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no-repeat 6px;background-position:center;margin-top:10px;min-width:55px;display:none;} @media (min-width:768px){.bYDOBI .floats-partial-section .floats-partial-footer .floats-partial-caption .expand_btn{display:none;}} .bYDOBI .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{-webkit-flex:9;-ms-flex:9;flex:9;text-align:left;padding:21px 37px 10px 0px;font-size:16px;font-weight:700;} @media (min-width:768px){.bYDOBI .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 18px 10px 18px;}} @media (min-width:992px){.bYDOBI .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 21px 10px 21px;}} .bYDOBI .floats-partial-section .floats-partial-footer .floats-partial-caption 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href="//www.newsama.com/journals/pm/" aria-label="Pulmonary Medicine">肺药</一个>/<一个class="sc-htpNat bUhGXt link sc-gGCbJM eslOan breadCrumb" href="//www.newsama.com/journals/pm/contents/year/2011/" aria-label="2011">2011年</一个>/<年代pan class="sc-lcpuFF dIyyAR">文章</年代pan> </div> <div class="threeColumn__ThreeColumnWrapper-sc-1bf4078-0 uVYyF threeColumnWrapper"> <div class="threeColumn__LeftWrapper-sc-1bf4078-1 fkVFlF leftWrapper"> <button type="button" class="sc-jeCdPy hPDggI section__button " id="sectionButton"><span class="sc-htoDjs diutvq icon__dots dots__detector icon-colored _3n-7Ho7DlfjMlZbrRr9Q4a icon-themeable" title="" font-size="22"></span>文章部分</gydF4y2Babutton> <div class="sc-gtfDJT eVAVoo static_contents__section_links links__hidden "> <div id="leftSectionMenu" class="sc-GMQeP fMysxi sc-eInJlc cfvYGB left_section_menu"> <p>在这一页上</gydF4y2Bap> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#abstract" aria-label="">文摘</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#introduction" aria-label="">介绍</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#methods-and-materials" aria-label="">方法和材料</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#results" aria-label="">结果</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#discussion" aria-label="">讨论</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#acknowledgments" aria-label="">确认</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#references" aria-label="">引用</一个></span> <span class="sc-hzDEsm gxpLsG grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-fOICqy iXqXlM" href="#copyright" aria-label="">版权</一个></span> </div> </div> </div> <div class="threeColumn__ContentWrapper-sc-1bf4078-3 bbzREB contentWrapper"> <div class="threeColumn__Content-sc-1bf4078-4 jknsZc content"> <div class="articleContent__ArticleContentsWrapper-sc-2yl9jy-0 eSvjPB article_contents"> <div class="articleContent__ArticleContentsSectionsWrapper-sc-2yl9jy-1 jntdRu article_contents__sections_wrapper"> <div class="articleContent__ArticleWrapper-sc-2yl9jy-2 hAzjHP"> <div class="sc-ebFjAB jxEVjH article_header_class"> <p class="sc-hzNEM exLcDH article_type">研究文章|<gydF4y2Ba!-- -->开放获取</gydF4y2Bap> <div class="sc-chbbiW kzNyka article_citation"> 体积<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- --> <span class="sc-cooIXK hCCmjz">|</年代pan>文章的ID<gydF4y2Ba!-- --> 419328年<gydF4y2Ba!-- --> <span class="sc-cooIXK hCCmjz">|</年代pan> <a class="sc-htpNat bUhGXt link sc-fcdeBU dJIaji" href="https://doi.org/10.1155/2011/419328" aria-label="Doi-link">https://doi.org/10.1155/2011/419328</一个> </div> <div class="sc-bmyXtO gDNLQN article_full_citation"> <div class="sc-jtggT bycqoT isHide"> <p>托马斯•Grydeland埃里卡·a . Rutten Sreekumar g .皮拉伊斯科特•赌注asg Dirksen,哈维·o·Coxson Amund Gulsvik, Emiel f·m·伍特斯/ s·巴克<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> ”<年代pan>定量CT:肺气肿之间的关联,在COPD气道壁厚和身体成分</年代pan>”,<gydF4y2Ba!-- --><i>肺药</我>,<gydF4y2Ba!-- --> 卷。<gydF4y2Ba!-- -->2011年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 文章的ID<gydF4y2Ba!-- -->419328年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 6<gydF4y2Ba!-- -->   页面<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- -->。<gydF4y2Ba!-- --> https://doi.org/10.1155/2011/419328</gydF4y2Bap> </div> <button class="sc-iAyFgw irxuxk sc-dEoRIm jkPgtr" color="">显示引用</gydF4y2Babutton> </div> <h1 class="sc-gPEVay iUuzmH sc-kxynE dZgsvk article_title heading-title">定量CT:肺气肿之间的关联,在COPD气道壁厚和身体成分</gydF4y2Bah1> </div> <div class="sc-gpHHfC cdKJIh article_authors"> <hr class="sc-gPzReC jVvWtU hr__author"> <span class=""><b>艾丽卡p . a . Rutten</gydF4y2Bab><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-gVyKpa kNPCsS icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a>,<年代up>1<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->2</年代up></span> <span class="">Thomas b . Grydeland<gydF4y2Ba!-- -->,<年代up>3<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->4</年代up></span> <span class="">Sreekumar g .皮拉伊<gydF4y2Ba!-- -->,<年代up>5</年代up></span> <span class="">斯科特赌注<gydF4y2Ba!-- -->,<年代up>1</年代up></span> <span class="">asg德克森<gydF4y2Ba!-- -->,<年代up>6</年代up></span> <span class="">哈维·o·Coxson<gydF4y2Ba!-- -->,<年代up>7</年代up></span> <span class="">Amund Gulsvik<gydF4y2Ba!-- -->,<年代up>3<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->4</年代up></span> <span class="">Emiel f·m·伍特斯<gydF4y2Ba!-- -->,<年代up>1<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->2</年代up> 和</年代pan> <span class="">每个美国巴克<年代up>3<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->4</年代up></span> <div class="sc-kQsIoO lnoGXA isHide"> <p><sup>1</年代up><span>中心的专业知识为慢性器官衰竭(Ciro), 6085纳米角、荷兰</年代pan></p> <p><sup>2</年代up><span>呼吸医学系,马斯特里赫特大学医学中心+ (MUMC +),邮政信箱616,6200 MD马斯特里赫特,荷兰</年代pan></p> <p><sup>3</年代up><span>Haukeland大学医院胸医学系,5021年卑尔根,挪威</年代pan></p> <p><sup>4</年代up><span>胸部分医学,医学研究所,5021卑尔根,挪威卑尔根大学</年代pan></p> <p><sup>5</年代up><span>葛兰素史克公司,美国27709数控,三角研究园</年代pan></p> <p><sup>6</年代up><span>呼吸医学系,根措夫特医院,哥本哈根大学,27709年丹麦哥本哈根</年代pan></p> <p><sup>7</年代up><span>放射学、温哥华总医院和詹姆斯·霍格iCAPTURE心血管和肺研究中心,温哥华,不列颠哥伦比亚大学,加拿大</年代pan></p> </div> <button class="sc-iAyFgw irxuxk sc-cpmKsF dxqSPm" color="">显示更多</gydF4y2Babutton> </div> <div class="articleContent__EditorWrapper-sc-2yl9jy-3 evMkvU"> <div class="articleContent__TextWrapper-sc-2yl9jy-8 fYrLtk"> <b>学术编辑器:</gydF4y2Bab>N Ambrosino</d我v> <div class="articleContent__PublicationTimeLineWrapper-sc-2yl9jy-4 fjviok"> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年8月29日</年代pan> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">修改后的</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年12月13日</年代pan> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2010年12月15日</年代pan> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC isPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</年代pan> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2011年1月16日</年代pan> </div> </div> </div> <article class="sc-hgHYgh bYDOBI article_body "> <div> <div class="xml-content"> <h4 class="header" id="abstract">文摘</gydF4y2Bah4> <p>本研究的目的是确定CT phenotypes-emphysema之间的关系由低衰减区和支气管炎气道壁厚度和身体成分的参数在一个大的主题,没有慢性阻塞性肺病。452年COPD受试者和459例慢性阻塞性肺病,CT扫描进行确定肺气肿(% LAA),肺气道壁厚(AWT-Pi10)和质量。肌肉萎缩基于FFMI评估生物电阻抗。在慢性阻塞性肺病的男性和女性,FFMI与% LAA负相关。FMI AWT-Pi10呈正相关的主题和慢性阻塞性肺病。在受试者与肌肉萎缩、肺气肿比例高,但温和的预测价值。总之,目前的研究加强了假设的子群慢性阻塞性肺病患者肌肉萎缩有肺气肿。气道壁厚是与脂肪质量指数呈正相关学科和慢性阻塞性肺病。</gydF4y2Bap> <span class="end-abs"></span> <h4 id="introduction">1。介绍</gydF4y2Bah4> <p>慢性阻塞性肺疾病(COPD)是,除了呼吸障碍,认为是一种全身性疾病,肺外表现。在过去,术语“粉红河豚”和“蓝色的鲱鱼”被用来形容“表型”的慢性阻塞性肺病,这意味着这种疾病过程延伸肺(<一个href="#B1">1</一个>]。粉色海豚被认为是肺气肿和瘦的身体体质,而蓝色的鲱鱼被视为肥胖,与很少或没有中央黄萎病肺气肿,通常被认为是慢性阻塞性肺病的慢性支气管炎亚型。</gydF4y2Bap> <p>目前利用胸腔定量计算机断层扫描(CT)技术使我们能够更好地描述这些表型。它最近表明,肺气肿的程度来衡量的比例低衰减区(% LAA)反向与身体质量指数(BMI:体重/身高<年代up>2</年代up>)[<一个href="#B2">2</一个>]。另一个最近的一篇论文显示确认这些数据之间的负相关% LAA和脂肪大规模免费指数(FFMI,骨骼肌质量的一个标志:脂肪质量(FFM) /高度自由<年代up>2</年代up>)和脂肪质量指数(FMI、脂肪量(FM) /高度<年代up>2</年代up>与COPD受试者的)(<一个href="#B3">3</一个>]。这两项研究[<一个href="#B2">2</一个>,<一个href="#B3">3</一个>)被限制重男性吸烟。</gydF4y2Bap> <p>气道壁厚,也来自CT扫描,最近与慢性支气管炎的症状(<一个href="#B9">4</一个>]。气道壁厚之间的关系和身体成分是有争议的。研究显示都没有(<一个href="#B2">2</一个>和积极的<一个href="#B4">5</一个>气道壁和BMI百分比之间的相关性。因为它是最近表明,气道壁增厚和肺气肿症状做出独立的贡献表明慢性阻塞性肺病(<一个href="#B5">6</一个>),相关的测试的区别的能力CT表型标记的COPD的肺外的特征像身体成分。</gydF4y2Bap> <p>基于上述发现,我们假设存在显著的桶状胸病变在CT扫描与定量措施的系统性软组织呈现负相关,也就是说,全身无脂质量。此外,我们假设气道壁厚与BMI呈正相关,FMI在COPD患者中,反映了支气管炎表型。为了这个目的,我们检查了一个大的主题与慢性阻塞性肺病和一群受试者没有慢性阻塞性肺病,男性和女性。</gydF4y2Bap> <h4 id="methods-and-materials">2。方法和材料</gydF4y2Bah4> <p>人口特征的细节给出其他地方(<一个href="#B6">7</一个>- - - - - -<一个href="#B8">9</一个>]。简而言之,这项研究包括452例慢性阻塞性肺病病例和459例慢性阻塞性肺病。入学标准自述白种人;年龄> 40岁;现任或前任吸烟者≥2.5包年的吸烟史;没有<年代vg height="11.825" id="M1" style="vertical-align:-3.27605pt;width:16.112499px;" version="1.1" viewbox="0 0 16.112499 11.825" width="16.112499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,7.675)"> <path d="M545 106q-67 -118 -134 -118q-24 0 -40 37.5t-30 129.5h-2q-47 -72 -103 -119.5t-108 -47.5q-47 0 -76 45.5t-29 119.5q0 113 85 204t174 91q47 0 70 -33.5t43 -119.5h3q32 47 80 140l55 13l10 -9q-47 -80 -138 -201q17 -99 27.5 -136t22.5 -37q23 0 69 61zM333 204 q-14 98 -31 149.5t-50 51.5q-49 0 -94 -70t-45 -164q0 -55 15.5 -86t40.5 -31q70 0 164 150z" id="x1D6FC"></path> </g> <g transform="matrix(.012,-0,0,-.012,9.712,11.762)"> <path d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" id="x31"></path> </g> </svg>抗胰蛋白酶缺乏症。医学伦理委员会批准了这项研究和书面知情同意是获得所有科目。研究对象接受肺量测定法根据at标准(<一个href="#B9">4</一个>),使用一个肺机能图2160 bronchodilation前后肺活量计400人<我>μ</我>克舒喘灵。慢性阻塞性肺病病例的诊断标准是postbronchodilator FEV1 / FVC的比率小于0.70,残不到80%的预测。无慢性阻塞性肺病者有postbronchodilator FEV1 / FVC的比率大于0.70,残大于80%的预测(<一个href="#B10">10</一个>]。受试者评估至少6周后任何呼吸道感染,但并不要求保留常规药物治疗。</gydF4y2Bap> <p>后续的评估身体身高和体重,全身阻抗测量使用bio-electrical阻抗方法(Bodystat)在一夜之间迅速。FFM的计算公式,老人被用于控制对象(<一个href="#B11">11</一个>),而COPD-specific公式用于COPD受试者(<一个href="#B12">12</一个>]。FM是按重量计算- FFM FFMI, FMI FFM和调频除以heigth分别计算<年代up>2</年代up>。肌肉萎缩是定义的否决Vestbo et al。<一个href="#B13">13</一个>]:FFMI < 17.1公斤/米<年代up>2</年代up>对于男人和< 14.6公斤/米<年代up>2</年代up>为女性。</gydF4y2Bap> <p>胸腔的CT扫描获得使用通用电气光速超CT扫描仪(120千伏峰值,200马;美国通用电气医疗集团,密尔沃基,WI),在暂停全部灵感使用1毫米片每隔20毫米厚度和使用高分辨率重建算法(“骨头”)。平均有<年代vg height="11.4" id="M2" style="vertical-align:-0.3003pt;width:66.199997px;" version="1.1" viewbox="0 0 66.199997 11.4" width="66.199997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.963)"> <use xlink:href="#x31"></use> </g> <g transform="matrix(.017,-0,0,-.017,8.222,10.963)"> <path d="M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5 q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z" id="x33"></path> </g> <g transform="matrix(.017,-0,0,-.017,16.381,10.963)"> <path d="M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z" id="x2E"></path> </g> <g transform="matrix(.017,-0,0,-.017,20.257,10.963)"> <path d="M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z" id="x34"></path> </g> <g transform="matrix(.017,-0,0,-.017,32.19,10.963)"> <path d="M535 290h-212v-206h-58v206h-213v50h213v193h58v-193h212v-50zM535 -22h-483v50h483v-50z" id="xB1"></path> </g> <g transform="matrix(.017,-0,0,-.017,45.942,10.963)"> <use xlink:href="#x31"></use> </g> <g transform="matrix(.017,-0,0,-.017,54.102,10.963)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,57.977,10.963)"> <path d="M137 343l67 33q37 17 63 17q79 0 129.5 -53t50.5 -131q0 -92 -58 -156.5t-147 -64.5t-147 68t-58 182q0 63 17 119t43 95.5t61.5 72t69 52t67.5 31.5q62 22 128 33l6 -32q-56 -11 -108 -35q-149 -71 -184 -231zM227 337q-47 0 -95 -27q-6 -23 -6 -70q0 -93 36 -155.5 t96 -62.5q53 0 78 45.5t25 105.5q0 68 -35 116t-99 48z" id="x36"></path> </g> </svg>CT图像/主题。以前描述的定量分析程序(<一个href="#B14">14</一个>]。肺气肿的程度是评估使用自定义软件(EmphylxJ)。一个主题被认为有肺气肿如果肺体素用x射线衰减值的百分比低于950−胡<年代vg height="15.0875" id="M3" style="vertical-align:-2.3205pt;width:103.625px;" version="1.1" viewbox="0 0 103.625 15.0875" width="103.625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,12.138)"> <path d="M300 -147l-18 -23q-106 71 -159 185.5t-53 254.5v1q0 139 53 252.5t159 186.5l18 -24q-74 -62 -115.5 -173.5t-41.5 -242.5q0 -130 41.5 -242.5t115.5 -174.5z" id="x28"></path> </g> <g transform="matrix(.017,-0,0,-.017,5.944,12.138)"> <path d="M594 629l-404 -661l-31 23l402 661zM194 635q70 0 107 -56t37 -125t-37.5 -125.5t-107.5 -56.5t-107 56.5t-37 124.5q0 70 37.5 126t107.5 56zM193 605q-28 0 -45 -29t-21.5 -59.5t-4.5 -62.5t4.5 -63t22 -60t45.5 -29q22 0 37.5 16t22 42t9 48t2.5 45q0 152 -72 152z M567 351q69 0 106 -56t37 -125t-37 -125.5t-107 -56.5t-107.5 56.5t-37.5 124.5q0 43 14.5 83t49 69.5t82.5 29.5zM566 322q-28 0 -45 -28.5t-22 -59.5t-5 -64q0 -23 3 -46t10.5 -48.5t23 -41.5t36.5 -16q28 0 45 29.5t21 59.5t4 62q0 24 -2.5 46.5t-9.5 48.5t-22 42t-37 16 z" id="x25"></path> </g> <g transform="matrix(.017,-0,0,-.017,18.795,12.138)"> <path d="M495 163l30 -6q-19 -99 -36 -157h-453v28q63 5 77.5 20t14.5 78v400q0 63 -13 77t-75 19v28h261v-28q-61 -5 -74.5 -19t-13.5 -77v-395q0 -41 5 -59t18 -25q24 -13 96 -13q85 0 112 31q30 33 51 98z" id="x4C"></path> </g> <g transform="matrix(.017,-0,0,-.017,28.076,12.138)"> <path d="M673 0h-245v28q47 6 58 16t1 39l-55 154h-213q-31 -87 -36 -129q-16 -47 -5 -61t68 -19v-28h-226v28q50 7 68.5 23.5t43.5 80.5l214 524l24 9l193 -536q23 -63 41.5 -79.5t68.5 -21.5v-28zM418 280l-81 255h-2q-74 -197 -101 -255h184z" id="x41"></path> </g> <g transform="matrix(.017,-0,0,-.017,39.823,12.138)"> <use xlink:href="#x41"></use> </g> <g transform="matrix(.017,-0,0,-.017,51.569,12.138)"> <path d="M275 270q0 -296 -211 -440l-19 23q75 62 116.5 174t41.5 243t-42 243t-116 173l19 24q211 -144 211 -440z" id="x29"></path> </g> <g transform="matrix(.017,-0,0,-.017,62.176,12.138)"> <path d="M512 230l-437 -233v58l378 199v2l-378 200v58l437 -233v-51z" id="x3E"></path> </g> <g transform="matrix(.017,-0,0,-.017,76.88,12.138)"> <path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8 l-26 -65h-233z" id="x35"></path> </g> <g transform="matrix(.017,-0,0,-.017,85.039,12.138)"> <use xlink:href="#x25"></use> </g> </svg>(<一个href="#B15">15</一个>]。标准化的气道壁增厚,内部的周长10毫米(AWT-Pi10)为每个主题分开计算。减少技术错误相关的非常小的航空公司,只有航空公司内部周长大于6毫米都包括在内。肺质量乘以计算CT计算肺密度(g / ml)的CT肺容积计算(ml)。CT图像分析詹姆斯·霍格iCAPTURE中心(加拿大温哥华BC)。进一步的细节CT分析可以找到其他地方(<一个href="#B9">4</一个>,<一个href="#B10">10</一个>]。</gydF4y2Bap> <h5 id="sec2.1">2.1。统计数据</gydF4y2Bah5> <p>所有数据都表示为平均数±标准差,检查正常,如果必要的日志转换(% LAA)。集团连续变量的比较测试使用方差分析(方差分析)测试和LSD事后或Dunnett-T3测试。斯皮尔曼相关系数计算测试CT变量和身体成分参数之间的关系。随后,多元线性回归分析和日志(% LAA) AWT-Pi10作为因变量进行调查与身体成分变量的关系。Covariables在这些分析年龄、包年,肺功能。肺气肿的分数高的患病率在分层测试了肌肉萎缩<年代vg height="20.275" id="M4" style="vertical-align:-3.56265pt;width:14.975px;" version="1.1" viewbox="0 0 14.975 20.275" width="14.975" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,15.775)"> <path d="M478 372q0 -39 -31 -97t-61 -98t-78 -98q-45 -55 -73 -102q-13 -79 -13 -197q-11 -11 -43.5 -25.5t-53.5 -15.5l-15 17q5 35 26 101.5t47 123.5q8 72 -1.5 174.5t-37.5 178.5q-14 37 -29 37q-20 0 -67 -65l-25 21q37 60 73 90.5t63 30.5q47 0 72 -112q13 -56 17.5 -141.5 t0.5 -143.5h2q155 193 155 297q0 26 -12 47q-5 8 -5 15q0 16 12.5 27t29.5 11q21 0 34 -21t13 -55z" id="x1D6FE"></path> </g> <g transform="matrix(.012,-0,0,-.012,8.575,7.613)"> <path d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" id="x32"></path> </g> </svg>测试。FFMI是独立与% LAA与COPD受试者,相关的测试为% LAA FFMI的区别的能力。为此,曲线下的面积(AUC)计算通过使用接收操作特征(ROC)曲线。0.7 - -0.8的AUC是代表和一个合理的歧视<年代vg height="11.6875" id="M5" style="vertical-align:-0.20473pt;width:74.3125px;" version="1.1" viewbox="0 0 74.3125 11.6875" width="74.3125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.363)"> <use xlink:href="#x41"></use> </g> <g transform="matrix(.017,-0,0,-.017,10.823,11.363)"> <path d="M716 650v-28q-46 -3 -65 -15.5t-22 -43.5q-6 -54 -6 -162v-82q0 -184 -75 -264q-68 -69 -180 -69q-98 0 -160 48q-88 67 -88 238v249q0 66 -13.5 81t-73.5 20v28h258v-28q-59 -4 -72.5 -19t-13.5 -82v-227q0 -122 48 -188t140 -66q189 0 189 286v75q0 111 -7 165 q-4 29 -24 40.5t-73 15.5v28h238z" id="x55"></path> </g> <g transform="matrix(.017,-0,0,-.017,23.334,11.363)"> <path d="M614 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635q70 0 116 -43t46 -105q0 -46 -28 -80q-22 -25 -80 -64q62 -35 97 -75t35 -99q0 -81 -63 -131t-135 -50q-83 0 -137.5 45.5t-54.5 123.5q0 52 45 95q29 28 89 64q-109 62 -109 155q0 66 50.5 115t128.5 49zM238 603q-42 0 -67.5 -31t-25.5 -72q0 -50 32.5 -79.5 t98.5 -62.5q61 48 61 124q0 59 -29.5 90t-69.5 31zM248 20q46 0 76.5 33.5t30.5 89.5q0 50 -39 85.5t-110 71.5q-81 -54 -81 -137q0 -67 35.5 -105t87.5 -38z" id="x38"></path> </g> </svg>建议良好的歧视(<一个href="#B16">16</一个>]。分析使用社会科学统计软件包(SPSS)对Windows 17.0版本。一个<年代vg height="12.4375" id="M6" style="vertical-align:-0.1638pt;width:91.987503px;" version="1.1" viewbox="0 0 91.987503 12.4375" width="91.987503" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,12.162)"> <path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 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0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path> </g> <g transform="matrix(.017,-0,0,-.017,36.066,12.162)"> <path d="M518 50v-26q-32 -4 -77 -16l-37 -11t-33 -9l-6 6v71q-56 -42 -74 -52q-43 -25 -77 -25q-55 0 -89.5 36.5t-34.5 112.5v196q0 38 -6.5 48.5t-26.5 15.5l-28 6v23q19 1 72 7q59 9 71 11q-3 -31 -3 -145v-135q0 -113 88 -113q59 0 108 48v234q0 38 -8 49t-34 15l-36 6v23 q44 2 90 8q37 4 67 10v-334q0 -37 8.5 -47t38.5 -12z" id="x75"></path> </g> <g transform="matrix(.017,-0,0,-.017,45.092,12.162)"> <path d="M380 106l15 -22q-42 -52 -87 -74t-76 -22q-89 0 -142 62t-53 151q0 103 66 175q67 73 146 73h1q61 0 105.5 -46.5t44.5 -105.5q0 -16 -4.5 -22.5t-18.5 -9.5q-54 -10 -262 -17q1 -95 46 -143.5t104 -48.5q61 0 115 50zM225 412q-35 0 -64.5 -32.5t-40.5 -90.5q83 0 170 3 q14 0 19 4.5t5 15.5q1 41 -23.5 70.5t-65.5 29.5z" id="x65"></path> </g> <g transform="matrix(.017,-0,0,-.017,57.025,12.162)"> <path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path> </g> <g transform="matrix(.017,-0,0,-.017,71.712,12.162)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,75.588,12.162)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,83.747,12.162)"> <use xlink:href="#x35"></use> </g> </svg>被认为是具有统计学意义。</gydF4y2Bap> <h4 id="results">3所示。结果</gydF4y2Bah4> <p>研究参与者展示在表的特性<一个href="//www.newsama.com/journals/pm/2011/419328/tab1/" target="_blank">1</一个>。COPD受试者没有年轻,FEV较高<年代ub>1</年代ub>,FEV<年代ub>1</年代ub>/ FVC、肺质量、重量、FFMI,但是低数量的包年熏,AWT-Pi10, % LAA主题与慢性阻塞性肺病。组内,男性有更高的体重,FFMI肺质量,数量的包年吸烟和AWT-Pi10 FMI低于女性。只有在与COPD女性、年龄和% LAA与慢性阻塞性肺病比男人低。</gydF4y2Bap> <div class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-content fig-content-tab1"> <table class="table-group" id="tab1"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr> <td align="left"></td> <td align="center" colspan="2">受试者没有慢性阻塞性肺病</tdgydF4y2Ba> <td align="center" colspan="2">主题与慢性阻塞性肺病</tdgydF4y2Ba> </tr> <tr> <td align="left"></td> <td align="center">男人</tdgydF4y2Ba> <td align="center">女性</tdgydF4y2Ba> <td align="center">男人</tdgydF4y2Ba> <td align="center">女性</tdgydF4y2Ba> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="left">不。的主题,<我>n</我></td> <td align="center">238年</tdgydF4y2Ba> <td align="center">221年</tdgydF4y2Ba> <td align="center">299年</tdgydF4y2Ba> <td align="center">164年</tdgydF4y2Ba> </tr> <tr> <td align="left">年龄、y</tdgydF4y2Ba> <td align="center">55.9±9.6</tdgydF4y2Ba> <td align="center">54.8±9.1</tdgydF4y2Ba> <td align="center"><span style="width: 71.012497px;"> <svg height="13.1" id="M7" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 71.012497 13.1" width="71.012497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代pan> </text> <text transform="matrix(1,0,0,-1,-20.32,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 79.212502px;"> <svg height="15.3375" id="M8" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 79.212502 15.3375" width="79.212502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代pan> </text> <text transform="matrix(1,0,0,-1,-20.32,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">残,% pred</tdgydF4y2Ba> <td align="center">93.9±8.4</tdgydF4y2Ba> <td align="center">95.9±9.4<年代up>__</年代up></td> <td align="center"><span style="width: 78.824997px;"> <svg height="13.1" id="M9" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.1" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.824997px;"> <svg height="13.225" id="M10" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.225" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.225)"> <g transform="translate(72,-61.42)"> <text transform="matrix(1,0,0,-1,-71.95,62.56)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">FEV1 / FVC的</tdgydF4y2Ba> <td align="center">0.79±0.04</tdgydF4y2Ba> <td align="center">0.79±0.04</tdgydF4y2Ba> <td align="center"><span style="width: 78.824997px;"> <svg height="13.1" id="M11" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.1" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 87.025002px;"> <svg height="15.3375" id="M12" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 87.025002 15.3375" width="87.025002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">体重公斤</tdgydF4y2Ba> <td align="center">86.0±13.1</tdgydF4y2Ba> <td align="center">70.9±12.8<年代up>__</年代up></td> <td align="center"><span style="width: 78.824997px;"> <svg height="13.1" id="M13" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.1" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 87.025002px;"> <svg height="15.4625" id="M14" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 87.025002 15.4625" width="87.025002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.4625)"> <g transform="translate(72,-59.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">BMI,公斤/米<年代up>2</年代up></td> <td align="center">27.0±3.4</tdgydF4y2Ba> <td align="center">25.8±4.5<年代up>__</年代up></td> <td align="center"><span style="width: 71.012497px;"> <svg height="13.1" id="M15" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 71.012497 13.1" width="71.012497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代pan> </text> <text transform="matrix(1,0,0,-1,-20.32,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center">24.9±5.6</tdgydF4y2Ba> </tr> <tr> <td align="left">FFMI,公斤/米<年代up>2</年代up></td> <td align="center">19.3±1.6</tdgydF4y2Ba> <td align="center">16.8±1.7<年代up>__</年代up></td> <td align="center"><span style="width: 71.012497px;"> <svg height="13.225" id="M16" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 71.012497 13.225" width="71.012497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.225)"> <g transform="translate(72,-61.42)"> <text transform="matrix(1,0,0,-1,-71.95,62.56)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代pan> </text> <text transform="matrix(1,0,0,-1,-20.32,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 79.212502px;"> <svg height="15.3375" id="M17" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 79.212502 15.3375" width="79.212502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 9</t年代pan> </text> <text transform="matrix(1,0,0,-1,-20.32,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">FMI,公斤/米<年代up>2</年代up></td> <td align="center">7.7±2.6</tdgydF4y2Ba> <td align="center">8.9±3.5<年代up>__</年代up></td> <td align="center"><span style="width: 63.1875px;"> <svg height="13.1" id="M18" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 63.1875 13.1" width="63.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="18.404415" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="29.744637" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="39.121887" y="0"> 8</t年代pan> </text> <text transform="matrix(1,0,0,-1,-26.57,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 62.9375px;"> <svg height="15.3375" id="M19" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 62.9375 15.3375" width="62.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="18.404415" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="29.744637" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="39.121887" y="0"> 9</t年代pan> </text> <text transform="matrix(1,0,0,-1,-26.57,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">肺质量,克</tdgydF4y2Ba> <td align="center">905.2±138.9</tdgydF4y2Ba> <td align="center">753.0±113.5<年代up>__</年代up></td> <td align="center"><span style="width: 94.449997px;"> <svg height="13.2875" id="M20" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 94.449997 13.2875" width="94.449997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.2875)"> <g transform="translate(72,-61.37)"> <text transform="matrix(1,0,0,-1,-71.95,62.51)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 5</t年代pan> </text> <text transform="matrix(1,0,0,-1,-1.56,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 102.65px;"> <svg height="15.3375" id="M21" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 102.65 15.3375" width="102.65" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 2</t年代pan> </text> <text transform="matrix(1,0,0,-1,-1.56,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">不。包年,y</tdgydF4y2Ba> <td align="center">21.2±14.4</tdgydF4y2Ba> <td align="center">17.2±12.6<年代up>__</年代up></td> <td align="center"><span style="width: 78.824997px;"> <svg height="13.225" id="M22" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.225" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.225)"> <g transform="translate(72,-61.42)"> <text transform="matrix(1,0,0,-1,-71.95,62.56)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 8</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 87.025002px;"> <svg height="15.3375" id="M23" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 87.025002 15.3375" width="87.025002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">AWT-Pi10,厘米</tdgydF4y2Ba> <td align="center">0.49±0.03</tdgydF4y2Ba> <td align="center">0.46±0.03<年代up>__</年代up></td> <td align="center"><span style="width: 78.824997px;"> <svg height="13.1" id="M24" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.824997 13.1" width="78.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 87.025002px;"> <svg height="15.3375" id="M25" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 87.025002 15.3375" width="87.025002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.3375)"> <g transform="translate(72,-59.73)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代pan> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left"><span style="width: 131px;"> <svg height="14.825" id="M26" style="vertical-align:-0.23825pt" version="1.1" viewbox="0 0 131 14.825" width="131" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.825)"> <g transform="translate(72,-60.14)"> <text transform="matrix(1,0,0,-1,-71.95,60.43)"> <tspan style="font-size: 12.50px; " x="0" y="0"> %</t年代pan> <tspan style="font-size: 12.50px; " x="9.3397408" y="0"> l</t年代pan> <tspan style="font-size: 12.50px; " x="16.966572" y="0"> 一个</t年代pan> <tspan style="font-size: 12.50px; " x="25.993736" y="0"> 一个</t年代pan> </text> <text transform="matrix(1,0,0,-1,-36.93,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> (</t年代pan> <tspan style="font-size: 8.75px; " x="2.9144161" y="0"> l</t年代pan> <tspan style="font-size: 8.75px; " x="5.3474722" y="0"> o</t年代pan> <tspan style="font-size: 8.75px; " x="9.7234716" y="0"> g</t年代pan> </text> <text transform="matrix(1,0,0,-1,-16.99,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> t</t年代pan> <tspan style="font-size: 8.75px; " x="2.4330561" y="0"> r</t年代pan> <tspan style="font-size: 8.75px; " x="5.329968" y="0"> 一个</t年代pan> <tspan style="font-size: 8.75px; " x="9.2158556" y="0"> n</t年代pan> <tspan style="font-size: 8.75px; " x="13.591856" y="0"> 年代</t年代pan> <tspan style="font-size: 8.75px; " x="16.996384" y="0"> f</t年代pan> <tspan style="font-size: 8.75px; " x="19.630735" y="0"> o</t年代pan> <tspan style="font-size: 8.75px; " x="24.006737" y="0"> r</t年代pan> <tspan style="font-size: 8.75px; " x="27.08744" y="0"> 米</t年代pan> <tspan style="font-size: 8.75px; " x="33.896496" y="0"> e</t年代pan> <tspan style="font-size: 8.75px; " x="37.782383" y="0"> d</t年代pan> </text> <text transform="matrix(1,0,0,-1,25.17,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> )</t年代pan> </text> </g> </g> </svg></span></td> <td align="center">1.04±1.05</tdgydF4y2Ba> <td align="center">0.72±0.89</tdgydF4y2Ba> <td align="center"><span style="width: 94.449997px;"> <svg height="13.1" id="M27" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 94.449997 13.1" width="94.449997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.1)"> <g transform="translate(72,-61.52)"> <text transform="matrix(1,0,0,-1,-71.95,62.66)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代pan> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代pan> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代pan> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 8</t年代pan> </text> <text transform="matrix(1,0,0,-1,-1.56,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 94.837502px;"> <svg height="15.4625" id="M28" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 94.837502 15.4625" width="94.837502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.4625)"> <g transform="translate(72,-59.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</t年代pan> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代pan> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代pan> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代pan> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代pan> </text> <text transform="matrix(1,0,0,-1,-7.82,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ,</t年代pan> <tspan style="font-size: 8.75px; " x="6.765296" y="0"> __</t年代pan> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="5"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>数据意味着±SD。残:在一秒钟用力呼气量,FEV1 / FVC的:tiffeneau指数(BMI:身体质量指数,FFMI:脱脂质量指数,FMI:脂肪质量指数,AWT-Pi10:标准化气道壁厚在内部的周长10毫米,% LAA:百分比低衰减地区低于950−胡。<年代vg height="11.9" id="M29" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 59.887501 11.9" width="59.887501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.9)"> <g transform="translate(72,-62.48)"> <text transform="matrix(1,0,0,-1,-71.95,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> <text transform="matrix(1,0,0,-1,-66.87,62.83)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代pan> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代pan> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 5</t年代pan> </text> </g> </g> </svg>与主题没有慢性阻塞性肺病,<年代vg height="14.15" id="M30" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 59.637501 14.15" width="59.637501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.15)"> <g transform="translate(72,-60.68)"> <text transform="matrix(1,0,0,-1,-71.95,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> __</t年代pan> </text> <text transform="matrix(1,0,0,-1,-67.08,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代pan> <tspan style="font-size: 12.50px; " x="10.902616" y="0"> <</t年代pan> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 5</t年代pan> </text> </g> </g> </svg>而男性。<gydF4y2Babr></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/pm/2011/419328/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 研究对象的一般特征为性别分层。</d我v> </div> </div> <p>的情况下,男性和女性的慢性阻塞性肺病% LAA与体重指数负相关,FFMI和FMI(表<一个href="//www.newsama.com/journals/pm/2011/419328/tab2/" target="_blank">2</一个>)。AWT-Pi10呈正相关,BMI、FFMI和FMI受试者和慢性阻塞性肺病。此外,只有在与COPD受试者,肺与% LAA质量显著相关(<年代vg height="11.225" id="M31" style="vertical-align:-0.1638pt;width:65.050003px;" version="1.1" viewbox="0 0 65.050003 11.225" width="65.050003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.963)"> <path d="M393 379q-9 -16 -28 -29q-15 -10 -23 -2q-19 19 -36 19q-21 0 -52 -38q-57 -72 -82 -126l-40 -197q-23 -3 -75 -18l-7 7q49 196 74 335q7 43 -2 43q-7 0 -30 -14.5t-47 -37.5l-16 23q37 42 82 73t67 31q41 0 15 -113l-11 -50h4q41 71 85 117t77 46q29 0 45 -26 q13 -21 0 -43z" id="x1D45F"></path> </g> <g transform="matrix(.017,-0,0,-.017,11.945,10.963)"> <path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path> </g> <g transform="matrix(.017,-0,0,-.017,26.649,10.963)"> <path d="M535 230h-483v50h483v-50z" id="x2212"></path> </g> <g transform="matrix(.017,-0,0,-.017,36.627,10.963)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,44.786,10.963)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,48.662,10.963)"> <use xlink:href="#x32"></use> </g> <g transform="matrix(.017,-0,0,-.017,56.821,10.963)"> <use xlink:href="#x36"></use> </g> </svg>,<年代vg height="11.375" id="M32" style="vertical-align:-0.1638pt;width:50.549999px;" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.112)"> <use xlink:href="#x1D443"></use> </g> <g transform="matrix(.017,-0,0,-.017,15.582,11.112)"> <use xlink:href="#x3C"></use> </g> <g transform="matrix(.017,-0,0,-.017,30.286,11.112)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,34.162,11.112)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,42.321,11.112)"> <use xlink:href="#x31"></use> </g> </svg>),相关仍FFMI校正后(<年代vg height="11.125" id="M33" style="vertical-align:-0.1638pt;width:65.050003px;" version="1.1" viewbox="0 0 65.050003 11.125" width="65.050003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,10.862)"> <use xlink:href="#x1D45F"></use> </g> <g transform="matrix(.017,-0,0,-.017,11.945,10.862)"> <use xlink:href="#x3D"></use> </g> <g transform="matrix(.017,-0,0,-.017,26.649,10.862)"> <use xlink:href="#x2212"></use> </g> <g transform="matrix(.017,-0,0,-.017,36.627,10.862)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,44.786,10.862)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,48.662,10.862)"> <use xlink:href="#x32"></use> </g> <g transform="matrix(.017,-0,0,-.017,56.821,10.862)"> <use xlink:href="#x33"></use> </g> </svg>,<年代vg height="11.375" id="M34" style="vertical-align:-0.1638pt;width:50.549999px;" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.112)"> <use xlink:href="#x1D443"></use> </g> <g transform="matrix(.017,-0,0,-.017,15.582,11.112)"> <use xlink:href="#x3C"></use> </g> <g transform="matrix(.017,-0,0,-.017,30.286,11.112)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,34.162,11.112)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,42.321,11.112)"> <use xlink:href="#x31"></use> </g> </svg>)。</gydF4y2Bap> <div class="floats-partial-section partial-other-wrapper" data-section="tab2"> <div class="floats-partial-content fig-content-tab2"> <table class="table-group" id="tab2"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr> <td align="left"></td> <td align="center" colspan="2">男人</tdgydF4y2Ba> <td align="center" colspan="2">女性</tdgydF4y2Ba> </tr> <tr> <td align="left"></td> <td align="center">% LAA</tdgydF4y2Ba> <td align="center">AWT-Pi10</tdgydF4y2Ba> <td align="center">% LAA</tdgydF4y2Ba> <td align="center">AWT-Pi10</tdgydF4y2Ba> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="center" colspan="5"><i>受试者没有慢性阻塞性肺病</我></td> </tr> <tr> <td align="left">身体质量指数</tdgydF4y2Ba> <td align="center">0.03</tdgydF4y2Ba> <td align="center">0.41<年代up>__</年代up></td> <td align="center">−0.10</tdgydF4y2Ba> <td align="center">0.32<年代up>__</年代up></td> </tr> <tr> <td align="left">FFMI</tdgydF4y2Ba> <td align="center">−0.02</tdgydF4y2Ba> <td align="center">0.23<年代up>__</年代up></td> <td align="center">−0.05</tdgydF4y2Ba> <td align="center">0.25<年代up>__</年代up></td> </tr> <tr> <td align="left">FMI</tdgydF4y2Ba> <td align="center">0.03</tdgydF4y2Ba> <td align="center">0.42<年代up>__</年代up></td> <td align="center">−0.10</tdgydF4y2Ba> <td align="center">0.27<年代up>__</年代up></td> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="center" colspan="5"><i>主题与慢性阻塞性肺病</我></td> </tr> <tr> <td align="left">身体质量指数</tdgydF4y2Ba> <td align="center">−0.40<年代up>__</年代up></td> <td align="center">0.33<年代up>__</年代up></td> <td align="center">−0.34<年代up>__</年代up></td> <td align="center">0.34<年代up>__</年代up></td> </tr> <tr> <td align="left">FFMI</tdgydF4y2Ba> <td align="center">−0.43<年代up>__</年代up></td> <td align="center">0.29<年代up>__</年代up></td> <td align="center">−0.39<年代up>__</年代up></td> <td align="center">0.37<年代up>__</年代up></td> </tr> <tr> <td align="left">FMI</tdgydF4y2Ba> <td align="center">−0.34<年代up>__</年代up></td> <td align="center">0.31<年代up>__</年代up></td> <td align="center">−0.30<年代up>__</年代up></td> <td align="center">0.32<年代up>__</年代up></td> </tr> <tr class="table-tr"> <td colspan="5"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>BMI:身体质量指数,FFMI:脱脂质量指数,FMI:脂肪质量指数,AWT-Pi10:标准化气道壁厚在内部的周长10毫米,% LAA:低衰减比例低于950−胡。显著相关:<年代vg height="11.9" id="M35" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 54.674999 11.9" width="54.674999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.9)"> <g transform="translate(72,-62.48)"> <text transform="matrix(1,0,0,-1,-71.95,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> <text transform="matrix(1,0,0,-1,-66.87,62.83)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代pan> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代pan> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 5</t年代pan> </text> </g> </g> </svg>,<年代vg height="14.15" id="M36" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 54.424999 14.15" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.15)"> <g transform="translate(72,-60.68)"> <text transform="matrix(1,0,0,-1,-71.95,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> __</t年代pan> </text> <text transform="matrix(1,0,0,-1,-67.08,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代pan> <tspan style="font-size: 12.50px; " x="10.902616" y="0"> <</t年代pan> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 。</t年代pan> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 0</t年代pan> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 1</t年代pan> </text> </g> </g> </svg>。<gydF4y2Babr></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表2</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/pm/2011/419328/tab2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 斯皮尔曼相关系数之间% LAA AWT-Pi10和身体成分的标志。</d我v> </div> </div> <p>在受试者没有慢性阻塞性肺病,多元回归分析显示,FMI % LAA显著相关,而与AWT-Pi10 FMI和FFMI都显著相关(表<一个href="//www.newsama.com/journals/pm/2011/419328/tab3/" target="_blank">3</一个>)。与COPD受试者,FFMI % LAA负协变量,而FMI AWT-Pi10积极的协变量。男人和女人之间的关联没有差别(数据没有显示)。</gydF4y2Bap> <div class="floats-partial-section partial-other-wrapper" data-section="tab3"> <div class="floats-partial-content fig-content-tab3"> <table class="table-group" id="tab3"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="7"> <hr></td> </tr> <tr> <td align="left"></td> <td align="center" colspan="3">日志<年代vg height="14.975" id="M37" style="vertical-align:-2.21957pt" version="1.1" viewbox="0 0 60.650002 14.975" width="60.650002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.975)"> <g transform="translate(72,-60.02)"> <text transform="matrix(1,0,0,-1,-71.95,62.28)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代pan> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> %</t年代pan> <tspan style="font-size: 12.50px; " x="13.50324" y="0"> l</t年代pan> <tspan style="font-size: 12.50px; " x="21.13007" y="0"> 一个</t年代pan> <tspan style="font-size: 12.50px; " x="30.157236" y="0"> 一个</t年代pan> <tspan style="font-size: 12.50px; " x="39.184402" y="0"> )</t年代pan> </text> <text transform="matrix(1,0,0,-1,-28.6,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> </g> </g> </svg></td> <td align="center" colspan="3">AWT。<年代vg height="12.0625" id="M38" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 40.875 12.0625" width="40.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.0625)"> <g transform="translate(72,-62.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> P</t年代pan> <tspan style="font-size: 12.50px; " x="6.9641709" y="0"> 我</t年代pan> <tspan style="font-size: 12.50px; " x="10.440005" y="0"> 1</t年代pan> <tspan style="font-size: 12.50px; " x="16.691505" y="0"> 0</t年代pan> </text> <text transform="matrix(1,0,0,-1,-49.01,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ∗</t年代pan> </text> </g> </g> </svg></td> </tr> <tr> <td align="left"></td> <td align="center">β</tdgydF4y2Ba> <td align="center">SE</tdgydF4y2Ba> <td align="center"><i>P</我>价值</tdgydF4y2Ba> <td align="center">β</tdgydF4y2Ba> <td align="center">SE</tdgydF4y2Ba> <td align="center"><i>P</我>价值</tdgydF4y2Ba> </tr> <tr> <td align="center" colspan="7"> <hr></td> </tr> <tr> <td align="center" colspan="7"><i>受试者没有慢性阻塞性肺病</我></td> </tr> <tr> <td align="left">FFMI</tdgydF4y2Ba> <td align="center">−0.04</tdgydF4y2Ba> <td align="center">0.02</tdgydF4y2Ba> <td align="center">.528</tdgydF4y2Ba> <td align="center">0.16</tdgydF4y2Ba> <td align="center">0.01</tdgydF4y2Ba> <td align="center">.002</tdgydF4y2Ba> </tr> <tr> <td align="left">FMI</tdgydF4y2Ba> <td align="center">0.09</tdgydF4y2Ba> <td align="center">0.01</tdgydF4y2Ba> <td align="center">.053</tdgydF4y2Ba> <td align="center">0.22</tdgydF4y2Ba> <td align="center">0.01</tdgydF4y2Ba> <td align="center"><措施</tdgydF4y2Ba> </tr> <tr> <td align="left"><i>调整R<年代up>2</年代up></i></td> <td align="center" colspan="3"><i>0.26</我></td> <td align="center" colspan="3"><i>0.33</我></td> </tr> <tr> <td align="center" colspan="7"> <hr></td> </tr> <tr> <td align="center" colspan="7"><i>主题与慢性阻塞性肺病</我></td> </tr> <tr> <td align="left">FFMI</tdgydF4y2Ba> <td align="center">−0.28</tdgydF4y2Ba> <td align="center">0.02</tdgydF4y2Ba> <td align="center">.002</tdgydF4y2Ba> <td align="center">0.08</tdgydF4y2Ba> <td align="center">0.02</tdgydF4y2Ba> <td align="center">.460</tdgydF4y2Ba> </tr> <tr> <td align="left">FMI</tdgydF4y2Ba> <td align="center">0.03</tdgydF4y2Ba> <td align="center">0.01</tdgydF4y2Ba> <td align="center">.686</tdgydF4y2Ba> <td align="center">0.20</tdgydF4y2Ba> <td align="center">0.01</tdgydF4y2Ba> <td align="center">.020</tdgydF4y2Ba> </tr> <tr> <td align="left"><i>调整R<年代up>2</年代up></i></td> <td align="center" colspan="3"><i>0.48</我></td> <td align="center" colspan="3"><i>0.30</我></td> </tr> <tr class="table-tr"> <td colspan="7"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>% LAA:百分比低衰减地区低于950−HU AWT-Pi10:标准化气道壁厚在内部的周长10毫米,FFMI:脱脂质量指数,FMI:脂肪质量指数。<gydF4y2Babr> <svg height="14.9375" id="M39" style="vertical-align:-2.7337pt" version="1.1" viewbox="0 0 62.512501 14.9375" width="62.512501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.9375)"> <g transform="translate(72,-60.05)"> <text transform="matrix(1,0,0,-1,-71.95,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> </text> <text transform="matrix(1,0,0,-1,-66.87,62.83)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 一个</t年代pan> <tspan style="font-size: 12.50px; " x="8.8146152" y="0"> d</t年代pan> <tspan style="font-size: 12.50px; " x="15.066115" y="0"> j</t年代pan> <tspan style="font-size: 12.50px; " x="18.541948" y="0"> u</t年代pan> <tspan style="font-size: 12.50px; " x="24.793449" y="0"> 年代</t年代pan> <tspan style="font-size: 12.50px; " x="29.557093" y="0"> t</t年代pan> <tspan style="font-size: 12.50px; " x="33.032925" y="0"> e</t年代pan> <tspan style="font-size: 12.50px; " x="38.584259" y="0"> d</t年代pan> </text> </g> </g> </svg>年龄,包年,FEV1 % pred),和AWT-Pi10,<gydF4y2Babr> <svg height="14.9375" id="M40" style="vertical-align:-2.7337pt" version="1.1" viewbox="0 0 68.237503 14.9375" width="68.237503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.9375)"> <g transform="translate(72,-60.05)"> <text transform="matrix(1,0,0,-1,-71.95,67.83)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ∗</t年代pan> <tspan style="font-size: 8.75px; " x="4.5772958" y="0"> ∗</t年代pan> </text> <text transform="matrix(1,0,0,-1,-62.3,62.83)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 一个</t年代pan> <tspan style="font-size: 12.50px; " x="8.8271179" y="0"> d</t年代pan> <tspan style="font-size: 12.50px; " x="15.078618" y="0"> j</t年代pan> <tspan style="font-size: 12.50px; " x="18.554453" y="0"> u</t年代pan> <tspan style="font-size: 12.50px; " x="24.805952" y="0"> 年代</t年代pan> <tspan style="font-size: 12.50px; " x="29.569595" y="0"> t</t年代pan> <tspan style="font-size: 12.50px; " x="33.045429" y="0"> e</t年代pan> <tspan style="font-size: 12.50px; " x="38.59676" y="0"> d</t年代pan> </text> </g> </g> </svg>年龄,包年,FEV1 (% pred), % LAA。<gydF4y2Babr></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表3</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/pm/2011/419328/tab3/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 多元线性回归分析肺气肿(% LAA)水平的变化和改变气道壁厚(AWT-Pi10)水平无脂质量指数(FFMI)和脂肪水平质量指数(FMI)。</d我v> </div> </div> <p>男性COPD的病例中,15.5%有肌肉萎缩;其中,88.9%有很高的肺气肿分数(图<一个href="//www.newsama.com/journals/pm/2011/419328/fig1/" target="_blank">1</一个>)。女性中,约有27%的慢性阻塞性肺病例肌肉萎缩;67.4%的人高肺气肿的分数。反过来,所有的男人肺气肿得分高(62.5%),只有22%的人肌肉萎缩。,47.5%的女性和肺气肿的分数高,约28%的人肌肉萎缩。辨别能力FFMI预测高% LAA呈现在图<一个href="//www.newsama.com/journals/pm/2011/419328/fig2/" target="_blank">2</一个>。的AUC FFMI在预测高% LAA为0.60(95%可信区间(CI): 0.55 - -0.65;灵敏度:26.7;特异性:90.2),表明适度的健康。</gydF4y2Bap> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig1"> <div class="floats-partial-content fig-content-fig1"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e="419328.fig.001a" src="https://static-01.hindawi.com/articles/pm/volume-2011/419328/figures/419328.fig.001a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e="419328.fig.001b" src="https://static-01.hindawi.com/articles/pm/volume-2011/419328/figures/419328.fig.001b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig1"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e="419328.fig.001a" src="https://static-01.hindawi.com/articles/pm/volume-2011/419328/figures/419328.fig.001a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e="419328.fig.001b" src="https://static-01.hindawi.com/articles/pm/volume-2011/419328/figures/419328.fig.001b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig1"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/pm/2011/419328/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 的男性(a)和女性(b)与正常或高% LAA肌肉萎缩。</t一个ble> </div> </div> </div> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig2"> <div class="floats-partial-content fig-content-fig2"> <div class="partial-carousel--single-image"> <img alt="" name="419328.fig.002" src="https://static-01.hindawi.com/articles/pm/volume-2011/419328/figures/419328.fig.002.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图2</年代pan> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/pm/2011/419328/fig2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 接收操作特征FFMI与COPD受试者。</t一个ble> </div> </div> </div> <h4 id="discussion">4所示。讨论</gydF4y2Bah4> <p>本研究的结果显示,无脂肪质量指数下降随着肺气肿的程度增加与慢性阻塞性肺病男性和女性。这种关系是独立于年龄、包年、FEV1 (% pred)、气道壁厚。然而,肌肉萎缩只是温和的歧视对肺气肿的存在。此外,气道壁厚脂肪质量指数呈正相关的主题和慢性阻塞性肺病。</gydF4y2Bap> <p>逆协会% LAA FFMI和/或FMI曾被观察到在一个极端的吸烟史的男性<一个href="#B2">2</一个>,<一个href="#B3">3</一个>]。我们扩展知识通过展示协会适用于男女双方,也存在于对象不吸烟负担(例如,意思是包年= 65 (<一个href="#B3">3</一个>)和30本研究)和肺气肿程度(例如,在[% LAA = 29%<一个href="#B3">3</一个>)在本研究对11%)。进一步,我们观察到FFMI是独立与肺气肿程度有关。这一发现加强缺陷再生过程的假说与COPD受试者的软组织和肺气肿的表现型。虽然原因尚不清楚,各种假设思维。肺气肿的特点是远端空域的扩大,破坏引起的气道壁(<一个href="#B17">17</一个>]。假设,炎症反应导致蛋白酶antiprotease失衡,因此从肺组织破坏扩展全身软组织。然而,呼吸道和系统性炎症过程之间的联系必须证明。另一种假说声称肺气肿是一种自身免疫性疾病影响肺癌和其他系统性elastin-rich肺气肿患者的组织(<一个href="#B18">18</一个>]。上述假设都是基于假设软组织是肺气肿的结果。事实上,严重肺气肿患者肺减容手术6个月后显示无脂肪的增加质量,这意味着疾病的系统性影响,至少在一定程度上,被逆转<一个href="#B19">19</一个>]。然而没有令人信服的数据来证实肌肉萎缩是次要的肺气肿。事实上,它已被证明,厌食症患者CT密度较低相比,健康受试者(<一个href="#B20">20.</一个>),指出饥饿的假设<我>本身</我>可以诱导二次肺气肿。此外,虽然大多数科目与肌肉萎缩肺气肿分数高,FFMI的预测价值肺气肿只是温和,表明各种途径参与肺气肿的发病机制。更多的研究是必要的为了揭开肌肉萎缩的时间序列,肺气肿表型的存在,以及两者之间的相互关系。</gydF4y2Bap> <p>在当前的研究中,FMI是一个积极的协变量AWT-Pi10受试者和慢性阻塞性肺病。先前的研究结果对气道壁厚之间的相关性和BMI是有争议的;研究显示没有(<一个href="#B2">2</一个>和积极的相关性<一个href="#B4">5</一个>]。直到现在,没有相关研究与FMI气道壁厚。两者之间的正相关在本研究加强了假说的支气管炎表型CT测量航空公司有关慢性支气管炎的症状(<一个href="#B15">15</一个>]。然而,协会不特异,质疑的有效性AWT-Pi10表型COPD的一个特定的标记。</gydF4y2Bap> <p>CT表型之间的关系和身体成分参数没有男人和女人之间的差异。我们最近发现,有特定性别差异% LAA和AWT-Pi10 [<一个href="#B6">7</一个>]。综上所述,这些研究表明男性更容易患肺气肿和气道壁厚而COPD的肺外表现表型可能性别独立,至少对身体成分。</gydF4y2Bap> <p>我们想解决一些研究的局限性和优势。首先,没有慢性阻塞性肺病的受试者比与COPD受试者,年轻甚至艰难的时代已经考虑在多元回归分析中,它仍然可以影响我们的结果。其次,在慢性阻塞性肺病被认为是一个小气道疾病和我们计算AWT-Pi10使用较大的航空公司(<年代vg height="11.375" id="M41" style="vertical-align:-0.1638pt;width:53.712502px;" version="1.1" viewbox="0 0 53.712502 11.375" width="53.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"> <g transform="matrix(.017,-0,0,-.017,.062,11.112)"> <path d="M46 650h247q112 0 169 -41q64 -49 64 -141q0 -91 -56.5 -143t-138.5 -62q-23 -3 -45 -1l-74 19v-157q0 -63 15.5 -77t83.5 -19v-28h-271v28q60 5 74 20t14 77v400q0 65 -12.5 79t-69.5 18v28zM212 559v-245q31 -12 73 -12q59 0 102 38t43 124q0 77 -42.5 115.5 t-108.5 38.5q-44 0 -56 -12q-11 -8 -11 -47z" id="x50"></path> </g> <g transform="matrix(.017,-0,0,-.017,9.48,11.112)"> <path d="M135 536q-20 0 -35 15.5t-15 35.5q0 22 15 37t36 15t35.5 -15t14.5 -37q0 -21 -15 -36t-36 -15zM252 0h-220v26q48 5 59 17t11 63v206q0 47 -9 58t-54 18v24q78 12 142 39v-345q0 -51 11.5 -63t59.5 -17v-26z" id="x69"></path> </g> <g transform="matrix(.017,-0,0,-.017,18.744,11.112)"> <use xlink:href="#x3E"></use> </g> <g transform="matrix(.017,-0,0,-.017,33.448,11.112)"> <use xlink:href="#x30"></use> </g> <g transform="matrix(.017,-0,0,-.017,41.607,11.112)"> <use xlink:href="#x2E"></use> </g> <g transform="matrix(.017,-0,0,-.017,45.483,11.112)"> <use xlink:href="#x36"></use> </g> </svg>厘米),研究表明,CT气道壁厚的估计与组织学测量小航空公司(<一个href="#B21">21</一个>]。最后,肥胖受试者有更多的皮下脂肪通过x射线穿透导致少x射线CT扫描仪和x射线能量检测的“射束硬化”效应导致微分影响x射线衰减值。在肥胖受试者腹部脂肪量的增加也会在仰卧位CT评估期间使用,往往会降低测量肺容积。这两个因素往往会掩盖了观察% LAA和体重指数之间的关系。然而,在受试者没有慢性阻塞性肺病,% LAA和体重之间不存在相关性,这意味着这个技术问题所带来的影响是最小的。本研究的优点是男女双方的大量的科目,没有慢性阻塞性肺病,和CT扫描的定量分析。</gydF4y2Bap> <p>最后,本研究加强了概念,慢性阻塞性肺病患者肌肉萎缩主要是由肺气肿表型特征,减少肺质量,尽管肌肉萎缩并不是歧视的肺气肿。气道壁厚是脂肪质量指数正相关的在这两个科目和慢性阻塞性肺病。气道壁厚是否一个特定的标记用于表型出现慢性阻塞性肺病必须进一步调查。这些发现提供了新的见解的系统性patho-physiology COPD及其表型。</gydF4y2Bap> <h4 id="acknowledgments">确认</gydF4y2Bah4> <p>这项研究是由葛兰素史克公司,挪威研究理事会和呼吸的基础研究,Haukeland大学医院,挪威。论文的作者的贡献如下:e . p . Rutten负责数据解释和写论文;p . s .巴克t . b . Grydeland负责数据收集、分析、解释和评估论文;a . Gulsvik导致了研究设计、数据收集、数据解释,在写论文,9 Pillai负责审查,a . Dirsken h . o . Coxson和S赌注负责数据解释,评估,和e . f . M武泰负责研究设计和审查。</gydF4y2Bap> </div> <div class="xml-content"> <h4 class="references" id="references">引用</gydF4y2Bah4> <ol> <li id="B1">g . f . Filley h . j . Beckwitt j·t·里夫斯和r·s·米切尔“慢性阻塞性支气管肺的疾病。二世。氧气运输两种临床类型,”<我>美国医学杂志》上</我>,44卷,不。1,26-38,1968页。<年代pan class="reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Chronic%20obstructive%20bronchopulmonary%20disease.%20II.%20Oxygen%20transport%20in%20two%20clinical%20types&author=G. F. Filley&author=H. J. Beckwitt&author=J. T. Reeves&author=&author=R. S. Mitchell&publication_year=1968" target="_blank">谷歌学术搜索</一个></span></li> <li id="B2">e . Ogawa y Nakano, t . 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height="24"><span class="text">下载引用</年代pan></span><span class="sc-htoDjs bqeMOy sc-jzgbtB bcxtxQ fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> <a class="sc-htpNat bUhGXt link sc-gFaPwZ hoOvRq sc-iFMziU bGHCWJ ref_desktop" href="//www.newsama.com/journals/pm/2011/419328.ris" aria-label="" target="" id="toolbar__dcNavSmall"><span><img alt="" class="sc-EHOje jOLhQl sc-fhYwyz ieulRf" title="" role="presentation" 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height="24"><span class="text">引用</年代pan></span><span class="sc-htoDjs bqeMOy sc-jzgbtB bcxtxQ fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> </div> </div> <div class="journal_article__ArticleStickyBottomToolbar-sc-12fk6zy-1 isgRZA article_sticky_bottom_toolbar"> <div class="sc-drKuOJ cBpQvD article_bottom_toolbar"> <div class="sc-gRnDUn cZpOzA accordion" property="background-color" color="#D8D8D8" id="toolbar__dofNav"> <span><img alt="" class="sc-EHOje jOLhQl sc-cHSUfg prPtb" title="" role="presentation" src="data:image/svg+xml;base64,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" height="24"><span class="sc-cugefK gzkcXu">下载其他格式</年代pan><span class="sc-fnwBNb iaVowO">更多的</年代pan></span> <span class="sc-htoDjs bMdQcY sc-cTjmhe jIQcJs icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="11"></span> </div> <div class="sc-cmjSyW cpuiKr"> <a class="sc-htpNat bUhGXt link sc-sdtwF hnolyX open_panel" href="//www.newsama.com/downloads/journals/pm/2011/419328.epub" aria-label="ePub" property="background-color" color="#D8D8D8"> <div class="sc-iYUSvU jmLwpf"> ePub</d我v><img alt="" class="sc-EHOje jOLhQl sc-cHSUfg prPtb" title="" role="presentation" 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height="24"><span class="sc-cugefK gzkcXu">订单打印副本</年代pan><span class="sc-fnwBNb iaVowO">订单</年代pan></span><span class="sc-htoDjs kNoiZu sc-cTjmhe jIQcJs right__icon icon-colored _32KP5uexH-Bgs7Kj8Gk1Tz icon-themeable" title="" font-size="16"></span></a> <div class="sc-cBdUnI blbVzE"> <div class="sc-exkUMo bzUZma"> <div> 的观点<年代pan>1713年</年代pan> </div> <div> 下载<年代pan>827年</年代pan> </div> </div> <div> <div class="sc-kcDeIU eatOFG"> <span class="__dimensions_badge_embed__" data-doi="10.1155/2011/419328" data-style="small_circle"></span>引用</d我v> </div> </div> <nav class="sc-Rmtcm hZsedb sc-iNhVCk gOltjj" id="toolbar__iconNav"> <h3 class="sc-csuQGl idXHYp">分享文章</gydF4y2Bah3> <ul class="sc-bRBYWo keayzM"> <li class="iconBorder"><a class="sc-htpNat bUhGXt link" href="https://twitter.com/share?url=https://doi.org/10.1155/2011/419328&via=Hindawi" aria-label="Sharing on Twitter" rel="noopener noreferrer" target="_blank"><img alt="" class="sc-EHOje jOLhQl socialTwitter" title="" role="presentation" 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