先天免疫代表了广泛的医疗领域的当前研究趋势。儿科胃肠学病理学是日常练习中最常见的病态。这两者之间的关系目前尚未完全理解，但全球多个研究人员强调了先天免疫在不同胃肠病疾病的病因中的重要贡献，例如胃炎，乳糜泻或炎症性肠病，其发病通常在儿童期间或青春期。

The existence of a relationship between innate immunity mechanisms (e.g. toll-like receptors) and the onset of certain gastroenterological pathologies is undoubtable, but a more thorough approach in this topic would be extremely useful to understand clearly the mechanistic pathways and to create a solid basis for potential prevention or treatment strategies. Innate immunity responses are involved in the development of both gastroenterological infectious disorders, such Helicobacter pylori-induced gastritis, and autoimmune disorders, such as celiac disease or inflammatory bowel disorders. Nevertheless, it remains to be seen whether these responses depend only on the individual’s susceptibility or whether they might be externally influenced. A complex and integrative mechanistic model of the relationship between innate immunity and multiple gastrointestinal tract pathologies would be extremely useful for opening multiple research directions. Moreover, paediatric populations are ideal for studying this topic not only because these pathologies usually occur in children, but also due to the optimal time of prevention and intervention in order to reduce the occurrence of further complications. Taking into account the associated life-threatening complications of these pathologies during childhood, a proper elucidation of these mechanisms might represent the cornerstone for decreasing both morbidity and mortality related to them. Another current challenge of the medical and research field is to define the role of gastrointestinal microbiota in the area of paediatric gastroenterology. Moreover, it has been found that the maternal microbiota might be involved in shaping postnatal immunity. Postnatal immunity responses seem to be influenced by other environmental factors including gastrointestinal microbiota. Innate immunity also seems to be involved in other maternal and gestational concerns with a great impact on birth outcomes.

这一特殊问题的主要目的是确定一个综合机制模型，以清楚地了解先天免疫和儿科胃肠内疾病之间的关系，以及其他因素，如母体微生物群或妊娠病理学。欢迎原始研究和审查文章。

潜在主题包括但不限于以下内容：

• 先天免疫在乳糜泻发作中的作用
• 儿科胃炎和先天免疫力
• 先天免疫，幽门螺杆菌感染和胃微生物群
• 先天免疫和儿童肥胖
• 先天免疫和炎症性肠病
• 先天免疫和牛奶蛋白过敏
• 先天免疫和儿科肝炎
• 免疫，炎症和胎儿结果
• 胃癌发生和先天免疫力
• 肠道致癌和先天免疫力
• 先天免疫和传染性腹泻