|
| 药物 |
不。主题 |
结果 |
严重不良事件 |
参考 |
|
|
绝对体重(公斤)(95%置信区间) |
≥5%的减肥 |
≥10%的减肥 |
改变WC (cm) |
|
|
|
| 安非他酮和环丙甲羟二羟吗啡酮(400毫克) |
安慰剂- 85 |
|
15% |
2% |
|
BN32 BN16恶心:3.5%,28.1%,39.7%,41% BN48 |
(22] |
|
N 48 mg-56 B-60 |
|
10% |
2% |
|
|
|
BN16 mg - 64 |
|
26% |
7% |
|
|
|
|
|
52%, |
17%, |
, |
|
|
BN 32毫克- 63 |
|
51%, |
19%, |
, |
|
|
BN 48 mg - 61 |
|
39%, |
15%, |
, |
|
|
| 安非他酮(120毫克/ 360毫克)+ Zonisamide(360毫克/ 360毫克) |
729(总) |
1.4∧P |
15%∧P |
4%∧P |
NA |
NA |
(97年] |
|
|
3.2∧Z120
Z360 |
27%∧Z120Z360 |
9%∧Z120
18%∧Z360 |
|
|
|
|
|
2.3∧B360 |
21%∧B360 |
11%∧B360 |
|
|
|
|
|
6.1∧ZB120
7.5∧ZB360 |
47%∧ZB120 ()60%∧ZB360 () |
25%∧ZB120
32%∧ZB360 |
|
|
|
|
| 利莫那班 |
p - 417 |
0.5 (0.3,1.3) |
NR |
NR |
1.0 (−0.2,1.9) |
精神:28.4% P, R, 43.4% |
(98年] |
|
r - 422 |
4.3 (3.5,5.1) |
|
|
4.5 (−3.7−5.4), |
严重的精神:3.5% P, R, 4.8% |
|
|
| 利莫那班∗ |
3165(总) |
安慰剂1.6
R为6.5 |
19.7%
50.8%, |
7.8%
27%, |
6.4
2.5 |
抑郁症:0.8% P, R, 1.9% NS焦虑:0.3便士,1.0%,R NS |
(96年] |
| Tesofensine |
Placebo-52 |
2.2 (0.9,3.5) |
13 (29%) |
3 (7%) |
−2.4 (0.7,4.2) |
愤怒和敌意:4%,14.3% T 1毫克, |
(99年] |
|
0.25 T mg-52 |
6.7 (5.4,8.0), |
29 (59%) |
17 (35%) |
−5.9 (4.0,7.8), |
增加困惑:P-NA, |
|
|
0.5 T mg-50 |
11.3 (9.9,12.7), |
41 (87%) |
25 (53%) |
9·4 (7.7,11.0), |
T 0.5毫克, |
|
|
1.0 T mg-49 |
12·8 (11.6,14.1), |
42 (91%) |
34 (74%) |
9·3 (7.6,11.0), |
T 1毫克 |
|
|
|
