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Kaushik Deb,太太Mohan查图尔维迪尤Kumar贾斯瓦尔, ”革兰氏阴性细菌LPS诱导小鼠子宫接受能力差和植入失败:改变IL-1β表达在胚胎和子宫角”,在妇产科感染性疾病, 卷。13, 文章的ID145690年, 9 页面, 2005年。 https://doi.org/10.1080/10647440500147885
革兰氏阴性细菌LPS诱导小鼠子宫接受能力差和植入失败:改变IL-1β表达在胚胎和子宫角
文摘
泌尿道束或系统性感染革兰氏阴性细菌的孕妇,导致流产,早产,和其他几个围产期并发症。有限合伙人是最有效的抗原成分的革兰氏阴性细菌细胞壁和调节各种促炎细胞因子的表达。在这里,我们调查的作用可溶性il - 1即形式。,IL-1β in the ‘minimum dose’ of LPS induced pregnancy loss in mice. Uterine cross-sections on each day of the preimplantation period of pregnancy were examined histopathologically for finding out LPS induced changes in the uterine preparation for embryo implantation. The expression of IL-1β in the various stages of the preimplantation period of pregnancy was studied by RT-PCR in the embryos and the uterine horns of the LPS treated and normal pregnant mice. We found that LPS significantly alters the proliferation of the glandular epithelium, luminal epithelium and stroma during the preimplantation period. We also found large infiltration of macrophages into the uterine horns of the LPS treated animals. The level and pattern of IL-1β expression in the preimplantation embryos and uterine horns were also altered in LPS treated animals. These observations indicate that LPS can alter the uterine preparation for blastocyst implantation, which could be due to the change in the IL-1β expression in the uterine horns. However, a change in the expression pattern of IL-1β in the preimplantation embryos underlines the significance of this molecule in LPS induced pregnancy loss or implantation failure in mouse.
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