文摘

唑吡坦(商品名安必恩)吸引了太多的利益作为睡眠代理也在研究。注意力主要集中在受体结合和电化学在中枢神经系统,简要讨论。提出了一种新颖的综合方法作用方式。要讨论的途径涉及碱度、还原电位,静电学、细胞信号传导、GABA受体结合,电子转移(ET)药效学、结构活性关系(SAR)和副作用。质子化作用形成的高度共轭吡啶盐脒的一部分提出的活性形式作为代理。外推的潜力减少相关化合物支持前提,唑吡坦可能充当等物种体内。从最近的文献报道,静电学被认为是药物作用中发挥重要作用。吡啶阳离子显示分子静电势大力很可能扮演一个角色或作为衔接机制。SAR分析类比与其他生理活性外源性物质,即苯二氮卓类和百草枯的共轭iminium类别。不活跃的代谢产物表明父母是唑吡坦的活动形式。 Absence of reactive oxygen species and oxidative stress is in line with minor side effects. In contrast, generally, the prior literature contains essentially no discussion of these fundamental biochemical relationships. Pharmacodynamics may play an important role. Concerning behavior at the blood-brain barrier, useful insight can be gained from investigations of the related cationic anesthetics that are structurally related to acetyl choline. Evidently, the neutral form of the drug penetrates the neuronal membrane, with the salt form operating at the receptor. The pathways of zolpidem have several clinical implications since the agent affects sedation, electroencephalographic activity, oxidative metabolites and receptors in the central nervous system. The drug acts at the GABA(A) receptor benzodiazepine site, displaying high and intermediate affinities to various receptor regions. Structural features for tight binding were determined. The sedative and anticonvulsant activities are due to its action on the alpha-1-GABA(A) receptors. One of the common adverse responses to zolpidem is hallucinations. Proposed mechanisms comprise changes in the GABA(A) receptor, pharmacodynamic interactions involving serotonin and neuronal-weak photon emission processes entailing redox phenomena. Reports cite cases of abuse with cravings based on anxiolytic and stimulating actions. It is important to recognize that insight concerning processes at the fundamental, molecular level can translate into beneficial results involving both positive and adverse side effects. In order for this to occur, interdisciplinary interaction is necessary. Suggestions are made for future research aimed at testing the various hypotheses.