研究文章
长非编码RNA段H19多态性之间的关系和冠状动脉疾病的风险在中国人口:病例对照研究
表2
协会lncRNA段H19多态性与急性冠脉综合征的危险分层的主机的特点。
|
| 变量 |
基因型 |
ACS和反对 |
一个 |
或(95%置信区间) |
|
| 段H19 rs2735971 |
|
|
|
|
| 性别 |
|
|
|
|
| 男性 |
GG |
176/162 |
|
1 (Ref)。 |
| 遗传算法 |
65/93 |
0.024 |
0.64 (0.44 - -0.94) |
| AA |
7/4 |
0.452 |
1.61 (0.46 - -5.62) |
| GA + AA和GG |
|
0.045 |
0.68 (0.47 - -0.99) |
| AA与GA + GG |
|
0.330 |
1.85 (0.54 - -6.41) |
| 与G |
|
0.137 |
0.78 (0.66 - -1.08) |
| 女 |
GG |
63/49 |
|
1 (Ref)。 |
| 遗传算法 |
14/25 |
0.028 |
0.43 (0.20 - -0.91) |
| AA |
2/6 |
0.101 |
0.25 (0.05 - -1.31) |
| GA + AA和GG |
|
0.012 |
0.40 (0.19 - -0.82) |
| AA与GA + GG |
|
0.174 |
0.32 (0.06 - -1.65) |
| 与G |
|
0.007 |
0.43 (0.23 - -0.79) |
| 年龄 |
|
|
|
|
| ≦60 |
GG |
143/121 |
|
1 (Ref)。 |
| 遗传算法 |
51/76 |
0.010 |
0.57 (0.37 - -0.88) |
| AA |
5/3 |
0.783 |
1.23 (0.28 - -5.34) |
| GA + AA和GG |
|
0.017 |
0.60 (0.39 - -0.91) |
| AA与GA + GG |
|
0.529 |
1.59 (0.37 - -6.80) |
| 与G |
|
0.064 |
0.65 (0.41 - -1.03) |
| > 60 |
GG |
96/90 |
|
1 (Ref)。 |
| 遗传算法 |
28/42 |
0.134 |
0.65 (0.37 - -1.14) |
| AA |
4/7 |
0.444 |
0.60 (0.17 - -2.20) |
| GA + AA和GG |
|
0.102 |
0.64 (0.37 - -1.09) |
| AA与GA + GG |
|
0.525 |
0.66 (0.19 - -2.37) |
| 与G |
|
0.056 |
0.70 (0.49 - -1.01) |
| 吸烟 |
|
|
|
|
| 曾经吸烟者 |
GG |
161/112 |
|
1 (Ref)。 |
| 遗传算法 |
58/63 |
0.041 |
0.63 (0.41 - -0.98) |
| AA |
5/4 |
0.903 |
0.92 (0.24 - -3.52) |
| GA + AA和GG |
|
0.047 |
0.65 (0.43 - -0.99) |
| AA与GA + GG |
|
0.926 |
1.07 (0.28 - -4.03) |
| 与G |
|
0.087 |
0.72 (0.50 - -1.05) |
| 从未吸烟者 |
GG |
78/99 |
|
1 (Ref)。 |
| 遗传算法 |
21/55 |
0.026 |
0.51 (0.28 - -0.92) |
| AA |
4/6 |
0.675 |
0.76 (0.20 - -2.81) |
| GA + AA和GG |
|
0.028 |
0.54 (0.31 - -0.94) |
| AA与GA + GG |
|
0.901 |
0.92 (0.25 - -3.39) |
| 与G |
|
0.055 |
0.63 (0.39 - -1.01) |
| 饮酒 |
|
|
|
|
| 饮酒者 |
GG |
56/119 |
|
1 (Ref)。 |
| 遗传算法 |
27/76 |
0.345 |
0.77 (0.45 - -1.33) |
| AA |
四四 |
0.314 |
2.08 (0.50 - -8.63) |
| GA + AA和GG |
|
0.491 |
0.83 (0.49 - -1.41) |
| AA与GA + GG |
|
0.256 |
2.27 (0.55 - -9.28) |
| 与G |
|
0.806 |
0.95 (0.62 - -1.48) |
| Nondrinker |
GG |
183/92 |
|
1 (Ref)。 |
| 遗传算法 |
52/42 |
0.041 |
0.60 (0.37 - -0.98) |
| AA |
5/6 |
0.298 |
0.52 (0.15 - -1.79) |
| GA + AA和GG |
|
0.028 |
0.59 (0.37 - -0.94) |
| AA与GA + GG |
|
0.417 |
0.60 (0.18 - -2.05) |
| 与G |
|
0.027 |
0.63 (0.42 - -0.95) |
| 段H19 rs2839698 |
|
|
|
|
| 性别 |
|
|
|
|
| 男性 |
CC |
140/139 |
|
1 (Ref)。 |
| CT |
111/109 |
0.934 |
1.02 (0.71 - -1.45) |
| TT |
17/28 |
0.109 |
0.59 (0.31 - -1.13) |
| CT + TT和CC |
|
0.669 |
0.93 (0.66 - -1.30) |
| TT与CT + CC |
|
0.112 |
0.60 (0.32 - -1.13) |
| T和C |
|
0.305 |
0.87 (0.67 - -1.13) |
| 女 |
CC |
41/61 |
|
1 (Ref)。 |
| CT |
37/21 |
0.005 |
2.61 (1.34 - -5.09) |
| TT |
9/5 |
0.097 |
2.68 (0.84 - -8.58) |
| CT + TT和CC |
|
0.002 |
2.62 (1.40 - -4.88) |
| TT与CT + CC |
|
0.284 |
1.86 (0.60 - -5.81) |
| T和C |
|
0.004 |
2.12 (1.28 - -3.50) |
| 年龄 |
|
|
|
|
| ≦60 |
CC |
113/111 |
|
1 (Ref)。 |
| CT |
80/84 |
0.710 |
0.93 (0.62 - -1.39) |
| TT |
17/20 |
0.589 |
0.82 (0.41 - -1.66) |
| CT + TT和CC |
|
0.640 |
0.91 (0.62 - -1.34) |
| TT与CT + CC |
|
0.671 |
0.86 (0.44 - -1.70) |
| T和C |
|
0.147 |
1.31 (0.91 - -1.89) |
| > 60 |
CC |
68/89 |
|
1 (Ref)。 |
| CT |
68/46 |
0.006 |
2.02 (1.22 - -3.34) |
| TT |
9/13 |
0.997 |
1.00 (0.40 - -2.51) |
| CT + TT和CC |
|
0.015 |
1.80 (1.12 - -2.89) |
| TT与CT + CC |
|
0.511 |
0.74 (0.30 - -1.81) |
| T和C |
|
0.603 |
0.92 (0.68 - -1.25) |
| 吸烟 |
|
|
|
|
| 曾经吸烟者 |
CC |
126/93 |
|
1 (Ref)。 |
| CT |
103/79 |
0.968 |
0.99 (0.66 - -1.48) |
| TT |
14/20 |
0.062 |
0.49 (0.23 - -1.04) |
| CT + TT和CC |
|
0.552 |
0.89 (0.61 - -1.31) |
| TT与CT + CC |
|
0.073 |
0.52 (0.25 - -1.06) |
| T和C |
|
0.221 |
0.83 (0.62 - -1.12) |
| 从未吸烟者 |
CC |
55/107 |
|
1 (Ref)。 |
| CT |
45/51 |
0.041 |
1.72 (1.02 - -2.90) |
| TT |
12/13 |
0.172 |
1.81 (0.77 - -4.24) |
| CT + TT和CC |
|
0.023 |
1.76 (1.08 - -2.87) |
| TT与CT + CC |
|
0.332 |
1.51 (0.66 - -3.47) |
| T和C |
|
0.024 |
1.56 (1.06 - -2.29) |
| 饮酒 |
|
|
|
|
| 饮酒者 |
CC |
51/111 |
|
1 (Ref)。 |
| CT |
35/80 |
0.794 |
0.93 (0.55 - -1.57) |
| TT |
6/21 |
0.262 |
0.58 (0.22 - -1.51) |
| CT + TT和CC |
|
0.557 |
0.86 (0.53 - -1.41) |
| TT与CT + CC |
|
0.302 |
0.61 (0.24 - -1.56) |
| T和C |
|
0.352 |
0.83 (0.56 - -1.23) |
| Nondrinker |
CC |
130/50 |
|
1 (Ref)。 |
| CT |
113/50 |
0.094 |
1.45 (0.94 - -2.25) |
| TT |
20/12 |
0.736 |
1.15 (0.52 - -2.53) |
| CT + TT和CC |
|
0.106 |
1.40 (0.93 - -2.12) |
| TT与CT + CC |
|
0.985 |
0.99 (0.47 - -2.12) |
| T和C |
|
0.205 |
1.24 (0.89 - -1.72) |
| 段H19 rs3024270 |
|
|
|
|
| 性别 |
|
|
|
|
| 男性 |
GG |
91/83 |
|
1 (Ref)。 |
| GC |
139/125 |
0.943 |
1.01 (0.69 - -1.49) |
| CC |
37/63 |
0.018 |
0.54 (0.33 - -0.90) |
| CC + GC和GG |
|
0.394 |
0.85 (0.60 - -1.23) |
| CC和GC + GG |
|
0.006 |
0.53 (0.34 - -0.83) |
| C与G |
|
0.035 |
0.77 (0.61 - -0.98) |
| 女 |
GG |
29/37 |
|
1 (Ref)。 |
| GC |
40/37 |
0.311 |
1.41 (0.73 - -2.74) |
| CC |
16/14 |
0.385 |
1.47 (0.62 - -3.50) |
| CC + GC和GG |
|
0.266 |
1.42 (0.77 - -2.64) |
| CC和GC + GG |
|
0.610 |
1.23 (0.56 - -2.70) |
| C与G |
|
0.289 |
1.26 (0.82 - -1.95) |
| 年龄 |
|
|
|
|
| ≦60 |
GG |
74/69 |
|
1 (Ref)。 |
| GC |
102/91 |
0.914 |
1.02 (0.66 - -1.58) |
| CC |
33/51 |
0.081 |
0.61 (0.35 - -1.06) |
| CC + GC和GG |
|
0.526 |
0.88 (0.59 - -1.32) |
| CC和GC + GG |
|
0.033 |
0.59 (0.36 - -0.96) |
| C与G |
|
0.868 |
0.97 (0.70 - -1.35) |
| > 60 |
GG |
46/51 |
|
1 (Ref)。 |
| GC |
77/71 |
0.424 |
1.24 (0.73 - -2.11) |
| CC |
20/26 |
0.883 |
0.95 (0.46 - -1.95) |
| CC + GC和GG |
|
0.556 |
1.16 (0.71 - -1.92) |
| CC和GC + GG |
|
0.621 |
0.85 (0.46 - -1.62) |
| C与G |
|
0.106 |
0.79 (0.61 - -1.05) |
| 吸烟 |
|
|
|
|
| 曾经吸烟者 |
GG |
81/56 |
|
1 (Ref)。 |
| GC |
126/86 |
0.935 |
1.02 (0.65 - -1.59) |
| CC |
34/45 |
0.029 |
0.53 (0.30 - -0.94) |
| CC + GC和GG |
|
0.445 |
0.85 (0.56 - -1.29) |
| CC和GC + GG |
|
0.009 |
0.51 (0.31 - -0.85) |
| C与G |
|
0.050 |
0.76 (0.58 - -1.00) |
| 从未吸烟者 |
GG |
39/64 |
|
1 (Ref)。 |
| GC |
53/76 |
0.715 |
1.11 (0.65 - -1.89) |
| CC |
19/32 |
0.992 |
1.00 (0.50 - -2.01) |
| CC + GC和GG |
|
0.731 |
1.09 (0.66 - -1.81) |
| CC和GC + GG |
|
0.805 |
0.92 (0.49 - -1.74) |
| C与G |
|
0.920 |
1.02 (0.72 - -1.44) |
| 饮酒 |
|
|
|
|
| 饮酒者 |
GG |
31/62 |
|
1 (Ref)。 |
| GC |
48/99 |
0.960 |
0.99 (0.57 - -1.72) |
| CC |
13/46 |
0.135 |
0.56 (0.26 - -1.20) |
| CC + GC和GG |
|
0.537 |
0.85 (0.50 - -1.44) |
| CC和GC + GG |
|
0.092 |
0.56 (0.29 - -1.10) |
| C与G |
|
0.171 |
0.78 (0.55 - -1.11) |
| Nondrinker |
GG |
89/58 |
|
1 (Ref)。 |
| GC |
131/63 |
0.281 |
1.29 (0.81 - -2.04) |
| CC |
40/31 |
0.541 |
0.83 (0.46 - -1.50) |
| CC + GC和GG |
|
0.539 |
1.14 (0.75 - -1.75) |
| CC和GC + GG |
|
0.214 |
0.72 (0.42 - -1.21) |
| C与G |
|
0.800 |
0.96 (0.72 - -1.29) |
|
|
|
一个逻辑回归调整按性别和年龄。ACS:急性冠脉综合征;置信区间:置信区间;反对:控制;或:优势比。
|
