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.expand_btn{-webkit-flex:1;-ms-flex:1;flex:1;background:url('data:image/svg+xml;base64,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') no-repeat 6px;background-position:center;margin-top:10px;min-width:55px;display:none;} @media (min-width:768px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .expand_btn{display:none;}} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{-webkit-flex:9;-ms-flex:9;flex:9;text-align:left;padding:21px 37px 10px 0px;font-size:16px;font-weight:700;} @media (min-width:768px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 18px 10px 18px;}} @media (min-width:992px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 21px 10px 21px;}} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{-webkit-flex:1;-ms-flex:1;flex:1;background:url('data:image/svg+xml;base64,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') no-repeat 6px;background-position:center;padding:16px 0 16px 0;min-width:62px;max-width:62px;} @media (min-width:768px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:16px 0 17px 0;min-width:52px;max-width:52px;}} @media (min-width:992px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:15px 0 17px 0;min-width:60px;max-width:60px;}} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url:hover{-webkit-text-decoration:none;text-decoration:none;} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption-text{font-size:14px;padding:0px 18px 17px 22px;} @media (min-width:768px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 15px 15px 18px;}} @media (min-width:992px){.ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 18px 19px 21px;}} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption-text figcaption{margin:0;padding:0;} .ejdfnh .floats-partial-section .floats-partial-footer .floats-partial-caption-text svg{max-width:100%;} .ejdfnh ol{font-size:16px;padding-left:32px;font-family:STIXGeneral-Regular;line-height:24px;margin:15px 0;} .ejdfnh ol li{margin:10px 0;padding-left:10px;word-break:normal;} .ejdfnh ol li a{word-break:break-all;} .ejdfnh ol li .reflinks{display:block;} .ejdfnh ol li .reflinks a{color:#4D8A17;-webkit-text-decoration:none;text-decoration:none;cursor:pointer;} .ejdfnh ol li .reflinks a:hover{-webkit-text-decoration:underline;text-decoration:underline;} .ejdfnh ol li .reflinks .sep{color:#000000;} .ejdfnh .table-wrapper{width:auto;overflow-x:auto;} .ejdfnh .table-wrapper::-webkit-scrollbar{-webkit-appearance:none;width:5px;height:5px;} .ejdfnh .table-wrapper::-webkit-scrollbar-thumb{border-radius:5px;background-color:rgba(0,0,0,.5);-webkit-box-shadow:0 0 1px rgba(255,255,255,.5);} @media (min-width:768px){.ejdfnh .table-wrapper{overflow-x:auto;width:auto;-webkit-break-word:word-break;break-word:word-break;margin:0 auto;}} @media (min-width:992px){.ejdfnh .table-wrapper{width:auto;}} @media (min-width:1324px){.ejdfnh .table-wrapper{width:auto;}} @media (min-width:320px){.ejdfnh{margin-bottom:33px;padding:0;}} @media (min-width:992px){.ejdfnh{padding:0;}} @media (min-width:1325px){} .ejdfnh .owl-stage{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;} .ejdfnh .floats-partial-middle--thumbs{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;} .ejdfnh .floats-partial-middle--thumbs .partial-carousel-dot svg{fill:#4D8A17;} .ejdfnh .floats-partial-middle--thumbs .partial-carousel-dot strong{color:#4D8A17;font-weight:500;} .ejdfnh .floats-partial-middle--thumbs .partial-carousel-dot.active strong{color:#007B8B;} .ejdfnh .floats-partial-middle--thumbs .partial-carousel-dot.active svg{fill:#007B8B;} .ejdfnh .floats-partial-middle--thumbs .partial-carousel-dot .nowrap{white-space:nowrap;} .ejdfnh .partial-carousel-dot{text-align:center;cursor:pointer;border:0;width:100px;padding-bottom:20px;background-color:#fff;display:table-cell;} .ejdfnh .partial-carousel-dot:focus-visible{outline-offset:-3px;} .ejdfnh .partial-carousel-dot strong{font-size:11px;padding-top:12px;} @media (min-width:767.5px){.ejdfnh .partial-carousel-dot strong{font-size:16px;}} .ejdfnh .partial-carousel-dot img{width:90px;height:90px;border:1px solid #979797;margin:10px 0;} .ejdfnh .partial-carousel-wrapper .floats-partial-middle{border-top:1px solid #e3e3e3;display:block;margin-bottom:50px;padding-top:1px;} @media (min-width:767.5px){.ejdfnh .partial-carousel-wrapper .floats-partial-middle{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;margin-bottom:0;}} .ejdfnh .partial-carousel--single-image{overflow:hidden;text-align:center;} .ejdfnh 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src="data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHhtbG5zOnhsaW5rPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rIiB3aWR0aD0iMTgiIGhlaWdodD0iMjIiIHZpZXdCb3g9IjAgMCAxOCAyMiI+PGRlZnM+PGNsaXBQYXRoIGlkPSJhIj48cGF0aCBkPSJNMywyMmEzLDMsMCwwLDEtMy0zVjNBMywzLDAsMCwxLDMsMGg4YS45OTEuOTkxLDAsMCwxLC41NzMuMTgxbDAsMCwuMDA4LjAwNmEuOTU1Ljk1NSwwLDAsMSwuMTIyLjFsNiw2YTEuMDI1LDEuMDI1LDAsMCwxLC4xLjEyMmwuMDA2LjAxLDAsMEExLDEsMCwwLDEsMTgsNi45NzVWMTlhMywzLDAsMCwxLTMsM1pNMiwzVjE5YTEsMSwwLDAsMCwxLDFIMTVhMSwxLDAsMCwwLDEtMVY4SDExYTEsMSwwLDAsMS0xLTFWMkgzQTEsMSwwLDAsMCwyLDNaTTEyLDZoMi41ODdMMTIsMy40MTRaTTgsMTdWMTVINmExLDEsMCwwLDEsMC0ySDhWMTFhMSwxLDAsMSwxLDIsMHYyaDJhMSwxLDAsMCwxLDAsMkgxMHYyYTEsMSwwLDAsMS0yLDBaIiB0cmFuc2Zvcm09InRyYW5zbGF0ZSgzIDEpIi8+PC9jbGlwUGF0aD48L2RlZnM+PGcgdHJhbnNmb3JtPSJ0cmFuc2xhdGUoLTMgLTEpIj48cGF0aCBkPSJNMywyMmEzLDMsMCwwLDEtMy0zVjNBMywzLDAsMCwxLDMsMGg4YS45OTEuOTkxLDAsMCwxLC41NzMuMTgxbDAsMCwuMDA4LjAwNmEuOTU1Ljk1NSwwLDAsMSwuMTIyLjFsNiw2YTEuMDI1LDEuMDI1LDAsMCwxLC4xLjEyMmwuMDA2LjAxLDAsMEExLDEsMCwwLDEsMTgsNi45NzVWMTlhMywzLDAsMCwxLTMsM1pNMiwzVjE5YTEsMSwwLDAsMCwxLDFIMTVhMSwxLDAsMCwwLDEtMVY4SDExYTEsMSwwLDAsMS0xLTFWMkgzQTEsMSwwLDAsMCwyLDNaTTEyLDZoMi41ODdMMTIsMy40MTRaTTgsMTdWMTVINmExLDEsMCwwLDEsMC0ySDhWMTFhMSwxLDAsMSwxLDIsMHYyaDJhMSwxLDAsMCwxLDAsMkgxMHYyYTEsMSwwLDAsMS0yLDBaIiB0cmFuc2Zvcm09InRyYW5zbGF0ZSgzIDEpIi8+PGcgY2xpcC1wYXRoPSJ1cmwoI2EpIj48cmVjdCB3aWR0aD0iMjQiIGhlaWdodD0iMjQiIGZpbGw9InJnYmEoMCwwLDAsMCkiLz48cmVjdCB3aWR0aD0iMjQiIGhlaWdodD0iMjQiIGZpbGw9IiNmZmYiLz48L2c+PC9nPjwvc3ZnPg==" 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href="//www.newsama.com/journals/art/" aria-label="AIDS Research and Treatment">艾滋病研究和治疗</gydF4y2Baa>/<gydF4y2Baa class="sc-htpNat bUhGXt link sc-eitiEO jXeALb breadCrumb" href="//www.newsama.com/journals/art/contents/year/2011/" aria-label="2011">2011年</gydF4y2Baa>/<年代pan class="sc-bhlBdH UVThf">文章</年代pan> </div> <div class="threeColumn__ThreeColumnWrapper-sc-1bf4078-0 dDyxFF threeColumnWrapper"> <div class="threeColumn__LeftWrapper-sc-1bf4078-1 fkVFlF leftWrapper"> <button type="button" class="sc-eKZiaR dzZrgS section__button " id="sectionButton"><span class="sc-htoDjs diutvq icon__dots dots__detector icon-colored _3n-7Ho7DlfjMlZbrRr9Q4a icon-themeable" title="" font-size="22"></span>文章部分</gydF4y2Babutton> <div class="sc-bEjcJn jLUVhb static_contents__section_links links__hidden "> <div id="leftSectionMenu" class="sc-cbkKFq prcY sc-bGbJRg dVCLgr left_section_menu"> <p>在这一页上</gydF4y2Bap> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#abstract" aria-label="">文摘</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#introduction" aria-label="">介绍</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#methods" aria-label="">方法</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#results" aria-label="">结果</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#discussion" aria-label="">讨论</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#references" aria-label="">引用</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#copyright" aria-label="">版权</gydF4y2Baa></span> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#related-articles" aria-label="">相关文章</gydF4y2Baa></span> </div> </div> </div> <div class="threeColumn__ContentWrapper-sc-1bf4078-3 bbzREB contentWrapper"> <div class="threeColumn__Content-sc-1bf4078-4 jknsZc content"> <div class="articleContent__ArticleContentsWrapper-sc-2yl9jy-0 eSvjPB article_contents"> <div class="articleContent__ArticleContentsSectionsWrapper-sc-2yl9jy-1 jntdRu article_contents__sections_wrapper"> <div class="articleContent__ArticleWrapper-sc-2yl9jy-2 hAzjHP"> <div class="sc-chbbiW mBGSe article_header_class"> <div class="sc-kxynE fgGykB"> <span class="sc-cooIXK gQxyld">特殊的问题</年代pan> <h2 class="sc-fcdeBU bVtmCk">抗逆转录病毒治疗在资源有限的环境中</gydF4y2Bah2> <a class="sc-htpNat bUhGXt link sc-gmeYpB hSHJbi" href="//www.newsama.com/journals/art/si/734278/" aria-label="">把这个特殊的问题</gydF4y2Baa> <hr class="sc-clNaTc ktFfKO"> </div> <p class="sc-kZmsYB bkiEfx article_type">临床研究|<gydF4y2Ba!-- -->开放获取</gydF4y2Bap> <div class="sc-RcBXQ ztvYg article_citation"> 体积<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- --> <span class="sc-fZwumE cUsFHx">|</年代pan>文章的ID<gydF4y2Ba!-- --> 434375年<gydF4y2Ba!-- --> <span class="sc-fZwumE cUsFHx">|</年代pan> <a class="sc-htpNat bUhGXt link sc-fQejPQ duuwge" href="https://doi.org/10.1155/2011/434375" aria-label="Doi-link">https://doi.org/10.1155/2011/434375</gydF4y2Baa> </div> <div class="sc-LKuAh lcOiDF article_full_citation"> <div class="sc-hzNEM gsmOCv isHide"> <p>鲁斯·e·巴斯,雨果·a . Tempelman罗伯特•Moraba安迪。m . Hoepelman<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> ”<年代pan class="adjust-article-svg-size">艾滋病毒治疗项目在非洲的农村地区的长期预后:病毒抑制尽管早期死亡率</年代pan>”,<gydF4y2Ba!-- --><i>艾滋病研究和治疗</gydF4y2Bai>,<gydF4y2Ba!-- --> 卷。<gydF4y2Ba!-- -->2011年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 文章的ID<gydF4y2Ba!-- -->434375年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 5<gydF4y2Ba!-- -->   页面<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- -->。<gydF4y2Ba!-- --> https://doi.org/10.1155/2011/434375</gydF4y2Bap> </div> <button class="sc-hSdWYo etauus sc-iBEsjs kPshFw" color="">显示引用</gydF4y2Babutton> </div> <h1 class="sc-iRbamj jZOxOO sc-iSDuPN kmVdUp article_title adjust-article-svg-size heading-title">艾滋病毒治疗项目在非洲的农村地区的长期预后:病毒抑制尽管早期死亡率</gydF4y2Bah1> </div> <div class="sc-jrIrqw eHMFfo article_authors"> <hr class="sc-cEvuZC XkrFe hr__author"> <span class=""><b>鲁斯·e·巴斯</gydF4y2Bab><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-hjRWVT irNWJI icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a>,<年代up>1</年代up></span> <span class="">雨果·a . Tempelman<gydF4y2Ba!-- -->,<年代up>2</年代up></span> <span class="">罗伯特Moraba<gydF4y2Ba!-- -->,<年代up>2</年代up> 和</年代pan> <span class="">安迪。m . Hoepelman<年代up>1</年代up></span> <div class="sc-fHxwqH dMuGGA isHide"> <p><sup>1</年代up><span>内科和传染病,乌特勒支大学医学中心,F02.126, Postbus 85500年,3508年乔治亚州乌得勒支荷兰</年代pan></p> <p><sup>2</年代up><span>Elandsdoorn Ndlovu医疗中心,邮政信箱1508,Groblersdal 0470年,南非</年代pan></p> </div> <button class="sc-hSdWYo etauus sc-iQtOjA kfDwZY" color="">显示更多</gydF4y2Babutton> </div> <div class="articleContent__EditorWrapper-sc-2yl9jy-3 evMkvU"> <div class="articleContent__TextWrapper-sc-2yl9jy-8 fYrLtk"> <b>学术编辑器:</gydF4y2Bab>埃斯珀卡拉斯</gydF4y2Badiv> <div class="articleContent__PublicationTimeLineWrapper-sc-2yl9jy-4 fjviok"> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年6月10</年代pan> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年10月18日</年代pan> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC isPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年11月21日</年代pan> </div> </div> </div> <article class="sc-jtRlXQ ejdfnh article_body "> <div> <div class="xml-content"> <h4 class="header" id="abstract">文摘</gydF4y2Bah4> <p><i>客观的</gydF4y2Bai>。定义长期(2 - 4年)临床和病毒学结果抗逆转录病毒治疗(ART)计划在农村的南非。<gydF4y2Bai>方法</gydF4y2Bai>。我们进行了回顾性观察性队列研究,包括735名患者发起的艺术。一年两次的监测,包括hiv rna测试执行。主要终点是病人保留;病毒学抑制(hiv rna < 50拷贝/毫升)和失败(hiv rna > 1000拷贝/毫升)是次要的端点。此外,治疗失败的可能因素进行了分析。<gydF4y2Bai>结果</gydF4y2Bai>。63%的患者(466/735)有一个完全抑制hiv rna,平均三年治疗后启动。早期死亡率高:14%死于治疗后3个月内开始。16%的病人经历过病毒学失败,但只有4%是转向二线的艺术。男性性别和低绩效评分与治疗失败;免疫失败是一个贫穷的病毒学失败的预测。<gydF4y2Bai>结论</gydF4y2Bai>。“全有或全无”的现象在农村南非艺术项目:高早期磨损,但良好的病毒学控制在余下的护理。继续努力是需要登记的病人。此外,观察到viro-immunological离解强调了需要做hiv rna测试的应用范围更加广泛。</gydF4y2Bap> <span class="end-abs"></span> <h4 id="introduction">1。介绍</gydF4y2Bah4> <p>撒哈拉以南非洲地区的房屋大部分的3300万人人类免疫缺陷病毒-全球(艾滋病毒)感染。扩大抗逆转录病毒治疗(ART)的推出,发生在这一地区在过去的十年令人印象深刻。因此,越来越多的治疗结果来自非洲艺术项目已发表的数据。尽管经常观察到早期死亡率高,艺术为大多数感染艾滋病毒的患者提供了明显的好处。通常,改善临床、免疫学和病毒学结果测量是在几个月后开始治疗。然而,长期数据(超过一年的跟踪)更容易获得(<gydF4y2Baa href="#B1">1</gydF4y2Baa>,<gydF4y2Baa href="#B2">2</gydF4y2Baa>]。此外,大多数可用的数据来自城市化地区,和许多艺术项目常规hiv rna监控是不可行的。临床或免疫下降是经常用来预测治疗失败在低收入国家(地方政府投资公司)。然而,几项研究描述有限等参数之间的相关性和病毒学失败(<gydF4y2Baa href="#B3">3</gydF4y2Baa>- - - - - -<gydF4y2Baa href="#B5">5</gydF4y2Baa>]。此外,最近,它已被证明在转换治疗早期病毒学监测结果和更高的CD4细胞计数<gydF4y2Baa href="#B6">6</gydF4y2Baa>]。</gydF4y2Bap> <p>Ndlovu医疗中心(NMC)位于南非农村。自年初以来的艺术项目,未来的病毒学监测已经完成所有的病人。以前,我们有利的短期(一年的跟踪)的结果报道在NMC接受ART治疗的病人<gydF4y2Baa href="#B7">7</gydF4y2Baa>]。这份报告的目的是描述长期(2到4年的跟踪)的结果。由于后续监控、纵向病毒学数据可以分析。此外,治疗失败的可能的预测进行了分析。</gydF4y2Bap> <h4 id="methods">2。方法</gydF4y2Bah4> <h5 id="sec2.1">2.1。队列描述和数据收集</gydF4y2Bah5> <p>Ndlovu MC位于一个贫穷、林波波河的农村地区,在东北一个省的南非共和国。NMC的细节和其艺术计划描述了其他地方<gydF4y2Baa href="#B7">7</gydF4y2Baa>]。在目前的研究中,所有的成年人都包括了一线艺术收集前至少24个月。世卫组织的临床四期和CD4 + t细胞计数低于200细胞/毫米<年代up>3</年代up>被用作治疗资格标准。治疗包括依法韦伦奈韦拉平+司他夫定或齐多夫定、拉米夫定。在病毒学失败的情况下,二线的艺术。为此,提高蛋白酶抑制剂(π,lopinavir /例如)添加到核苷逆转录酶抑制剂(NRTI)骨干。</gydF4y2Bap> <p>从医学图表数据进行回顾性收集。身体质量指数(BMI体重/身高<年代up>2</年代up>在每个访问)计算。正欲CD4 + t细胞计数(FACSCount系统、生物科学,圣何塞,CA)和血浆hiv rna水平(拜耳公司系统340 bDNA分析仪、勒沃库森、德国,检出限50拷贝/毫升)定期测量治疗开始之前和之后(四次在第一和连续期间每两年)。病人被艾滋病顾问在每个诊所访问以提供信息和刺激治疗依从性。</gydF4y2Bap> <h5 id="sec2.2">2.2。结果定义</gydF4y2Bah5> <p>病人保持率被定义为患者剩余的比例在NMC保健,结合患者的比例转移到其他诊所。病人消耗编译的全因死亡率和人跟踪。</gydF4y2Bap> <p>实现一个hiv rna低于50拷贝/毫升被用来定义病毒学抑制。一个hiv rna / 1000拷贝/毫升后至少三个月的艺术被认为是病毒学失败的象征。</gydF4y2Bap> <p>病人消耗和病毒学失败定义相结合治疗失败。</gydF4y2Bap> <p>免疫失败的定义根据世界卫生组织的指导方针是(1)六个月的治疗后CD4 + t细胞计数低于100细胞/毫米<年代up>3</年代up>或低于治疗前计数或(2)下降50%从治疗高峰CD4 + t细胞计数的值<gydF4y2Baa href="#B8">8</gydF4y2Baa>]。</gydF4y2Bap> <h5 id="sec2.3">2.3。统计分析</gydF4y2Bah5> <p>病人保留率主要终点。二次结果是病毒学抑制和治疗失败。</gydF4y2Bap> <p>正面和负面预测值(NPV和PPV、职责)的免疫失败,确定病毒学失败,计算。此外,定义预测治疗失败,我们比较分布的几个因素(性别;年龄;基线BMI, CD4 + t细胞计数,Karnofsky分数和日志hiv rna;(N)种转录;就业状况和年治疗起始)患者治疗这些经历成功和失败。为此,所有患者开始艺术都包括在分析中。同样的决定因素是用于定义病毒学失败的预测。为了减少早期死亡的影响,只有患者超过三个月的跟踪是包含在这些分析。</gydF4y2Bap> <p>与学生的连续数据比较<年代vg height="10.3875" id="M1" style="vertical-align:-0.1638pt;width:5.9250002px;" version="1.1" viewbox="0 0 5.9250002 10.3875" width="5.9250002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.125)"> <path d="M324 430l-26 -36l-112 -4l-55 -265q-13 -66 7 -66q13 0 44.5 20t50.5 40l17 -24q-38 -40 -85.5 -73.5t-87.5 -33.5q-50 0 -21 138l55 262h-80l-2 8l25 34h66l25 99l78 63l10 -9l-37 -153h128z" id="x1D461"></path> </g> </svg>以及或配对<年代vg height="10.3875" id="M2" style="vertical-align:-0.1638pt;width:5.9250002px;" version="1.1" viewbox="0 0 5.9250002 10.3875" width="5.9250002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.125)"> <use xlink:href="#x1D461"></use> </g> </svg>以及适当的。比例相比<年代vg height="20.5625" id="M3" style="vertical-align:-3.7947pt;width:16.35px;" version="1.1" viewbox="0 0 16.35 20.5625" width="16.35" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,15.775)"> <path d="M565 434q-29 -30 -107.5 -131t-125.5 -168q22 -126 55 -265q8 -35 12.5 -45.5t11.5 -10.5q26 0 76 59l23 -23q-77 -111 -134 -111q-42 0 -63 96l-43 222q-148 -211 -219 -335h-10q-30 45 9 103l209 291q-27 155 -42 214q-7 27 -11.5 35.5t-12.5 8.5q-19 0 -62 -57l-21 21 q73 110 126 110q18 0 31.5 -22.5t19.5 -52.5l35 -184l160 234l74 25z" id="x1D712"></path> </g> <g transform="matrix(.012,-0,0,-.012,9.95,7.613)"> <path d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" id="x32"></path> </g> </svg>测试和数据不是正态分布进行了分析通过Mann-Whitney U或Wilcoxon测试。kaplan meier生存分析被用来估计抗逆转录病毒疗法的时间从起始病毒学抑制和时间从最初的抑制后续病毒学失败。优势比和95%置信区间(95% CI)使用逻辑回归分析计算。Cox比例风险模型被用来确定端点的独立预测因素。为此,决定因素与结果相关的单变量分析(定义为一个<年代vg height="12.4375" id="M4" style="vertical-align:-0.1638pt;width:95.537498px;" version="1.1" viewbox="0 0 95.537498 12.4375" width="95.537498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,12.162)"> <path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5 t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path> </g> <g transform="matrix(.017,-0,0,-.017,10.874,12.162)"> <path d="M300 253l-14 -55h-229l14 55h229z" id="x2D"></path> </g> <g transform="matrix(.017,-0,0,-.017,16.925,12.162)"> <path d="M478 437v-26q-39 -5 -53 -17.5t-35 -57.5q-68 -149 -142 -347h-28q-47 128 -138 350q-17 43 -30.5 54.5t-53.5 17.5v26h205v-26q-40 -4 -46.5 -14.5t6.5 -42.5q41 -115 95 -247q43 101 89 238q12 36 3.5 48.5t-50.5 17.5v26h178z" id="x76"></path> </g> <g transform="matrix(.017,-0,0,-.017,24.796,12.162)"> <path d="M433 39l-85 -51q-27 0 -47 20q-16 16 -24 44q-5 -3 -24 -16.5t-27 -18.5t-23 -13.5t-25 -12t-19 -3.5q-52 0 -86 36.5t-34 85.5q0 71 81 99q128 43 155 65v17q0 54 -23 83.5t-62 29.5q-28 0 -45 -19t-29 -66q-7 -23 -29 -23q-15 0 -29 13t-14 30t31 40q25 19 68.5 40.5 t81.5 29.5q49 0 82 -27q45 -39 45 -123v-185q0 -60 35 -60q18 0 36 11zM275 84v156q-12 -6 -49 -23t-41 -19q-31 -14 -46 -31t-15 -43q0 -35 22.5 -55.5t48.5 -20.5q19 0 42 10.5t38 25.5z" id="x61"></path> </g> <g transform="matrix(.017,-0,0,-.017,32.326,12.162)"> <path d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path> </g> <g transform="matrix(.017,-0,0,-.017,36.44,12.162)"> <path d="M518 50v-26q-32 -4 -77 -16l-37 -11t-33 -9l-6 6v71q-56 -42 -74 -52q-43 -25 -77 -25q-55 0 -89.5 36.5t-34.5 112.5v196q0 38 -6.5 48.5t-26.5 15.5l-28 6v23q19 1 72 7q59 9 71 11q-3 -31 -3 -145v-135q0 -113 88 -113q59 0 108 48v234q0 38 -8 49t-34 15l-36 6v23 q44 2 90 8q37 4 67 10v-334q0 -37 8.5 -47t38.5 -12z" id="x75"></path> </g> <g transform="matrix(.017,-0,0,-.017,45.466,12.162)"> <path d="M380 106l15 -22q-42 -52 -87 -74t-76 -22q-89 0 -142 62t-53 151q0 103 66 175q67 73 146 73h1q61 0 105.5 -46.5t44.5 -105.5q0 -16 -4.5 -22.5t-18.5 -9.5q-54 -10 -262 -17q1 -95 46 -143.5t104 -48.5q61 0 115 50zM225 412q-35 0 -64.5 -32.5t-40.5 -90.5q83 0 170 3 q14 0 19 4.5t5 15.5q1 41 -23.5 70.5t-65.5 29.5z" id="x65"></path> </g> <g transform="matrix(.017,-0,0,-.017,63.077,12.162)"> <path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path> </g> <g transform="matrix(.017,-0,0,-.017,83.441,12.162)"> <path d="M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z" id="x2E"></path> </g> <g transform="matrix(.017,-0,0,-.017,87.317,12.162)"> <path d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" id="x31"></path> </g> </svg>)包含在多变量分析。一个<年代vg height="12.9125" id="M5" style="vertical-align:-0.546pt;width:98.037498px;" version="1.1" viewbox="0 0 98.037498 12.9125" width="98.037498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,12.162)"> <use xlink:href="#x1D443"></use> </g> <g transform="matrix(.017,-0,0,-.017,10.874,12.162)"> <use xlink:href="#x2D"></use> </g> <g transform="matrix(.017,-0,0,-.017,16.925,12.162)"> <use xlink:href="#x76"></use> </g> <g transform="matrix(.017,-0,0,-.017,24.796,12.162)"> <use xlink:href="#x61"></use> </g> <g transform="matrix(.017,-0,0,-.017,32.326,12.162)"> <use xlink:href="#x6C"></use> </g> <g transform="matrix(.017,-0,0,-.017,36.44,12.162)"> <use xlink:href="#x75"></use> </g> <g transform="matrix(.017,-0,0,-.017,45.466,12.162)"> <use xlink:href="#x65"></use> </g> <g transform="matrix(.017,-0,0,-.017,63.077,12.162)"> <path d="M531 71l-474 214v50l474 215v-56l-416 -184l416 -183v-56zM531 -40h-474v50h474v-50z" id="x2264"></path> </g> <g transform="matrix(.017,-0,0,-.017,77.764,12.162)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,81.64,12.162)"> <path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105 q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path> </g> <g transform="matrix(.017,-0,0,-.017,89.799,12.162)"> <path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8 l-26 -65h-233z" id="x35"></path> </g> </svg>被认为是具有统计学意义。数据处理和统计分析使用SPSS完成版本15。</gydF4y2Bap> <h4 id="results">3所示。结果</gydF4y2Bah4> <h5 id="sec3.1">3.1。病人的特点</gydF4y2Bah5> <p>第一个735成年人开始艺术在NMC包括在分析中。治疗之间的时间启动和数据收集中值为35个月(范围24-59)。女人当家作主的(526/735,72%)。失业率高达70%;24%的患者进行了不到六年上学。中值基准CD4 + t细胞数量(68个细胞/毫米<年代up>3</年代up>差20 - 140)和BMI(19.8公斤/米<年代up>2</年代up>,差17.4 - -23.0)表明,许多病人在开始治疗的晚期疾病。大多数人最初收到stavudine-containing艺术疗法(579/735,79%);在26%(151/579)的患者中,司他夫定随后转向齐多夫定,因为它们显示神经病变或脂肪代谢障碍的迹象。依法韦伦是最常用的NNRTI (58%。426/735)。</gydF4y2Bap> <h5 id="sec3.2">3.2。临床和病毒学的结果</gydF4y2Bah5> <p>病人后续年底的保留率为65% (476/735)。大多数(429/476,90%)患者仍在NMC的护理和治疗,但10%(47/476)患者转移到其他诊所。剩下的35%(259/735)的患者死亡或失去跟踪。死亡率减员的主要原因(171/259,66%)。磨损通常在治疗后很快发生启动;三个月内,五人不在关心了(<年代vg height="11.125" id="M6" style="vertical-align:-0.1638pt;width:52.5625px;" version="1.1" viewbox="0 0 52.5625 11.125" width="52.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.862)"> <path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2 q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path> </g> <g transform="matrix(.017,-0,0,-.017,13.305,10.862)"> <path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path> </g> <g transform="matrix(.017,-0,0,-.017,28.008,10.862)"> <use xlink:href="#x31"></use> </g> <g transform="matrix(.017,-0,0,-.017,36.168,10.862)"> <use xlink:href="#x35"></use> </g> <g transform="matrix(.017,-0,0,-.017,44.327,10.862)"> <use xlink:href="#x32"></use> </g> </svg>,图<gydF4y2Baa href="//www.newsama.com/journals/art/2011/434375/fig1/" target="_blank">1</gydF4y2Baa>)。</gydF4y2Bap> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig1"> <div class="floats-partial-content fig-content-fig1"> <div class="partial-carousel--single-image"> <img alt="" name="434375.fig.001" src="https://static-01.hindawi.com/articles/art/volume-2011/434375/figures/434375.fig.001.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/art/2011/434375/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 病毒学治疗结果。</gydF4y2Batable> </div> </div> </div> <p>562/735例(76%)达到病毒学抑制在第一线的艺术。抑制成立的中位数在治疗后12周开始。没有达到病毒学抑制主要是由于早期磨损治疗开始后三个月内(133/173,77%)。</gydF4y2Bap> <p>纵向病毒学监测显示,大多数病人持续病毒学控制一线艺术(466/735,63%)。这一比例增加到80%(466/583)如果只有超过三个月跟踪被包括在内。病毒学失败在117/735例(16%:20%的{117/583}> 3个月跟踪)。平均持续时间之间的最初反应和随后的失败是18个月。只有4%(31/735)的患者开始一线艺术转向二线的艺术。他们中的大多数达到病毒学抑制后切换(25/31,81%)。病毒学结果数据图进行了总结<gydF4y2Baa href="//www.newsama.com/journals/art/2011/434375/fig1/" target="_blank">1</gydF4y2Baa>。</gydF4y2Bap> <p>持续的病毒复制是有限的在患者接受一线的艺术。在完整的跟踪,只有不到10%的患者仍在保健有hiv rna > 1000拷贝/毫升,绝大多数患者(71 - 82%)显示完整,病毒学抑制(hiv rna < 50拷贝/毫升,图<gydF4y2Baa href="//www.newsama.com/journals/art/2011/434375/fig2/" target="_blank">2</gydF4y2Baa>)。</gydF4y2Bap> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig2"> <div class="floats-partial-content fig-content-fig2"> <div class="partial-carousel--single-image"> <img alt="" name="434375.fig.002" src="https://static-01.hindawi.com/articles/art/volume-2011/434375/figures/434375.fig.002.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图2</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/art/2011/434375/fig2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 病毒复制在第一线的艺术。</gydF4y2Batable> </div> </div> </div> <h5 id="sec3.3">3.3。预测失败的</gydF4y2Bah5> <p>证据显示九十五例免疫失败(13%)。免疫参数的基础上,病毒学失败会错过66/117例(56%)和44/95(46%)的患者也错误地分类为经历病毒学失败。免疫失败因此显示PPV和NPV病毒学失败的54%和87%,分别。</gydF4y2Bap> <p>总的来说,治疗失败(磨损和/或病毒学失败)发生在337名患者(46%)在跟踪。的所有基线因素与单变量分析治疗失败(低BMI和CD4 + t细胞计数,Karnofsky分数≤50,Zidovudine-use和性别),只有低性能(Karnofsky)得分(-7.1或3.6,95% CI 1.8)和男性性别(或1.7,95%可信区间1.2 - -2.3)保持独立与多变量分析(表后的结果<gydF4y2Baa href="//www.newsama.com/journals/art/2011/434375/tab1/" target="_blank">1</gydF4y2Baa>)。</gydF4y2Bap> <div class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-content fig-content-tab1"> <table class="table-group" id="tab1"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr class="thead"> <td align="left">行列式</gydF4y2Batd> <td align="center">治疗成功*<gydF4y2Babr> <svg height="11.0375" id="M7" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 50.724998 11.0375" width="50.724998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.6773224" y="0"> =</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.71771" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.969212" y="0"> 9</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="34.220711" y="0"> 8</gydF4y2Batspan> </text> </g> </g> </svg></td> <td align="center">治疗失败* *<gydF4y2Babr> <svg height="10.9125" id="M8" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 50.724998 10.9125" width="50.724998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.6773224" y="0"> =</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.71771" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.969212" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="34.220711" y="0"> 7</gydF4y2Batspan> </text> </g> </g> </svg></td> <td align="center">单变量<gydF4y2Babr>(<年代vg height="10.325" id="M9" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>值)</gydF4y2Batd> <td align="center">多元<gydF4y2Babr>(<年代vg height="10.325" id="M10" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>值)</gydF4y2Batd> </tr> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr> <td align="left">男性的性别<gydF4y2Babr> <svg height="7.1374998" id="M11" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>(%)</gydF4y2Batd> <td align="center"><span style="width: 47px;"> <svg height="13.6375" id="M12" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 47 13.6375" width="47" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="16.666498" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="20.829998" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 54.8125px;"> <svg height="13.45" id="M13" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.45" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 34.712502px;"> <svg height="11.0625" id="M14" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 34.712502 11.0625" width="34.712502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.153636" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 19.6625px;"> <svg height="11.075" id="M15" style="vertical-align:-0.16302pt" version="1.1" viewbox="0 0 19.6625 11.075" width="19.6625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.075)"> <g transform="translate(72,-63.14)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="3.1257501" y="0"> </gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">平均年龄(岁)</gydF4y2Batd> <td align="center"><span style="width: 27.475px;"> <svg height="11.1" id="M16" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 27.475 11.1" width="27.475" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.1)"> <g transform="translate(72,-63.12)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 27.475px;"> <svg height="11.1" id="M17" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 27.475 11.1" width="27.475" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.1)"> <g transform="translate(72,-63.12)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 19.6625px;"> <svg height="10.9125" id="M18" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 19.6625 10.9125" width="19.6625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</gydF4y2Batd> </tr> <tr> <td align="left">平均体重指数(<年代vg height="14.7125" id="M19" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 38.224998 14.7125" width="38.224998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.41)"> <tspan style="font-size: 12.50px; " x="0" y="0"> k</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.1514759" y="0"> g</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.402976" y="0"> /</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.87881" y="0"> 米</gydF4y2Batspan> </text> <text transform="matrix(1,0,0,-1,-46.34,60.28)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</gydF4y2Batspan> </text> </g> </g> </svg>)</gydF4y2Batd> <td align="center"><span style="width: 27.475px;"> <svg height="10.8625" id="M20" style="vertical-align:-0.13794pt" version="1.1" viewbox="0 0 27.475 10.8625" width="27.475" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.8625)"> <g transform="translate(72,-63.31)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 27.475px;"> <svg height="11.0375" id="M21" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 27.475 11.0375" width="27.475" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 9</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 34.712502px;"> <svg height="11.0625" id="M22" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 34.712502 11.0625" width="34.712502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.153636" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 11.85px;"> <svg height="10.8625" id="M23" style="vertical-align:-0.13794pt" version="1.1" viewbox="0 0 11.85 10.8625" width="11.85" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.8625)"> <g transform="translate(72,-63.31)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="3.1257501" y="0"> 4</gydF4y2Batspan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">Karnofsky得分<gydF4y2Babr> <svg height="11.25" id="M24" style="vertical-align:-1.29163pt" version="1.1" viewbox="0 0 15.175 11.25" width="15.175" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,64.34)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ≤</gydF4y2Batspan> </text> </g> </g> </svg>50<年代vg height="7.1374998" id="M25" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>(%)</gydF4y2Batd> <td align="center"><span style="width: 39.1875px;"> <svg height="13.45" id="M26" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 39.1875 13.45" width="39.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="16.666498" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="20.829998" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 47px;"> <svg height="13.6375" id="M27" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 47 13.6375" width="47" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="16.666498" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="20.829998" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 34.712502px;"> <svg height="11.0625" id="M28" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 34.712502 11.0625" width="34.712502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.153636" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 34.712502px;"> <svg height="11.0625" id="M29" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 34.712502 11.0625" width="34.712502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.153636" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">CD4(中位数<年代vg height="14.8625" id="M30" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 63.525002 14.8625" width="63.525002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.8625)"> <g transform="translate(72,-60.11)"> <text transform="matrix(1,0,0,-1,-71.95,63.41)"> <tspan style="font-size: 12.50px; " x="0" y="0"> c</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="5.551332" y="0"> e</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="11.102664" y="0"> l</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="14.578498" y="0"> l</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="18.054333" y="0"> 年代</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> /</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="26.393833" y="0"> 米</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="36.121166" y="0"> 米</gydF4y2Batspan> </text> <text transform="matrix(1,0,0,-1,-26.1,60.28)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 3</gydF4y2Batspan> </text> </g> </g> </svg>)</gydF4y2Batd> <td align="center"><span style="width: 15.75px;"> <svg height="10.9125" id="M31" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 15.75 10.9125" width="15.75" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 15.75px;"> <svg height="11.1" id="M32" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 15.75 11.1" width="15.75" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.1)"> <g transform="translate(72,-63.12)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 34.712502px;"> <svg height="11.0625" id="M33" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 34.712502 11.0625" width="34.712502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="15.153636" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 11.85px;"> <svg height="10.8625" id="M34" style="vertical-align:-0.13794pt" version="1.1" viewbox="0 0 11.85 10.8625" width="11.85" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.8625)"> <g transform="translate(72,-63.31)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="3.1257501" y="0"> 2</gydF4y2Batspan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">意思是10日志hiv rna</gydF4y2Batd> <td align="center"><span style="width: 19.6625px;"> <svg height="11.0375" id="M35" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 19.6625 11.0375" width="19.6625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 19.6625px;"> <svg height="11.0375" id="M36" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 19.6625 11.0375" width="19.6625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 11.85px;"> <svg height="10.9125" id="M37" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 11.85 10.9125" width="11.85" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="3.1257501" y="0"> 8</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</gydF4y2Batd> </tr> <tr> <td align="left">自开始以来<gydF4y2Babr>艺术<年代vg height="7.1374998" id="M38" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>(%)</gydF4y2Batd> <td align="center"></td> <td align="center"></td> <td align="center"><span style="width: 11.85px;"> <svg height="10.9125" id="M39" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 11.85 10.9125" width="11.85" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 。</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="3.1257501" y="0"> 3</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</gydF4y2Batd> </tr> <tr> <td align="left">(我)2 - 3年</gydF4y2Batd> <td align="center"><span style="width: 54.8125px;"> <svg height="13.6375" id="M40" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.6375" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 7</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 54.8125px;"> <svg height="13.575" id="M41" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.575" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.575)"> <g transform="translate(72,-61.14)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 8</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"></td> <td align="center"></td> </tr> <tr> <td align="left">(2)3 - 4年</gydF4y2Batd> <td align="center"><span style="width: 54.8125px;"> <svg height="13.45" id="M42" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.45" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 54.8125px;"> <svg height="13.45" id="M43" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.45" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"></td> <td align="center"></td> </tr> <tr> <td align="left">(3)<年代vg height="8.8500004" id="M44" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,8.85)"> <g transform="translate(72,-64.92)"> <text transform="matrix(1,0,0,-1,-71.95,65.27)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ></gydF4y2Batspan> </text> </g> </g> </svg>4年</gydF4y2Batd> <td align="center"><span style="width: 47px;"> <svg height="13.6375" id="M45" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 47 13.6375" width="47" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="16.666498" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="20.829998" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 47px;"> <svg height="13.575" id="M46" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 47 13.575" width="47" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.575)"> <g transform="translate(72,-61.14)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="16.666498" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="20.829998" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 8</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"></td> <td align="center"></td> </tr> <tr> <td align="left">依法韦伦使用<gydF4y2Babr> <svg height="7.1374998" id="M47" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>(%)</gydF4y2Batd> <td align="center"><span style="width: 54.8125px;"> <svg height="13.6375" id="M48" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.6375" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 6</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 54.8125px;"> <svg height="13.575" id="M49" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.575" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.575)"> <g transform="translate(72,-61.14)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 6</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 1</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 11.85px;"> <svg height="10.8625" id="M50" 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style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>(%)</gydF4y2Batd> <td align="center"><span style="width: 54.8125px;"> <svg height="13.6375" id="M57" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.6375" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6375)"> <g transform="translate(72,-61.09)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 5</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 7</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="33.332996" y="0"> 4</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="39.584499" y="0"> )</gydF4y2Batspan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 54.8125px;"> <svg height="13.45" id="M58" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 54.8125 13.45" width="54.8125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 7</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="22.917999" y="0"> (</gydF4y2Batspan> <tspan style="font-size: 12.50px; " x="27.081497" y="0"> 7</gydF4y2Batspan> <tspan 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style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1375)"> <g transform="translate(72,-66.29)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </gydF4y2Batspan> </text> </g> </g> </svg>:患者的数量。%:病人的比例。体重:体重指数。CD4: CD4 + t细胞计数。艺术:抗逆转录病毒治疗。<gydF4y2Babr></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/art/2011/434375/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 治疗失败的预测。</gydF4y2Badiv> </div> </div> <p>超过三个月的跟踪,患者基线CD4 + t细胞计数(<年代vg height="11.375" id="M61" style="vertical-align:-0.1638pt;width:50.549999px;" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.112)"> <use xlink:href="#x1D443"></use> </g> <g transform="matrix(.017,-0,0,-.017,15.582,11.112)"> <use xlink:href="#x3D"></use> </g> <g transform="matrix(.017,-0,0,-.017,30.286,11.112)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,34.162,11.112)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,42.321,11.112)"> <path d="M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5 q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z" id="x33"></path> </g> </svg>)和年龄(<年代vg height="11.375" id="M62" style="vertical-align:-0.1638pt;width:50.549999px;" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.112)"> <use xlink:href="#x1D443"></use> </g> <g transform="matrix(.017,-0,0,-.017,15.582,11.112)"> <use xlink:href="#x3D"></use> </g> <g transform="matrix(.017,-0,0,-.017,30.286,11.112)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,34.162,11.112)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,42.321,11.112)"> <path d="M447 623l8 -12l-283 -613l-74 -10l-7 11q174 283 297 551h-216q-48 0 -62.5 -12t-33.5 -63h-29q10 60 18 148h382z" id="x37"></path> </g> </svg>)在单变量分析与病毒学失败有关。既保持独立与多变量分析后这一结果。</gydF4y2Bap> <h4 id="discussion">4所示。讨论</gydF4y2Bah4> <p>平均三年的治疗开始后,一半的患者接受抗逆转录病毒治疗在这个南非农村诊所仍在保健和完全抑制hiv rna。近四分之一的患者死亡,其中大部分是在早期。百分之十六的患者出现病毒学失败;只有少数人转向二线治疗。除了在基线Karnofsky分数低,男性是治疗失败的预测。免疫学和病毒学失败之间的相关性,另一方面是最小的。</gydF4y2Bap> <p>早期高死亡率可能很大程度上归功于先进的临床分期患者在寻求护理,作为其他非洲军团被描述,患者通常在疾病晚期当寻求保健(<gydF4y2Baa href="#B1">1</gydF4y2Baa>,<gydF4y2Baa href="#B9">9</gydF4y2Baa>]。这可能解释了大量的人去世后不久开始的艺术。回归分析确实显示了低绩效评分与治疗失败有关。因此,需要继续努力,登记患者,在临床疾病变得明显。男性也仍然作为一个独立的治疗失败的预测分析。类似联想之前已经观察到(<gydF4y2Baa href="#B10">10</gydF4y2Baa>,<gydF4y2Baa href="#B11">11</gydF4y2Baa>),但其他人没有发现性别是影响艺术的结果(<gydF4y2Baa href="#B12">12</gydF4y2Baa>,<gydF4y2Baa href="#B13">13</gydF4y2Baa>]。相比之下,CD4 + t细胞计数与治疗失败仍不显著相关,表明艺术开始前临床疾病更重要的不仅仅是避免低CD4 + t细胞计数。</gydF4y2Bap> <p>当治疗艾滋病病毒耐药性的发展是一个主要问题。病毒可以选择耐药性突变的理想药物水平。艺术的持续使用尽管持续的病毒复制,积累的阻力可能发生(<gydF4y2Baa href="#B14">14</gydF4y2Baa>- - - - - -<gydF4y2Baa href="#B16">16</gydF4y2Baa>]。死亡率在我们组治疗失败的主要原因。此外,观察持续病毒学控制大多数病人仍在照顾。由于这种观察到的“全有或全无”的现象,经历的人数持续的病毒复制的艺术是有限的。</gydF4y2Bap> <p>在许多地方政府投资公司常规hiv rna测试是不可行的。按照世卫组织准则、治疗变化经常单独基于免疫学的标准(<gydF4y2Baa href="#B8">8</gydF4y2Baa>,<gydF4y2Baa href="#B17">17</gydF4y2Baa>]。免疫失败是一个贫穷的预示经历病毒学失败在我们的队列。治疗决定基于免疫参数会导致不必要的治疗开关在大量的患者中,正如前面描述的(<gydF4y2Baa href="#B4">4</gydF4y2Baa>,<gydF4y2Baa href="#B5">5</gydF4y2Baa>]。我们不过显示,患者的比例,会错误地继续失败的方案如果治疗决定仅仅是基于免疫参数更大。这样viro-immunological离解凸显了病毒学监测所有患者接受抗逆转录病毒治疗的必要性。</gydF4y2Bap> <p>在当前的研究中,定期(一年两次的)病毒学监测。尽管如此,大量的病人继续显示后一线艺术病毒学失败的第一个证据。病毒学失败和治疗之间的延时开关可能是由于照护者专注于额外的依从性咨询,切换到之前唯一可用的二线治疗方案。病毒学失败的基础上,仅16%的患者在我们的群有一个治疗开关的指示。最近的评论报道近两倍的患者在低收入和中等收入国家需要二线方案(26 - 32%,<gydF4y2Baa href="#B17">17</gydF4y2Baa>]),但其他报告了类似的数字在我们所观察到的队列(<gydF4y2Baa href="#B18">18</gydF4y2Baa>- - - - - -<gydF4y2Baa href="#B20">20.</gydF4y2Baa>]。大多数病人在二线艺术达到病毒学抑制,与持续的病毒复制的人数可能进一步降低如果开关是由早期治疗。然而,未来的成本效益分析来确定最优开关。</gydF4y2Bap> <p>对我们的研究有一定的局限性。诊断潜在的疾病和文档的不良事件是有限的。因此,摩擦的原因未知。此外,由于我们的研究的回顾性质,偏见不能排除其他因素共同作用造成的。</gydF4y2Bap> <p>总之,在这个农村南非艺术计划访问病毒学监测、早期磨损是治疗失败的主要原因。在那些留在护理病毒学失败是有限的。需要继续努力早登记病人护理。此外,观察到viro-immunological离解强调了需要做hiv rna测试的应用范围更加广泛。</gydF4y2Bap> </div> <div class="xml-content"> <h4 class="references" id="references">引用</gydF4y2Bah4> <ol> <li id="B1">s . Rosen m·p·福克斯和c·j·吉尔,“病人保留在非洲撒哈拉沙漠以南地区的抗逆转录病毒治疗项目:系统回顾,“<gydF4y2Bai>《公共科学图书馆·医学》杂志上</gydF4y2Bai>,4卷,不。10篇文章e298 1691 - 1701年,2007页。<年代pan class="reflinks">视图:<gydF4y2Baa href="https://doi.org/10.1371/journal.pmed.0040298">出版商的网站</gydF4y2Baa><span class="sep">|</年代pan><a href="https://scholar.google.com/scholar_lookup?title=Patient%20retention%20in%20antiretroviral%20therapy%20programs%20in%20sub-Saharan%20Africa:%20a%20systematic%20review&author=S. Rosen&author=M. P. Fox&author=&author=C. J. 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Walker&publication_year=2006" target="_blank">谷歌学术搜索</gydF4y2Baa></span></li> </ol> </div> <div class="xml-content"> <h4 class="copyright" id="copyright">版权</gydF4y2Bah4> <p>版权©2011鲁斯·e·巴斯等。这是一个开放的分布式下文章<gydF4y2Baa rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</gydF4y2Baa>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</gydF4y2Bap> </div> </div> </article> </div> </div> </div> <div class="biblio__StyledBibblio-sc-1nou1lz-0 eSVfHT"> <div id="takeover" class="biblio__TakeoverWrapper-sc-1nou1lz-2 htjhiS"> <div id="bib--hide-takeover-element-mobile"> <div id="bib--takeover-element-mobile"> <h4 class="biblio__H4-sc-1nou1lz-4 lhUKwc">相关文章</gydF4y2Bah4> <div id="bib--rcm-takeover-element-mobile"> 对本文没有相关内容可用。</gydF4y2Badiv> </div> </div> </div> </div> <div class="biblio__StyledBibblio-sc-1nou1lz-0 eSVfHT"> <div class="biblio__FooterWrapper-sc-1nou1lz-3 etZutQ mobile-widget" id="related-articles-hidden"> <div id="bib--hide-footer-element-mobile"> <hr 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height="24"><span class="text">下载引用</年代pan></span><span class="sc-htoDjs bqeMOy sc-dqBHgY cQgXqt fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> <a class="sc-htpNat bUhGXt link sc-jtRfpW dUABlg sc-BngTV hmDWcT ref_desktop" href="//www.newsama.com/journals/art/2011/434375.ris" aria-label="" target="" id="toolbar__dcNavSmall"><span><img alt="" class="sc-EHOje jOLhQl sc-kTUwUJ eujois" title="" role="presentation" 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height="24"><span class="sc-dRFtgE jrsDZP">下载其他格式</年代pan><span class="sc-gkFcWv gWTCXQ">更多的</年代pan></span> <span class="sc-htoDjs bMdQcY sc-gbOuXE jGPvPL icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="11"></span> </div> <div class="sc-fnwBNb etzuBr"> <a class="sc-htpNat bUhGXt link sc-iNhVCk gWgCNb open_panel" href="//www.newsama.com/downloads/journals/art/2011/434375.epub" aria-label="ePub" property="background-color" color="#D8D8D8"> <div class="sc-eAKXzc WHkfb"> ePub</gydF4y2Badiv><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" 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height="24"><span class="sc-dRFtgE jrsDZP">订单打印副本</年代pan><span class="sc-gkFcWv gWTCXQ">订单</年代pan></span><span class="sc-htoDjs kNoiZu sc-gbOuXE jGPvPL right__icon icon-colored _32KP5uexH-Bgs7Kj8Gk1Tz icon-themeable" title="" font-size="16"></span></a> <div class="sc-hBbWxd kdRRST"> <div class="sc-dyGzUR cHatnS"> <div> 的观点<年代pan>1809年</年代pan> </div> <div> 下载<年代pan>1058年</年代pan> </div> </div> <div> <div class="sc-drKuOJ kxdGAZ"> <span class="__dimensions_badge_embed__" data-doi="10.1155/2011/434375" data-style="small_circle"></span>引用</gydF4y2Badiv> </div> </div> <nav class="sc-bRBYWo fXBKFa sc-hUfwpO jHPgUP" id="toolbar__iconNav"> <h3 class="sc-Rmtcm hNPrIr">分享文章</gydF4y2Bah3> <ul class="sc-hzDkRC bnbfTS"> <li class="iconBorder"><a class="sc-htpNat bUhGXt link" href="https://twitter.com/share?url=https://doi.org/10.1155/2011/434375&via=Hindawi" aria-label="Sharing on Twitter" rel="noopener noreferrer" target="_blank"><img alt="" class="sc-EHOje jOLhQl socialTwitter" title="" 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