O]Cl O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen.
Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)O]Cl O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. In vivo and in vitro biological activities of the chn complex were compared with the chemical nuclease [Cu(phen)(nal)O]N O (cpn) where phen is phenanthroline.">
的合成、表征及生物活性研究铜(II)混合与组胺和萘啶酸化合物</t我tle>
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<span class="articleHeader__authors_author">Egla Yareth Bivian-Castro<gydF4y2Ba!-- -->,<年代up>1、2</年代up></年代p一个n><年代pan class="articleHeader__authors_author">奔驰g·洛佩兹<gydF4y2Ba!-- -->,<年代up>3</gydF4y2Ba年代up></年代p一个n><年代pan class="articleHeader__authors_author">马里奥Pedraza-Reyes<gydF4y2Ba!-- -->,<年代up>4</gydF4y2Ba年代up></年代p一个n><年代pan class="articleHeader__authors_author">Sylvain伯尔尼<gydF4y2Ba!-- -->,<年代up>5</gydF4y2Ba年代up></年代p一个n><年代pan class="articleHeader__authors_author">和<年代trong>吉尔勒莫Mendoza-Diaz</年代trong><a href="//www.newsama.com/cdn-cgi/l/email-protection" aria-label="Mail Option"><span role="img" class="anticon">
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<h4 class="header" id="abstract">文摘</h4><p>gydF4y2Ba混合铜复杂deprotonated萘啶酸(nal)和组胺(hsm)合成和红外光谱、紫外-元素分析和电导率。铜的晶体结构(hsm) (nal)<年代vg height="14.375" id="M1" style="vertical-align:-3.13504pt;width:17.5px;" version="1.1" viewbox="0 0 17.5 14.375" width="17.5" xmlns="http://www.w3.org/2000/svg">
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<svg height="14.6" id="M3" style="vertical-align:-3.13504pt;width:25.3125px;" version="1.1" viewbox="0 0 25.3125 14.6" width="25.3125" xmlns="http://www.w3.org/2000/svg">
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</g>
</svg>O (<b>gydF4y2Ba中文</b>)gydF4y2Ba显示pentacoordinated库珀(II)在一个方形锥体几何从hsm两个N原子包围,从喹诺酮两个O原子,和一顶水氧。细菌的DNA结构的改变和/或关联函数体内的铜(hsm)(部分)<年代vg height="14.375" id="M4" style="vertical-align:-3.13504pt;width:17.5px;" version="1.1" viewbox="0 0 17.5 14.375" width="17.5" xmlns="http://www.w3.org/2000/svg">
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<svg height="14.6" id="M6" style="vertical-align:-3.13504pt;width:25.3125px;" version="1.1" viewbox="0 0 25.3125 14.6" width="25.3125" xmlns="http://www.w3.org/2000/svg">
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</svg>证明了感应的<我>recA-lacZ</gydF4y2Ba我>融合集成在<我>一个米yE</我>位点的重组<我>枯草芽孢杆菌</我>压力。结果从圆二色性和变性的小牛胸腺DNA (CT-DNA)建议增加大量的铜复杂能够稳定DNA的双螺旋结构体外主要由之间的氢键的形成<b>gydF4y2Ba中文</b>gydF4y2Ba和糖的DNA小沟。在体内和体外生物活性<b>gydF4y2Ba中文</b>gydF4y2Ba比较复杂的化学核酸酶(铜(苯酚的)(部分)<年代vg height="14.375" id="M7" style="vertical-align:-3.13504pt;width:17.5px;" version="1.1" viewbox="0 0 17.5 14.375" width="17.5" xmlns="http://www.w3.org/2000/svg">
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<svg height="14.6" id="M10" style="vertical-align:-3.13504pt;width:25.3125px;" version="1.1" viewbox="0 0 25.3125 14.6" width="25.3125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
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3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
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</svg>O (<b>gydF4y2Ba尼泊尔共产党</b>),gydF4y2Ba苯酚的邻二氮杂菲。</p><年代p一个ncl一个年代年代="end-abs"></span>
<h4 id="introduction">1。介绍</h4><p>gydF4y2Ba因为Lescher和上校准备1962年的萘啶酸(<一个href="#B1">1</一个>),合成新的喹诺酮类(图<一个href="//www.newsama.com/journals/bca/2009/603651/fig1/" target="_blank">1</一个>)。喹诺酮家族的第一代抗生素对革兰氏阴性细菌有效光通常发现在泌尿系统疾病(<一个href="#B2">2</一个>];这些药物萘啶酸的例子,奥索利酸和Cinoxacin。第二代氟喹诺酮类原料药,如环丙沙星对革兰氏阳性细菌同样有效;他们可以用于尿、皮肤或呼吸道感染(<一个href="#B3">3</一个>]。左氧氟沙星和sparfloxacin是第三代喹诺酮类的例子,也称为氟喹诺酮类原料药,但他们更有效对抗gram-positives有机体。它们用于治疗肺炎、支气管炎、鼻窦炎,淋病感染。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图1</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig1/" title="" target="_blank"></a>
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<td>某些喹诺酮和氟喹诺酮类药物的化学结构。</tgydF4y2Bad>
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<p>第四代喹诺酮类包括trovofloxacin的有效性对厌氧生物(<一个href="#B4">4</一个>]。喹诺酮抑制细菌DNA合成(<一个href="#B2">2</一个>),有几种假说来解释他们的作用机理。其中一个假设表明抑制亚基的DNA-gyrase存在ATP (<一个href="#B5">5</一个>- - - - - -<一个href="#B7">7</一个>]。另一种假说支持quinolone-DNA-DNA-gyrase[合作关系的存在<一个href="#B8">8</一个>- - - - - -<一个href="#B11">11</一个>]。同时,建议喹诺酮可能形成协调配合物与过渡金属离子存在于细胞质中或用金属biocomplex;这种金属离子可以铜(II) (<一个href="#B12">12</一个>]。铜在生物系统通常是发现包围组氨酸残基的咪唑根(<一个href="#B13">13</一个>,<gydF4y2Ba一个href="#B14">14</一个>]。铜浓度增加当疾病如关节炎或肿瘤存在;因此在压力造成的疾病、铜可用一些内生的或者外生的化合物,为配合肽和药物等。有鉴于此,不同喹诺酮类的交互与铜和其他金属离子多年来一直研究[<一个href="#B15">15</一个>]。hsm-copper (II)系统可用于模拟环境中金属离子的生物系统。组胺分子是一个很好的配位体,不仅包含N个原子(咪唑环和脂肪族氨合物),但还氢原子,有利于氢键的形成,因此在分子识别是有用的。因为这些特征的一些组胺复合物与铜最近报道(<一个href="#B16">16</一个>,<gydF4y2Ba一个href="#B17">17</一个>]。在目前的工作我们报道的合成、表征和生物活动的结果铜混合复杂(见图<一个href="#sch1">1</一个>),h年代米和萘啶酸。本研究有助于获得更好的知识如何需要金属离子携带他们的网站的喹诺酮类行动并阐明金属环境如何影响喹诺酮类药物的生物作用。</p><h4gydF4y2Baid="experimental">2。实验</h4><h5gydF4y2Baid="sec2.1">2.1。材料和物理测量</h5><p>gydF4y2Ba组胺盐酸盐、萘啶酸(Sigma-Aldrich产品),和<年代vg height="14.7125" id="M11" style="vertical-align:-3.13504pt;width:87.112503px;" version="1.1" viewbox="0 0 87.112503 14.7125" width="87.112503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.930502" y="0">
l</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-45.54,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-37.89,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-16.26,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-11.38,63.41)">
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O</t年代p一个n></text>
</g>
</g>
</svg>(j·t·贝克产品)被用作提供。远红外光谱被带到力量IFS-55分光光度计聚乙烯颗粒。Medium-IR光谱进行了优秀的分光光度计模型。英国《金融时报》1600年KBr丸。电子光谱被记录在一个安捷伦8453紫外可见分光光度计使用水作为溶剂。摩尔电导率的测量是用Conductronic PC18 nickel-platinezed电极电导率桥细胞准备使用前用水解决方案。元素分析是由沙漠分析,有机微量分析、Tuczon AZ,美国。</p><h5我d="sec2.2">2.2。合成的混合复合物</h5><p>(<ggydF4y2BaydF4y2Ba年代vg height="14.7125" id="M12" style="vertical-align:-3.13504pt;width:113px;" version="1.1" viewbox="0 0 113 14.7125" width="113" xmlns="http://www.w3.org/2000/svg">
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h</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="25.006001" y="0">
年代</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.869667" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="39.597" y="0">
)</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="43.760502" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="47.924" y="0">
n</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="54.175499" y="0">
一个</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="59.72683" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="63.202663" y="0">
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H</t年代p一个n></text>
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</svg>]<年代vg height="14.7125" id="M13" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
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2</t年代p一个n></text>
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</svg>:萘啶酸(232.2毫克,1更易)溶解<年代vg height="10.9125" id="M14" style="vertical-align:-0.17554pt;width:40.637501px;" version="1.1" viewbox="0 0 40.637501 10.9125" width="40.637501" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
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N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.8021116" y="0">
一个</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.353444" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="23.38061" y="0">
H</t年代p一个n></text>
</g>
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</svg>(40毫克,1更易)在70毫升的水。这个解决方案添加到先前准备的克分子数相等的混合组胺盐酸盐(184.07毫克,1更易)和<年代vg height="14.7125" id="M15" style="vertical-align:-3.13504pt;width:87.112503px;" version="1.1" viewbox="0 0 87.112503 14.7125" width="87.112503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.930502" y="0">
l</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-45.54,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-37.89,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-16.26,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-11.38,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
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</svg>(170.48毫克,1更易)溶解在15毫升的水的总量。最终的解决办法是pH值7.5,留给缓慢结晶在冰箱里(<年代vg height="10.825" id="M16" style="vertical-align:-0.0pt;width:12.3875px;" version="1.1" viewbox="0 0 12.3875 10.825" width="12.3875" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-63.34)">
<text transform="matrix(1,0,0,-1,-71.95,63.39)">
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4</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-65.7,68.56)">
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∘</t年代p一个n></text>
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</g>
</svg>C)。紫色晶体适合x射线分析孤立。<我>肛交。</我>C一个lc。为<年代vg height="14.8625" id="M17" style="vertical-align:-3.25793pt;width:112.725px;" version="1.1" viewbox="0 0 112.725 14.8625" width="112.725" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.8625)">
<g transform="translate(72,-60.11)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-63.61,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="4.3759999" y="0">
7</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-54.36,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-45.33,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="4.3759999" y="0">
1</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-36.08,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
N</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-12.46,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
5</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-7.59,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,1.44,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
8</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,6.31,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n></text>
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</svg>:C, 38.35;H, 5.87;13.15 N,。发现:C, 39.82;H, 5.50;N, 13.65%。红外(KBr,<年代vg height="13.925" id="M18" style="vertical-align:-0.12538pt;width:32.8125px;" version="1.1" viewbox="0 0 32.8125 13.925" width="32.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.925)">
<g transform="translate(72,-60.86)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">
c</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.551332" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>):1634 (s), 1607 (m), 1522 (m), 1501 (m), 539 (s)、503 (m)紫外可见。<年代vg height="14.6" id="M19" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>海里):<年代vg height="14.5875" id="M20" style="vertical-align:-3.22282pt;width:31.6875px;" version="1.1" viewbox="0 0 31.6875 14.5875" width="31.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.5875)">
<g transform="translate(72,-60.33)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-65.19,60.47)">
<tspan style="font-size: 8.75px; " x="0" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="6.8090558" y="0">
一个</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="10.694944" y="0">
x</t年代p一个n></text>
</g>
</g>
</svg>212年<年代vg height="18" id="M21" style="vertical-align:-3.13504pt;width:181.55px;" version="1.1" viewbox="0 0 181.55 18" width="181.55" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,18)">
<g transform="translate(72,-57.6)">
<text transform="matrix(1,0,0,-1,-71.95,60.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="4.1634989" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-61.74,57.65)">
<tspan style="font-size: 8.75px; " x="0" y="0">
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2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.291889" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="24.543388" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="30.794889" y="0">
7</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="37.046391" y="0">
4</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="45.373386" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="55.100719" y="0">
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2</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="4.3759999" y="0">
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7</t年代p一个n></text>
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2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.279387" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="24.530886" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="30.782387" y="0">
9</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="37.033886" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="45.373386" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="55.100719" y="0">
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3</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="4.3759999" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="8.7519999" y="0">
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1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.279387" y="0">
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1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="30.782387" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="37.033886" y="0">
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6</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="4.3759999" y="0">
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5</t年代p一个n></text>
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</svg>得到正如前面引用指示(<一个href="#B18">18</一个>]。</p><h5gydF4y2Baid="sec2.3">2.3。晶体的研究</h5><p>gydF4y2Ba一个水晶标本<年代vg height="14.1625" id="M29" style="vertical-align:-0.3135pt;width:149.08749px;" version="1.1" viewbox="0 0 149.08749 14.1625" width="149.08749" xmlns="http://www.w3.org/2000/svg">
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1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="44.148094" y="0">
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4</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.656635" y="0">
8</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.908134" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="42.247639" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="53.362804" y="0">
g</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="59.614304" y="0">
/</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="63.090137" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,25.21,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
</g>
</g>
</svg>,<年代vg height="16.637501" id="M46" style="vertical-align:-2.29482pt;width:107.3125px;" version="1.1" viewbox="0 0 107.3125 16.637501" width="107.3125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.6375)">
<g transform="translate(72,-58.69)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="11.077658" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="23.118048" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.369547" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="32.495296" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="38.746796" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="44.998299" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="55.413296" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="65.140633" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,2.93,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>4796收集的反射(<年代vg height="15.025" id="M47" style="vertical-align:-3.22281pt;width:206.675px;" version="1.1" viewbox="0 0 206.675 15.025" width="206.675" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,15.025)">
<g transform="translate(72,-59.98)">
<text transform="matrix(1,0,0,-1,-71.95,63.24)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.3772497" y="0">
8</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="15.62875" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="25.34358" y="0">
<</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="37.383968" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="47.411377" y="0">
<</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="59.451763" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="65.703262" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="71.954765" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="75.080513" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="81.332016" y="0">
0</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,15.64,68.56)">
<tspan style="font-size: 8.75px; " x="0" y="0">
∘</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,19.2,63.24)">
<tspan style="font-size: 12.50px; " x="0" y="0">
,</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.2012482" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,33.66,60.12)">
<tspan style="font-size: 8.75px; " x="0" y="0">
我</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="2.4330561" y="0">
n</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="6.8090558" y="0">
t</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,46.87,63.24)">
<tspan style="font-size: 12.50px; " x="0" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.027886" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.279387" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.405136" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.656635" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.908134" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.159637" y="0">
6</t年代p一个n></text>
</g>
</g>
</svg>),最后<年代vg height="10.325" id="M48" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>指数(<年代vg height="11.0625" id="M49" style="vertical-align:-0.30096pt;width:44px;" version="1.1" viewbox="0 0 44 11.0625" width="44" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0625)">
<g transform="translate(72,-63.15)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.4647713" y="0">
></t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.505159" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.75666" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>(<我>我</我>)),<gydF4y2Ba年代vg height="14.7875" id="M50" style="vertical-align:-3.13504pt;width:85.362503px;" version="1.1" viewbox="0 0 85.362503 14.7875" width="85.362503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7875)">
<g transform="translate(72,-60.17)">
<text transform="matrix(1,0,0,-1,-67.78,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.53,60.22)">
<tspan style="font-size: 8.75px; " x="0" y="0">
1</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-50.18,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.027886" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.279387" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.405136" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.656635" y="0">
4</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.908134" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.159637" y="0">
5</t年代p一个n></text>
</g>
</g>
</svg>,<年代vg height="15.425" id="M51" style="vertical-align:-3.65294pt;width:91.862503px;" version="1.1" viewbox="0 0 91.862503 15.425" width="91.862503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,15.425)">
<g transform="translate(72,-59.66)">
<text transform="matrix(1,0,0,-1,-69.87,60.22)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.59,62.39)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.33,59.71)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-44.99,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.040389" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.291889" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.417639" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.66914" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.920639" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.172138" y="0">
3</t年代p一个n></text>
</g>
</g>
</svg>,<年代vg height="10.325" id="M52" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>指数(所有数据)<年代vg height="14.7875" id="M53" style="vertical-align:-3.13504pt;width:80.150002px;" version="1.1" viewbox="0 0 80.150002 14.7875" width="80.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7875)">
<g transform="translate(72,-60.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.7,60.22)">
<tspan style="font-size: 8.75px; " x="0" y="0">
1</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-54.35,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.027886" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.279387" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.405136" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.656635" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.908134" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.159637" y="0">
5</t年代p一个n></text>
</g>
</g>
</svg>,<年代vg height="15.3625" id="M54" style="vertical-align:-3.65294pt;width:91.862503px;" version="1.1" viewbox="0 0 91.862503 15.3625" width="91.862503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,15.3625)">
<g transform="translate(72,-59.71)">
<text transform="matrix(1,0,0,-1,-69.87,60.27)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.59,62.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.33,59.76)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-44.99,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.040389" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.291889" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.417639" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.66914" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.920639" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.172138" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>。选择债券的长度和角度提出了表<一个href="//www.newsama.com/journals/bca/2009/603651/tab1/" target="_blank">1</一个>。所有数据可用在剑桥晶体数据中心;见补充材料。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab1">
<div class="floats-partial-footer">
<div class="floats-partial-caption">
<span class="caption-text">表1</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/tab1/" title="" target="_blank"></a>
</div>
<div class="floats-partial-caption-text">
选择债券的长度(A)和键角(<年代vg height="10.6125" id="M55" style="vertical-align:-0.0pt;width:4.5749998px;" version="1.1" viewbox="0 0 4.5749998 10.6125" width="4.5749998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6125)">
<g transform="translate(72,-63.51)">
<text transform="matrix(1,0,0,-1,-71.95,68.56)">
<tspan style="font-size: 8.75px; " x="0" y="0">
∘</t年代p一个n></text>
</g>
</g>
</svg>(铜)(hsm) (nal)<年代vg height="14.6" id="M56" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M57" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>。</gydF4y2Badiv>
<a class="table-thumb-overlay" href="//www.newsama.com/journals/bca/2009/603651/tab1" target="_blank" aria-label="View full page"></a>
</div>
</div>
<h5 id="sec2.4">2.4。生物测试</h5><h6gydF4y2Baid="sec2.4.1">2.4.1。生物和生长条件</h6><p><我>枯草芽孢杆菌</我>应变携带pCCR202 (yb - 3001<我>矩形</我>一个-<我>虫胶</我>Z融合集成的<我>艾米</我>E轨迹)请提供博士罗纳德·E·Yasbin(内华达大学拉斯维加斯)。传播这一毒株,仅有Bertani(磅)中使用。氯霉素在最后添加到培养基浓度的3<年代vg height="9.6750002" id="M60" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.675)">
<g transform="translate(72,-64.26)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
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</g>
</g>
</svg>克/毫升。</p><h6gydF4y2Baid="sec2.4.2">2.4.2。诱导实验</h6><p><我>枯草芽孢杆菌</我>yb - 3001生长在600纳米光学密度0.3,并在这一点上,文化是分成6次文化。文化被用来控制之一,和其他五个补充<年代vg height="14.7125" id="M61" style="vertical-align:-3.13504pt;width:39.224998px;" version="1.1" viewbox="0 0 39.224998 14.7125" width="39.224998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.930502" y="0">
l</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-45.54,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
</g>
</g>
</svg>、萘啶酸、<年代vg height="16.862499" id="M62" style="vertical-align:-2.21957pt;width:78.824997px;" version="1.1" viewbox="0 0 78.824997 16.862499" width="78.824997" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.8625)">
<g transform="translate(72,-58.51)">
<text transform="matrix(1,0,0,-1,-71.95,60.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="4.1634989" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.503" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.754499" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.917999" y="0">
h</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.169498" y="0">
年代</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.033165" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="43.760502" y="0">
)</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="47.924" y="0">
]</t年代p一个n></text>
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</svg>DNA片段</h6><p>gydF4y2Ba实验描述金属络合物的核酸酶活性进行了使用196作为衬底<b>gydF4y2Ba英国石油公司</b>PCgydF4y2BaR片段包括开放阅读框的一部分和启动子区域的<我>ytk</gydF4y2Ba我>D基因<我>B</gydF4y2Ba我>。<我>细小</我>(<gydF4y2Ba一个href="#B22">22</一个>]。扩增的DNA片段进行了使用0.1<年代vg height="9.6750002" id="M69" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
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</svg>g染色体DNA<我>枯草芽孢杆菌</我>168年寡核苷酸引物<年代vg height="13.175" id="M70" style="vertical-align:-0.17555pt;width:12.2875px;" version="1.1" viewbox="0 0 12.2875 13.175" width="12.2875" xmlns="http://www.w3.org/2000/svg">
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</svg>(反向)。放大与通风进行DNA聚合酶(新英格兰生物学实验室,贝弗利,MA)。196年的英国石油公司获得的DNA纯化从低熔点琼脂糖凝胶(如前所述<一个href="#B23">23</一个>]。</p><p>gydF4y2Ba一个典型的反应混合物包含在最后一个25的体积<年代vg height="9.6750002" id="M74" style="vertical-align:-2.29482pt;width:9.6374998px;" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-56.67,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>在文献[<一个href="#B24">24</一个>]。</p><h6gydF4y2Baid="sec2.4.5">2.4.5。CD光谱</h6><p>CDgydF4y2Ba光谱被记录在增加(铜(hsm)(部分)<年代vg height="14.6" id="M85" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
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</g>
</svg>]<年代vg height="14.7125" id="M86" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>/ CT-DNA比(<年代vg height="10.9125" id="M87" style="vertical-align:-0.17555pt;width:45.424999px;" version="1.1" viewbox="0 0 45.424999 10.9125" width="45.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.5645552" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.604944" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="26.856443" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.982195" y="0">
0</t年代p一个n></text>
</g>
</g>
</svg>,0.048,0.14,0.24,0.38,0.48)。DNA浓度一直等于<年代vg height="14.375" id="M88" style="vertical-align:-0.3135pt;width:88.400002px;" version="1.1" viewbox="0 0 88.400002 14.375" width="88.400002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.3772497" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="15.62875" y="0">
7</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="23.955748" y="0">
×</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.04567" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.297169" y="0">
0</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-25.4,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
4</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-12.44,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
米</t年代p一个n></text>
</g>
</g>
</svg>在所有的实验。经过1小时的潜伏期在37°C,每个样本的光谱被记录在jasco - 715分光偏振计在室温下不断的氮气冲洗。200和300 nm之间的波长范围是监控。</p><p>gydF4y2Ba所有CD光谱进行了5毫米钠甲次砷酸盐,0.6 M氯化钠,<年代vg height="14.075" id="M89" style="vertical-align:-2.72116pt;width:58.150002px;" version="1.1" viewbox="0 0 58.150002 14.075" width="58.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.075)">
<g transform="translate(72,-60.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
p</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
H</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.741997" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="30.782387" y="0">
7</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="37.033886" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.159637" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>缓冲区,使用石英电池。类似的实验是用(铜(苯酚的)(部分)<年代vg height="14.6" id="M90" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.6" id="M91" style="vertical-align:-3.13504pt;width:78.237503px;" version="1.1" viewbox="0 0 78.237503 14.6" width="78.237503" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.9021358" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="17.929302" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="26.956469" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="33.307991" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="39.55949" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-23.36,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-18.48,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>复杂。钠甲次砷酸盐缓冲被雇佣为背景。</p><h6gydF4y2Baid="sec2.4.6">2.4.6。熔化温度的研究</h6><p>gydF4y2Ba热变性实验中执行相同的缓冲CD光谱,用石英比色皿安捷伦8453紫外可见分光光度计配备了珀尔帖效应系统。中文/ CT-DNA摩尔比率<年代vg height="10.9125" id="M92" style="vertical-align:-0.17555pt;width:45.424999px;" version="1.1" viewbox="0 0 45.424999 10.9125" width="45.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.5645552" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.604944" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="26.856443" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.982195" y="0">
0</t年代p一个n></text>
</g>
</g>
</svg>,0.096,0.28,0.48,0.77和0.96。经过1小时的潜伏期在37°C,样本不断加热1°C<年代vg height="14.0875" id="M93" style="vertical-align:-0.0pt;width:38.025002px;" version="1.1" viewbox="0 0 38.025002 14.0875" width="38.025002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.0875)">
<g transform="translate(72,-60.73)">
<text transform="matrix(1,0,0,-1,-71.95,60.78)">
<tspan style="font-size: 12.50px; " x="0" y="0">
米</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.727334" y="0">
我</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.203168" y="0">
n</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-52.5,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>。随着温度增加,吸光度的变化在260 nm记录。调查间隔的温度范围从37°C到90°C。DNA浓度等于<年代vg height="14.375" id="M94" style="vertical-align:-0.3135pt;width:73.637497px;" version="1.1" viewbox="0 0 73.637497 14.375" width="73.637497" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.3772497" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="15.62875" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="24.655916" y="0">
×</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="35.433502" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="41.685001" y="0">
0</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-24.01,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
4</t年代p一个n></text>
</g>
</g>
</svg>M。在进行了类似的实验<b>gydF4y2Ba尼泊尔共产党</b>gydF4y2Ba复杂。</p><h4gydF4y2Baid="results-and-discussions">3所示。结果和讨论</h4><h5gydF4y2Baid="sec3.1">3.1。的结构和光谱特性复杂的复合体</h5><p>gydF4y2Ba的分子结构(铜(hsm) (nal)<年代vg height="14.6" id="M95" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M96" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>复杂的图<一个href="//www.newsama.com/journals/bca/2009/603651/fig2/" target="_blank">2</一个>显示了一个扭曲的方形锥体铜离子周围的几何参数的建议的扭曲<年代vg height="6.8874998" id="M97" style="vertical-align:-0.0627pt;width:8.125px;" version="1.1" viewbox="0 0 8.125 6.8874998" width="8.125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,6.8875)">
<g transform="translate(72,-66.49)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>。Tau-descriptor (<年代vg height="6.8874998" id="M98" style="vertical-align:-0.0627pt;width:8.125px;" version="1.1" viewbox="0 0 8.125 6.8874998" width="8.125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,6.8875)">
<g transform="translate(72,-66.49)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>)五协调配合物表示为债券的区别角度O(2)铜(1)- n(3)和O(3)铜(1)- n(8)除以60给值为0.13,1的理想值为三方晶系的双锥体和0平方金字塔(<一个href="#B25">25</一个>]。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图2</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig2/" title="" target="_blank"></a>
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<td>ORTEP情节表现的分子结构(铜(hsm)(部分)<年代vg height="14.6" id="M99" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M100" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>复杂。椭圆体概率在50%。</tgydF4y2Bad>
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<p>金字塔的底部是由两个氧原子nalidixate配体(一个氧羧酸盐集团和其它的酮组,Cu (II) - o (2) = 1.934 (3), Cu (II) - o(3) = 1.961(2)职责。)和组胺配体的两个N原子(脂肪族氮和另一个咪唑氮、Cu-N (8) = 1.996 (3), Cu-N(3) = 1.966(3)职责。)。C (24) - o(1)键长较长C (24) - o(2)预期的羧基金属协调。铜和O (3) O(2)和N(3)几乎是共面,它们定义均方平面金字塔的基础(<年代vg height="13.6375" id="M101" style="vertical-align:-2.21957pt;width:335.96249px;" version="1.1" viewbox="0 0 335.96249 13.6375" width="335.96249" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.6375)">
<g transform="translate(72,-61.09)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.2515001" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.3772497" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="15.62875" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.880251" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="28.13175" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.383251" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="38.546749" y="0">
4</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="44.798248" y="0">
)</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="48.961746" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="61.614784" y="0">
+</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="72.955002" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="79.206505" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="82.332253" y="0">
5</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="88.583755" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="94.835258" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="101.08675" y="0">
9</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="107.33826" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="111.50175" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="117.75326" y="0">
)</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="121.91676" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="131.38153" y="0">
+</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="142.72174" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="148.97325" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="152.099" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="158.35049" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="164.60199" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="170.8535" y="0">
8</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="177.105" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="181.26849" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="187.51999" y="0">
)</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="195.15933" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="207.19972" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="213.45122" y="0">
6</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="219.70271" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="222.82846" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="229.07997" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="235.33147" y="0">
9</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="241.58296" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="247.83447" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="251.99797" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="258.24945" y="0">
8</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="264.50098" y="0">
)</t年代p一个n></text>
</g>
</g>
</svg>)。这些原子的重大偏差<年代vg height="10.9125" id="M102" style="vertical-align:-0.17555pt;width:46px;" version="1.1" viewbox="0 0 46 10.9125" width="46" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.5645552" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.816055" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="17.941805" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="24.193304" y="0">
7</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="30.444805" y="0">
7</t年代p一个n></text>
</g>
</g>
</svg>
<svg height="0.125" id="M103" style="vertical-align:-0.0pt;width:5.3375001px;" version="1.1" viewbox="0 0 5.3375001 0.125" width="5.3375001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,0.125)">
<g transform="translate(72,-71.9)"></g>
</g>
</svg>而N(8),也就是说,也形成了金字塔的一部分基地约0.244(3)高于飞机。在顶端位置一个水分子是协调(Cu-O (4) = 2.344 (3))。均值之间形成的角平面金字塔的基础和顶端配体是87.73<年代vg height="13.5875" id="M104" style="vertical-align:-2.21957pt;width:30.612499px;" version="1.1" viewbox="0 0 30.612499 13.5875" width="30.612499" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.5875)">
<g transform="translate(72,-61.13)">
<text transform="matrix(1,0,0,-1,-71.95,63.39)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="4.1634989" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="10.414999" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="16.666498" y="0">
)</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-51.12,68.56)">
<tspan style="font-size: 8.75px; " x="0" y="0">
∘</t年代p一个n></text>
</g>
</g>
</svg>。组胺的氨基是协调在反式位置酮组类似于铜复杂报告之前(<一个href="#B26">26</一个>]。在图<一个href="//www.newsama.com/journals/bca/2009/603651/fig3/" target="_blank">3</一个>,可以观察到在很大程度上是由包装模式<年代vg height="7.0124998" id="M105" style="vertical-align:-0.16302pt;width:55.012501px;" version="1.1" viewbox="0 0 55.012501 7.0124998" width="55.012501" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="10.37749" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.71771" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>叠加力量nalidixate阴离子的芳香环之间的相互作用距离为3.771以及氢键相互作用,因为晶体结构包括一个不协调的氯离子和三个水分子氢键网络身子提供晶体的稳定性。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图3</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig3/" title="" target="_blank"></a>
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<table>
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<tr>
<td>深成岩体情节之间的叠加显示nalidixate环和氢结合的晶体(铜(hsm)(部分)<年代vg height="14.6" id="M106" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
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H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
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2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
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O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M107" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
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O</t年代p一个n></text>
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</g>
</svg>复杂。</tgydF4y2Bad>
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<p>(铜(hsm)的红外光谱(nal)<b>)</b><ggydF4y2BaydF4y2Ba年代vg height="14.6" id="M108" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
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H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M109" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>化合物非常复杂,由于存在大量的官能团的分子;节中列出选择信号<一个href="#sec2">2</一个>。相对应的中红外光谱显示带两个配体。一个宽带3500左右<年代vg height="13.925" id="M110" style="vertical-align:-0.12538pt;width:32.8125px;" version="1.1" viewbox="0 0 32.8125 13.925" width="32.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.925)">
<g transform="translate(72,-60.86)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
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c</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.551332" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,66.03)">
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−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>可以分配给晶格水分子的地伸展振动。也在3261年和2661年之间<年代vg height="13.925" id="M111" style="vertical-align:-0.12538pt;width:32.8125px;" version="1.1" viewbox="0 0 32.8125 13.925" width="32.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.925)">
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c</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.551332" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>一些媒介乐队出现相应的胺和酰胺的振动形式。1634年和1501年之间的宽带<年代vg height="13.925" id="M112" style="vertical-align:-0.12538pt;width:32.8125px;" version="1.1" viewbox="0 0 32.8125 13.925" width="32.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.925)">
<g transform="translate(72,-60.86)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
c</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.551332" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
</g>
</g>
</svg>这是分裂,包括振动<年代vg height="11.3" id="M113" style="vertical-align:-3.22282pt;width:14.825px;" version="1.1" viewbox="0 0 14.825 11.3" width="14.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.3)">
<g transform="translate(72,-62.96)">
<text transform="matrix(1,0,0,-1,-71.95,66.22)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-65.62,63.1)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>(首席运营官)和<年代vg height="11.3125" id="M114" style="vertical-align:-3.2316pt;width:13.475px;" version="1.1" viewbox="0 0 13.475 11.3125" width="13.475" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.3125)">
<g transform="translate(72,-62.95)">
<text transform="matrix(1,0,0,-1,-71.95,66.22)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-65.62,63.1)">
<tspan style="font-size: 8.75px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>(CO)存在,显示这些团体之间的相互作用(4-oxo和3-carboxylate组)与金属离子。类似的结果是远红外光谱的观察。在538年和503年<年代vg height="13.925" id="M115" style="vertical-align:-0.12538pt;width:32.8125px;" version="1.1" viewbox="0 0 32.8125 13.925" width="32.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.925)">
<g transform="translate(72,-60.86)">
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c</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="5.551332" y="0">
米</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-56.67,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
1</t年代p一个n></text>
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</svg>两个乐队分配给铜-<年代vg height="14.375" id="M116" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.375" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.9,60.55)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
</g>
</g>
</svg>组合模式出现,之前已经报道(<一个href="#B26">26</一个>]。紫外可见光谱显示宽带围绕625海里,也就是说,观察到由于d d转换为铜(II)对应于一个典型的方形锥体铜(II)与两个氮原子协调复杂。在紫外区域三个对应的强烈的乐队出现<年代vg height="7.0124998" id="M117" style="vertical-align:-0.16302pt;width:36.775002px;" version="1.1" viewbox="0 0 36.775002 7.0124998" width="36.775002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.0125)">
<g transform="translate(72,-66.39)">
<text transform="matrix(1,0,0,-1,-71.95,66.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="10.37749" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.71771" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>配体的过渡显示在类似歌舞青春复杂之前报道(<一个href="#B26">26</一个>]。这是非凡的化学结构的相似性(铜(hsm)(部分)<年代vg height="14.6" id="M118" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M119" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>与铜化合物(苯酚的)(nal)<年代vg height="14.6" id="M120" style="vertical-align:-3.13504pt;width:34px;" version="1.1" viewbox="0 0 34 14.6" width="34" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-67.78,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.76,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.88,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.75" id="M121" style="vertical-align:-3.25793pt;width:76.525002px;" version="1.1" viewbox="0 0 76.525002 14.75" width="76.525002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
<g transform="translate(72,-60.2)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.9021358" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-54.02,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-46.37,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-24.73,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-19.86,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>复杂的(<一个href="#B18">18</一个>]。而<b>gydF4y2Ba尼泊尔共产党</b>gydF4y2Ba由于邻二氮杂菲配体复杂有理想的平面性,另一方面<b>gydF4y2Ba中文</b>gydF4y2Ba复杂的有可能由于组胺配体形成氢键。</p><h5gydF4y2Baid="sec3.2">3.2。生物活性的研究(铜(hsm) (nal<年代vg height="14.6" id="M122" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; font-family: 'XITSItalic';" x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>
<svg height="14.7125" id="M123" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-51,63.41)">
<tspan style="font-size: 12.50px; font-family: 'XITSItalic';" x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-44.75,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; font-family: 'XITSItalic';" x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>与铜(苯酚的)(nal进行比较<年代vg height="14.6" id="M124" style="vertical-align:-3.13504pt;width:34px;" version="1.1" viewbox="0 0 34 14.6" width="34" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-67.78,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.76,60.37)">
<tspan style="font-size: 8.75px; font-family: 'XITSItalic';" x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.88,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>
<svg height="14.675" id="M125" style="vertical-align:-3.19647pt;width:76.525002px;" version="1.1" viewbox="0 0 76.525002 14.675" width="76.525002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.675)">
<g transform="translate(72,-60.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.9021358" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-54.02,60.37)">
<tspan style="font-size: 8.75px; font-family: 'XITSItalic';" x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-46.37,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-40.01,63.5)">
<tspan style="font-size: 12.50px; font-family: 'XITSItalic';" x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-33.76,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-24.73,60.37)">
<tspan style="font-size: 8.75px; font-family: 'XITSItalic';" x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-19.86,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg></h5>
<p>的能力(铜(苯酚的)(nal)<年代vg height="14.75" id="M126" style="vertical-align:-3.25793pt;width:115.6px;" version="1.1" viewbox="0 0 115.6 14.75" width="115.6" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
<g transform="translate(72,-60.2)">
<text transform="matrix(1,0,0,-1,-67.78,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.76,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.88,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.0928" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-22.76,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-15.11,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,6.53,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,11.4,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>金属络合物与体内DNA及其能力促进还原条件下完全降解质粒和染色体DNA之前已经报道过(<一个href="#B27">27</一个>]。因此,我们调查是否(铜(hsm)(部分)<年代vg height="14.6" id="M127" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M128" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-30.85,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>复杂的也有类似的生物活性。为此,我们调查是否在这里<b>gydF4y2Ba中文</b>gydF4y2Ba复杂的行为作为一个化学核酸酶诱导下的双链DNA降解,还原,nonreductive条件。作为一个积极的控制我们使用<b>gydF4y2Ba尼泊尔共产党</b>gydF4y2Ba复杂的在同一浓度。在图所示的结果<一个href="//www.newsama.com/journals/bca/2009/603651/fig4/" target="_blank">4</一个>透露,<b>gydF4y2Ba中文</b>gydF4y2Ba复杂甚至不具备化学核酸酶活性的巯基丙酸(MPA)(图<一个href="//www.newsama.com/journals/bca/2009/603651/fig4/" target="_blank">4</一个>,车道3和4)。另一方面,正如前面的报道<b>gydF4y2Ba尼泊尔共产党</b>gydF4y2Ba复杂的行为与一个完整的thiol-dependent化学核酸酶降解的DNA浓度(图<一个href="//www.newsama.com/journals/bca/2009/603651/fig4/" target="_blank">4</一个>巷6)[<一个href="#B27">27</一个>]。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图4</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig4/" title="" target="_blank"></a>
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<td>(铜(hsm)活动(部分)<年代vg height="14.6" id="M129" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 34 14.6" width="34" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-67.78,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.76,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.88,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M130" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 68 14.7125" width="68" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-67.78,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-31.56,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-26.68,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>劈理的质粒DNA。375 ng的196 bp的DNA被孵化(车道3、4)或没有(通道1,2)铜(hsm)(部分)<年代vg height="14.6" id="M131" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
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</svg>米)在(通道2、4、6)存在与否(通道1,3,5)巯基丙酸,(MPA)(7毫米),50分钟37°C。</tgydF4y2Bad>
</tr>
</tbody>
</table>
</div>
</div>
</div>
</div>
<p>调查之间的相互作用<b>gydF4y2Ba中文</b>gydF4y2Ba与细菌的DNA我们利用呜咽革兰氏阳性微生物的响应<我>枯草芽孢杆菌</我>。这种反应,类似的SOS反应在几个方面<我>大肠杆菌</我>由物理化学引发剂,促进DNA的结构,当改变<我>枯草芽孢杆菌</我>种植条件下,诱导基因的能力(<一个href="#B27">27</一个>- - - - - -<一个href="#B29">29日</一个>]。因此,应变<我>枯草芽孢杆菌</我>YB3001,包含一个副本<我>矩形</我>一个<我>虫胶</我>Z融合集成的<我>一个米yE</我>轨迹,是处理(铜(hsm)(部分)<年代vg height="14.6" id="M137" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
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</svg>]<年代vg height="14.7125" id="M138" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
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l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
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</svg>复杂的和它的每个组件,(<年代vg height="14.7125" id="M139" style="vertical-align:-3.13504pt;width:39.224998px;" version="1.1" viewbox="0 0 39.224998 14.7125" width="39.224998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
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l</t年代p一个n></text>
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<tspan style="font-size: 8.75px; " x="0" y="0">
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</g>
</svg>,歌舞青春,,和<年代vg height="16.862499" id="M140" style="vertical-align:-2.21957pt;width:78.824997px;" version="1.1" viewbox="0 0 78.824997 16.862499" width="78.824997" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.8625)">
<g transform="translate(72,-58.51)">
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C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.503" y="0">
u</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="18.754499" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.917999" y="0">
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+</t年代p一个n></text>
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</g>
</svg>)。如图<一个href="//www.newsama.com/journals/bca/2009/603651/fig5/" target="_blank">5</一个>的水平<年代vg height="13.425" id="M141" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
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</svg>(铜牛乳糖诱导的(hsm) (nal)<年代vg height="14.6" id="M142" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
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</svg>]<年代vg height="14.7125" id="M143" style="vertical-align:-3.13504pt;width:62.787498px;" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
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</g>
</g>
</svg>类似引发的复杂比下降了20%(铜(苯酚的)(部分)<年代vg height="14.75" id="M144" style="vertical-align:-3.25793pt;width:110.3875px;" version="1.1" viewbox="0 0 110.3875 14.75" width="110.3875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
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H</t年代p一个n></text>
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</g>
</g>
</svg>复杂的(<一个href="#B27">27</一个>]。然而很明显,所有的组件(铜(hsm)(部分)<年代vg height="14.7125" id="M145" style="vertical-align:-3.13504pt;width:96.650002px;" version="1.1" viewbox="0 0 96.650002 14.7125" width="96.650002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
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H</t年代p一个n></text>
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O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.530167" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.781666" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.13319" y="0">
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H</t年代p一个n></text>
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</g>
</g>
</svg>复杂的能够诱导<年代vg height="13.425" id="M146" style="vertical-align:-2.29482pt;width:8.8500004px;" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
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<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>牛乳糖的活动<我>矩形</我>一个-<我>虫胶</我>Z融合水平与那些观察到完整的复杂,无论是其活动可以被解释为一个独立的组件的累加效应。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图5</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig5/" title="" target="_blank"></a>
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<td>:最大的水平<我>矩形</我>一个直接<年代vg height="13.425" id="M147" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 8.8500004 13.425" width="8.8500004" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
<g transform="translate(72,-61.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n></text>
</g>
</g>
</svg>牛乳糖诱导获得的响应(铜的加入(hsm)(部分)<年代vg height="14.6" id="M148" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
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H</t年代p一个n></text>
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<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.7125" id="M149" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 62.787498 14.7125" width="62.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.194025" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-35.72,60.28)">
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2</t年代p一个n></text>
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<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
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</g>
</svg>(中文)(铜(苯酚的)(nal)<年代vg height="14.75" id="M150" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 110.3875 14.75" width="110.3875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
<g transform="translate(72,-60.2)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.105305" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-26.93,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-19.28,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,2.36,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,7.23,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>、(cpn)复合物或他们的一些分子组件的文化<我>枯草芽孢杆菌</我>YB3001。最高百分比表示比较的活动遇到(cpn = 100%)。</tgydF4y2Bad>
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<p>因此,我们可以得出结论,复杂的行为作为一个整体,能够穿过细胞膜,与DNA直接交互。</p><p>gydF4y2Ba调查的方式(铜(hsm)(部分)<年代vg height="14.7125" id="M151" style="vertical-align:-3.13504pt;width:107.075px;" version="1.1" viewbox="0 0 107.075 14.7125" width="107.075" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-67.78,63.41)">
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H</t年代p一个n></text>
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2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-53.88,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="17.354164" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="25.693665" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="31.945166" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="38.296688" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="44.548187" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-0.3,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,4.58,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
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</svg>DNA相互作用,体外相互作用的<b>gydF4y2Ba中文</b>gydF4y2Ba和<b>gydF4y2Ba尼泊尔共产党</b>gydF4y2Ba在分析了CT-DNA融化的温度和圆二色性(CD)。在图<一个href="//www.newsama.com/journals/bca/2009/603651/fig6/" target="_blank">6</一个>它显示的CD光谱CT-DNA后添加越来越多的[铜(hsm)(部分)<年代vg height="14.7125" id="M152" style="vertical-align:-3.13504pt;width:96.650002px;" version="1.1" viewbox="0 0 96.650002 14.7125" width="96.650002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.28)">
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2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.530167" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.781666" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.13319" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.384689" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-8.63,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-3.76,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>。</p><gydF4y2Badiv class="partial-carousel-wrapper">
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<span class="caption-text">图6</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/fig6/" title="" target="_blank"></a>
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<td>CD CT-DNA滴定与越来越多的(铜(hsm)(部分)<年代vg height="14.7125" id="M153" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 96.650002 14.7125" width="96.650002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.7125)">
<g transform="translate(72,-60.23)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.530167" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.781666" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.13319" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.384689" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-8.63,60.28)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-3.76,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>(a)和(铜(苯酚的)(nal)<年代vg height="14.75" id="M154" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 110.3875 14.75" width="110.3875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
<g transform="translate(72,-60.2)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="22.105305" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-26.93,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-19.28,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,2.36,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,7.23,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>(b)复合物的摩尔比率:<年代vg height="10.9125" id="M155" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 45.424999 10.9125" width="45.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.9125)">
<g transform="translate(72,-63.27)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.5645552" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.604944" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="26.856443" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="29.982195" y="0">
0</t年代p一个n></text>
</g>
</g>
</svg>,0.048,0.14,0.24,0.38和0.48。(复杂/ DNA)。<年代vg height="16.424999" id="M156" style="vertical-align:-1.95624pt" version="1.1" viewbox="0 0 145.14999 16.424999" width="145.14999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.425)">
<g transform="translate(72,-58.86)">
<text transform="matrix(1,0,0,-1,-71.95,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
(</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="4.1634989" y="0">
D</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.992777" y="0">
一个</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="31.019943" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="38.646774" y="0">
=</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="50.68716" y="0">
2</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="56.938663" y="0">
。</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="60.064411" y="0">
0</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="66.31591" y="0">
7</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="72.567413" y="0">
</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="79.444061" y="0">
1</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="85.695564" y="0">
0</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,20,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">
−</t年代p一个n><t年代p一个n style="font-size: 8.75px; " x="5.99512" y="0">
4</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,32.96,60.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">
米</t年代p一个n></text>
</g>
</g>
</svg>对所有实验。</tgydF4y2Bad>
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<p>结果表明,这种复杂诱发小CD的变化。类似的行为被发现对于复杂(铜(苯酚的)(部分)<年代vg height="14.6" id="M157" style="vertical-align:-3.13504pt;width:28.7875px;" version="1.1" viewbox="0 0 28.7875 14.6" width="28.7875" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.6)">
<g transform="translate(72,-60.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-62.92,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-58.05,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>]<年代vg height="14.75" id="M158" style="vertical-align:-3.25793pt;width:76.525002px;" version="1.1" viewbox="0 0 76.525002 14.75" width="76.525002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.75)">
<g transform="translate(72,-60.2)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.9021358" y="0">
O</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-54.02,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
3</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-46.37,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-24.73,60.37)">
<tspan style="font-size: 8.75px; " x="0" y="0">
2</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-19.86,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">
O</t年代p一个n></text>
</g>
</g>
</svg>。提到复合物都是很重要的CD不活跃。CD光谱中观察到的变化表明,两个配合物与DNA相互作用通过糖磷酸骨头,小沟。这个结果是同意的增量熔点时观察到复杂的浓度增加,(见图<一个href="//www.newsama.com/journals/bca/2009/603651/fig7/" target="_blank">7</一个>),表明复合物和DNA链之间的主要交互可能槽氢键相互作用。结果表明,在低浓度复合物增加<年代vg height="14.375" id="M159" style="vertical-align:-3.13504pt;width:18.8125px;" version="1.1" viewbox="0 0 18.8125 14.375" width="18.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.375)">
<g transform="translate(72,-60.5)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">
T</t年代p一个n></text>
<text transform="matrix(1,0,0,-1,-64.31,60.55)">
<tspan style="font-size: 8.75px; " x="0" y="0">
米</t年代p一个n></text>
</g>
</g>
</svg>CT-DNA(表<一个href="//www.newsama.com/journals/bca/2009/603651/tab2/" target="_blank">2</一个>)。然而在更高浓度观察两种复合物之间的不同的行为。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab2">
<div class="floats-partial-footer">
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<span class="caption-text">表2</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/tab2/" title="" target="_blank"></a>
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Expermental融化温度(Tm)和差分CT-DNA Tm (<年代vg height="10.6625" id="M160" style="vertical-align:-0.0pt;width:11.4125px;" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
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C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.3395014" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="14.591001" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="20.942526" y="0">
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O</t年代p一个n></text>
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3</t年代p一个n></text>
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⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
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</svg>复合物。</gydF4y2Badiv>
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<td>小牛胸腺DNA<年代vg height="10.6625" id="M171" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.4125 10.6625" width="11.4125" xmlns="http://www.w3.org/2000/svg">
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O</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="9.0271664" y="0">
]</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="13.190665" y="0">
C</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="21.530167" y="0">
l</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="27.781666" y="0">
⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="34.13319" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="40.384689" y="0">
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N</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="8.9021358" y="0">
O</t年代p一个n></text>
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3</t年代p一个n></text>
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⋅</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="6.3515239" y="0">
3</t年代p一个n><t年代p一个n style="font-size: 12.50px; " x="12.603024" y="0">
H</t年代p一个n></text>
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</svg>复合物。</tgydF4y2Bad>
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<p>这区别复合物应与协调氨合物的类型。被组胺能够形成较强的氢键,它是合理的推测,当复杂的浓度增加,更多的氢键将因此更加稳定形成双螺旋结构。另一方面,phenantroline diammine在低浓度时,有可能是主要的复杂和DNA之间的相互作用是由氢键抗生素,但当浓度增加时,可以有两种类型的复杂和DNA之间的相互作用,如前所述,通过氢键和第二个弱由于邻二氮杂菲环的夹层,将反映在双螺旋结构的不稳定。总之,这项研究可能说喹诺酮类的行为非常相似的配体;也可以看出他们的协调模式是相对独立的协调diammine的类型。然而活动作为化学核酸酶diammine的强烈依赖。我们的工作表明,复合物的家庭喹诺酮药物与铜协调其他氨合物可能是活跃的,即使核酸酶活动不存在在那些与phenantroline复合物。看来dna复合交互主要是形成氢键类型,因此铜新的潜在药物的设计应该考虑这一点。</p><div class="floats-partial-section">
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<span class="caption-text">方案1</年代p一个n><一个一个ria-label="View full page" class="caption-partial-url" href="//www.newsama.com/journals/bca/2009/603651/sch1/" title="" target="_blank"></a>
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<td>合成、表征及晶体结构的铜(II)混合复杂的组胺和萘啶酸喹诺酮家族的一种化合物,铜(hsm) (nal) H<年代ub>2</gydF4y2Ba年代ub>O]Cl<gydF4y2Ba我>∙</gydF4y2Ba我>3h<gydF4y2Ba年代ub>2</gydF4y2Ba年代ub>O是报道。生物研究执行这种化合物显示它与DNA相互作用<我>在活的有机体内</我>诱导呜咽的反应<我>枯草芽孢杆菌</我>然而,核酸酶活动不是观察体外实验</tgydF4y2Bad>
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1857年</gydF4y2Badiv>
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1083年</gydF4y2Badiv>
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