原文
提取物的生物活性标记基于药代动力学评价传统的药用植物,Piper sarmentosum
表3
药代动力学参数sarmentine后大鼠口服剂量(500毫克公斤−1)的乙醇提取的水果p . sarmentosum。
|
| 老鼠 |
1 |
2 |
3 |
4 |
5 |
6 |
平均数±标准差 |
|
| AUC0 -∞(ng h毫升−1) |
5078.443 |
5304.598 |
4674.769 |
4684.233 |
4749.764 |
4900.847 |
4898.776±251.1527 |
| AUMC0 -∞ |
55 489.980 |
60 942.670 |
55 318.870 |
51 450.740 |
51 587.150 |
52 239.930 |
54 504.890±3634.530 |
| 捷运(h) |
10.927 |
11.489 |
11.834 |
10.984 |
10.861 |
10.659 |
11.126±0.443 |
| T1/2(h) |
10.380 |
11.873 |
13.183 |
7.668 |
9.714 |
9.023 |
10.307±1.985 |
| C马克斯(ng毫升−1) |
196.547 |
194.318 |
166.476 |
194.929 |
194.54 |
202.669 |
191.580±12.691 |
| T马克斯(h) |
6.000 |
6.000 |
6.000 |
6.000 |
6.000 |
6.000 |
6.000±0.000 |
| K埃尔(h−1) |
0.089 |
0.078 |
0.070 |
0.121 |
0.095 |
0.103 |
0.093±0.018 |
| Cl |
0.004 |
0.004 |
0.004 |
0.005 |
0.005 |
0.004 |
0.004±0.000 |
| VD |
0.042 |
0.052 |
0.059 |
0.038 |
0.048 |
0.039 |
0.047±0.008 |
|
|
