研究文章
临床特点和危险因素COVID-19 ICU住院的糖尿病患者
表1
COVID-19 non-DM或DM患者的临床特征。
|
| 参数 |
(总
) |
Non-DM (
) |
DM (
) |
价值 |
|
| 临床特点 |
|
|
|
|
| 年龄、平均(IOR)年 |
48.5 (34.3 - -62.0) |
47.0 (33.0 - -61.0) |
62.5 (55.50 - -64.75) |
< 0.0001 |
| 年龄(年) |
|
|
|
|
| ≤30 |
44 (15.3%) |
44 (16.7%) |
0 (0.0%) |
< 0.0001 |
| 30 - 45 |
87例(30.2%) |
85例(32.2%) |
2 (8.3%) |
|
| 45 - 65 |
116例(40.3%) |
97例(36.7%) |
19 (79.2%) |
|
| > 65 |
41 (14.2%) |
38 (14.4%) |
3 (12.5%) |
|
| 女,(%) |
157例(54.5%) |
143例(54.2%) |
14 (58.3%) |
0.695 |
| 糖尿病持续时间(年) |
NA |
NA |
10.8 (6.5 - -15.6) |
NA |
| 类型的糖尿病 |
|
|
|
|
| 1型 |
NA |
NA |
2 (8.3%) |
NA |
| 2型 |
NA |
NA |
22 (91.7%) |
NA |
| 并发症 |
|
|
|
|
| 高血压 |
84例(29.2%) |
68例(25.8%) |
16 (66.7%) |
< 0.0001 |
| 化学汽相淀积 |
85例(29.5%) |
69例(26.1%) |
16 (66.7%) |
< 0.0001 |
| 慢性阻塞性肺病 |
5 (1.7%) |
4 (1.5%) |
1 (4.2%) |
0.343 |
| 慢性肾脏疾病 |
8 (2.8%) |
6 (2.3%) |
2 (8.3%) |
0.084 |
| 慢性肝病 |
10 (3.5%) |
8 (3.0%) |
2 (8.3%) |
0.174 |
| 症状和体征 |
|
|
|
|
| 发烧 |
201例(69.8%) |
181例(68.6%) |
20 (83.3%) |
0.131 |
| 寒冷 |
55 (19.1%) |
52 (19.7%) |
3 (12.5%) |
0.390 |
| 咳嗽 |
163例(56.6%) |
148例(56.1%) |
15 (62.5%) |
0.542 |
| 吐痰 |
58 (20.1%) |
52 (19.7%) |
6 (25.0%) |
0.535 |
| 肌痛 |
35 (12.2%) |
31 (11.7%) |
4 (16.7%) |
0.480 |
| 疲劳 |
43 (14.9%) |
40 (15.2%) |
3 (12.5%) |
0.727 |
| 喉咙痛 |
67例(23.3%) |
64例(24.2%) |
3 (12.5%) |
0.192 |
| 头痛 |
26 (9.0%) |
24 (9.1%) |
2 (8.3%) |
0.901 |
| 恶心或呕吐 |
29 (10.1%) |
28 (10.6%) |
1 (4.2%) |
0.316 |
| 腹泻 |
11 (3.8%) |
10 (3.8%) |
1 (4.2%) |
0.926 |
| 呼吸每分钟呼吸 |
19 (6.6%) |
14 (5.3%) |
5 (20.8%) |
0.003 |
| 单方面的肺炎 |
31 (10.8%) |
30 (11.4%) |
1 (4.2%) |
0.274 |
| 双边肺炎 |
241例(83.7%) |
219例(83.0%) |
22 (91.7%) |
0.269 |
| 实验室的变量 |
|
|
|
|
| 白血细胞(×109/ L) |
5.20 (4.14 - -6.44) |
5.20 (4.10 - -6.40) |
5.39 (4.62 - -7.12) |
0.840 |
| 白细胞计数,×109/ L(没有。(%)) |
|
|
|
|
| ≤4 |
62例(21.5%) |
58 (22.0%) |
4 (16.7%) |
0.825 |
| 4到10 |
216例(75.0%) |
197例(74.6%) |
19 (79.2%) |
|
| > 10 |
10 (3.5%) |
9 (3.4%) |
1 (4.2%) |
|
| 淋巴细胞计数(×109/ L) |
1.42 (1.04 - -1.96) |
1.42 (1.04 - -1.95) |
1.40 (1.07 - -2.16) |
0.314 |
| 淋巴细胞计数,×109/ L(没有。(%)) |
|
|
|
|
| < 1.1 |
91例(31.6%) |
83例(31.4%) |
8 (33.3%) |
0.848 |
| 血小板计数(×109/ L) |
194.5 (158 - 247) |
196.0 (160 - 247) |
186.5 (142 - 228.5) |
0.679 |
| 血红蛋白(g / L) |
135.5 (123 - 147) |
136.0 (123 - 147) |
133.5 (121 - 145.8) |
0.656 |
| 血糖(更易/ L) |
4.97 (4.39 - -5.76) |
4.56 (4.16 - -5.52) |
7.95 (6.57 - -11.85) |
0.001 |
| 糖化血红蛋白(%) |
NA |
NA |
6.81 (5.91 - -7.95) |
NA |
| 糖化血红蛋白(没有。(%)) |
|
|
|
|
| < 7% |
NA |
NA |
9 (37.5%) |
NA |
| ≥7% |
NA |
NA |
15 (62.5%) |
|
| 血清胰岛素(个人/ L) |
NA |
NA |
20.68 (11.82 - -36.55) |
NA |
| 原降钙素(ng / mL) |
0.13 (0.04 - -32.60) |
0.13 (0.04 - -33.55) |
0.097 (0.038 - -20.20) |
0.733 |
| c反应蛋白(毫克/升) |
9.00 (8.00 - -22.72) |
9.00 (8.00 - -21.50) |
21.15 (8.25 - -47.09) |
0.039 |
| c反应蛋白,mg / L(不。(%)) |
|
|
|
|
| ≤10 |
175例(60.8%) |
167例(63.3%) |
8 (33.3%) |
0.004 |
| > 10 |
113例(39.2%) |
97例(36.7%) |
16 (66.7%) |
|
| 肺动脉栓塞(μg / L) |
1100年(700 - 1700) |
1090年(680 - 1700) |
1190年(850 - 1770) |
0.198 |
| 肺动脉栓塞(没有。(%)) |
|
|
|
|
| < 1000 |
125例(43.9%) |
116例(44.3%) |
9 (39.1%) |
0.634 |
| ≥1000 |
160例(56.1%) |
146例(55.7%) |
14 (60.9%) |
|
| 肌红蛋白(μg / L) |
15.00 (8.85 - -22.46) |
14.75 (8.70 - -22.25) |
19.00 (9.20 - -32.40) |
0.003 |
| 肌红蛋白,μg / L (No。(%)) |
|
|
|
|
| < 106 |
269例(97.1%) |
247例(97.2%) |
22 (95.7%) |
0.662 |
| ≥106 |
8 (2.9%) |
7 (2.8%) |
1 (4.3%) |
|
| 肌钙蛋白I (μg / L) |
0.004 (0.001 - -0.009) |
0.003 (0.001 - -0.009) |
0.008 (0.002 - -0.017) |
0.784 |
| 肌酸激酶(U / L) |
52.00 (36.00 - -80.00) |
52.00 (36.00 - -80.75) |
51.00 (38.00 - -78.00) |
0.351 |
| 肌酸激酶,U / L(不。(%)) |
|
|
|
|
| ≤310 |
283例(98.6%) |
261例(98.9%) |
22 (95.7%) |
0.208 |
| > 310 |
4 (1.4%) |
3 (1.1%) |
1 (4.3%) |
|
| 肌酐(μ摩尔/升) |
61.80 (50.25 - -76.58) |
62.05 (50.05 - -76.68) |
60.00 (51.63 - -73.95) |
0.616 |
| ALT (U / L) |
22.45 (14.30 - -34.50) |
22.40 (14.30 - -34.15) |
24.25 (14.50 - -52.27) |
0.889 |
| ALT, U / L(不。(%)) |
|
|
|
|
| ≤50 |
254例(88.2%) |
237例(89.8%) |
17 (70.8%) |
0.006 |
| > 50 |
34 (11.8%) |
27 (10.2%)) |
7 (29.2%) |
|
| AST (U / L) |
18.35 (14.9 - -25.63) |
18.20 (14.53 - -24.48) |
24.75 (16.88 - -44.50) |
< 0.0001 |
| AST, U / L(不。(%)) |
|
|
|
|
| ≤40 |
256例(88.9%) |
240例(90.9%) |
16 (66.7%) |
< 0.0001 |
| > 40 |
32 (11.1%) |
24 (9.1%) |
8 (33.3%) |
|
|
|
|
数据作为中位数(四分位范围)或数量(百分比)。缩写:差:四分位范围;拿拿淋:不适用;心血管疾病:心血管疾病;慢性阻塞性肺病:慢性阻塞性肺疾病;糖化血红蛋白:糖化血红蛋白;ALT:丙氨酸氨基转移酶;AST:天冬氨酸转氨酶。
|
