研究文章
在MicroRNA基因多态性与精神分裂症的易感性相关但不与MECT的有效性
表3
基因型和等位基因分布rs1625579, rs6577555, rs2296616病例和控制。
|
| 单核苷酸多态性 |
SCZ (
) |
控制(
) |
HWE价值 |
或(95%置信区间) |
价值 |
或(95%置信区间)# |
价值# |
|
| mir - 137 rs1625579 |
|
|
|
|
|
|
|
| TT |
112例(74.67%) |
127例(84.67%) |
0.053 |
1.000(参考) |
|
1.000(参考) |
|
| TG |
26 (17.33%) |
20 (13.33%) |
1.474 (0.746 - -2.921) |
0.23 |
1.206 (0.854 - -1.578) |
0.299 |
| GG |
12 (8.00%) |
3 (2.00%) |
4.536 (1.152 - -20.814) |
0.013 |
1.707 (1.073 - -2.060) |
0.026 |
| 占主导地位的模式 |
|
|
|
1.873 (1.014 - -3.474) |
0.031 |
1.329 (1.007 - -1.662) |
0.045 |
| 隐性的模型 |
|
|
|
1.261 (1.089 - -19.458) |
0.017 |
1.652 (1.043 - -1.986) |
0.034 |
| T |
250例(83.33%) |
274例(91.33%) |
|
1.000(参考) |
|
1.000(参考) |
|
| G |
50 (16.67%) |
26 (8.67%) |
|
2.108 (1.239 - -3.600) |
0.003 |
1.379 (1.108 - -1.634) |
0.005 |
| miR-34 rs6577555 |
|
|
|
|
|
|
|
| CC |
81例(54.00%) |
91例(60.67%) |
0.104 |
1.000(参考) |
|
1.000(参考) |
|
| CA |
39 (26.00%) |
47 (31.33%) |
0.932 (0.536 - -1.620) |
0.791 |
0.963 (0.705 - -1.282) |
0.895 |
| AA |
30 (20.00%) |
12 (8.00%) |
2.809 (1.279 - -6.254) |
0.005 |
1.517 (1.121 - -1.882) |
0.008 |
| 占主导地位的模式 |
|
|
|
1.314 (0.809 - -2.135) |
0.243 |
1.145 (0.899 - -1.446) |
0.293 |
| 隐性的模型 |
|
|
|
2.875 (1.343 - -6.247) |
0.003 |
1.536 (1.150 - -1.871) |
0.005 |
| C |
201例(67.00%) |
229例(76.33%) |
|
1.000(参考) |
|
1.000(参考) |
|
| 一个 |
99例(33.00%) |
71例(23.67%) |
|
1.589 (1.092 - -2.312) |
0.011 |
1.246 (1.045 - -1.463) |
0.014 |
| mir - 107 rs2296616 |
|
|
|
|
|
|
|
| AA |
105例(70.00%) |
132例(88.00%) |
0.08 |
1.000(参考) |
|
1.000(参考) |
|
| AG) |
28 (18.67%) |
16 (10.67%) |
2.200 (1.079 - -4.516) |
0.018 |
1.436 (1.041 - -1.826) |
0.028 |
| GG |
17 (11.33%) |
2 (1.33%) |
10.686 (2.296 - -68.554) |
< 0.001 |
2.020 (1.437 - -2.251) |
< 0.001 |
| 占主导地位的模式 |
|
|
|
3.143 (1.654 - -6.018) |
< 0.001 |
1.612 (1.263 - -1.945) |
< 0.001 |
| 隐性的模型 |
|
|
|
9.459 (2.045 - -60.437) |
< 0.001 |
1.890 (1.353 - -2.100) |
0.001 |
| 一个 |
238例(79.33%) |
280例(93.33%) |
|
1.000(参考) |
|
1.000(参考) |
|
| G |
62例(20.67%) |
20 (6.67%) |
|
3.647 (2.081 - -6.443) |
< 0.001 |
1.646 (1.374 - -1.879) |
< 0.001 |
|
|
或:优势比;95%置信区间:95%置信区间。 原油或和95%可信区间; #或者和95%可信区间调整年龄、性别和地位的吸烟和喝酒。
|
