circITGA7海绵mir - 370 - 3在PCa - p细胞。(a)生物信息学分析与米兰达,TargetScan, CircInteractome。(b)地理数据集分析显示mir - 370 - 3的表达在PCa - p细胞和正常前列腺上皮细胞。(c)的表达水平,mir - 370 - 3 - p在28对PCa和paracancerous组织检测。(d)评估的相关性circITGA7和mir - 370 - 3 - p在PCa组织由皮尔森相关系数表达式。mir - 370 (e) - 3 - p在circITGA7的过度表达下调。(f)中存在被用来检测的相对表达mir - 370 - 3 - p细胞转染mir - 370 - 3 - p模仿或消极的控制。(g)的示意图表示的结合位点与circITGA7 mir - 370 - 3 - p。相对荧光素酶活性(h)是由双荧光素酶记者在PCa分析细胞cotransfected与mir - 370 - 3 - p模仿和WT circITGA7或者狗circITGA7。(i, j)之间的交互mir - 370 - 3 - p和circITGA7被撕裂试验进一步证实。 Data were presented as mean ± SD of three independent experiments. Statistically significant differences were indicated: 。