n=24) and non-underground personnel (controls, n=17) were taken as controls. All coal miners were stable and had no systemic infection or disease. Standard posterio-anterior chest radiographs and pulmonary function tests were performed to exclude any diseases other than CWP. Serum proMMP-3 was analysed using the sandwich enzyme-linked immunosorbent assay according to the manufacturer's instructions (The Binding Site, Birmingham, UK).Mean proMMP-3 values of the all three groups were compared and a significant statistical difference obtained (p<0.001). In addition, a statistically significant difference was found between categories of the disease and proMMP-3 values (p<0.05). The effects of age, exposure duration and cigarette smoking on proMMP-3 values in coal miners with CWP were investigated. There were no correlations between age, smoking and proMMP-3 values. However, a positive correlation was found between exposure duration and proMMP-3 values (r=0.447, p=0.008).In conclusion, proMMP-3 (prostromelysin 1) may play an essential role in degrading and remodeling the ECM in workers with pneumoconiosis. ProMMP-3 may also reflect the stage of pneumoconiosis disease."> 的存在promatrix metalloproteinase-3及其与不同类别的煤炭工人肺尘埃沉着病 - raybet雷竞app,雷竞技官网下载,雷电竞下载苹果

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体积 13 |文章的ID 569097年 | https://doi.org/10.1080/09629350410001688549

Remzi Altin Levent卡丁车,İshak Tekin, Ferah Armutcu, Meltem Tor, Tacettin Ornek, ”的存在promatrix metalloproteinase-3及其与不同类别的煤炭工人肺尘埃沉着病”,炎症介质, 卷。13, 文章的ID569097年, 5 页面, 2004年。 https://doi.org/10.1080/09629350410001688549

的存在promatrix metalloproteinase-3及其与不同类别的煤炭工人肺尘埃沉着病

Remzi Altin,¹ 莱维小型赛车,¹ İshak Tekin,² Ferah Armutcu,³ Meltem Tor,¹ 和 Tacettin Ornek¹

¹肺医学系,医学院,Zonguldak Karaelmas大学,土耳其

²医学院免疫学系,Zonguldak Karaelmas大学,土耳其

³医学院生物化学系,Zonguldak Karaelmas大学,土耳其

文摘

细胞外基质(ECM)形成和重塑至关重要事件与肺纤维化的发病机制有关。基质金属蛋白酶降解中起着关键作用,ECM重塑。在这项研究中,我们试图展示的存在和相关性promatrix metalloproteinase-3 (proMMP-3) (metalloproteinase-3的活动形式)水平在煤炭工人肺尘埃沉着病(CWP)与不同的类别。研究人口由44名矿工CWP (pos CWP)。煤矿工人没有CWP (neg CWP, n = 24 )和non-underground人员(控制, n = 17 )被控制。煤矿工人都是稳定的,没有系统性感染或疾病。标准posterio-anterior胸片和肺功能测试进行比CWP排除其他疾病。血清使用夹心酶联免疫吸附试验分析了proMMP-3根据制造商的指示(英国伯明翰绑定网站)。意味着proMMP-3值的所有三组比较,获得显著的统计学差异( p < 0.001 )。此外,统计上的显著差异被发现疾病和proMMP-3类别之间的值( p < 0.05 )。年龄的影响,暴露时间和吸烟在煤矿工人proMMP-3值CWP。没有年龄之间的相关性,吸烟和proMMP-3值。然而,一个积极的曝光时间和proMMP-3值之间的相关性被发现( r = 0.447 , p = 0.008 )。总之,proMMP-3 (prostromelysin 1)中可能发挥重要作用在退化和重塑ECM与尘肺工人。ProMMP-3也反映了尘肺病的阶段。

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