染色体不平衡与Metastasis-Free乳腺癌患者的生存期

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多个染色体不平衡已确定在乳腺癌使用比较基因组杂交(CGH)。协会的主要肿瘤的潜力建立远处转移是未知的。在这项研究中,我们调查了39个乳腺浸润性癌的意思是遵循了里的99个月(max。193个月)通过全息确定染色体的预后价值收益和损失。每个肿瘤染色体失衡的平均数为6.5±0.7(范围2 - 18)。最常见的改变超过1/3的病例中确定收益染色体11个问题,12抓起,16日,17日,20问,损失2 q和13问。明显不同的染色体畸变频率(p≤0.05)被发现之间的DNA的二倍体和非二倍体肿瘤(获得17号染色体上)。之间的差异还指出肿瘤发展到远处转移的时期内和那些不遵循量(收益问题11日和12抓起;损失12问)。重要的单变量相关性(p≤0.05)转移检测——自由生存的患者被发现淋巴结状态、cytometrical确定DNA倍性(二倍体/非二倍体应承担)和anisokaryosis, DNA和收益问题,11日12抓起,17日和18 p。 An unexpected inverse correlation was found between clinical outcome and gains on 11q13 and 12q24. In multivariate analysis independent prognostic value, in addition to lymph node status, was found for chromosomal gains on 11q13, 12q24, 17 and 18p. Amplification on 20q, which did not correlate with metastasis‐free survival in a univariate analysis, showed weak prognostic significance in combination with the nodal status. The prognostic value of chromosomal alterations – some of them by inverse correlation – suggests an interaction and/or compensation of the involved amplified genes and their effects on the occurrence of distant metastases in breast cancer patients.

分析细胞病理学

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