研究文章
在体外Antiplasmodial、血红素聚合和细胞毒性的Hydroxyxanthone衍生品
表1
疟原虫的百分比增长抑制hydroxyxanthone衍生品和氯喹恶性疟原虫3于和FCR-3。
|
| 复合 |
浓度(μ米) |
生长抑制作用恶性疟原虫(%) |
| 菌株3于 |
应变FCR-3 |
|
| 1、6、8- - - - - -Trihydroxyxanthone (HX1) |
102.38 |
75.864±0.471 |
73.671±4.277 |
| 51.19 |
69.033±0.888 |
64.446±0.671 |
| 25.59 |
64.726±0.861 |
60.171±2.739 |
| 12.8 |
61.479±0.710 |
55.160±3.588 |
| 6.39 |
47.405±5.857 |
50.894±2.308 |
|
| 1、6- - - - - -Dihidroxyxanthone (HX2) |
876.42 |
90.560±0.665 |
87.623±2.239 |
| 438.21 |
73.618±0.713 |
74.226±1.318 |
| 219.11 |
67.164±0.601 |
67.144±2.757 |
| 109.55 |
54.805±2.433 |
50.248±2.629 |
| 54.78 |
49.172±1.606 |
47.192±0.687 |
|
| 1、5、6- - - - - -Trihydroxyxanthone (HX3) |
409.5 |
87.438±1.154 |
82.978±1.396 |
| 204.75 |
80.923±0.679 |
71.858±7.842 |
| 102.38 |
68.886±0.151 |
51.920±0.466 |
| 51.19 |
63.400±0.421 |
43.133±0.126 |
| 25.59 |
47.295±0.611 |
38.265±1.186 |
|
| 1- - - - - -Hydroxy-5-chloroxanthone (HX4) |
810.86 |
74.002±0.923 |
72.933±1.345 |
| 405.43 |
64.513±0.418 |
61.202±3.024 |
| 202.71 |
57.136±1.574 |
56.371±3.792 |
| 101.36 |
50.963±0.361 |
49.754±3.361 |
| 50.68 |
46.473±0.800 |
47.388±0.736 |
|
| 1,6-Dihydroxy-5-methylxanthone (HX5) |
330.25 |
93.288±0.956 |
84.664±0.902 |
| 165.13 |
75.364±1.287 |
73.462±1.596 |
| 82.56 |
54.180±1.574 |
46.519±0.816 |
| 41.28 |
45.041±0.563 |
41.140±0.396 |
| 20.64 |
37.886±0.441 |
33.632±0.327 |
|
| 氯喹 |
0.037 |
97.766±0.690 |
84.189±2.449 |
| 0.029 |
97.490±0.517 |
82.599±2.945 |
| 0.023 |
96.581±1.330 |
79.923±3.863 |
| 0.016 |
96.354±1.131 |
78.570±4.507 |
| 0.008 |
54.415±12.42 |
18.748±9.233 |
|
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