模型的新陈代谢apo (a)。1-Lipoprotein (a)生产(肝细胞水平)。四个阶段可能负责apo (a) Lp (a)在肝细胞生产:(a) (a)人群的基因的转录和apo (a) mRNA的稳定核;(B) (a)朊翻译对生产的影响率;(c)呃,posttranslation apo (a) kringles修改和折叠;(D) Golgi-specific apo (a)的碳水化合物的添加和修改;和(E)运输到细胞表面。2-Assembly Lp (a): Lp (a)的装配是有争议的。(一)细胞表面。(B) Disse的空间。 (C) Plasma. 3—Apo(a) associates with a recently made TG-abundant molecule to form Lp(a) with VLDL properties and/or with a cholesterol-abundant molecule with LDL properties. 4—TG-abundant Lp(a) may be transformed into a cholesterol-abundant molecule with LDL properties. 5—Catabolism and clearance: The two Lp(a) components become separated. The generation of apo(a) fragments is most likely from proteolytic cleavage by elastases or metalloproteinases secreted by cells in the arterial wall. (5—A) This permits apo(a) to unite the apo(a) pool recently produced by the hepatocytes. (5-B) Hepatocyte internalization and uptake by megalin, gp330 receptor, macrophage scavenger receptor-BI, lipoprotein receptor, VLDL receptor, PlgRKT receptor, asialoglycoprotein receptor (ASGPR), and LDLR. (5-B) Kidney cellular internalization and uptake. (5-C) Vascular wall deposition. Solid lines represent metabolic pathways; dotted lines represent hypothesized metabolic pathways.