="68.912498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
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<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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0</GÿdF4y2Batspan>
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</text>
</g>
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</svg>CØ米pared to LPS/Saline group) and could not be distinguished from LPS/BMDMSC group at 6 hours. By 24 hours Cys levels normalized in all three treatment groups.</p>
<div class="floats-partial-section partial-carousel-wrapper" data-section="fig5">
<div class="floats-partial-content fig-content-fig5">
<div class="partial-carousel--single-image">
<img alt="（一个）GÿdF4y2Ba" name="868076.fig.005a" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005a.jpg">
<br>
<strong>（一个）</小号trong>
</div>
<div class="partial-carousel--single-image">
<img alt="（b）中GÿdF4y2Ba" name="868076.fig.005b" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005b.jpg">
<br>
<strong>（b）中</小号trong>
</div>
<div class="partial-carousel--single-image">
<img alt="（C）GÿdF4y2Ba" name="868076.fig.005c" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005c.jpg">
<br>
<strong>（C）</小号trong>
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<div class="floats-partial-middle">
<div class="floats-partial-middle--thumbs fig-thumbs-fig5">
<button class="partial-carousel-dot" aria-label="(a)"><img alt="（一个）GÿdF4y2Ba" name="868076.fig.005a" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005a.jpg"><br><strong>（一个）</小号trong></button>
<button class="partial-carousel-dot" aria-label="(b)"><img alt="（b）中GÿdF4y2Ba" name="868076.fig.005b" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005b.jpg"><br><strong>（b）中</小号trong></button>
<button class="partial-carousel-dot" aria-label="(c)"><img alt="（C）GÿdF4y2Ba" name="868076.fig.005c" src="https://static-01.hindawi.com/articles/sci/volume-2010/868076/figures/868076.fig.005c.jpg"><br><strong>（C）</小号trong></button>
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<span class="caption-text">图5</小号pan>
<a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/sci/2010/868076/fig5/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
<i>BMDMSC输注对等离子体的Cys的内毒素引起的耗尽和氧化的Cys / CySS氧化还原状态的。</GÿdF4y2Bai>
<math id="M95" xmlns="http://www.w3.org/1998/Math/MathML">
<mrow>
<msub>
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</math>
<sup>一个</小号up>
<sup>b</小号up>
<table>
C五7BL/6J mice were treated with 1 mg/kg i.p LPS followed by i.v infusion of either 500,000 BMDMSC (LPS/BMDMSC), Lung fibroblasts (LPS/Lung fibroblast), or 0.1 mL Saline (LPS/Saline) alone. At 2 hours, 6 hours, and 24 hours mice were sacrificed and plasma was collected for HPLC analysis of Cys (a) and CySS (b). In (c),利用Nernst方程，由Cys和CySS浓度计算Cys/CySS。数据表示为means + SEM。GÿdF4y2Ba值在LPS / BMDMSC组从时间匹配的LPS /生理盐水组显著不同。GÿdF4y2BaLPS/BMDMSC组与时间匹配的LPS/肺成纤维细胞组差异显著。</GÿdF4y2Batable>
</div>
</div>
</div>
<p>Plasma levels of the disulfide of Cys, CySS, increased significantly at 2 hours with endotoxin treatment and was not altered due to BMDMSC infusion (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig5/" target="_blank">图5（b）</一个>;等离子体CySS（<小号vg height="9.6750002" id="M96" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
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</text>
</g>
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</svg>M），控制<小号vg height="12.2375" id="M97" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.2375" width="69.875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
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6</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
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2</GÿdF4y2Batspan>
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<tspan style="font-size: 12.50px; " x="40.159637" y="0">
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<tspan style="font-size: 12.50px; " x="49.536884" y="0">
五</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>;LPS /盐水，<小号vg height="12.2375" id="M98" style="vertical-align:-1.09097pt;width:77.6875px;" version="1.1" viewbox="0 0 77.6875 12.2375" width="77.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
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<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">
2</GÿdF4y2Batspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">
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3</GÿdF4y2Batspan>
</text>
</g>
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</svg>;LPS / BMDMSC，<小号vg height="12.175" id="M99" style="vertical-align:-1.09097pt;width:77.6875px;" version="1.1" viewbox="0 0 77.6875 12.175" width="77.6875" xmlns="http://www.w3.org/2000/svg">
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</svg>;<小号vg height="11.0625" id="M100" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.0625" width="48.337502" xmlns="http://www.w3.org/2000/svg">
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</svg>而控制)。HØwever, CySS levels in LPS/Lung fibroblast group were significantly decreased at 2 hours and increased at 6 hours prior to normalization at 24 hours (LPS/Lung fibroblast; 2 hours,<小号vg height="12.2375" id="M101" style="vertical-align:-1.09097pt;width:69.875px;" version="1.1" viewbox="0 0 69.875 12.2375" width="69.875" xmlns="http://www.w3.org/2000/svg">
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3</GÿdF4y2Batspan>
</text>
</g>
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</svg>;6小时,<小号vg height="12.2375" id="M102" style="vertical-align:-1.09097pt;width:77.6875px;" version="1.1" viewbox="0 0 77.6875 12.2375" width="77.6875" xmlns="http://www.w3.org/2000/svg">
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8</GÿdF4y2Batspan>
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4</GÿdF4y2Batspan>
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</svg>;<小号vg height="11.25" id="M103" style="vertical-align:-0.30096pt;width:48.337502px;" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
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</svg>相比于LPS /盐水和LPS / BMDMSC组）。</GÿdF4y2Bap>
<p>尽管CySS没有变化，由BMDMSC输注血浆半胱氨酸的保护导致<小号vg height="14.35" id="M104" style="vertical-align:-3.22282pt;width:18.2125px;" version="1.1" viewbox="0 0 18.2125 14.35" width="18.2125" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-63.02,60.66)">
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</text>
</g>
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</svg>Cÿ小号/Cÿ小号小号being, on average, 8 mV more reduced, compared to LPS/Saline group at 6 hours (Figure<一个Href="//www.newsama.com/journals/sci/2010/868076/fig5/" target="_blank">图5（c）</一个>;<小号vg height="14.35" id="M105" style="vertical-align:-3.22282pt;width:18.2125px;" version="1.1" viewbox="0 0 18.2125 14.35" width="18.2125" xmlns="http://www.w3.org/2000/svg">
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</svg>的Cys / CySS也在LPS /肺成纤维细胞组中观察<小号vg height="13.6375" id="M110" style="vertical-align:-2.21957pt;width:74.0625px;" version="1.1" viewbox="0 0 74.0625 13.6375" width="74.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>相比于LPS /盐水）。因此，该数据表明，BMDMSC输注导致等离子体的Cys的适度但显著保存和<小号vg height="14.35" id="M112" style="vertical-align:-3.22282pt;width:18.2125px;" version="1.1" viewbox="0 0 18.2125 14.35" width="18.2125" xmlns="http://www.w3.org/2000/svg">
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</svg>Cÿ小号/Cÿ小号小号一个t 6 hours. However, this effect was not specific because similar responses were observed in the LPS/Lung fibroblast group. Together, the combined observations show that BMDMSC infusion resulted in sequential preservation of Cys and GSH redox states at 6 hours and 24 hours, respectively. The preservation of GSH was specific to BMDMSC infusion while Cys redox state was preserved with BMDMSC and Lung fibroblast infusion.</p>
<h4 id="discussion">4.讨论</H4GÿdF4y2Ba>
<p>本研究的主要发现是BMDMSCs的该输注与增加全身Cys和GSH水平，其结果在Cys和GSH的保存期间内毒素血症氧化还原态相关联。这些数据是第一次，就我们所知，证明BMDMSC输液改善全身的硫醇/二硫化物氧化还原状态的体内。</GÿdF4y2Bap>
<p>一些证据表明，生物巯基/二硫化氧化还原环境使然反应，炎症刺激。在体外单核细胞和Cys和GSH水平会改变细胞因子产生的实验操作[<一个Href="#B19">19</一个>]变造淋巴细胞活化[<一个Href="#B20">20</一个>]。体内<GÿdF4y2Bai>，</GÿdF4y2Bai>小鼠口服GSH和n -乙酰半胱氨酸(NAC)预处理可降低脂多糖诱导的TNF-<小号vg height="7.1750002" id="M113" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>在循环和在脾脏[<一个Href="#B21">21</一个>]。因此，Cys和GSH是免疫系统的激活期间的细胞因子产生的关键决定因素。然而，在本研究中，我们观察到，在TNF-α下降<小号vg height="7.1750002" id="M114" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>和IL-1<小号vg height="13.425" id="M115" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>一个t 2 hours precedes the increase in plasma Cys and GSH levels at 6 hours. This suggests that the improved homeostasis of these redox couples by BMDMSC infusion is not upstream to the decrease in proinflammatory cytokine levels. Nonetheless, because Cys and GSH redox systems are fundamental to basic cellular processes such as proliferation, differentiation, and apoptosis [<一个Href="#B22">22</一个>]，在血浆Cys和GSH指数改进可以具有在衰减肺损伤和/或促进修复治疗效果。因此，巯基/二硫化物氧化还原环境的保存可以表示BMDMSC输注的附加的治疗效果。</GÿdF4y2Bap>
<p>通过该BMDMSC输注提高GSH稳态的潜在机制可涉及从组织增加Cys和GSH的流出，增加的循环，和/或增加GSH合成。这可以通过的可溶性生长因子的分泌来介导由BMDMSCs，或通过BMDMSCs与宿主细胞或二者的相互作用。候选人生长因子BMDMSCs的氧化还原调节作用可能是负责角质细胞生长因子（KGF）。BMDMSCs组成型产生KGF [<一个Href="#B23">23</一个>]，在小鼠同种异体骨髓移植模型中的研究表明，皮下注射KGF可以提高肝脏GSH水平[<一个Href="#B24">24</一个>]。因为50％-80血浆GSH的％依赖于流出从肝脏[<一个Href="#B25">25</一个>]，增加肝脏中谷胱甘肽可提高血浆GSH水平。此外，促炎细胞因子水平升高可GSH平衡产生不利影响。在肺的内皮细胞，肿瘤坏死因子<小号vg height="7.1750002" id="M116" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>降低细胞GSH和GSSG增大水平[<一个Href="#B26">26</一个>]。因此，BMDMSC介导的血浆中TNF-α减少<小号vg height="7.1750002" id="M117" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.175)">
<g transform="translate(72,-66.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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</text>
</g>
</g>
</svg>和IL-1<小号vg height="13.425" id="M118" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>升evels at 2 hours could also have led to improved GSH homeostasis at subsequent time points.</p>
<p>虽然只有BMDMSC组的血浆GSH稳态得到改善，但肺成纤维细胞组的血浆Cys动态相似。这表明血浆Cys的改善不是BMDMSC灌注的特异性反应。需要进一步的研究来比较基质细胞，如间充质干细胞和肺成纤维细胞与上皮和内皮细胞类型，以更好地阐明体内Cys稳态的调节是一种依赖于细胞类型还是独立的现象。然而，由于Cys和GSH氧化还原系统与炎症、修复和再生密切相关，BMDMSCs对这两种氧化还原系统的保护具有重要的治疗意义。</GÿdF4y2Bap>
<p>虽然本观测是第一次证明了BMDMSCs在体内具有的氧化还原调节作用，有证据支持MSC的抗氧化能力。例如，Kim和同事已经证明，脂肪组织来源的MSC的抗氧化能力条件培养基（ADCM）相当于100 <小号vg height="9.6750002" id="M119" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</GÿdF4y2Batspan>
</text>
</g>
</g>
</svg>中号抗坏血酸[<一个Href="#B27">27</一个>]。此外，培养叔丁基氢过氧化物处理过的与ADCM真皮成纤维细胞提高细胞生存力，这表明MSC衍生因子对抗氧化损伤保护。这项研究表明，其可在炎症性肺部疾病，如ALI的设定赋予保护的MSC积极分泌抗氧化因子。HØwever, studies in matrigel angiogenesis assay have demonstrated that direct contact of MSCs with endothelial cells (EC : MSC ratio; 1 : 1 to 1 : 3) led to increased ROS production resulting in endothelial cell apoptosis and ultimately to capillary degeneration [<一个Href="#B28">28</一个>]。观察到细胞毒性将一滴当MSC号是由一个数量级减少。这些研究表明，在体内MSC的效应可能会有所不同，这取决于MSC数目和相互作用的细胞群<bGÿdF4y2Ba>。</bGÿdF4y2Ba>进一步的研究调查BMDMSC的影响，空调的硫醇/二硫化物氧化还原状态的媒体将提供更大的机械见解BMDMSCs在体内的作用。</GÿdF4y2Bap>
<p>In conclusion, the present study demonstrates that in a murine model of endotoxin-induced inflammation, infusion of syngeneic BMDMSCs improved plasma Cys and GSH redox indices at 6 h and 24 hours, respectively. These studies are the first, to our knowledge, to demonstrate the antioxidant effects of BMDMSC in vivo. Further studies are needed to investigate the mechanistic basis for the improvement of thiol/disulfide redox status by BMDMSCs.</p>
<h4 id="acknowledgments">致谢</H4GÿdF4y2Ba>
<p>这项工作是由美国国立卫生研究院资助ES009047，ES011195（D. P.琼斯）和5K01HL084683-02（M.罗哈斯）的支持。一些在这项工作中所使用的材料是由杜兰中心基因治疗，通过从美国国立卫生研究院的NCRR，格兰特，没有补助金提供的。P40RR017447。</GÿdF4y2Bap>
</div>
<div class="xml-content">
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<li id="B18">S. S. Iyer, D. P. Jones, K. L. Brigham, M. Rojas，“内毒素诱导的肺损伤中血浆半胱氨酸/胱氨酸氧化状态的氧化”，<GÿdF4y2Bai>美国呼吸细胞和分子生物学的</GÿdF4y2Bai>卷。40，没有。1，第90-98，2009年。<小号pan class="reflinks">查看在：<一个Href="https://doi.org/10.1165/rcmb.2007-0447OC">出版商网站</一个><span class="sep">|</小号pan><a href="https://scholar.google.com/scholar_lookup?title=Oxidation%20of%20plasma%20cysteine/cystine%20redox%20state%20in%20endotoxin-induced%20lung%20injury&author=S. S. Iyer&author=D. P. Jones&author=K. L. Brigham&author=&author=M. Rojas&publication_year=2009" target="_blank">谷歌学术</一个></span></li>
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</math>、IL-6和IL-8被人肺泡巨噬细胞吞噬。”<GÿdF4y2Bai>欧洲呼吸杂志</GÿdF4y2Bai>卷。14，没有。1期，第98-105，1999年。<小号pan class="reflinks">查看在：<一个Href="https://doi.org/10.1034/j.1399-3003.1999.14a17.x">出版商网站</一个><span class="sep">|</小号pan><a href="https://scholar.google.com/scholar_lookup?title=Thiol%20regulation%20of%20the%20production%20of%20TNF-a,%20IL-6%20and%20IL-8%20by%20human%20alveolar%20macrophages&author=P. Gosset&author=B. Wallaert&author=A. B. Tonnel&author=&author=C. Fourneau&publication_year=1999" target="_blank">谷歌学术</一个></span></li>
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</math>在谷胱甘肽介导的降低而增加的肺血管内皮细胞的灵敏度<米一个th id="M122" xmlns="http://www.w3.org/1998/Math/MathML">
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</msub>
</math>”<GÿdF4y2Bai>临床研究杂志</GÿdF4y2Bai>卷。89，没有。3，第794-802，1992。<小号pan class="reflinks">查看在：<一个Href="https://scholar.google.com/scholar_lookup?title=Tumor%20necrosis%20factor-a-mediated%20decrease%20in%20glutathione%20increases%20the%20sensitivity%20of%20pulmonary%20vascular%20endothelial%20cells%20to%20H2O2&author=Y. Ishii&author=C. A. Partridge&author=P. J. Del Vecchio&author=&author=A. B. Malik&publication_year=1992" target="_blank">谷歌学术</一个></span></li>
<li id="B27">W. S.金，B. S.公园，H. K. Kim等人，“证据支持脂肪来源干细胞的抗氧化作用：从氧化应激的人类真皮成纤维细胞的保护”，<GÿdF4y2Bai>皮肤病学杂志科学</GÿdF4y2Bai>卷。49，没有。2，第133-142，2008。<小号pan class="reflinks">查看在：<一个Href="https://doi.org/10.1016/j.jdermsci.2007.08.004">出版商网站</一个><span class="sep">|</小号pan><a href="https://scholar.google.com/scholar_lookup?title=Evidence%20supporting%20antioxidant%20action%20of%20adipose-derived%20stem%20cells:%20protection%20of%20human%20dermal%20fibroblasts%20from%20oxidative%20stress&author=W. S. Kim&author=B. S. Park&author=H. K. Kim et al.&publication_year=2008" target="_blank">谷歌学术</一个></span></li>
<li id="B28">K.大津，S.达斯，S. D.豪泽，S. K.夸德里，S.查亚，和J.查亚，“血管生成的浓度 - 依赖性抑制间质干细胞，”<GÿdF4y2Bai>血液</GÿdF4y2Bai>卷。113，没有。18，第4197-4205，2009。<小号pan class="reflinks">查看在：<一个Href="https://doi.org/10.1182/blood-2008-09-176198">出版商网站</一个><span class="sep">|</小号pan><a href="https://scholar.google.com/scholar_lookup?title=Concentration-dependent%20inhibition%20of%20angiogenesis%20by%20mesenchymal%20stem%20cells&author=K. Otsu&author=S. Das&author=S. D. Houser&author=S. K. Quadri&author=S. Bhattacharya&author=&author=J. Bhattacharya&publication_year=2009" target="_blank">谷歌学术</一个></span></li>
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<p>©2010史密塔S. Iyer等。这是下发布的开放式访问文章<一个rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享署名许可</一个>，其允许在任何介质无限制地使用，分发和再现时，所提供的原始工作正确的引用。</GÿdF4y2Bap>
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height="24"><span class="text">引文</小号pan></span><img alt="" class="sc-EHOje ggEPYc sc-fYiAbW eBEQa fileArrow" title="" role="presentation" 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<li><a class="sc-htpNat bUhGXt link journals" href="//www.newsama.com/journals/" aria-label="Journals"><img alt="" class="sc-EHOje jRIjVn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="14">期刊</一个></li>
<li><a class="sc-htpNat bUhGXt link article_processing_charges" href="//www.newsama.com/publish-research/authors/article-processing-charges/" aria-label="Article Processing Charges"><img alt="" class="sc-EHOje jRIjVn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="14">文章加工费</一个></li>
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</ul>
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<li><a class="sc-htpNat bUhGXt link authors" href="//www.newsama.com/publish-research/authors/" aria-label="Authors"><img alt="" class="sc-EHOje jRIjVn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="14">作者</一个></li>
<li><a class="sc-htpNat bUhGXt link editors" href="//www.newsama.com/publish-research/editors/" aria-label="Editors"><img alt="" class="sc-EHOje jRIjVn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="14">编者</一个></li>
<li><a class="sc-htpNat bUhGXt link reviewers" href="//www.newsama.com/publish-research/reviewers/" aria-label="Reviewers"><img alt="" class="sc-EHOje jRIjVn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="14">评审</一个></li>
</ul>
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