原位 原位 免疫组织化学染色和荧光gonadoblastoma杂交(鱼)和癌病变的病人1。(一)代表苏木精和伊红染色。生殖细胞存在于GB和独联体染色阳性(b) OCT3/4(棕色),(c) TSPY(红色)和(d)自洽场(布朗)。独联体(e)的支持细胞病变SOX9积极(棕色染色)和FOXL2是负面的。GB (f),支持细胞染色阳性FOXL2(棕色染色)和负SOX9。(f)在每一个图像显示了GB损伤左侧(胚胎生殖细胞与granulose-like混杂在一起支持细胞),独联体含有细精管右侧(CIS细胞与支持细胞基膜)。放大200倍和400倍。幻灯片(b) - (f)与苏木精复染色。(g)代表鱼Y-centromere-specific探测器(红色所示)和X-centomere-specific探测器(绿色)所示。放大630倍。 (h) Schematic representation of the different moments in time of clinical intervention, blue arrow, identification of a malignant type II germ cell tumor, together with GB and CIS as precursor lesions at the age of 26 years. Review of the clinical history showed hypospadias and cryptorchid testes, signs of TDS/DSD which were not recognized at an early age. Grey-dashed arrows; early recognition of TDS/DSD could have allowed early detection and treatment of the malignancy, thereby, preventing the need for additional systemic treatment.