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Journal of Toxicology
Journal of Toxicology/2020/Article/Tab 2

Review Article

Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators

Table 2

Selected natural products with iron chelation/radical scavenging properties (in vitrostudies).
Natural product Experimental model Constituents responsible for activity Mechanism (s) 药理作用/结果 References
Garcinia kola Microsomal lipid peroxidation Kolaviron Antioxidation and chelating properties Mitigation of iron/ascorbate-induced damage to microsomal lipids [97]
Azadirachta indica(neem) leaves Ferric reducing antioxidant plasma (FRAP) assay Flavonoid and phenolic compounds Anti-oxidation, scavenging and reduction of the power of ferric ion (Fe3+)亚铁离子(Fe2+) Antioxidant activity [107]
Lotus (Nelumbonucifera Gaertn) leaves Iron loaded human hepatocellular (HepG2) cells Polyphenolic compounds Antioxidation, iron chelating and scavenging properties Dose-dependent decrease in labile iron pool [154]
Bergamot and orange juices Iron overloaded human lung epithelial cells (A549 cells) Flavonoids Antioxidation chelating and blockade of the redox activity of iron Reduced generation of reactive oxygen species and membrane lipid peroxidation. Inhibition of DNA-oxidative damage [155]
Spondias pinnatastem bark In vitroassays (IC50measurements) Flavonoids and phenolic compounds Antioxidation, radical scavenging, Iron reducing, and chelating properties Decrease in the level of labile iron pool [156]
Essential oils ofOcimum basilicumL.,Origanum vulgareL., andThymus vulgarisL. In vitroassays (IC50measurements) Essential oils Antioxidation and chelating properties Inhibition of lipid peroxidation induced by Fe(2+)/ascorbate or by Fe(2+)/H(2)O(2) [157]
Red ginger (Zingiber officinalevar. Rubra) and white ginger (Zingiber officinaleRoscoe) Inhibitory effect on Fe2+-induced lipid peroxidation in rat brainin vitro Flavonoids and phenolic compounds Fe(2+) chelating ability, OH scavenging and iron reducing power activities Protective effect by reducing malondialdehyde contents of the brain [158]
Unripe pawpaw (Carica papaya) fruit Inhibitory effect on Fe2+-induced lipid peroxidation in rat’s pancreasin vitro Flavonoids and phenolic compounds Antioxidation, iron chelating and radical scavenging properties Reduced malondialdehyde contents in the pancreas; Inhibition of lipid peroxidation [159]
Primula heterochroma Inhibitory effect on Fe2+-induced lipid peroxidation and oxidative stress in rat brainin vitro Flavonoids and phenolic compounds Fe(2+) chelating, radical scavenging and reducing power activities Protective effect by reducing brain thiobarbituric acid reactive substances (TBARS) levels [160]

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