临床研究
协会的骨质流失的Upregulation Survival-Related基因的差别和伴随的对这些哺乳动物雷帕霉素靶和成骨细胞Differentiation-Related基因外周血的晚绝经后女性骨质疏松性
表2
相关系数及其意义(
)所示为细胞生长和differentiation-related基因的表达与BMD在绝经后女性骨质疏松性。
|
|
mTOR |
TGFβ1 |
RUNX2 |
肿瘤坏死因子α |
il - 1β |
Caspase-3 |
|
| RUNX2 |
0.768 |
0.768 |
|
|
|
|
| (P< 0.001) |
(P< 0.001) |
|
| 肿瘤坏死因子α |
0.664 |
|
0.504 |
|
|
|
| (P= 0.005) |
(P= 0.03) |
|
| il - 1β |
0.424 |
0.696 |
0.496 |
0.494 |
|
|
| (P= 0.06) |
(P< 0.001) |
(P= 0.01) |
(P= 0.03) |
|
| Caspase-3 |
0.666 |
0.481 |
0.519 |
0.867 |
0.637 |
|
| (P= 0.003) |
(P= 0.03) |
(P= 0.01) |
(P< 0.001) |
(P= 0.002) |
|
|
| p21 |
0.580 |
0.868 |
0.680 |
0.715 |
0.675 |
0.715 |
| (P= 0.009) |
(P< 0.001) |
(P= 0.001) |
(P= 0.002) |
(P= 0.001) |
(P= 0.001) |
|
| TGFβ1 |
0.632 |
|
|
|
|
|
| P= 0.004 |
|
| 组织蛋白酶K |
0.542 |
|
|
0.516 |
|
|
| (P= 0.03) |
|
|
(P= 0.07) |
|
|
|
| 腰椎 |
|
|
|
|
|
|
|
| 股骨颈 |
|
|
|
|
|
|
|
| 转子 |
|
|
0.548 |
|
|
|
|
|
(P= 0.01) |
|
|
|
|
| 沃德三角形 |
|
|
0.516 |
|
|
|
|
|
(P= 0.02) |
|
|
|
|
| 总股骨 |
|
0.524 |
0.605 |
|
|
|
|
(P= 0.02) |
(P= 0.005) |
|
|
|
|
|
