文摘

许多真菌毒素表现出体外和体内抗肿瘤药对各种癌症细胞类型的影响。Luteoskyrin,羟基蒽醌已经被证明是一个强有力的抑制剂对埃利希腹水瘤细胞。比较抗肿瘤活性和抗氧化状态MT81及其结构类似物(醋酸acid-MT81 (Aa-MT81)]有polyhydroxyanthraquinone结构评估对埃利希腹水癌(EAC)肿瘤在小鼠体内。体外细胞毒性是衡量EAC细胞的生存能力直接治疗后的化合物。在体内研究中,MT81及其结构类似物管理(i.p)两种不同剂量(5、7毫克MT81;Aa-MT81 8.93, 11.48毫克/公斤体重),24小时后7天。肿瘤接种。活动评估使用平均生存时间(MST),增加寿命(ILS),肿瘤体积,可行的肿瘤细胞计数,腹膜细胞计数、蛋白质百分比和血液参数。抗氧化剂地位是由丙二醛(MDA)和减少谷胱甘肽(GSH)含量,以及超氧化物歧化酶(SOD)和过氧化氢酶的活性(CA T) MT81及其结构类似物增加了平均生存时间,正常腹膜细胞计数。他们减少肿瘤体积,可行的肿瘤细胞计数,血红蛋白和包装细胞体积百分比。 Differential counts of WBC, total counts of RBC & WBC that altered by EAC inoculation, were restored in a dose-dependent manner. Increased MDA and decreased GSH content and reduced activity of SOD, and catalase in EAC bearing mice were returned towards normal after the treatment of MT81 and its structural analogue. Being less toxic than parent toxin MT81, the structural analogue showed more prominent antineoplastic activities against EAC cells compared to MT81. At the same time, both compounds exhibit to some extent antioxidant potential for the EAC-bearing mice.