研究文章
如何有效的无创性检测诊断恶性周边神经鞘肿瘤患者神经纤维瘤病1型?NF1患者的诊断对于
表2
敏感性,特异性,阳性预测值,阴性预测值,连同相关的置信区间,为恶性肿瘤的潜在因素。其中包括肿瘤特征(深度相对于筋膜和大小直径> 5厘米),核磁共振的发现(任何坏死,或坏死> 25%),宠物的发现(SUV马克斯> 5,SUV峰> 4.5,TLR > 3),和临床结果(疼痛、扩大和神经症状)。成像结果(SUV的组合峰>或< 4.5宠物和任何或> 25%的坏死MRI)和临床结果(1,2,3,或3 3症状)也包括在内。
|
|
|
灵敏度 |
特异性 |
PPV |
净现值 |
精度 |
|
| 肿瘤的特点 |
深 |
100.0 (88.0 - -100.0) |
20.7 (8.7 - -40.3) |
61.0 (47.4 - -73.2) |
100.0 (51.7 - -100.0) |
64.6 |
| > 5厘米大小 |
68.0 (46.4 - -84.2) |
53.5 (34.2 - -72.0) |
56.7 (37.7 - -74.0) |
65.2 (42.8 - -82.8) |
60.4 |
|
| 核磁共振的发现 |
坏死(任何) |
87.5 (60.4 - -97.8) |
76.1 (52.4 - -90.9) |
51.4 (34.7 - -67.8) |
73.7 (32.2 - -65.3) |
81.1 |
| 坏死(> 25%) |
75.0 (47.4 - -91.7) |
95.2 (74.1 - -99.8) |
92.3 (62.1 -100) |
83.3 (61.8 - -94.5) |
86.5 |
|
| 宠物的发现 |
运动型多功能车马克斯> 5 |
89.3 (70.6 - -97.2) |
73.3 (50.8 - -87.0) |
75.8 (57.4 - -88.2) |
88.0 (67.7 - -96.8) |
78.0 |
| 运动型多功能车峰> 4.5 |
94.7 (71.9 - -99.7) |
70.8 (48.8 - -86.6) |
72.0 (50.4 - -87.1) |
94.4 (70.6 - -99.7) |
78.0 |
| TLR > 3 |
91.7 (71.5 - -98.5) |
73.9 (51.3 - -88.90 |
78.6 (58.5 - -91.0) |
89.5 (65.5 - -98.2) |
82.1 |
| 视觉的分数 |
94.1 (69.2 - -99.7) |
70.8 (48.7 - -86.6) |
69.6 (47.0 - -86.0) |
94.4 (70.6 - -99.7) |
80.5 |
|
| 结合PET / MRI发现 |
运动型多功能车峰> 4.5 (PET)或任何坏死(MRI) |
95.5 (75.1 -100) |
66.7 (47.1 - -82.1) |
67.7 (48.5 - -82.7) |
95.2 (74.1 -100) |
78.8 |
| 运动型多功能车峰> 4.5 (PET)和任何坏死(MRI) |
56.2 (30.6 - -79.2) |
93.9 (78.4 - -98.9) |
81.8 (47.8 - -96.8) |
81.6 (65.1 - -91.7) |
81.6 |
| SUVpeak > 4.5 (PET)或坏死> 25% (MRI) |
72.2 (46.5 - -90.3) |
50.0 (26.0 - -74.0) |
60.1 (36.7 - -78.5) |
64 (42.8 - -81.2) |
61.1 |
| SUVpeak > 4.5 (PET)和坏死> 25% (MRI) |
61.5 (31.6 - -86.14) |
100 (81.5 -100) |
100 (59.8 -100) |
78.3 (64.4 - -87.6) |
83.9 |
|
| 临床研究结果 |
疼痛 |
85.2 (65.4 - -95.1) |
28.1 (14.4 - -47.0) |
50 (35.1 - -64.9) |
69.2 (38.9 - -89.6) |
54.2 |
| 增长 |
85.2 (65.4 - -95.1) |
25.0 (12.1 - -43.8) |
48.9 (34.3 - -63.7) |
66.7 (35.4 - -88.7) |
52.5 |
| 神经症状 |
44.8 (26.9 - -64.0) |
75.0 (57.5 - -87.3) |
59.1 (36.7 - -78.5) |
62.3 (46.7 - -76.6) |
61.0 |
|
| 结合临床表现 |
1 3发现 |
92.9 (75.0 - -98.8) |
9.68 (2.53 - -26.9) |
48.1 (34.5 - -62.0) |
60.0 (17.0 - -92.7) |
49.1 |
| 2的3发现 |
89.3 (70.6 - -97.2) |
43.8 (26.8 - -62.1) |
58.1 (42.2 - -72.6) |
82.3 (55.8 - -95.3) |
65.0 |
| 3的结果 |
32.1 (16.6 - -5.24) |
78.1 (60.0 - -90.1) |
56.2 (30.6 - -79.2) |
43.2 (28.7 - -58.9) |
56.7 |
|
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