研究文章
基因变异及等离子体水平在捷克慢性牙周炎患者和糖尿病
表2
il - 1基因型和等位基因频率在CP患者,T1DM (T1DM + CP组),2型糖尿病(2型糖尿病+ CP组),与健康对照组。
|
| 基因型等位基因 |
控制(
) |
CP (
) |
或(95%置信区间) |
T1DM (
) |
或(95%置信区间) |
T1DM + CP (
) |
或(95%置信区间) |
2型糖尿病(
) |
或(95%置信区间) |
2型糖尿病+ CP (
) |
或(95%置信区间) |
| IL-1A(−889 c / T) |
(%) |
(%) |
|
(%) |
|
(%) |
|
(%) |
|
(%) |
|
|
| CC |
105 (46.7) |
145 (54.9) |
1.00 |
61 (46.2) |
1.00 |
20 (52.6) |
1.00 |
198 (50.1) |
1.00 |
46 (51.7) |
1.00 |
| CT |
102 (45.3) |
104 (39.4) |
0.74 (0.51 - -1.07) |
62 (47.0) |
1.05 (0.67 - -1.63) |
15 (39.5) |
0.77 (0.37 - -1.59) |
160 (40.5) |
0.83 (0.59 - -1.17) |
34 (38.2) |
0.76 (0.45 - -1.28) |
| TT |
18 (8.0) |
15 (5.7) |
0.70 (0.34 - -1.36) |
9 (6.8) |
0.86 (0.36 - -2.03) |
3 (7.9) |
0.88 (0.24 - -3.25) |
37 (9.4) |
1.09 (0.59 - -2.01) |
9 (10.1) |
1.14 (0.48 - -2.73) |
| C等位基因 |
312 (69.3) |
394 (74.6) |
1.00 |
184 (69.7) |
1.00 |
55 (72 4) |
1.00 |
556 (70.4) |
1.00 |
126 (70.8) |
1.00 |
| T等位基因 |
138 (30.7) |
134 (25.4) |
0.77 (0.58 - -1.02) |
80 (30.3) |
0.98 (0.71 - -1.37) |
21日(27.6) |
0.86 (0.50 - -1.48) |
234 (29.6) |
0.95 (0.74 - -1.22) |
52 (29.2) |
0.93 (0.64 - -1.36) |
|
| IL-1B(+ 3953 c / T) |
|
|
|
|
|
|
|
|
|
|
|
| CC |
115 (51.1) |
164 (62.1) |
1.00 |
73 (55.3) |
1.00 |
18 (47.4) |
1.00 |
220 (55.7) |
1.00 |
50 (56.2) |
1.00 |
| CT |
94 (41.8) |
87 (33.0) |
0.65 (0.45 - -0.95) |
48 (36.4) |
0.80 (0.51 - -1.27) |
17 (44.7) |
1.16 (0.56 - -2.37) |
143 (36.2) |
0.80 (0.56 - -1.12) |
30 (33.7) |
0.73 (0.43 - -1.25) |
| TT |
16 (7.1) |
13 (4.9) |
0.57 (0.26 - -1.23) |
11 (8.3) |
1.08 (0.48 - -2.46) |
3 (7.9) |
1.20 (0.32 - -4.53) |
32 (8.1) |
1.05 (0.55 - -1.98) |
9 (10.1) |
1.29 (0.54 - -3.12) |
| C等位基因 |
324 (72.0) |
415 (78.6) |
1.00 |
194 (73.5) |
1.00 |
53 (69.7) |
1.00 |
584 (73.8) |
1.00 |
130 (73.0) |
1.00 |
| T等位基因 |
126 (28.0) |
113 (21.4) |
0.70 (0.52 - -0.94) |
70 (26.5) |
0.93 (0.66 - -1.31) |
23日(30.3) |
1.12 (0.66 - -1.90) |
206 (26.2) |
0.91 (0.70 - -1.18) |
48 (27.0) |
0.95 (0.64 - -1.40) |
|
| IL-1RN(VNTR)§ |
|
|
|
|
|
|
|
|
|
|
|
| 11 |
108 (48.0) |
121 (45.8) |
1.00 |
83 (62.9) |
1.00 |
19日(50.0) |
1.00 |
220 (55.7) |
1.00 |
48 (53.9) |
1.00 |
| 12 |
87 (38.7) |
110 (41.7) |
1.13 (0.77 - -1.65) |
31 (23.5) |
0.46 (0.28 - -0.76) |
11 (28.9) |
0.72 (0.32 - -1.59) |
129 (32.7) |
0.73 (0.51 - -1.04) |
25 (28.1) |
0.65 (0.37 - -1.13) |
| 13 |
8 (3.6) |
1 (0.4) |
0.11 (0.01 - -0.91) |
1 (0.8) |
0.16 (0.02 - -1.33) |
1 (2.6) |
0.71 (0.08 - -6.01) |
3 (0.8) |
0.18 (0.05 - -0.71) |
1 (1.1) |
0.28 (0.03 - -2.31) |
| 14 |
3 (1.3) |
8 (3.0) |
2.38 (0.62 - -9.20) |
4 (3.0) |
1.73 (0.38 - -7.96) |
1 (2.6) |
1.89 (0.19 - -19.19) |
9 (2.3) |
1.47 (0.39 - -5.55 |
4 (4.5) |
3.00 (0.65 - -13.93) |
| 22 |
17 (7.6) |
17 (6.4) |
0.89 (0.43 - -1.83) |
8 (6.1) |
0.61 (0.25 - -1.49) |
2 (5.3) |
0.67 (0.14 - -3.13) |
31 (7.8) |
0.90 (0.47 - -1.69) |
9 (10.1) |
1.19 (0.50 - -2.86) |
| 23 |
0 |
1 (0.4) |
# |
1 (0.8) |
# |
1 (2.6) |
# |
0 |
# |
0 |
# |
| 24 |
2 (0.9) |
5 (1.9) |
2.23 (0.42 - -11.74) |
3 (2.3) |
1.95 (0.32 - -11.95) |
2 (5.3) |
5.68 (0.75 - -42.84) |
3 (0.8) |
0.74 (0.12 - -4.47) |
2 (2.2) |
1.38 (0.19 - -10.04) |
| 44 |
0 |
0 |
# |
1 (0.8) |
# |
1 (2.6) |
# |
0 |
# |
0 |
# |
| 16 |
0 |
1 (0.4)§§ |
# |
0 |
# |
0 |
# |
0 |
# |
0 |
# |
| L等位基因 |
327 (72.7) |
376 (71.5) |
1.00 |
213 (80.7) |
1.00 |
58 (76.3) |
1.00 |
596 (75.4) |
1.00 |
133 (74.7) |
1.00 |
| S等位基因 |
123 (27.3) |
150 (28.5) |
1.06 (0.80 - -1.40) |
51 (19.3) |
0.64 (0.44 - -0.92) |
18 (23.7) |
0.83 (0.47 - -1.46) |
194 (24.6) |
0.87 (0.67 - -1.13) |
45 (25.3) |
0.90 (0.61 - -1.34) |
|
|
CI =置信区间;CP =慢性牙周炎;或=优势比;T1DM = 1型糖尿病;2型糖尿病= 2型糖尿病。 与健康对照组相比(确切概率法评估,没有修正多个比较)。 #不能因为小的数字。 §等位基因与超过两个重复单元被组合在一起 IL-1RN
∗L(“长”等位基因)和2重复单位被标记为 IL-1RN
(“短”等位基因)。 §§样品与罕见的基因型 IL-1RN16岁被排除在等位基因频率和单体型分析。
|
