研究文章
四个ABC转运蛋白基因在遗传易感性在约旦的乳腺癌患者
表2
种代号为ABCB1的协会的调查ABCC1、ABCC2, ABCG2 SNPs和乳腺癌(BC)。
|
| 基因 |
SNP ID |
等位基因和基因型频率的情况下和控制 |
| 等位基因和基因型 |
情况下 |
控制 |
假定值 |
卡方 |
| (n = 222) |
(n = 218) |
|
| ABCC1 |
rs35626 |
G |
283 (0.65) |
256 (0.59) |
0.073 |
3.214 |
| T |
155 (0.35) |
180 (0.41) |
|
|
| GG |
95 (0.43) |
81 (0.37) |
0.216 |
3.063 |
| GT |
93 (0.42) |
94 (0.43) |
|
|
| TT |
31 (0.14) |
43 (0.2) |
|
|
| rs35628 |
一个 |
394 (0.9) |
388 (0.89) |
0.788 |
0.072 |
| G |
44 (0.1) |
46 (0.11) |
|
|
| AA |
180 (0.82) |
175 (0.81) |
0.820 |
0.395 |
| AG) |
34 (0.16) |
38 (0.18) |
|
|
| GG |
5 (0.02) |
4 (0.02) |
|
|
| rs4148351 |
C |
369 (0.84) |
346 (0.8) |
0.082 |
3.021 |
| T |
69 (0.16) |
88 (0.2) |
|
|
| CC |
160 (0.73) |
138 (0.64) |
0.068 |
5.374 |
| CT |
49 (0.22) |
70 (0.32) |
|
|
| TT |
10 (0.05) |
9 (0.04) |
|
|
|
| ABCC2 |
rs2273697 |
G |
332 (0.75) |
331 (0.76) |
0.778 |
0.079 |
| 一个 |
108 (0.25) |
103 (0.24) |
|
|
| AA |
13 (0.06) |
17 (0.08) |
0.412 |
1.773 |
| 遗传算法 |
82 (0.37) |
69 (0.32) |
|
|
| GG |
125 (0.57) |
131 (0.6) |
|
|
| rs3740065 |
一个 |
341 (0.77) |
345 (0.79) |
0.478 |
0.503 |
| G |
101 (0.23) |
91 (0.21) |
|
|
| AA |
131 (0.59) |
141 (0.65) |
0.285 |
2.51 |
| AG) |
79 (0.36) |
63 (0.29) |
|
|
| GG |
11 (0.05 |
14 (0.06) |
|
|
| s717620 |
C |
387 (0.88) |
377 (0.87) |
0.285 |
2.51 |
| T |
55 (0.12) |
57 (0.13) |
|
|
| CC |
170 (0.77) |
165 (0.76) |
0.928 |
0.149 |
| CT |
47 (0.21) |
47 (0.22) |
|
|
| TT |
4 (0.02) |
5 (0.02) |
|
|
|
| ABCB1 |
rs1045642 |
C |
288 (0.65) |
248 (0.57) |
0.012 |
6.364 |
| T |
152 (0.35) |
186 (0.43) |
|
|
| CC |
102 (0.46) |
79 (0.36) |
0.063 |
5.499 |
| CT |
84 (0.38) |
90 (0.41) |
|
|
| TT |
34 (0.15) |
48 (0.22) |
|
|
| rs1128503 |
一个 |
278 (0.64) |
242 (0.56) |
0.016 |
5.791 |
| G |
158 (0.36) |
192 (0.44) |
|
|
| AA |
36 (0.17) |
49 (0.23) |
0.074 |
5.189 |
| 遗传算法 |
86 (0.39) |
94 (0.43) |
|
|
| GG |
96 (0.44) |
74 (0.34) |
|
|
| rs2032582 |
一个 |
144 (0.33) |
174 (0.43) |
0.035 |
6.668 |
| C |
284 (0.65) |
252 (0.58) |
|
|
| T |
12 (0.03) |
6 (0.01) |
|
|
| AA |
29 (0.13) |
41 (0.19) |
1 e-8 |
44.386 |
| CA |
82 (0.37) |
90 (0.42) |
|
|
| CC |
97 (0.44) |
79 (0.37) |
|
|
| 助教 |
49 (0.02) |
2 (0.0093) |
|
|
| TC |
8 (0.04) |
4 (0.02) |
|
|
|
| ABCG2 |
rs2231142 |
T |
17 (0.04) |
16 (0.04) |
0.902 |
0.015 |
| G |
425 (0.96) |
418 (0.96) |
|
|
| GG |
204 (0.92) |
201 (0.93) |
0.899 |
0.016 |
| GT |
17 (0.08) |
16 (0.07) |
|
|
|
|
|
P值< 0.05被认为是重要的。
|
