研究文章
90天口服Methylurate嘌呤生物碱Theacrine的毒理学评价
|
| 集团(毫克/公斤体重/天) |
|
器官重量相对于体重(%) |
| 大脑 |
肝 |
肾脏 |
心 |
胸腺 |
脾 |
睾丸或子宫 |
附睾或卵巢 |
肾上腺 |
甲状腺 |
|
| 男性 |
|
| 控制() |
的意思是 |
0.512 |
2.371 |
0.538 |
0.271 |
0.104 |
0.167 |
0.825 |
0.384 |
0.018 |
0.007 |
| SD |
0.031 |
0.206 |
0.032 |
0.017 |
0.027 |
0.019 |
0.051 |
0.024 |
0.003 |
0.001 |
| 180 () |
的意思是 |
0.519 |
2.551 |
0.564 |
0.269 |
0.096 |
0.183 |
0.831 |
0.391 |
0.018 |
0.005 |
| SD |
0.021 |
0.137 |
0.034 |
0.037 |
0.018 |
0.011 |
0.060 |
0.031 |
0.003 |
0.001 |
| ±% |
1 |
8 |
5 |
−1 |
−8 |
10 |
1 |
2 |
−5 |
−19 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 300 () |
的意思是 |
0.540 |
2.502 |
0.593 |
0.305 |
0.082 |
0.203 |
0.692 |
0.347 |
0.022 |
0.005 |
| SD |
0.054 |
0.099 |
0.045 |
0.031 |
0.011 |
0.021 |
0.201 |
0.046 |
0.003 |
0.001 |
| ±% |
5 |
6 |
10 |
13 |
−21 |
22 |
−16 |
−10 |
18 |
−20 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 375 () |
的意思是 |
0.549 |
2.519 |
0.588 |
0.329 |
0.079 |
0.189 |
0.379 |
0.304 |
0.025 |
0.006 |
| SD |
0.040 |
0.148 |
0.043 |
0.047 |
0.009 |
0.019 |
0.187 |
0.040 |
0.003 |
0.001 |
| ±% |
7 |
6 |
9 |
22 |
−23 |
13 |
−54 |
−21 |
35 |
−5 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
|
| 女性 |
|
| 控制() |
的意思是 |
0.807 |
2.739 |
0.663 |
0.343 |
0.170 |
0.226 |
0.274 |
0.068 |
0.037 |
0.009 |
| SD |
0.064 |
0.215 |
0.058 |
0.032 |
0.023 |
0.041 |
0.036 |
0.014 |
0.005 |
0.002 |
| 180 () |
的意思是 |
0.831 |
3.051 |
0.656 |
0.316 |
0.155 |
0.260 |
0.359 |
0.064 |
0.035 |
0.009 |
| SD |
0.040 |
0.110 |
0.049 |
0.023 |
0.017 |
0.034 |
0.107 |
0.013 |
0.007 |
0.002 |
| ±% |
3 |
11 |
−1 |
−8 |
−9 |
15 |
31日 |
−6 |
−4 |
7 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 300 () |
的意思是 |
0.794 |
2.828 |
0.625 |
0.367 |
0.132 |
0.244 |
0.233 |
0.059 |
0.037 |
0.009 |
| SD |
0.054 |
0.204 |
0.025 |
0.031 |
0.019 |
0.029 |
0.078 |
0.012 |
0.005 |
0.001 |
| ±% |
−2 |
3 |
−6 |
7 |
−23 |
8 |
−15 |
−13 |
0 |
2 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
| 375 () |
的意思是 |
0.796 |
2.892 |
0.628 |
0.384 |
0.125 |
0.245 |
0.231 |
0.061 |
0.038 |
0.009 |
| SD |
0.071 |
0.200 |
0.039 |
0.048 |
0.023 |
0.026 |
0.068 |
0.013 |
0.006 |
0.002 |
| ±% |
−1 |
6 |
−5 |
12 |
−27 |
8 |
−15 |
−10 |
5 |
5 |
| 党卫军 |
|
|
|
|
|
|
|
|
|
|
|
|
±%,百分比偏差与控制、毫克/公斤体重/天,毫克每千克体重每天;SD,标准偏差;党卫军,统计学意义;动物的数量。
< 0.05;< 0.01。
|