研究文章
在体外Antiplasmodial、血红素聚合和细胞毒性的Hydroxyxanthone衍生品
表4
的集成电路50值hydroxyxanthone化合物的维洛细胞24小时后使用MTT测定方法孵化。
|
| 化合物 |
浓度(μ米) |
维洛细胞生长抑制(%)24小时后孵化 |
集成电路50(µ米) |
|
| HX1 |
8190.01 |
89.43±1.90 |
3394.90±435.44 |
| 4095.00 |
45.86±5.51 |
| 2047.50 |
27.96±5.69 |
| 1023.75 |
15.89±8.24 |
| 511.88 |
−4.13±8.21 |
| 255.94 |
−50.32±17.18 |
|
| HX2 |
1734.91 |
86.09 |
308.32 |
| 867.45 |
67.03 |
| 433.73 |
59.75 |
| 216.86 |
38.93 |
| 108.26 |
31.75 |
| 54.13 |
15.63 |
|
| HX3 |
2047.50 |
88.86 |
224.45 |
| 1023.75 |
79.92 |
| 511.88 |
68.04 |
| 255.94 |
55.70 |
| 127.76 |
39.58 |
| 63.88 |
20.70 |
|
| HX4 |
2027.14 |
89.96 |
330.68 |
| 1013.57 |
68.87 |
|
| 506.78 |
54.41 |
| 253.39 |
43.17 |
| 126.49 |
32.49 |
| 63.25 |
19.04 |
|
| HX5 |
2064.07 |
88.76 |
417.57 |
| 1032.03 |
68.13 |
| 516.02 |
48.33 |
| 258.01 |
37.83 |
| 128.80 |
27.88 |
| 64.40 |
−5.19 |
|
|
