研究文章
NLRC4基因单核苷酸多态性与预后的相关Hemophagocytic Lymphohistiocytosis
表3
比较基因型和等位基因频率在rs385076轨迹和rs479333轨迹NLRC4基因通过死亡组和生存组的病人。
|
|
死亡(
) |
生存(
) |
RR(95%置信区间)# |
|
|
| rs385076 |
|
|
|
|
| 基因型 |
|
|
|
|
| TT |
11 (50.00%) |
36 (90.00%) |
1.00(参考) |
|
| TC |
6 (27.27%) |
2 (5.00%) |
3.205 (1.277 - -4.788) |
0.012 |
| CC |
5 (22.73%) |
2 (5.00%) |
3.052 (1.098 - -4.753) |
0.031 |
| 占主导地位的模式 |
|
|
3.133 (1.543 - -5.029) |
0.001 |
| 隐性的模型 |
|
|
2.311 (0.882 - -3.393) |
0.091 |
| 等位基因 |
|
|
|
|
| T |
27 (61.36%) |
70例(87.50%) |
1.00(参考) |
|
| C |
17 (38.64%) |
10 (12.50%) |
2.262 (1.359 - -3.347) |
0.002 |
| rs479333 |
|
|
|
|
| 基因型 |
|
|
|
|
| CC |
9 (40.91%) |
34 (85.00%) |
1.00(参考) |
|
| CG |
8 (36.36%) |
3 (7.50%) |
3.475 (1.488 - -5.775) |
0.003 |
| GG |
5 (22.73%) |
3 (7.50%) |
2.986 (1.014 - -5.570) |
0.047 |
| 占主导地位的模式 |
|
|
3.269 (1.580 - -6.092) |
0.001 |
| 隐性的模型 |
|
|
1.985 (0.741 - -3.250) |
0.188 |
| 等位基因 |
|
|
|
|
| C |
26 (59.09%) |
71例(88.75%) |
1.00(参考) |
|
| G |
18 (40.91%) |
9 (11.25%) |
2.487 (1.518 - -3.607) |
< 0.001 |
|
|
|
RR:相对风险;置信区间:置信区间。#调整了年龄、性别、体重指数、高血压史、糖尿病、冠心病、EBV感染通过病人。
|
