比较铜离子之间的相互作用与阿尔茨海默氏症β淀粉样肽和人类血清白蛋白</t我tle> <link rel="preload stylesheet" as="style" type="text/css" href="https://cdn.bibblio.org/rcm/4.28.0/bib-related-content.min.css"> <link rel="preload" href="https://static.hindawi.com/new/next_assets/2023-08-03-0017a694320dbe69a559e8120be98c/_next/static/css/b2661f2cd4bd618b.css" as="style"> <link rel="stylesheet" href="https://static.hindawi.com/new/next_assets/2023-08-03-0017a694320dbe69a559e8120be98c/_next/static/css/b2661f2cd4bd618b.css" data-n-g=""> <style id="__jsx-903e4b2e5d3241e4">div#__next{display:-webkit-box;display:-webkit-flex;display:-moz-box;display:-ms-flexbox;display:flex;min-height:100vh;-webkit-box-orient:vertical;-webkit-box-direction:normal;-webkit-flex-direction:column;-moz-box-orient:vertical;-moz-box-direction:normal;-ms-flex-direction:column;flex-direction:column}</style> </head> <body> <div id="__next"> <section class="ant-layout"> <div> <header class="ant-layout-header"> <div class="header__width-wrapper"> <div class="ant-anchor-wrapper ant-anchor-logo" style="max-height:100vh"> <div class="ant-anchor ant-anchor-fixed"> <div class="ant-anchor-ink"> <span class="ant-anchor-ink-ball"></span> </div> <div class="ant-anchor-link ant-link-logo"> <a class="ant-anchor-link-title" href="//www.newsama.com/" title=""> <div class="ant-image"> <img alt="标志" class="ant-image-img ant-image-logo" src="https://static.hindawi.com/new/next_assets/2023-08-03-0017a694320dbe69a559e8120be98c/public/logo.svg"> </div></a> </div> </div> </div> <div class="TopNavigation_topNavigationWrapper__QzFKB"> <div class="TopNavigation_rightSideMenuItems__0bKf1"> <ul class="ant-menu-overflow ant-menu ant-menu-root ant-menu-horizontal ant-menu-light header-ant-menu-horizontal" role="menu" tabindex="0" data-menu-list="true" data-testid="desktop-menu"> <li class="ant-menu-overflow-item ant-menu-item ant-menu-item-only-child" style="opacity:1;order:0" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/journals/" aria-label="Journals">期刊</一个></span></li> <li class="ant-menu-overflow-item ant-menu-item ant-menu-item-only-child" style="opacity:1;order:1" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publish-research/" aria-label="Publish with us">雷电竞下载苹果</a></span></li> <li class="ant-menu-overflow-item ant-menu-item ant-menu-item-only-child" style="opacity:1;order:2" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publishing-partnerships/" aria-label="Publishing partnerships">raybet推荐吗</a></span></li> <li class="ant-menu-overflow-item ant-menu-item ant-menu-item-only-child" style="opacity:1;order:3" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/about/" aria-label="About us">关于我们</一个></span></li> <li class="ant-menu-overflow-item ant-menu-item ant-menu-item-only-child" style="opacity:1;order:4" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/blog/" aria-label="Blog">博客</一个></span></li> <li class="ant-menu-overflow-item ant-menu-overflow-item-rest ant-menu-submenu ant-menu-submenu-horizontal" style="opacity:0;height:0;overflow-y:hidden;order:9007199254740991;pointer-events:none;position:absolute" aria-hidden="true" role="none"> <div role="menuitem" class="ant-menu-submenu-title" tabindex="-1" aria-expanded="false" aria-haspopup="true"> <span role="img" aria-label="ellipsis" class="anticon anticon-ellipsis"> <svg viewbox="64 64 896 896" focusable="false" data-icon="ellipsis" width="1em" height="1em" fill="currentColor" aria-hidden="true"> <path d="M176 511a56 56 0 10112 0 56 56 0 10-112 0zm280 0a56 56 0 10112 0 56 56 0 10-112 0zm280 0a56 56 0 10112 0 56 56 0 10-112 0z"></path> </svg></span> <i class="ant-menu-submenu-arrow"></i> </div></li> </ul> <div style="display:none" aria-hidden="true"></div> <button data-testid="search-button-icon" aria-label="Search" type="button" class="ant-btn ant-btn-default SearchToggleButton_btn__kmpSM"><span role="img" class="anticon SearchToggleButton_icon__nurvY"> <svg width="1em" height="1em" viewbox="0 0 26 26" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M22.1,23.813l-5.478-5.479a10.282,10.282,0,1,1,1.709-1.709L23.813,22.1a1.209,1.209,0,0,1-1.71,1.71ZM2.416,10.27A7.851,7.851,0,0,0,15.78,15.864l.041-.043.043-.041A7.853,7.853,0,1,0,2.416,10.27Z" fill="currentColor"></path> </svg></span></button> <div></div> <button data-testid="menu-button-icon" aria-label="Menu" type="button" class="ant-btn ant-btn-default MenuToggleButton_btn__Go00X"><span role="img" class="anticon MenuToggleButton_icon__5uVd5"> <svg width="1em" height="1em" viewbox="0 -2 28 28" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.833,25.667a1.834,1.834,0,0,1,0-3.668H25.667a1.834,1.834,0,0,1,0,3.668Zm0-11a1.833,1.833,0,0,1,0-3.666H25.667a1.833,1.833,0,0,1,0,3.666Zm0-11A1.833,1.833,0,1,1,1.833,0H25.667a1.833,1.833,0,0,1,0,3.666Z" fill="currentColor"></path> </svg></span></button> <div></div> </div> </div> </div> </header> </div> <main class="ant-layout-content ArticleLayout_articleLayoutWrapper__oukM3"> <div> <div id="journal-header" class=" JournalNavigation_journalHeader__vGN2X" data-istranslated="false"> <a href="//www.newsama.com/journals/bca" class="JournalNavigation_journalHeader__titleLink__sZyGb"><h1 id="journal-header-title" data-testid="journal-header-title" class="JournalNavigation_small__sXDLc JournalNavigation_journalHeader__title__fsEHD">生物无机化学与应用</h1></a> <div class="JournalNavigation_navigationBarHorizontal__YojZL"> <div id="navigation-bar-horizontal" class="navigation-bar-horizontal"> <button id="Journal overview" type="button" class="ant-btn ant-btn-default ant-dropdown-trigger bordered"><span role="img" class="anticon"> <svg width="1em" height="1em" viewbox="0 0 32 32" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M17.773 23.453l11.2-11.265a1.918 1.918 0 000-2.641 1.75 1.75 0 00-2.542 0l-9.929 10.101-9.933-10.1a1.75 1.75 0 00-2.542 0 1.919 1.919 0 000 2.64L15.23 23.453c.352.365.811.547 1.271.547.46 0 .92-.182 1.271-.547z" fill="currentColor"></path> </svg></span><span>日报》概述</span></button> <a class="bordered" href="//www.newsama.com/journals/bca/guidelines">对于作者</一个><一个class="bordered" href="//www.newsama.com/publish-research/reviewers">对于审查员</一个><一个class="bordered" href="//www.newsama.com/publish-research/editors">的编辑器</一个><一个class="bordered" href="//www.newsama.com/journals/bca/contents/">表的内容</一个><button id="Special Issues" type="button" class="ant-btn ant-btn-default ant-dropdown-trigger"><span role="img" class="anticon"> <svg width="1em" height="1em" viewbox="0 0 32 32" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M17.773 23.453l11.2-11.265a1.918 1.918 0 000-2.641 1.75 1.75 0 00-2.542 0l-9.929 10.101-9.933-10.1a1.75 1.75 0 00-2.542 0 1.919 1.919 0 000 2.64L15.23 23.453c.352.365.811.547 1.271.547.46 0 .92-.182 1.271-.547z" fill="currentColor"></path> </svg></span><span>特殊的问题</span></button> </div> </div> </div> </div> <nav class="ant-breadcrumb ArticleLayout_breadcrumbs__hsc4o"> <ol> <li><span class="ant-breadcrumb-link"><a href="//www.newsama.com/journals/bca/" aria-label="Bioinorganic Chemistry and Applications">生物无机化学与应用</一个></span><span class="ant-breadcrumb-separator">/</span></li> <li><span class="ant-breadcrumb-link"><a href="//www.newsama.com/journals/bca/contents/year/2012/" aria-label="2012">2012年</一个></span><span class="ant-breadcrumb-separator">/</span></li> <li><span class="ant-breadcrumb-link">文章</span><span class="ant-breadcrumb-separator">/</span></li> </ol> </nav> <div class="ant-row ThreeColumnLayout_wrapper__gPK_l"> <div class="ant-col ThreeColumnLayout_leftColumn__yqNgV"> <div> <div> <div id="article-table-of-contents" data-ismobile="false"> <div class="TableOfContents_tableOfContents__0jAuv"> <div class="TableOfContents_tableOfContents__title__CH9Lz"> 在这一页上</d我v> <a class="TableOfContents_tableOfContents__item__JJil1" href="#abstract">文摘</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#introduction">介绍</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#materials-and-method">材料</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#results-and-discussion">结果与讨论</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#conclusion">结论</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#references">引用</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#copyright">版权</一个><一个class="TableOfContents_tableOfContents__item__JJil1" href="#related-articles">相关文章</一个></d我v> </div> </div> </div> </div> <div class="ant-col ThreeColumnLayout_middleColumn__sbd41"> <div class="ArticleMiddleSection_articleMiddleSection__gAv9z"> <div class="articleHeader"> <strong>研究文章|开放获取</strong> <div class="articleHeader__meta"> <span>体积2012年|</span> <span>文章的ID208641年|</span> <span class="articleHeader__meta_doiLink"><a href="https://doi.org/10.1155/2012/208641" aria-label="Doi-link" target="_blank" rel="noreferrer">https://doi.org/10.1155/2012/208641</一个></span> </div> <div class="simpleShowMore"> <button class="simpleShowMore__button">显示引用</button> </div> <h1 class="articleHeader__title">比较与阿尔茨海默氏症的铜离子之间的相互作用<我>β</我>淀粉样肽和人类血清白蛋白</h1> <div class="articleHeader__authors"> <span class="articleHeader__authors_author"><strong>g·雷Behbehani</strong><a href="//www.newsama.com/cdn-cgi/l/email-protection" aria-label="Mail Option"><span role="img" class="anticon"> <svg version="1.0" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="0 0 1401 1101"> <path fill="#6ba439" d="M132.5 2.1C101.4 6 71.1 20.5 48.3 42.4c-22.7 21.7-37.5 48.3-44.6 80l-2.2 10.1v837l2.2 10.1c6.7 30 19.3 53.9 39.8 75.3 23.3 24.3 56.4 40.9 90 45 12.8 1.6 1122.2 1.6 1135 0 38.9-4.8 75.9-25.6 100-56.4 15-19.3 24.2-39 29.8-63.9l2.2-10.1v-837l-2.2-10.1c-7.1-31.8-21.9-58.3-44.6-80.1-20.2-19.2-43.9-31.7-73.6-38.5l-9.6-2.3L705 1.4c-321.9-.1-568.5.2-572.5.7zm1123.4 99.5c1.7.4 3.1 1 3.1 1.4 0 .5-125.6 87.7-279 194L700.9 490.2 422 297C268.5 190.7 143 103.4 143 103c0-.5 1-1.1 2.3-1.3 3.5-.7 1107.1-.8 1110.6-.1zM401 404c164.4 113.8 299.4 207 300 207 .6 0 135.6-93.2 300.1-207 164.5-113.9 299.3-207 299.5-207 .2 0 .4 170.9.4 379.7 0 417.9.5 386-6.1 398.3-6.2 11.6-19 21.4-31.9 24.4-5.8 1.4-67.4 1.6-562 1.6s-556.2-.2-562-1.6c-12.9-3-25.7-12.8-31.9-24.4-6.6-12.3-6.1 19.6-6.1-398.3 0-208.8.2-379.7.5-379.7S236.6 290.1 401 404z"></path> </svg></span></a>,<sup>1</sup></span> <span class="articleHeader__authors_author">l . Barzegar,<sup>2</sup></span> <span class="articleHeader__authors_author">m . Mohebbian,<sup>1</sup></span> <span class="articleHeader__authors_author">和答:a . Saboury<sup>3</sup></span> </div> <div class="simpleShowMore"> <button class="simpleShowMore__button">显示更多</button> </div> <div class="articleHeader__academicEditor"> <strong>学术编辑器:</strong> <span>Govindasamy Mugesh</span> </div> <div class="articleHeader__timeline"> <div class="articleHeader__timeline_item "> <strong>收到了</strong> <span>2012年04月02</span> </div> <div class="articleHeader__timeline_item "> <strong>接受</strong> <span>2012年5月15</span> </div> <div class="articleHeader__timeline_item articleHeader__timeline_item_sticky"> <strong>发表</strong> <span>09年7月2012年</span> </div> </div> </div> <div class="articleBody"> <div class="xml-content"> <h4 class="header" id="abstract">文摘</h4> <p>铜之间的相互作用<sup>2 +</sup>与第一个16阿尔茨海默氏症amyliod的残留物<我>β</我>肽,<我>Aβ</我>(1- 16),研究了人血清白蛋白(HSA)在体外通过等温滴定量热法在溶液的pH值7.2和310 K。溶解参数恢复从延长溶解模型表明,HSA参与铜离子的运输。之间的配合物<我>Aβ</我>(1- 16),提出了铜离子是一个异常的相互作用在阿尔茨海默病的发展,铜的地方<sup>2 +</sup>参与<我>Aβ</我>(1- 16)聚合。稳定的指标表明,HSA铜移除<sup>2 +</sup>从<我>Aβ</我>(1- 16),迅速,减少Cu-induced聚合的<我>Aβ</我>(1- 16),降低了毒性<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>显著。</p> <span class="end-abs"></span> <h4 id="introduction">1。介绍</h4> <p>阿尔茨海默病的特点之一是积累的淀粉样斑块之间在大脑中神经细胞(神经元)。β淀粉样蛋白是一种蛋白质片段剪掉的淀粉样前体蛋白(APP)。在一个健康的大脑中,这些蛋白质碎片分解和消除。在阿尔茨海默病,碎片积累形成困难,不溶性斑块。阿尔茨海默氏症和心脏病是严重过剩的铜和铁。研究人员仍在试图全面了解其斑块和神经元纤维缠结导致记忆丧失和其他症状以及如何逆转这些变化防止疾病或停止。然而,今天可供选择的治疗方法,可以帮助病人管理阿尔茨海默氏症的症状和延迟它的进展。乙酰胆碱有助于某些大脑细胞参与记忆之间传递消息。在阿尔茨海默氏症,这些脑细胞开始死亡和乙酰胆碱的数量减少。胆碱酯酶抑制剂降低乙酰胆碱的分解和提高其水平。 This reduces some of the symptoms of Alzheimer's disease. HSA carries metal ions, including physiological Ca<sup>2 +</sup>、锌<sup>2 +</sup>、有限公司<sup>2 +</sup>,铜<sup>2 +</sup>,以及有毒的Cd<sup>2 +</sup>和倪<sup>2 +</sup>(<一个href="#B1">1</一个>- - - - - -<一个href="#B5">5</一个>]。</p> <p>虽然认知障碍的病因在阿尔茨海默病(AD)并不完全了解,据报道,acetylcholine-producing神经元退化老年痴呆症患者的大脑中。胆碱能的损失程度与认知障碍的程度和淀粉样蛋白斑块的密度。</p> <p>加兰他敏、三级生物碱,是一种竞争、可逆的乙酰胆碱酯酶的抑制剂。可以假设加兰他敏的行动疗效增强胆碱能功能。这是通过增加乙酰胆碱的浓度通过可逆抑制胆碱酯酶的水解。如果这种机制是正确的,加兰他敏的影响可能减少疾病过程的进步和更少的胆碱能神经元功能完好无损。在人类中,铜<sup>2 +</sup>的发展是必要的结缔组织,神经覆盖物,骨头。铜<sup>2 +</sup>还参与铁和能量代谢。铜<sup>2 +</sup>作为还原剂的酶、超氧化物歧化酶、细胞色素氧化酶、赖氨酰化氧,多巴胺羟化酶,和其他几个氧化酶类,减少氧气分子。铜<sup>2 +</sup>人体缺乏是罕见的,但当它发生导致正常红血球的,着色不足的贫血,白细胞减少和neuropenia,包容儿童的骨质疏松症。过度饮食锌<sup>2 +</sup>会导致铜<sup>2 +</sup>缺乏。慢性铜<sup>2 +</sup>在人类毒性是罕见的,主要与肝损伤相关。姜黄素与解决和预防阿尔茨海默疾病有关的斑块或存款体内和体外。流行病学资料表明,姜黄素的消耗与阿尔茨海默病的发病率较低。然而,水溶液的姜黄素的溶解度极低,这限制了其系统性吸收和治疗的潜力。提出了一种新的方法来治疗或预防注射与阿尔茨海默病相关淀粉样斑块形成高度集中的血液serum-solubilized姜黄素(<一个href="#B2">2</一个>,<一个href="#B6">6</一个>- - - - - -<一个href="#B11">10</一个>]。本研究的目的是评估HSA的构象变化<我>Aβ</我>(1- 16)由于他们<我>Aβ</我>(1- 16)绑定到铜<sup>2 +</sup>离子。</p> <h4 id="materials-and-method">2。材料和方法</h4> <p>人血清白蛋白(HSA);MW = 66411 gr /摩尔)和三羟甲基氨基甲烷盐液从西格玛化工有限公司获得的等温滴定微量热实验研究四通道商业微量热系统。铜的解决方案(4毫米)是通过使用汉密尔顿注射器注入量热滴定容器,装有1.8毫升HSA (27.43<svg height="9.6750002" id="M2" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>米)。注入铜溶液灌注血管重复了28次,10<svg height="9.6750002" id="M3" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>L /注射。热量信号的数字电压表测量是计算机记录系统的一部分。每个注入的热计算的“测温Digitam 3”软件程序。铜溶液的稀释热测量如上所述除了HSA被排除在外。HSA +铜的热<sup>2 +</sup>kJmol交互计算<sup>−1</sup>,如图<一个href="//www.newsama.com/journals/bca/2012/208641/fig1/" target="_blank">1</一个>。</p> <div class="partial-carousel-wrapper"> <div class="floats-partial-section"> <div class="floats-partial-content"> <div class="partial-carousel--full-image partial-carousel-cae2d60e21c3a367a50c3ed9003e7346"> <div class="partial-carousel--single-image"> <img loading="lazy" alt="" src="https://static.hindawi.com/articles/bca/volume-2012/208641/figures/208641.fig.001.jpg"> <br> <strong></strong> </div> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs"> <div class="partial-carousel-dots-cae2d60e21c3a367a50c3ed9003e7346 partial-carousel-thumbnail"> <button aria-label="Slide to " class="partial-carousel-dot"><img loading="lazy" alt="" src="https://static.hindawi.com/articles/bca/volume-2012/208641/thumbnails/208641.fig.001_th.jpg"><br><strong></strong></button> </div> </div> <div class="floats-partial-middle--nav"> <div class="partial-carousel-next-prev-cae2d60e21c3a367a50c3ed9003e7346 partial-carousel-next-prev"> <button aria-label="Previous" class="carousel-prev"></button> <button aria-label="Next" class="carousel-next"></button> </div> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</span> <a aria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/208641/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> <tbody> <tr> <td>对比实验加热在310 K (O),对HSA +铜<sup>2 +</sup>交互和计算数据(行)通过(<一个href="https://static.hindawi.com/articles/bca/volume-2012/208641/figures/208641/">1</一个>)。(铜<sup>2 +</sup>)值的浓度(铜(没有<sub>3</sub>)<sub>2</sub>)解决方案<svg height="9.6750002" id="M4" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>M。</td></tr> </tbody> </table> </div> </div> </div> </div> <p>等温滴定量热法(ITC)测量在VP-ITC超灵敏微热量计(MicroCal,北安普顿,MA)<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>交互。的程序如下。</p> <p>铜<sup>2 +</sup>(0.7毫米)和解决方案<我>Aβ</我>(1- 16)(75<svg height="9.6750002" id="M5" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>米)的解决方案也准备了玫瑰缓冲区(20毫米,150毫米氯化钠,pH值7.2,在310 K)。在滴定,8<svg height="9.6750002" id="M6" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>L的铜<sup>2 +</sup>解决方案是注射5分钟间隔到量热滴定容器,装有1.46毫升<我>Aβ</我>(1- 16)。细胞在307 rpm搅拌。滴定法是由310 K。肽浓度估计的BCA化验(皮尔斯生物技术)。注入铜<sup>2 +</sup>解决方案到容器重复30次,8<svg height="13.325" id="M7" style="vertical-align:-2.29482pt;width:19.1875px;" version="1.1" viewbox="0 0 19.1875 13.325" width="19.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.325)"> <g transform="translate(72,-61.34)"> <text transform="matrix(1,0,0,-1,-71.95,63.67)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="7.6018238" y="0"> l</tspan> </text> </g> </g> </svg>每注入。热量信号的数字电压表测量是计算机记录系统的一部分。每个注入的热计算的“测温Digitam 3”软件程序。热稀释的铜<sup>2 +</sup>测量解决方案如上所述扣除<我>Aβ</我>(1- 16)。热稀释的铜<sup>2 +</sup>解决方案被减去的焓变<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>交互。稀释的加热<我>Aβ</我>(1- 16)可以忽略不计。微热量计是经常校准电过程中学习。的热<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>kJmol交互计算<sup>−1</sup>,如图<一个href="//www.newsama.com/journals/bca/2012/208641/fig2/" target="_blank">2</一个>。</p> <div class="partial-carousel-wrapper"> <div class="floats-partial-section"> <div class="floats-partial-content"> <div class="partial-carousel--full-image partial-carousel-75f722cb344f7140cc4f9e22d0943cd5"> <div class="partial-carousel--single-image"> <img loading="lazy" alt="" src="https://static.hindawi.com/articles/bca/volume-2012/208641/figures/208641.fig.002.jpg"> <br> <strong></strong> </div> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs"> <div class="partial-carousel-dots-75f722cb344f7140cc4f9e22d0943cd5 partial-carousel-thumbnail"> <button aria-label="Slide to " class="partial-carousel-dot"><img loading="lazy" alt="" src="https://static.hindawi.com/articles/bca/volume-2012/208641/thumbnails/208641.fig.002_th.jpg"><br><strong></strong></button> </div> </div> <div class="floats-partial-middle--nav"> <div class="partial-carousel-next-prev-75f722cb344f7140cc4f9e22d0943cd5 partial-carousel-next-prev"> <button aria-label="Previous" class="carousel-prev"></button> <button aria-label="Next" class="carousel-next"></button> </div> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图2</span> <a aria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/208641/fig2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> <tbody> <tr> <td>对比实验加热(O)在310 K<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>交互和计算数据(行)通过(<一个href="https://static.hindawi.com/articles/bca/volume-2012/208641/figures/208641/">1</一个>)。(铜<sup>2 +</sup>)值的浓度(铜(没有<sub>3</sub>)<sub>2</sub>)解决方案<svg height="9.6750002" id="M8" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.675)"> <g transform="translate(72,-64.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>M。</td></tr> </tbody> </table> </div> </div> </div> </div> <h4 id="results-and-discussion">3所示。结果与讨论</h4> <p>我们先前已经表明,加热水溶剂的配体+ HSA交互系统,可以通过以下方程计算(<一个href="#B11">10</一个>- - - - - -<一个href="#B20">19</一个>]:<span class="equation" id="EEq1"> <svg height="19.475" id="M9" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 19.475" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,19.475)"> <g transform="translate(72,-56.42)"> <text transform="matrix(1,0,0,-1,40.78,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="9.1897049" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="21.230095" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,67.74,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> 一个</tspan> <tspan style="font-size: 8.75px; " x="10.694944" y="0"> x</tspan> </text> <text transform="matrix(1,0,0,-1,84.77,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,91.64,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> <text transform="matrix(1,0,0,-1,101.36,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</tspan> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,118.99,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> <text transform="matrix(1,0,0,-1,127.35,58.52)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="5.8499999" y="-2.51"> </tspan> </text> <text transform="matrix(1,0,0,-1,140.08,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.1400003"> </tspan> </text> <text transform="matrix(1,0,0,-1,146.85,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,155.71,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,165.26,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</tspan> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,183.48,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> <text transform="matrix(1,0,0,-1,190.42,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,199.27,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,206.21,58.52)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="8.6300001" y="-2.51"> −</tspan> <tspan style="font-size: 12.50px; " x="19.969999" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="25.82" y="-2.51"> </tspan> </text> <text transform="matrix(1,0,0,-1,238.32,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> <text transform="matrix(1,0,0,-1,244.76,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</tspan> <tspan style="font-size: 12.50px; " x="8.5645552" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,259.62,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.2299995"> </tspan> </text> <text transform="matrix(1,0,0,-1,266.39,58.52)"> <tspan style="font-size: 12.50px; " x="13.79" y="-2.51"> </tspan> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="7.9269018" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,287.05,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.1400003"> </tspan> </text> <text transform="matrix(1,0,0,-1,293.83,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,302.68,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,312.23,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</tspan> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,330.45,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> <text transform="matrix(1,0,0,-1,337.39,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,346.24,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,353.18,58.52)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="7.9400001" y="-2.51"> </tspan> </text> <text transform="matrix(1,0,0,-1,367.99,66.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> <text transform="matrix(1,0,0,-1,374.93,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</tspan> <tspan style="font-size: 12.50px; " x="99.190002" y="-0.050000001"> (</tspan> <tspan style="font-size: 12.50px; " x="103.3535" y="-0.050000001"> 1</tspan> <tspan style="font-size: 12.50px; " x="109.605" y="-0.050000001"> )</tspan> </text> </g> </g> </svg></span> <svg height="9.875" id="M10" style="vertical-align:-2.29482pt;width:13.1125px;" version="1.1" viewbox="0 0 13.1125 9.875" width="13.1125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.875)"> <g transform="translate(72,-64.1)"> <text transform="matrix(1,0,0,-1,-67.78,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>是HSA的加热+铜<sup>2 +</sup>交互和<svg height="11.0375" id="M11" style="vertical-align:-3.22282pt;width:30.387501px;" version="1.1" viewbox="0 0 30.387501 11.0375" width="30.387501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-66.22,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> 一个</tspan> <tspan style="font-size: 8.75px; " x="10.694944" y="0"> x</tspan> </text> </g> </g> </svg>代表所有HSA的热值在饱和或<我>Aβ</我>(1- 16)。的参数<svg height="18.975" id="M12" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M13" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>的索引是生物分子稳定的低和高铜<sup>2 +</sup>离子的浓度,分别。<svg height="17.575001" id="M14" style="vertical-align:-4.02643pt;width:17.4px;" version="1.1" viewbox="0 0 17.4 17.575001" width="17.4" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.575)"> <g transform="translate(72,-57.94)"> <text transform="matrix(1,0,0,-1,-71.95,62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.07,67.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> </g> </g> </svg>可以表示如下:<span class="equation" id="EEq2"> <svg height="33.287498" id="M15" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 33.287498" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,33.2875)"> <g transform="translate(72,-45.37)"> <text transform="matrix(1,0,0,-1,168.14,57.3)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,175.02,62.3)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> <text transform="matrix(1,0,0,-1,185.43,57.3)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="27.120001" y="-9.1400003"> </tspan> <tspan style="font-size: 12.50px; " x="33.233967" y="-9.1400003"> </tspan> </text> <text transform="matrix(1,0,0,-1,225.54,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <g> <path d="m 198.67,60.42 47.7,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,198.67,48.54)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,205.54,45.42)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,215.1,48.54)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</tspan> <tspan style="font-size: 12.50px; " x="11.327718" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="17.441685" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,239.43,45.42)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,247.56,57.3)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</tspan> <tspan style="font-size: 12.50px; " x="226.56" y="1.74"> (</tspan> <tspan style="font-size: 12.50px; " x="230.7235" y="1.74"> 2</tspan> <tspan style="font-size: 12.50px; " x="236.97501" y="1.74"> )</tspan> </text> </g> </g> </svg></span> <svg height="17.575001" id="M16" style="vertical-align:-4.02643pt;width:17.4px;" version="1.1" viewbox="0 0 17.4 17.575001" width="17.4" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.575)"> <g transform="translate(72,-57.94)"> <text transform="matrix(1,0,0,-1,-71.95,62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.07,67.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> </g> </g> </svg>绑定的一部分铜吗<sup>2 +</sup>离子的结合位点<svg height="17.725" id="M17" style="vertical-align:-4.1493pt;width:79.3125px;" version="1.1" viewbox="0 0 79.3125 17.725" width="79.3125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.725)"> <g transform="translate(72,-57.82)"> <text transform="matrix(1,0,0,-1,-71.95,62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.07,67.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.1400003"> </tspan> </text> <text transform="matrix(1,0,0,-1,-54.83,62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 1</tspan> <tspan style="font-size: 12.50px; " x="21.067554" y="0"> −</tspan> <tspan style="font-size: 12.50px; " x="32.407776" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-15.54,67.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="0" y="9.0200005"> </tspan> </text> </g> </g> </svg>是游离铜的分数吗<sup>2 +</sup>离子。我们可以表达<svg height="10.925" id="M18" style="vertical-align:-3.13504pt;width:17.4px;" version="1.1" viewbox="0 0 17.4 10.925" width="17.4" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.925)"> <g transform="translate(72,-63.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.07,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>分数,如总铜<sup>2 +</sup>浓度除以最大浓度的铜<sup>2 +</sup>在饱和的储蓄帐户如下:<span class="equation" id="EEq3"> <svg height="47.125" id="M19" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 47.125" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,47.125)"> <g transform="translate(72,-34.3)"> <text transform="matrix(1,0,0,-1,119.64,50.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,126.51,47.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,136.93,50.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="21.74" y="-8.0600004"> </tspan> <tspan style="font-size: 12.50px; " x="26.530001" y="-10.57"> C</tspan> <tspan style="font-size: 12.50px; " x="34.869499" y="-10.57"> u</tspan> </text> <text transform="matrix(1,0,0,-1,178.05,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> +</tspan> </text> <text transform="matrix(1,0,0,-1,188.92,58.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <g> <path d="m 150.16,53.41 52.06,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,150.16,36.92)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="4.79" y="-2.52"> C</tspan> <tspan style="font-size: 12.50px; " x="13.129501" y="-2.52"> u</tspan> </text> <text transform="matrix(1,0,0,-1,169.54,44.61)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> +</tspan> </text> <text transform="matrix(1,0,0,-1,180.41,36.92)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,185.2,34.44)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> 一个</tspan> <tspan style="font-size: 8.75px; " x="10.694944" y="0"> x</tspan> </text> <text transform="matrix(1,0,0,-1,203.42,50.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</tspan> <tspan style="font-size: 12.50px; " x="29.294529" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,239.6,47.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,249.85,50.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</tspan> <tspan style="font-size: 12.50px; " x="21.055052" y="0"> −</tspan> <tspan style="font-size: 12.50px; " x="32.395271" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,289.13,47.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,296.07,50.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</tspan> <tspan style="font-size: 12.50px; " x="178.05" y="0.27000001"> (</tspan> <tspan style="font-size: 12.50px; " x="182.2135" y="0.27000001"> 3</tspan> <tspan style="font-size: 12.50px; " x="188.465" y="0.27000001"> )</tspan> </text> </g> </g> </svg></span>(铜<sup>2 +</sup>是铜的浓度<sup>2 +</sup>离子和<svg height="18" id="M20" style="vertical-align:-3.22282pt;width:65.462502px;" version="1.1" viewbox="0 0 65.462502 18" width="65.462502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18)"> <g transform="translate(72,-57.6)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</tspan> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> C</tspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> u</tspan> </text> <text transform="matrix(1,0,0,-1,-53.2,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> +</tspan> </text> <text transform="matrix(1,0,0,-1,-42.33,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ]</tspan> </text> <text transform="matrix(1,0,0,-1,-38.16,57.74)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> 一个</tspan> <tspan style="font-size: 8.75px; " x="10.694944" y="0"> x</tspan> </text> </g> </g> </svg>是铜的最大浓度<sup>2 +</sup>离子在HSA饱和。<svg height="13.55" id="M21" style="vertical-align:-2.29482pt;width:34.974998px;" version="1.1" viewbox="0 0 34.974998 13.55" width="34.974998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="9.5772982" y="0"> ></tspan> <tspan style="font-size: 12.50px; " x="21.617687" y="0"> 1</tspan> </text> </g> </g> </svg>或<svg height="13.55" id="M22" style="vertical-align:-2.29482pt;width:34.974998px;" version="1.1" viewbox="0 0 34.974998 13.55" width="34.974998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="9.5772982" y="0"> <</tspan> <tspan style="font-size: 12.50px; " x="21.617687" y="0"> 1</tspan> </text> </g> </g> </svg>表明积极或消极的协同的高分子与配体结合,分别;<svg height="13.55" id="M23" style="vertical-align:-2.29482pt;width:34.974998px;" version="1.1" viewbox="0 0 34.974998 13.55" width="34.974998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="9.5772982" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="21.617687" y="0"> 1</tspan> </text> </g> </g> </svg>表明非合作的绑定。<svg height="14.2375" id="M24" style="vertical-align:-3.13504pt;width:19.6625px;" version="1.1" viewbox="0 0 19.6625 14.2375" width="19.6625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.2375)"> <g transform="translate(72,-60.61)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>和<svg height="14.2375" id="M25" style="vertical-align:-3.13504pt;width:19.862499px;" version="1.1" viewbox="0 0 19.862499 14.2375" width="19.862499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.2375)"> <g transform="translate(72,-60.61)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>是游离和结合金属离子的相对贡献的加热稀释在缺乏HSA的稀释热的,可以计算铜<sup>2 +</sup>离子在缓冲区,<svg height="11.0375" id="M26" style="vertical-align:-3.22281pt;width:27.975px;" version="1.1" viewbox="0 0 27.975 11.0375" width="27.975" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-66.22,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> 我</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> l</tspan> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> u</tspan> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> t</tspan> </text> </g> </g> </svg>,如下所示:<span class="equation" id="EEq4"> <svg height="38.575001" id="M27" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 38.575001" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,38.575)"> <g transform="translate(72,-41.14)"> <text transform="matrix(1,0,0,-1,59.96,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,68.81,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,79.06,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,96.82,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> 我</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> l</tspan> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> u</tspan> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> t</tspan> </text> <text transform="matrix(1,0,0,-1,116.15,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</tspan> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,134.37,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,143.39,46.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="10.58" y="-16.549999"> </tspan> <tspan style="font-size: 12.50px; " x="16.95653" y="-16.549999"> </tspan> </text> <text transform="matrix(1,0,0,-1,166.08,59.55)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> 我</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> l</tspan> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> u</tspan> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> t</tspan> </text> <g> <path d="m 153.97,56.57 28.66,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,158.2,44.69)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,171.46,41.57)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,183.83,46.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="11.46" y="-7.3299999"> ,</tspan> <tspan style="font-size: 12.50px; " x="36.59103" y="-7.3299999"> </tspan> </text> <text transform="matrix(1,0,0,-1,229.27,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,239.69,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,257.45,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> 我</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> l</tspan> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> u</tspan> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> t</tspan> </text> <text transform="matrix(1,0,0,-1,276.78,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</tspan> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,295,50.32)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,303.86,46.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="10.57" y="-16.549999"> </tspan> <tspan style="font-size: 12.50px; " x="16.946529" y="-16.549999"> </tspan> </text> <text transform="matrix(1,0,0,-1,326.54,59.55)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</tspan> <tspan style="font-size: 8.75px; " x="4.3759999" y="0"> 我</tspan> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> l</tspan> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> u</tspan> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> t</tspan> </text> <g> <path d="m 314.43,56.57 28.66,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,318.66,44.69)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,331.92,41.57)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,344.29,46.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="11.46" y="-7.3299999"> 。</tspan> <tspan style="font-size: 12.50px; " x="129.83" y="-7.3299999"> (</tspan> <tspan style="font-size: 12.50px; " x="133.9935" y="-7.3299999"> 4</tspan> <tspan style="font-size: 12.50px; " x="140.245" y="-7.3299999"> )</tspan> </text> </g> </g> </svg></span></p> <p>HSA +铜的热<sup>2 +</sup>和<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>相互作用,<svg height="9.875" id="M28" style="vertical-align:-2.29482pt;width:7.9124999px;" version="1.1" viewbox="0 0 7.9124999 9.875" width="7.9124999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.875)"> <g transform="translate(72,-64.1)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> </g> </g> </svg>被安装(<一个href="#EEq1">1</一个>整个铜)<sup>2 +</sup>组成。在拟合过程中,可调参数<svg height="13.55" id="M29" style="vertical-align:-2.29482pt;width:18.174999px;" version="1.1" viewbox="0 0 18.174999 13.55" width="18.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</tspan> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="10.277466" y="0"> )</tspan> </text> </g> </g> </svg>改变直到最好的实验和计算数据之间的协议是接近(数据吗<一个href="//www.newsama.com/journals/bca/2012/208641/fig1/" target="_blank">1</一个>和<一个href="//www.newsama.com/journals/bca/2012/208641/fig2/" target="_blank">2</一个>)。这些交互恢复绑定参数(<一个href="#EEq1">1</一个>)都列在表中<一个href="//www.newsama.com/journals/bca/2012/208641/tab1/" target="_blank">1</一个>和<一个href="//www.newsama.com/journals/bca/2012/208641/tab2/" target="_blank">2</一个>。计算和实验结果(图之间的协议<一个href="//www.newsama.com/journals/bca/2012/208641/fig2/" target="_blank">2</一个>)是引人注目的,给了很大的支持的使用(<一个href="#EEq1">1</一个>)。<svg height="18.975" id="M30" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M31" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值HSA +铜<sup>2 +</sup>相互作用是积极的,这表明在低和高铜的浓度<sup>2 +</sup>离子,HSA的结构是稳定的。<svg height="13.55" id="M32" style="vertical-align:-2.29482pt;width:34.974998px;" version="1.1" viewbox="0 0 34.974998 13.55" width="34.974998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> <tspan style="font-size: 12.50px; " x="9.5772982" y="0"> =</tspan> <tspan style="font-size: 12.50px; " x="21.617687" y="0"> 1</tspan> </text> </g> </g> </svg>表明bindingis非合作。的<svg height="18.975" id="M33" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M34" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>相互作用是消极的(不稳定的<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>复杂),表明微量的铜离子可以诱导β-淀粉样蛋白的积累和学习能力可以显著延缓一个困难的跟踪调节的任务。HSA +铜<sup>2 +</sup>复杂的更稳定<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>复杂,导致铜转移<我>Aβ</我>人类血清白蛋白(1 - 16),可以抑制聚合,减少<我>Aβ</我>(1- 16)毒性。消极的<svg height="18.975" id="M35" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M36" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>复杂的不稳定,导致聚合<我>Aβ</我>(1- 16)肽,对其fibrillization产生影响。大的和积极的<svg height="18.975" id="M37" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M38" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明,稳定HSA +铜<sup>2 +</sup>复杂的原因把铜的强劲趋势<sup>2 +</sup>离子从<我>Aβ</我>(1- 16)HSA和减少老年痴呆症的风险。这些解释表明,铜转移<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>人血清白蛋白抑制聚合,减少<我>Aβ</我>(1- 16)毒性。稳定性指标表明,HSA为铜更高的亲和力<sup>2 +</sup>离子。因此,可以建议保险公司是一个很好的竞争反应物去除铜<sup>2 +</sup>离子从<我>Aβ</我>(1- 16)。铜离子在溶液中强烈的互动与人类血清白蛋白就是明证大的和积极的<svg height="18.975" id="M39" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M40" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值显著和稳定了HSA结构。提出了一种新的方法来防止淀粉样斑块形成与阿尔茨海默病相关的注射血清白蛋白HSA +铜为了保持稳定<sup>2 +</sup>复杂主要针对不稳定<我>Aβ</我>(1- 16)+铜<sup>2 +</sup>的人。我们的研究结果表明,HSA优先结合有毒的<我>Aβ</我>(1- 16)抑制其增长更大<我>Aβ</我>(1- 16)程序集。</p> <div class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</span> <a aria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/208641/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 绑定参数对HSA +铜<sup>2 +</sup>交互。积极的和大<svg height="18.975" id="M41" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M42" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明,铜<sup>2 +</sup>可能影响HSA强烈和稳定的结构显著HSA结构。</d我v> <a class="table-thumb-overlay" href="//www.newsama.com/journals/bca/2012/208641/tab1" target="_blank" aria-label="View full page"></a> </div> </div> <div class="floats-partial-section partial-other-wrapper" data-section="tab2"> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表2</span> <a aria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2012/208641/tab2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 绑定参数<我>β</我>(1- 16)+铜<sup>2 +</sup>交互。负<svg height="18.975" id="M50" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M51" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明,铜<sup>2 +</sup>可能影响的结构吗<我>β</我>(1- 16)和破坏<我>β</我>(1- 16)结构明显。不稳定的一个<我>β</我>(1- 16)+铜<sup>2 +</sup>复杂的原因的聚合<我>β</我>(1- 16)在大脑中。</d我v> <a class="table-thumb-overlay" href="//www.newsama.com/journals/bca/2012/208641/tab2" target="_blank" aria-label="View full page"></a> </div> </div> <p>希望这个建议被证明成功,人类的应用将小说有利于预防阿尔茨海默病斑形成或可能逆转现有的斑块。</p> <p>我们假设<我>Aβ</我>(1- 16)聚合诱导铜(就是负值<svg height="18.825001" id="M59" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>)中扮演着重要角色在阿尔茨海默病的神经病理学。上面的解释与我们的结果一致。协会绑定常量的铜<我>β</我>要大得多,而这对HSA亲和力较低。<我>Aβ</我>(1- 16)结构大大动摇的结果绑定到铜<sup>2 +</sup>离子−29.967的价值就体现了这一点<svg height="18.825001" id="M60" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>。</p> <h4 id="conclusion">4所示。结论</h4> <p>大的和积极的<svg height="18.975" id="M61" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M62" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明,铜<sup>2 +</sup>稳定HSA结构明显。消极的<svg height="18.975" id="M63" style="vertical-align:-4.177pt;width:15.825px;" version="1.1" viewbox="0 0 15.825 18.975" width="15.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.975)"> <g transform="translate(72,-56.82)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.2299995"> </tspan> </text> </g> </g> </svg>和<svg height="18.825001" id="M64" style="vertical-align:-4.05412pt;width:16.0375px;" version="1.1" viewbox="0 0 16.0375 18.825001" width="16.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.825)"> <g transform="translate(72,-56.94)"> <text transform="matrix(1,0,0,-1,-71.95,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </tspan> </text> <text transform="matrix(1,0,0,-1,-65.66,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </tspan> <tspan style="font-size: 8.75px; " x="-0.5" y="9.1099997"> </tspan> </text> </g> </g> </svg>值表明,复合物之间<我>Aβ</我>(1- 16),提出了铜离子是一个异常的交互与阿尔茨海默病的发展,铜的地方<sup>2 +</sup>参与<我>Aβ</我>(1- 16)聚合。宝贵的方法可以预测大约治疗使用扩展的体外溶解模型。</p> <h4 id="acknowledgment">承认</h4> <p>伊玛目霍梅尼国际大学和大学的金融支持德黑兰。</p> </div> </div> <div class="ArticleReferences_xmlContent__p_40j"> <h4 class="ArticleReferences_references__GH2t_" id="references">引用</h4> <ol class="ArticleReferences_orderedReferences__mJr9M"> <li class="ArticleReferences_articleReference__ouEuh" id="B1"> <div class="referenceContent"> <p class="referenceText">h .渡边,Kragh-Hansen,美国没有试图推高日圆et al .,“人血清白蛋白的构象稳定性和warfarin-binding性质研究了重组突变体,“<我>生物化学杂志</我>,卷357,不。1,第274 - 269页,2001。</p>视图: <a href="https://doi.org/10.1042/0264-6021:3570269" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Conformational%20stability%20and%20warfarin-binding%20properties%20of%20human%20serum%20albumin%20studied%20by%20recombinant%20mutants&author=H.%20Watanabe&author=U.%20Kragh-Hansen&author=S.%20Tanase&publication_year=2001" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B2"> <div class="referenceContent"> <p class="referenceText">t·彼得斯,血清白蛋白,<我>蛋白质化学的进步</我>37卷,第245 - 161页,1985年。</p>视图: <a href="https://doi.org/10.1016/S0065-3233(08)60065-0" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Serum%20albumin&author=T.%20Peters&publication_year=1985" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B3"> <div class="referenceContent"> <p class="referenceText">f . Kratz“白蛋白作为药物载体:高活性化合物设计、药物配合和纳米颗粒”<我>《控释</我>,卷132,不。3、171 - 183年,2008页。</p>视图: <a href="https://doi.org/10.1016/j.jconrel.2008.05.010" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Albumin%20as%20a%20drug%20carrier%3A%20design%20of%20prodrugs%2C%20drug%20conjugates%20and%20nanoparticles&author=F.%20Kratz&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B4"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . Divsalar A . A . Saboury和m . j .阿訇“热力学研究人类血清白蛋白的结合与新合成抗癌症Pd (II)复杂,“<我>溶液化学杂志</我>,37卷,不。12日,第1794 - 1785页,2008年。</p>视图: <a href="https://doi.org/10.1007/s10953-008-9322-y" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20thermodynamic%20study%20on%20the%20binding%20of%20human%20serum%20albumin%20with%20new%20synthesized%20anti%20cancer%20Pd%20(II)%20complex&author=G.%20R.%20Behbehani&author=A.%20Divsalar&author=A.%20A.%20Saboury&author=M.%20J.%20Bagheri&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B5"> <div class="referenceContent"> <p class="referenceText">d . c .卡特和j . x Ho“血清白蛋白的结构,”<我>蛋白质化学的进步</我>,45卷,第203 - 153页,1994年。</p>视图: <a href="https://scholar.google.com/scholar_lookup?title=Structure%20of%20serum%20albumin&author=D.%20C.%20Carter&author=J.%20X.%20Ho&publication_year=1994" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B6"> <div class="referenceContent"> <p class="referenceText">x m .他和卡特特区”,血清白蛋白的构象的解决方案:结合磷光depolarization-hydrodynamic建模研究中,“<我>自然</我>,卷358,不。6383年,第215 - 209页,1992年。</p>视图: <a href="https://scholar.google.com/scholar_lookup?title=The%20conformation%20of%20serum%20albumin%20in%20solution%3A%20a%20combined%20phosphorescence%20depolarization-hydrodynamic%20modeling%20study&author=X.%20M.%20He&author=D.%20C.%20Carter&publication_year=1992" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B8"> <div class="referenceContent"> <p class="referenceText">j . n .运动和g·e·杰克逊”相互作用的热力学和光谱研究铜(II)、镍(II)、锌(II)和Ca (II)离子2-amino-N——(2-oxo-2 - (2 - (pyridin-2-yl)乙基氨基)乙基)乙酰胺,pseudo-mimic人血清白蛋白,”<我>多面体</我>,26卷,不。12日,第2404 - 2395页,2007年。</p>视图: <a href="https://doi.org/10.1016/j.poly.2006.11.053" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Thermodynamic%20and%20spectroscopic%20study%20of%20the%20interaction%20of%20Cu(II)%2C%20Ni(II)%2C%20Zn(II)%20and%20Ca(II)%20ions%20with%202-amino-N-(2-oxo-2-(2-(pyridin-2-yl)ethyl%20amino)ethyl)acetamide%2C%20a%20pseudo-mimic%20of%20human%20serum%20albumin&author=J.%20N.%20Zvimba&author=G.%20E.%20Jackson&publication_year=2007" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B9"> <div class="referenceContent"> <p class="referenceText">c·g·弗拉加,“相关性、重要性和毒性的微量元素在人类健康,”<我>分子医学方面</我>,26卷,不。4 - 5,235 - 244年,2005页。</p>视图: <a href="https://doi.org/10.1016/j.mam.2005.07.013" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Relevance%2C%20essentiality%20and%20toxicity%20of%20trace%20elements%20in%20human%20health&author=C.%20G.%20Fraga&publication_year=2005" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B10"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani和m . Mirzaie高性能热力学研究方法结合铜离子和甘氨酸与阿尔茨海默病淀粉样蛋白<我>β</我>肽”,<我>热分析和量热法杂志》上</我>,卷96,不。2、631 - 635年,2009页。</p>视图: <a href="https://doi.org/10.1007/s10973-008-9311-9" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20high%20performance%20method%20for%20thermodynamic%20study%20on%20the%20binding%20of%20copper%20ion%20and%20glycine%20with%20Alzheimer's%20amyloid%20%CE%B2%20peptide&author=G.%20R.%20Behbehani&author=M.%20Mirzaie&publication_year=2009" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B11"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . Divsalar A . A . Saboury f . Faridbod和m . r . Ganjali“高性能热力学研究方法与氯化铒人类血清白蛋白的结合,“<我>热分析和量热法杂志》上</我>,卷96,不。2、663 - 668年,2009页。</p>视图: <a href="https://doi.org/10.1007/s10973-008-9385-4" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20high%20performance%20method%20for%20thermodynamic%20study%20on%20the%20binding%20of%20human%20serum%20albumin%20with%20erbium%20chloride&author=G.%20R.%20Behbehani&author=A.%20Divsalar&author=A.%20A.%20Saboury&author=F.%20Faridbod&author=M.%20R.%20Ganjali&publication_year=2009" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B12"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani a . a . Saboury a . f . Baghery和a . Abedini”应用程序的一个扩展绑定的镁离子溶剂化作用理论研究与髓鞘碱性蛋白,”<我>热分析和量热法杂志》上</我>,卷93,不。2、479 - 483年,2008页。</p>视图: <a href="https://doi.org/10.1007/s10973-007-8674-7" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Application%20of%20an%20extended%20solvation%20theory%20to%20study%20on%20the%20binding%20of%20magnesium%20ion%20with%20myelin%20basic%20protein&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=A.%20F.%20Baghery&author=A.%20Abedini&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B13"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . Divsalar A . A . Saboury和A·赫克马特”绑定的热力学研究PEG-stearic酸共聚物与溶菌酶”<我>溶液化学杂志</我>,38卷,不。2、219 - 229年,2009页。</p>视图: <a href="https://doi.org/10.1007/s10953-008-9360-5" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20thermodynamic%20study%20on%20the%20binding%20of%20PEG-stearic%20acid%20copolymer%20with%20lysozyme&author=G.%20R.%20Behbehani&author=A.%20Divsalar&author=A.%20A.%20Saboury&author=A.%20Hekmat&publication_year=2009" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B14"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . A . Saboury和A . f . Baghery”绑定的热力学研究钙离子与髓鞘碱性蛋白,”<我>溶液化学杂志</我>,36卷,不。10日,1311 - 1320年,2007页。</p>视图: <a href="https://doi.org/10.1007/s10953-007-9181-y" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20thermodynamic%20study%20on%20the%20binding%20of%20calcium%20Ion%20with%20myelin%20basic%20protein&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=A.%20F.%20Baghery&publication_year=2007" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B15"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . A . Saboury和e . Taleshi”的比较研究的直接量热测定溶菌酶的变性焓溴化十二烷基硫酸钠和dodecyltrimethylammonium解决方案,“<我>溶液化学杂志</我>,37卷,不。5,619 - 629年,2008页。</p>视图: <a href="https://doi.org/10.1007/s10953-008-9267-1" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20comparative%20study%20of%20the%20direct%20calorimetric%20determination%20of%20the%20denaturation%20enthalpy%20for%20lysozyme%20in%20sodium%20dodecyl%20sulfate%20and%20dodecyltrimethylammonium%20bromide%20solutions&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=E.%20Taleshi&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B16"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani和A . A . Saboury”热的新方法——动态研究绑定镁与人类生长激素”<我>热分析和量热法杂志》上</我>卷,89年,第861 - 852页,2007年。</p>视图: <a href="https://scholar.google.com/scholar_lookup?title=A%20new%20method%20for%20thermo-%20dynamic%20study%20on%20the%20binding%20of%20magnesium%20with%20human%20growth%20hormone&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&publication_year=2007" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B17"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani a . a . Saboury和e . Taleshi”部分展开焓测定溶菌酶在溴化与dodecyltrimethylammonium交互使用延长溶解模型,”<我>《分子识别</我>,21卷,不。2、132 - 135年,2008页。</p>视图: <a href="https://doi.org/10.1002/jmr.881" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Determination%20of%20partial%20unfolding%20enthalpy%20for%20lysozyme%20upon%20interaction%20with%20dodecyltrimethylammonium%20bromide%20using%20an%20extended%20solvation%20model&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=E.%20Taleshi&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B18"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani A . A . Saboury和e . Taleshi”直接量热测定溶菌酶的变性焓十二烷基硫酸钠,”<我>胶体和表面B</我>,卷61,不。2、224 - 228年,2008页。</p>视图: <a href="https://doi.org/10.1016/j.colsurfb.2007.08.007" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20direct%20calorimetric%20determination%20of%20denaturation%20enthalpy%20for%20lysozyme%20in%20sodium%20dodecyl%20sulfate&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=E.%20Taleshi&publication_year=2008" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B19"> <div class="referenceContent"> <p class="referenceText">g . r . Behbehani a . a . Saboury e . Poorakbar和l . Barzegar”申请延长溶解模型的热力学研究铜离子结合杰克大豆脲酶,”<我>热分析和量热法杂志》上</我>,卷102,不。3、1141 - 1146年,2010页。</p>视图: <a href="https://doi.org/10.1007/s10973-010-0842-5" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=Application%20of%20the%20extended%20solvation%20model%20for%20thermodynamic%20study%20of%20copper%20ion%20binding%20to%20Jack%20bean%20urease&author=G.%20R.%20Behbehani&author=A.%20A.%20Saboury&author=E.%20Poorakbar&author=L.%20Barzegar&publication_year=2010" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> <li class="ArticleReferences_articleReference__ouEuh" id="B20"> <div class="referenceContent"> <p class="referenceText">b·g·雷“小说热力学方法研究与阿尔茨海默氏症amyliod绑定的铜离子<我>β</我>肽”,<我>科学通报</我>,54卷,不。6,1037 - 1042年,2009页。</p>视图: <a href="https://doi.org/10.1007/s11434-009-0065-y" target="_blank" rel="noreferrer">出版商的网站</一个><span class="sep">|</span> <a href="https://scholar.google.com/scholar_lookup?title=A%20novel%20method%20for%20thermodynamic%20study%20on%20binding%20of%20copper%20ion%20with%20Alzheimer's%20amyliod%20%CE%B2%20peptide&author=B.%20G.%20Rezaei&publication_year=2009" target="_blank" rel="noreferrer">谷歌学术搜索</一个></d我v></li> </ol> </div> <h4 class="copyright-title" id="copyright">版权</h4> <div class="copyright-body"> 版权©2012 g·雷Behbehani等。这是一个开放的分布式下文章<一个rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</一个>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</d我v> <div id="related-articles"></div> </div> </div> <div class="ant-col ThreeColumnLayout_rightColumn__b_MuL"> <div> <div> <div class="ArticleRightSection_articleRightSection__rG8Zh"> <div class="ArticleToolbar_articleToolbar__8fsAH"> <a href="https://downloads.hindawi.com/journals/bca/2012/208641.pdf" class="ButtonGroup_buttonGroupWrapper__Rqhy0" role="button" type="primary" aria-label="PDF" tabindex="0" unselectable="on" target="_blank" data-testid="download-pdf"><span class="ButtonGroup_leftGroup__FJAmS"><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="0 0 19 24"> <path d="M16.772,24H2.227A2.163,2.163,0,0,1,0,21.746V2.255A2.159,2.159,0,0,1,2.227,0H12.415L12.9.494h.03V.523L19,6.669V21.746A2.161,2.161,0,0,1,16.772,24ZM2.334,1A1.276,1.276,0,0,0,1,2.358V21.642A1.283,1.283,0,0,0,2.334,23H16.665A1.276,1.276,0,0,0,18,21.642V7.087l-.032-.033H14.215A2.131,2.131,0,0,1,12.02,4.832V1.005L12.015,1ZM13,2V4.745A1.192,1.192,0,0,0,14.261,6H17ZM4.012,20A1.032,1.032,0,0,1,3,18.923a2.505,2.505,0,0,1,.967-1.539,8.15,8.15,0,0,1,2.377-1.418c.344-.779.65-1.6.92-2.327l.008-.022.017-.046.009-.024c.2-.539.453-1.209.71-1.827a4.545,4.545,0,0,1-.372-3.862c.267-.569.6-.858.976-.858.556,0,.964.621,1.015,1.546a7.125,7.125,0,0,1-.681,3.143c.158.305.343.624.55.949a7.127,7.127,0,0,0,1.806,1.9,8.681,8.681,0,0,1,2.023-.279,4.23,4.23,0,0,1,1.468.238c.118.047,1.156.478,1.2,1.143a.688.688,0,0,1-.412.67,2.509,2.509,0,0,1-1.164.242,4.757,4.757,0,0,1-.671-.052,6.631,6.631,0,0,1-2.608-1.025c-.163.042-.323.086-.514.138l-.1.026-.15.041c-.235.067-.464.13-.679.185l-.292.076-.025.006-.019,0c-.794.205-1.615.418-2.4.705A14.033,14.033,0,0,1,6,18.437C5.832,18.7,4.941,20,4.012,20ZM6,17a6.865,6.865,0,0,0-1.287.871A1.927,1.927,0,0,0,4,18.831a.12.12,0,0,0,.041.1A.165.165,0,0,0,4.17,19c.327,0,.965-.631,1.356-1.219C5.671,17.564,5.83,17.3,6,17Zm7.044-2A4.632,4.632,0,0,0,12,15.131a4.76,4.76,0,0,0,1.675.792A2.906,2.906,0,0,0,14.32,16a1.629,1.629,0,0,0,.68-.13,2.672,2.672,0,0,0-.584-.528A2.752,2.752,0,0,0,13.045,15ZM8.166,13c-.177.449-.343.884-.481,1.25l-.01.025-.009.024-.007.02-.035.092-.032.085c-.156.409-.37.97-.59,1.5.6-.181,1.229-.341,1.733-.469l.031-.008.055-.014.028-.007.028-.007.307-.078c.191-.048.4-.105.674-.179l.03-.008.005,0,.036-.01.036-.01.01,0,.01,0,.016,0a8.291,8.291,0,0,1-1.566-1.767C8.341,13.285,8.264,13.16,8.166,13Zm.516-5a1.64,1.64,0,0,0-.34.365A2.425,2.425,0,0,0,8.437,11a4.012,4.012,0,0,0,.553-2.22A1.309,1.309,0,0,0,8.681,8Z" fill="currentColor"></path> </svg></span><span>PDF</span></span><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg width="1em" height="1em" viewbox="0 0 20 22"> <defs> <clippath> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </clippath> </defs> <g> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </g> </svg></span></a> <a href="//www.newsama.com/journals/bca/2012/208641.ris" class="ButtonGroup_buttonGroupWrapper__Rqhy0" role="button" type="ghost" aria-label="Download Citation" tabindex="0" unselectable="on" data-testid="download-citation"><span class="ButtonGroup_leftGroup__FJAmS"><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg width="1em" height="1em" viewbox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M16 12H8C7.44772 12 7 12.4477 7 13C7 13.5523 7.44772 14 8 14H16C16.5523 14 17 13.5523 17 13C17 12.4477 16.5523 12 16 12Z" fill="currentColor"></path> <path d="M16 16H8C7.44772 16 7 16.4477 7 17C7 17.5523 7.44772 18 8 18H16C16.5523 18 17 17.5523 17 17C17 16.4477 16.5523 16 16 16Z" fill="currentColor"></path> <path d="M10 8H8C7.44772 8 7 8.44772 7 9C7 9.55228 7.44772 10 8 10H10C10.5523 10 11 9.55228 11 9C11 8.44772 10.5523 8 10 8Z" fill="currentColor"></path> <path d="M15 2C15 1.44772 14.5523 1 14 1C13.4477 1 13 1.44772 13 2V8C13 8.55228 13.4477 9 14 9H20C20.5523 9 21 8.55228 21 8C21 7.44772 20.5523 7 20 7H15V2Z" fill="currentColor"></path> <path fill-rule="evenodd" clip-rule="evenodd" d="M14.7071 1.29289C14.5196 1.10536 14.2652 1 14 1H6C4.34315 1 3 2.34315 3 4V20C3 21.6569 4.34315 23 6 23H18C19.6569 23 21 21.6569 21 20V8C21 7.73478 20.8946 7.48043 20.7071 7.29289L14.7071 1.29289ZM6 3H13.5858L19 8.41421V20C19 20.5523 18.5523 21 18 21H6C5.44772 21 5 20.5523 5 20V4C5 3.44772 5.44772 3 6 3Z" fill="currentColor"></path> </svg></span><span>下载引用</span></span><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg width="1em" height="1em" viewbox="0 0 20 22"> <defs> <clippath> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </clippath> </defs> <g> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </g> </svg></span></a> <div class="ant-collapse ant-collapse-icon-position-end articleToolbarOtherFormats_otherFormatsCollapse__VHaOL"> <div class="ant-collapse-item"> <div class="ant-collapse-header" aria-expanded="false" aria-disabled="false" role="button" tabindex="0"> <div class="ant-collapse-expand-icon"> <span role="img" class="anticon ant-collapse-arrow"> <svg width="1em" height="1em" viewbox="0 0 32 32" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M17.773 23.453l11.2-11.265a1.918 1.918 0 000-2.641 1.75 1.75 0 00-2.542 0l-9.929 10.101-9.933-10.1a1.75 1.75 0 00-2.542 0 1.919 1.919 0 000 2.64L15.23 23.453c.352.365.811.547 1.271.547.46 0 .92-.182 1.271-.547z" fill="currentColor"></path> </svg></span> </div> <span class="ant-collapse-header-text"><span><span role="img" class="anticon articleToolbarOtherFormats_atofDownloadIcon__YRM5T"> <svg width="1em" height="1em" viewbox="0 0 20 22"> <defs> <clippath> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </clippath> </defs> <g> <path fill-rule="evenodd" clip-rule="evenodd" d="M3,22a3,3,0,0,1-3-3V16a1,1,0,0,1,2,0v3a1,1,0,0,0,1,1H17a1,1,0,0,0,1-1V16a1,1,0,1,1,2,0v3a3,3,0,0,1-3,3Zm6.288-6.3-4-4a1,1,0,0,1,1.414-1.414L9,12.586V1a1,1,0,0,1,2,0V12.586l2.293-2.293a1,1,0,0,1,1.414,1.414l-4,4a1,1,0,0,1-1.423,0Z" fill="currentColor"></path> </g> </svg></span><span>下载其他格式</span></span></span> </div> </div> </div> <a href="//www.newsama.com/reprints/208641/confirm" class="ButtonGroup_buttonGroupWrapper__Rqhy0" role="button" type="ghost" aria-label="Order printed copies" tabindex="0" unselectable="on" target="_blank"><span class="ButtonGroup_leftGroup__FJAmS"><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg width="1em" height="1em" viewbox="0 0 24 24" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M7.41667 1H18.6667C19.1269 1 19.5 1.44772 19.5 2V22C19.5 22.5523 19.1269 23 18.6667 23H7.41667C5.80584 23 4.5 21.433 4.5 19.5V4.5C4.5 2.567 5.80584 1 7.41667 1ZM6.16667 16.3368V4.5C6.16667 3.67157 6.72631 3 7.41667 3H17.8333V16H7.41667C6.96933 16 6.54552 16.1208 6.16667 16.3368ZM17.8333 18H7.41667C6.72631 18 6.16667 18.6716 6.16667 19.5C6.16667 20.3284 6.72631 21 7.41667 21H17.8333V18Z" fill="currentColor"></path> </svg></span><span>订单打印副本</span></span><span role="img" class="anticon ButtonGroup_buttonGroupWrapperIcon__CFikg"> <svg width="1em" height="1em" viewbox="0 0 18 14"> <defs> <clippath id="a"> <path d="M10.293,13.707a1,1,0,0,1,0-1.414L14.586,8H1A1,1,0,0,1,1,6H14.586L10.293,1.707A1,1,0,0,1,11.707.293l6,6a1,1,0,0,1,.172.231h0l.01.019,0,.005.007.014.006.012,0,.008.008.018v0a1,1,0,0,1-.009.817l0,0L17.9,7.44l0,.009-.005.011-.007.013,0,.008-.008.015,0,.005-.01.016,0,0-.011.017,0,0-.012.018,0,0-.012.017,0,0L17.8,7.6l0,0-.011.014,0,.006-.01.012-.009.011-.006.007-.015.017h0l-.04.042-6,6a1,1,0,0,1-1.414,0Z" transform="translate(3 5)"></path> </clippath> </defs> <g transform="translate(-3 -5)"> <path d="M10.293,13.707a1,1,0,0,1,0-1.414L14.586,8H1A1,1,0,0,1,1,6H14.586L10.293,1.707A1,1,0,0,1,11.707.293l6,6a1,1,0,0,1,.172.231h0l.01.019,0,.005.007.014.006.012,0,.008.008.018v0a1,1,0,0,1-.009.817l0,0L17.9,7.44l0,.009-.005.011-.007.013,0,.008-.008.015,0,.005-.01.016,0,0-.011.017,0,0-.012.018,0,0-.012.017,0,0L17.8,7.6l0,0-.011.014,0,.006-.01.012-.009.011-.006.007-.015.017h0l-.04.042-6,6a1,1,0,0,1-1.414,0Z" transform="translate(3 5)" fill="currentColor"></path> </g> </svg></span></a> <div class="articleToolbarStatistics_articleToolbarStatistics__8_woN"> <div class="articleToolbarStatistics_column__R2GqD"> <div> <div> <span>的观点</span> <div class="articleToolbarStatistics_amount__vJIDp"> 1813年</d我v> </div> <div> <span>下载</span> <div class="articleToolbarStatistics_amount__vJIDp"> 1509年</d我v> </div> </div> </div> <div class="articleToolbarStatistics_column__R2GqD articleToolbarStatistics_dimensions__pe7pO"> <div> 引用</d我v> <span class="__dimensions_badge_embed__ articleToolbarStatistics_circle__p2dSc" data-doi="10.1155/2012/208641" data-style="small_circle"></span> </div> </div> <ul class="articleToolbarSocials_articleToolbarSocials__g02HH"> <li><a href="https://twitter.com/share?url=https://doi.org/10.1155/2012/208641&via=Hindawi" unselectable="on" title="" rel="noopener noreferrer" target="_blank"><span role="img" class="anticon"> <svg xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="126.444 2.281 589 589"> <circle cx="420.944" cy="296.781" r="294.5" fill="#2daae1"></circle> <path d="M609.773 179.634c-13.891 6.164-28.811 10.331-44.498 12.204 16.01-9.587 28.275-24.779 34.066-42.86a154.78 154.78 0 0 1-49.209 18.801c-14.125-15.056-34.267-24.456-56.551-24.456-42.773 0-77.462 34.675-77.462 77.473 0 6.064.683 11.98 1.996 17.66-64.389-3.236-121.474-34.079-159.684-80.945-6.672 11.446-10.491 24.754-10.491 38.953 0 26.875 13.679 50.587 34.464 64.477a77.122 77.122 0 0 1-35.097-9.686v.979c0 37.54 26.701 68.842 62.145 75.961-6.511 1.784-13.344 2.716-20.413 2.716-4.998 0-9.847-.473-14.584-1.364 9.859 30.769 38.471 53.166 72.363 53.799-26.515 20.785-59.925 33.175-96.212 33.175-6.25 0-12.427-.373-18.491-1.104 34.291 21.988 75.006 34.824 118.759 34.824 142.496 0 220.428-118.052 220.428-220.428 0-3.361-.074-6.697-.236-10.021a157.855 157.855 0 0 0 38.707-40.158z" fill="#fff"></path> </svg></span></a></li> <li><a href="https://www.linkedin.com/shareArticle/?url=https://doi.org/10.1155/2012/208641" unselectable="on" title="" rel="noopener noreferrer" target="_blank"><span role="img" class="anticon"> <svg xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="0 0 256 256" xml:space="preserve"> <g transform="translate(-373.642 -318.344)"> <path fill="#1D8CB5" d="M583.659 328.849H419.625c-19.599 0-35.487 15.888-35.487 35.487v164.015c0 19.599 15.888 35.486 35.487 35.486h164.033c19.599 0 35.487-15.888 35.487-35.486V364.337c.001-19.599-15.888-35.488-35.486-35.488z"></path> <lineargradient id="a" gradientunits="userSpaceOnUse" x1="-808.873" y1="199.892" x2="-860.569" y2="49.203" gradienttransform="rotate(180 -17.27 206.273) scale(.5915)"> <stop offset="0" style="stop-color:#fff"></stop> <stop offset="1" style="stop-color:#fff;stop-opacity:0"></stop> </lineargradient> <path opacity=".781" fill="url(#a)" d="M557.056 338.895H446.227c-29.337 0-52.955 23.81-52.955 53.385v108.127c.95 23.087 4.603 8.491 11.555-17.075 8.081-29.713 34.396-55.682 66.445-75.145 24.461-14.855 51.84-24.341 101.679-25.244 28.265-.511 25.77-36.683-15.895-44.048z"></path> </g> <g fill="#FFF"> <path d="M81.604 207.76V101.49h-35.32v106.27h35.32zM63.951 86.98c12.308 0 19.981-8.161 19.981-18.36-.228-10.426-7.673-18.36-19.75-18.36-12.087 0-19.984 7.934-19.984 18.36 0 10.199 7.662 18.36 19.52 18.36h.233zM101.151 207.76h35.326v-59.345c0-3.178.23-6.352 1.165-8.621 2.547-6.35 8.363-12.92 18.118-12.92 12.784 0 17.893 9.748 17.893 24.032v56.855h35.319v-60.936c0-32.643-17.422-47.83-40.665-47.83-19.053 0-27.421 10.647-32.068 17.902h.238V101.49h-35.326c.469 9.97 0 106.27 0 106.27z"></path> </g> </svg></span></a></li> <li><a href="https://www.facebook.com/sharer/sharer.php?u=https://doi.org/10.1155/2012/208641" unselectable="on" title="" rel="noopener noreferrer" target="_blank"><span role="img" class="anticon"> <svg xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="0 0 14222 14222"> <circle cx="7111" cy="7112" r="7111" fill="#1977f3"></circle> <path d="M9879 9168l315-2056H8222V5778c0-562 275-1111 1159-1111h897V2917s-814-139-1592-139c-1624 0-2686 984-2686 2767v1567H4194v2056h1806v4969c362 57 733 86 1111 86s749-30 1111-86V9168z" fill="#fff"></path> </svg></span></a></li> <li><a href="//www.newsama.com/cdn-cgi/l/email-protection" unselectable="on" title="" rel="noopener noreferrer" target="_blank"><span role="img" class="anticon"> <svg version="1.0" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em" viewbox="0 0 1401 1101"> <path fill="#6ba439" d="M132.5 2.1C101.4 6 71.1 20.5 48.3 42.4c-22.7 21.7-37.5 48.3-44.6 80l-2.2 10.1v837l2.2 10.1c6.7 30 19.3 53.9 39.8 75.3 23.3 24.3 56.4 40.9 90 45 12.8 1.6 1122.2 1.6 1135 0 38.9-4.8 75.9-25.6 100-56.4 15-19.3 24.2-39 29.8-63.9l2.2-10.1v-837l-2.2-10.1c-7.1-31.8-21.9-58.3-44.6-80.1-20.2-19.2-43.9-31.7-73.6-38.5l-9.6-2.3L705 1.4c-321.9-.1-568.5.2-572.5.7zm1123.4 99.5c1.7.4 3.1 1 3.1 1.4 0 .5-125.6 87.7-279 194L700.9 490.2 422 297C268.5 190.7 143 103.4 143 103c0-.5 1-1.1 2.3-1.3 3.5-.7 1107.1-.8 1110.6-.1zM401 404c164.4 113.8 299.4 207 300 207 .6 0 135.6-93.2 300.1-207 164.5-113.9 299.3-207 299.5-207 .2 0 .4 170.9.4 379.7 0 417.9.5 386-6.1 398.3-6.2 11.6-19 21.4-31.9 24.4-5.8 1.4-67.4 1.6-562 1.6s-556.2-.2-562-1.6c-12.9-3-25.7-12.8-31.9-24.4-6.6-12.3-6.1 19.6-6.1-398.3 0-208.8.2-379.7.5-379.7S236.6 290.1 401 404z"></path> </svg></span></a></li> </ul> </div> </div> </div> </div> </div> </div> </main> <div> <footer class="ant-layout-footer"> <div class="footer-main-nav-section"> <div class="footer-main-nav"> <div class="ant-col footer-main-nav__column"> <ul class="ant-menu ant-menu-root ant-menu-vertical ant-menu-light footer-main-nav__menu" role="menu" tabindex="0" data-menu-list="true"> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/about/" aria-label="About Us">关于我们</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/about/contact/" aria-label="Contact us">联系我们</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publishing-partnerships/" aria-label="Partnerships">合作伙伴关系</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/blog/" aria-label="Blog">博客</一个></span></li> </ul> <div style="display:none" aria-hidden="true"></div> </div> <div class="ant-col footer-main-nav__column"> <ul class="ant-menu ant-menu-root ant-menu-vertical ant-menu-light footer-main-nav__menu" role="menu" tabindex="0" data-menu-list="true"> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/journals/" aria-label="Journals">期刊</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publish-research/authors/article-processing-charges/" aria-label="Article Processing Charges">文章处理费用</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/print-editions/" aria-label="Print editions">印刷版</一个></span></li> </ul> <div style="display:none" aria-hidden="true"></div> </div> <div class="ant-col footer-main-nav__column"> <ul class="ant-menu ant-menu-root ant-menu-vertical ant-menu-light footer-main-nav__menu" role="menu" tabindex="0" data-menu-list="true"> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publish-research/authors/" aria-label="Authors">作者</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publish-research/editors/" aria-label="Editors">编辑器</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publish-research/reviewers/" aria-label="Reviewers">评论家</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/publishing-partnerships/" aria-label="Partnerships">合作伙伴关系</一个></span></li> </ul> <div style="display:none" aria-hidden="true"></div> </div> <div class="ant-col footer-main-nav__column"> <ul class="ant-menu ant-menu-root ant-menu-vertical ant-menu-light footer-main-nav__menu" role="menu" tabindex="0" data-menu-list="true"> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/hindawi-xml-corpus/" aria-label="Hindawi XML Corpus">雷电竞APP</a></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/open-archives-initiative/" aria-label="Open Archives Initiative">开放档案计划</一个></span></li> <li class="ant-menu-item ant-menu-item-only-child footer-main-nav__item" role="menuitem" tabindex="-1"><span class="ant-menu-title-content"><a href="//www.newsama.com/preventing-and-protecting-against-fraud/" aria-label="Fraud prevention">欺诈防范</一个></span></li> </ul> <div style="display:none" aria-hidden="true"></div> </div> </div> <div class="social-links"> 遵循我们:<d我v class="social-links__icons"> <a aria-label="Twitter" rel="noopener noreferrer" href="https://twitter.com/hindawi" target="_blank" class="social-links__icon"><span role="img" class="anticon"> <svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewbox="0 0 40 40" fill="none"> <path fill-rule="evenodd" clip-rule="evenodd" d="M0 20C0 8.95599 8.95599 0 20 0C31.044 0 40 8.95599 40 20C40 31.044 31.044 40 20 40C8.95599 40 0 31.044 0 20ZM29.1449 16.1871C29.1449 15.9885 29.1406 15.7907 29.1318 15.5939C30.0281 14.946 30.8072 14.1373 31.4215 13.2166C30.5991 13.5822 29.7141 13.8284 28.7854 13.9395C29.7333 13.371 30.4608 12.4719 30.8041 11.4005C29.917 11.9263 28.9349 12.3083 27.8891 12.5146C27.0514 11.6223 25.8588 11.0641 24.5383 11.0641C22.0032 11.0641 19.9472 13.1201 19.9472 15.6543C19.9472 16.0144 19.9878 16.3647 20.0665 16.701C16.2512 16.5091 12.868 14.6823 10.6042 11.9046C10.21 12.583 9.9826 13.371 9.9826 14.212C9.9826 15.8047 10.7928 17.2107 12.0255 18.0331C11.2723 18.0099 10.5649 17.803 9.94629 17.4591C9.94568 17.4783 9.94568 17.4969 9.94568 17.5177C9.94568 19.7406 11.528 21.597 13.6285 22.0175C13.2428 22.1228 12.8369 22.1793 12.4179 22.1793C12.1228 22.1793 11.835 22.15 11.5552 22.0963C12.1399 23.9203 13.8342 25.2475 15.8438 25.2847C14.2725 26.5161 12.2931 27.2498 10.1422 27.2498C9.77203 27.2498 9.40643 27.2287 9.04724 27.1863C11.0788 28.4885 13.4912 29.2484 16.0837 29.2484C24.5276 29.248 29.1449 22.2531 29.1449 16.1871Z" fill="#F2F2F2"></path> </svg></span></a> <a aria-label="Linkedin" rel="noopener noreferrer" href="https://www.linkedin.com/company/hindawilimited/" target="_blank" class="social-links__icon"><span role="img" class="anticon"> <svg width="40" height="40" viewbox="0 0 40 40" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M0 20C0 8.95599 8.95599 0 20 0C31.044 0 40 8.95599 40 20C40 31.044 31.044 40 20 40C8.95599 40 0 31.044 0 20ZM9.31732 30.2344H14.1882V15.5801H9.31732V30.2344ZM11.7529 13.5791H11.7212C10.0867 13.5791 9.02954 12.4539 9.02954 11.0477C9.02954 9.60968 10.119 8.51562 11.7853 8.51562C13.4515 8.51562 14.4769 9.60968 14.5087 11.0477C14.5087 12.4539 13.4515 13.5791 11.7529 13.5791ZM26.8814 30.2344H31.7517V21.8317C31.7517 17.3306 29.3488 15.2362 26.1441 15.2362C23.5599 15.2362 22.4017 16.6565 21.7545 17.655V15.5801H16.8839C16.9476 16.955 16.8839 30.2344 16.8839 30.2344H21.7545V22.0508C21.7545 21.6129 21.7859 21.1752 21.9147 20.8621C22.2668 19.9872 23.0682 19.0808 24.4138 19.0808C26.1761 19.0808 26.8814 20.4245 26.8814 22.3947V30.2344Z" fill="#F2F2F2"></path> </svg></span></a> <a aria-label="Youtube" rel="noopener noreferrer" href="https://www.youtube.com/channel/UCDIK_O7FATPEkhad_sQVaSg" target="_blank" class="social-links__icon"><span role="img" class="anticon"> <svg width="40" height="40" viewbox="0 0 40 40" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M17.2973 23.7838L23.7838 20L17.2973 16.2162V23.7838Z" fill="#F2F2F2"></path> <path fill-rule="evenodd" clip-rule="evenodd" d="M0 20C0 8.95599 8.95599 0 20 0C31.044 0 40 8.95599 40 20C40 31.044 31.044 40 20 40C8.95599 40 0 31.044 0 20ZM31.9824 26.0324C32.4969 24.0765 32.4969 20.0204 32.4969 20.0204C32.4969 20.0204 32.5177 15.9442 31.9824 13.9883C31.694 12.9178 30.8499 12.0734 29.7794 11.7853C27.8235 11.25 20 11.25 20 11.25C20 11.25 12.1765 11.25 10.2206 11.7648C9.17053 12.0529 8.30566 12.9178 8.01758 13.9883C7.50275 15.9442 7.50275 20 7.50275 20C7.50275 20 7.50275 24.0765 8.01758 26.0117C8.30597 27.0822 9.15009 27.9266 10.2206 28.2147C12.197 28.75 20 28.75 20 28.75C20 28.75 27.8235 28.75 29.7794 28.2352C30.8499 27.9471 31.694 27.103 31.9824 26.0324Z" fill="#F2F2F2"></path> </svg></span></a> <a aria-label="Facebook" rel="noopener noreferrer" href="https://www.facebook.com/HindawiLimited/" target="_blank" class="social-links__icon"><span role="img" class="anticon"> <svg width="40" height="39" viewbox="0 0 40 39" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M40 19.4595C40 8.71394 31.044 0 20 0C8.95599 0 0 8.71394 0 19.4595C0 30.205 8.95599 38.9189 20 38.9189C20.1175 38.9189 20.2344 38.9165 20.3516 38.9145V23.7661H16.0547V18.8938H20.3516V15.3084C20.3516 11.1502 22.9605 8.88705 26.7728 8.88705C28.5983 8.88705 30.1675 9.01948 30.625 9.07857V13.4244H27.9962C25.9222 13.4244 25.5206 14.3835 25.5206 15.7906V18.8938H30.4797L29.8334 23.7661H25.5206V38.1671C33.8803 35.8353 40 28.3418 40 19.4595Z" fill="#F2F2F2"></path> </svg></span></a> </div> </div> </div> <div class="footer-minor-nav"> <span><a href="//www.newsama.com/privacy/" class="footer-minor-nav__link" aria-label="Privacy Policy">隐私政策</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a href="//www.newsama.com/terms/" class="footer-minor-nav__link" aria-label="Terms of Service">服务条款</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a href="//www.newsama.com/responsible-disclosure-policy/" class="footer-minor-nav__link" aria-label="Responsible Disclosure Policy">负责信息披露政策</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a href="//www.newsama.com/cookie-policy/" class="footer-minor-nav__link" aria-label="Cookie Policy">饼干的政策</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a href="//www.newsama.com/copyright/" class="footer-minor-nav__link" aria-label="Copyright">版权</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a href="//www.newsama.com/modern-slavery-statement/" class="footer-minor-nav__link" aria-label="Modern slavery statement">现代奴隶制的声明</一个><d我v class="ant-divider ant-divider-vertical" role="separator"></div></span> <span><a class="footer-minor-nav__link" aria-label="Cookie Preferences">饼干的偏好</一个></span> </div> </footer> </div> </section> <noscript> <iframe src="https://www.newsama.com/ns.html?id=GTM-MQ4MGW" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> </div> </body> </html>