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.expand_btn{-webkit-flex:1;-ms-flex:1;flex:1;background:url('data:image/svg+xml;base64,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') no-repeat 6px;background-position:center;margin-top:10px;min-width:55px;display:none;} @media (min-width:768px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .expand_btn{display:none;}} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{-webkit-flex:9;-ms-flex:9;flex:9;text-align:left;padding:21px 37px 10px 0px;font-size:16px;font-weight:700;} @media (min-width:768px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 18px 10px 18px;}} @media (min-width:992px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 21px 10px 21px;}} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{-webkit-flex:1;-ms-flex:1;flex:1;background:url('data:image/svg+xml;base64,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') no-repeat 6px;background-position:center;padding:16px 0 16px 0;min-width:62px;max-width:62px;} @media (min-width:768px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:16px 0 17px 0;min-width:52px;max-width:52px;}} @media (min-width:992px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:15px 0 17px 0;min-width:60px;max-width:60px;}} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url:hover{-webkit-text-decoration:none;text-decoration:none;} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption-text{font-size:14px;padding:0px 18px 17px 22px;} @media (min-width:768px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 15px 15px 18px;}} @media (min-width:992px){.gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 18px 19px 21px;}} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption-text figcaption{margin:0;padding:0;} .gtIExW .floats-partial-section .floats-partial-footer .floats-partial-caption-text svg{max-width:100%;} .gtIExW ol{font-size:16px;padding-left:32px;font-family:STIXGeneral-Regular;line-height:24px;margin:15px 0;} .gtIExW ol li{margin:10px 0;padding-left:10px;word-break:normal;} .gtIExW ol li a{word-break:break-all;} .gtIExW ol li .reflinks{display:block;} .gtIExW ol li .reflinks a{color:#4D8A17;-webkit-text-decoration:none;text-decoration:none;cursor:pointer;} .gtIExW ol li .reflinks a:hover{-webkit-text-decoration:underline;text-decoration:underline;} .gtIExW ol li .reflinks .sep{color:#000000;} .gtIExW .table-wrapper{width:auto;overflow-x:auto;} .gtIExW .table-wrapper::-webkit-scrollbar{-webkit-appearance:none;width:5px;height:5px;} .gtIExW .table-wrapper::-webkit-scrollbar-thumb{border-radius:5px;background-color:rgba(0,0,0,.5);-webkit-box-shadow:0 0 1px rgba(255,255,255,.5);} @media (min-width:768px){.gtIExW .table-wrapper{overflow-x:auto;width:auto;-webkit-break-word:word-break;break-word:word-break;margin:0 auto;}} @media (min-width:992px){.gtIExW .table-wrapper{width:auto;}} @media (min-width:1324px){.gtIExW .table-wrapper{width:auto;}} @media (min-width:320px){.gtIExW{margin-bottom:33px;padding:0;}} @media (min-width:992px){.gtIExW{padding:0;margin-bottom:100px;}} @media (min-width:1325px){.gtIExW{margin-bottom:100px;}} .gtIExW .owl-stage{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;} .gtIExW .floats-partial-middle--thumbs{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;} .gtIExW .floats-partial-middle--thumbs .partial-carousel-dot svg{fill:#4D8A17;} .gtIExW .floats-partial-middle--thumbs .partial-carousel-dot strong{color:#4D8A17;font-weight:500;} .gtIExW .floats-partial-middle--thumbs .partial-carousel-dot.active strong{color:#007B8B;} .gtIExW .floats-partial-middle--thumbs .partial-carousel-dot.active svg{fill:#007B8B;} .gtIExW .floats-partial-middle--thumbs .partial-carousel-dot .nowrap{white-space:nowrap;} .gtIExW .partial-carousel-dot{text-align:center;cursor:pointer;border:0;width:100px;padding-bottom:20px;background-color:#fff;display:table-cell;} .gtIExW .partial-carousel-dot:focus-visible{outline-offset:-3px;} .gtIExW .partial-carousel-dot strong{font-size:11px;padding-top:12px;} @media (min-width:767.5px){.gtIExW .partial-carousel-dot strong{font-size:16px;}} .gtIExW .partial-carousel-dot img{width:90px;height:90px;border:1px solid #979797;margin:10px 0;} .gtIExW .partial-carousel-wrapper .floats-partial-middle{border-top:1px solid #e3e3e3;display:block;margin-bottom:50px;padding-top:1px;} @media (min-width:767.5px){.gtIExW .partial-carousel-wrapper .floats-partial-middle{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;margin-bottom:0;}} .gtIExW .partial-carousel--single-image{overflow:hidden;text-align:center;} .gtIExW .partial-carousel--single-image img{width:100%;max-height:239px;height:auto;} @media (min-width:767.5px){.gtIExW .partial-carousel--single-image img{max-height:357px;}} @media (min-width:991.5px){.gtIExW .partial-carousel--single-image img{max-height:417px;}} .gtIExW .partial-carousel--single-image strong{font-size:11px;padding-top:12px;} @media (min-width:767.5px){.gtIExW .partial-carousel--single-image strong{font-size:16px;}} .gtIExW .owl-nav,.gtIExW .owl-dots{display:none;} .gtIExW .partial-carousel-wrapper .owl-loaded{position:relative;height:auto;max-height:287px;} @media (min-width:767.6px){.gtIExW .partial-carousel-wrapper .owl-loaded{max-height:414px;}} @media (min-width:767.5px){.gtIExW .partial-carousel-wrapper .owl-loaded{max-height:477px;}} .gtIExW .partial-carousel-wrapper .floats-partial-content,.gtIExW .owl-stage-outer,.gtIExW .owl-stage{max-height:287px;height:auto;} @media 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href="//www.newsama.com/journals/mse/" aria-label="Modelling and Simulation in Engineering">建模和模拟在工程</一个>/<一个class="sc-htpNat bUhGXt link sc-eitiEO jXeALb breadCrumb" href="//www.newsama.com/journals/mse/contents/year/2012/" aria-label="2012">2012年</一个>/<年代p一个nclass="sc-bhlBdH UVThf">文章</年代p一个n> </div> <div class="threeColumn__ThreeColumnWrapper-sc-1bf4078-0 dDyxFF threeColumnWrapper"> <div class="threeColumn__LeftWrapper-sc-1bf4078-1 fkVFlF leftWrapper"> <button type="button" class="sc-eKZiaR dzZrgS section__button " id="sectionButton"><span class="sc-htoDjs diutvq icon__dots dots__detector icon-colored _3n-7Ho7DlfjMlZbrRr9Q4a icon-themeable" title="" font-size="22"></span>文章部分</button> <div class="sc-bEjcJn jLUVhb static_contents__section_links links__hidden "> <div id="leftSectionMenu" class="sc-cbkKFq prcY sc-bGbJRg dVCLgr left_section_menu"> <p>在这一页上</p> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD 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href="//www.newsama.com/journals/mse/si/808107/" aria-label="">把这个特殊的问题</一个> <hr class="sc-clNaTc ktFfKO"> </div> <p class="sc-kZmsYB bkiEfx article_type">研究文章|开放获取</p> <div class="sc-RcBXQ ztvYg article_citation"> 体积 2012年 <span class="sc-fZwumE cUsFHx">|</年代p一个n>文章的ID 419087年 <span class="sc-fZwumE cUsFHx">|</年代p一个n> <a class="sc-htpNat bUhGXt link sc-fQejPQ duuwge" href="https://doi.org/10.1155/2012/419087" aria-label="Doi-link">https://doi.org/10.1155/2012/419087</一个> </div> <div class="sc-LKuAh lcOiDF article_full_citation"> <div class="sc-hzNEM gsmOCv isHide"> <p>Marjan Molavi Zarandi,罗塞尔Mongrain奥利维尔·f·伯特兰, ”<年代p一个nclass="adjust-article-svg-size">流条件下测定冠状动脉分叉病变麦地那的上下文分类</年代p一个n>”,<i>建模和模拟在工程</我>, 卷。2012年, 文章的ID419087年, 10   页面, 2012年。 https://doi.org/10.1155/2012/419087</p> </div> <button class="sc-hSdWYo etauus sc-iBEsjs kPshFw" color="">显示引用</button> </div> <h1 class="sc-iRbamj jZOxOO sc-iSDuPN jVSHWt article_title adjust-article-svg-size heading-title">流条件下测定冠状动脉分叉病变麦地那的上下文分类</h1> </div> <div class="sc-jrIrqw eHMFfo article_authors"> <hr class="sc-cEvuZC XkrFe hr__author"> <span class="">Marjan Molavi Zarandi,<年代up>1</年代up></span> <span class=""><b>罗塞尔Mongrain</b><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-hjRWVT irNWJI icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a>,<年代up>1,2</年代up> 和</年代p一个n> <span class="">奥利维尔·f·伯特兰<年代up>3,4</年代up></span> <div class="sc-fHxwqH dMuGGA isHide"> <p><sup>1</年代up><span>机械工程系,QC,加拿大蒙特利尔麦吉尔大学</年代p一个n></p> <p><sup>2</年代up><span>心血管外科学系蒙特利尔心脏研究所,QC,加拿大蒙特利尔</年代p一个n></p> <p><sup>3</年代up><span>魁北克拉瓦尔医院心肺研究所,魁北克市,加拿大的QC</年代p一个n></p> <p><sup>4</年代up><span>拉瓦尔大学医学院,魁北克市,QC,加拿大</年代p一个n></p> </div> <button class="sc-hSdWYo etauus sc-iQtOjA kfDwZY" color="">显示更多</button> </div> <div class="articleContent__EditorWrapper-sc-2yl9jy-3 evMkvU"> <div class="articleContent__TextWrapper-sc-2yl9jy-8 fYrLtk"> <b>学术编辑器:</b>关亨杨紫琼</div> <div class="articleContent__PublicationTimeLineWrapper-sc-2yl9jy-4 fjviok"> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年1月10</年代p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年3月3日</年代p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC isPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年5月22日</年代p一个n> </div> </div> </div> <article class="sc-jtRlXQ gtIExW article_body "> <div> <div class="xml-content"> <h4 class="header" id="abstract">文摘</h4> <p>冠状动脉分叉病变是复杂的,提出了几个分类来形容他们。最近,麦地那分类提出了。这个分类使用二进制值表征狭窄。流条件根据麦地那分类并没有被描述。摘要分叉病变解剖麦地那相应病变分类比较的基础上,流和壁面切应力(WSS)。健康和狭窄的冠状动脉分支,计算模型((1,1,1),(0,1,1)和(1,0,- 1))中度和重度狭窄50%和75%的直径进行了分析。结果表明,流条件下不同分叉病变类型根据面向临床麦地那分类。某人的流分岔麦地那病变类型的依赖和影响在病变类型(1,0,- 1)。WSS的震级分叉病变的内部和外墙的某人(1 0 1)post-stenotic地区和沿动脉壁小于分岔病变(0,1,1),分别为(1,1,1)。我们的研究结果表明,某人的分叉病变(1,0,- 1)是更倾向于动脉粥样硬化进展相比,类型(0,1,1)和(1,1,1)。</p> <span class="end-abs"></span> <h4 id="introduction">1。介绍</h4> <p>从临床实践,众所周知,冠状动脉分支和地区流动强烈扰动,并容易发生动脉粥样硬化病变的发展。作为一个定义,分叉病变是一个冠状动脉狭窄,可能涉及近端主要血管,远端主要血管,侧枝[<一个href="#B1">1</一个>]。分叉病变经皮治疗总是代表着一个重大的挑战[<一个href="#B2">2</一个>- - - - - -<一个href="#B5">5</一个>]。部分挑战是各种相关冠状动脉病变位于一个存在广泛的分歧解剖形态。目前,有七个冠状动脉分叉病变分类方案在文献[<一个href="#B6">6</一个>- - - - - -<一个href="#B13">13</一个>]。这些分类是基于内重要的血管造影狭窄的存在与否的三个分叉的船只。发布的分类都是在描述一个给定的分叉病变非常相似。不同的损伤类型使用数字或字母命名。大多数的分类很难记住<一个href="#B6">6</一个>- - - - - -<一个href="#B11">11</一个>]。第一次尝试克服一些以前的分类的局限性和简化这些分类成功由麦地那et al。<一个href="#B12">12</一个>]。麦地那的分类很简单,不需要记忆,尽管它提供了所有其他分类中包含的信息。在这个分类,分岔分为三个部分:主干近端(MBP),远端(MBD)的主要分支,分支(某人)。任何缩小关键狭窄50%以上的任何部分接收二进制值1;否则,一个二进制值0分配从左到右。三个后缀之间用逗号分隔。在这种背景下,麦地那分类本质上是一种解剖学分类。</p> <p>冠状动脉病理检查表明,动脉粥样硬化病变可能获胜在船是弯曲的地方,分叉,有一个结,侧枝,或其他突然改变流几何,当流动是不稳定的<一个href="#B13">13</一个>- - - - - -<一个href="#B16">16</一个>]。血流动力学因素扮演了重要的角色在动脉粥样硬化的发生和发展<一个href="#B17">17</一个>- - - - - -<一个href="#B19">19</一个>]。研究表明,动脉区域暴露于低和非均匀剪切应力更倾向于动脉粥样硬化病变发展(<一个href="#B20">20.</一个>- - - - - -<一个href="#B23">23</一个>]。</p> <p>到目前为止,还没有报告研究流条件分叉病变与麦地那病变相关的分类。利用计算流体动力学(CFD)的分析,我们研究了(1)流条件MBP, MBD,和某人,和(2)壁剪切应力(WSS)分布在分岔病变(1,1,1),(0,1,1)和(1,0,- 1)。</p> <h4 id="material-and-methods">2。材料和方法</h4> <p>血流动力学分析进行了研究WSS的流动条件和量化冠状动脉分叉的动脉粥样硬化斑块积累最重要的网站(<一个href="#B24">24</一个>- - - - - -<一个href="#B26">26</一个>]。仿真是利用COMSOL 3.5专用multi-physics和工程应用。这个软件使用有限元方法解决方程支配的血流量计算域。计算域是网状的,两者的结合对瞬态,动量方程和连续性方程的牛顿模型血液流动进行了分析。</p> <p>冠状动脉分叉的几何模型被认为是模拟之间的分歧的左主冠状动脉左冠状动脉前降(LMCA)和(小伙子)[<一个href="#B26">26</一个>]。图<一个href="//www.newsama.com/journals/mse/2012/419087/fig1/" target="_blank">1</一个>显示二维血管造影的几何模型预测的分歧(主干近端(MBP),主干远端(MBD)和侧分支(某人))以及相关的分叉病变麦地那病变分类(<一个href="#B3">3</一个>]。在我们的模型中,MBP的维度,MBD,和某人是4毫米,3.4毫米,2.7毫米,某人选择基于冠状动脉造影术的数据(<一个href="#B27">27</一个>]。有充分发展流动在进口和下游狭窄,我们考虑一个分支长度<年代vg height="14.7875" id="M1" style="vertical-align:-3.13504pt;width:50.775002px;" version="1.1" viewbox="0 0 50.775002 14.7875" width="50.775002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7875)"> <g transform="translate(72,-60.17)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> D</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-50.42,60.22)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> </g> </g> </svg>作为一个总分支长度。MBD的分支长度和某人计算中心的分岔结束,等于<年代vg height="14.6" id="M2" style="vertical-align:-3.13504pt;width:52.587502px;" version="1.1" viewbox="0 0 52.587502 14.6" width="52.587502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.6)"> <g transform="translate(72,-60.32)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> D</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-50.42,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> D</t年代p一个n> </text> </g> </g> </svg>和<年代vg height="14.75" id="M3" style="vertical-align:-3.25792pt;width:37.650002px;" version="1.1" viewbox="0 0 37.650002 14.75" width="37.650002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-59.45,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> D</t年代p一个n> <tspan style="font-size: 8.75px; " x="6.318944" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.185056" y="0"> B</t年代p一个n> </text> </g> </g> </svg>,分别。6毫米的病变长度(L)是位于船底座认为分叉病变。中心线的夹角LMCA和小伙子中心线MBD和某人之间的角度(75°)对应于生理解剖范围(<一个href="#B28">28</一个>]。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig1"> <div class="floats-partial-content fig-content-fig1"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.001a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.001a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.001b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.001b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig1"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.001a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.001a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.001b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.001b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig1"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <a href="#B26">26</一个> <a href="#B29">29日</一个> <table> 血管造影冠状动脉分叉的,)和相应的几何模型(a)和相关的麦地那冠状动脉分叉病变分类(b)。</t一个ble> </div> </div> </div> <p>一个类似的二维模型最近提出了一个狭窄的分岔情况(<一个href="#B30">30.</一个>]。</p> <p>在狭窄的分岔,“真正的”这个词分叉病变时使用狭窄的近端或远端部分主要涉及船舶和侧枝[<一个href="#B31">31日</一个>]。因此,根据麦地那病变分类、分叉病变类型(1,1,1),(0,1,1)和(1,0,- 1)是真正的分叉病变。麦地那分类似乎直观,最梗阻性疾病分岔是标记为(1,1,1)。本研究的第二个目的是评估,WSS基础,如果分岔类型(1 1 1)对应于最严重的状况。</p> <p>研究血液流动,我们假设血液可以表示为一个不可压缩流体由质量守恒和动量守恒导致navier - stokes和连续性方程:<年代p一个nclass="equation" id="EEq1"> <svg height="66.349998" id="M4" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 66.349998" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,66.35)"> <g transform="translate(72,-18.92)"> <text transform="matrix(1,0,0,-1,116.38,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.3599997" y="7.3299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="18.940001" y="-7.25"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="32.06815" y="-7.25"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.329033" y="-7.25"> </t年代p一个n> </text> <g> <path d="m 135.32,56.57 12.31,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,136.32,44.69)"> <tspan style="font-size: 12.50px; " x="56.75" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="129.28" y="-6.2399998"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="135.13" y="-8.7600002"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3890328" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.28" y="-8.7600002"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.371841" y="-8.7600002"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.632725" y="-8.7600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="35.322308" y="-8.7600002"> ⋅</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.686337" y="-8.7600002"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.577648" y="-8.7600002"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="50.838531" y="-8.7600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="69.599998" y="-8.7600002"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="81.640388" y="-8.7600002"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="90.204941" y="-8.7600002"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="99.344635" y="-8.7600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="108.23427" y="-8.7600002"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="119.57449" y="-8.7600002"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,280.59,58.45)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,292.22,53.45)"> <tspan style="font-size: 12.50px; " x="-0.82999998" y="2.52"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="7.1100001" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.7516198" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-107.35" y="30.73"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="-95.434639" y="30.73"> ⋅</t年代p一个n> <tspan style="font-size: 12.50px; " x="-82.331497" y="30.73"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="-89.070618" y="30.73"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-79.680862" y="30.73"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="-67.640472" y="30.73"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="-61.388973" y="30.73"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="181.89999" y="11.11"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="186.06349" y="11.11"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="192.315" y="11.11"> )</t年代p一个n> </text> </g> </g> </svg></span>在那里,<我><i>ρ</我></i>表示流体的密度(公斤米<年代up>−3</年代up>),<年代vg height="12.1375" id="M5" style="vertical-align:-0.11285pt;width:7.5374999px;" version="1.1" viewbox="0 0 7.5374999 12.1375" width="7.5374999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.1375)"> <g transform="translate(72,-62.29)"> <text transform="matrix(1,0,0,-1,-65.2,62.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.7391171" y="0"> </t年代p一个n> </text> </g> </g> </svg>速度矢量(m s<年代up>−1</年代up>),<我>p</我>(Pa)的压力,和<我><i>μ</我></i>动态粘度的液体(宾夕法尼亚州)。</p> <p>壁剪切应力测定粘度的产品(<我><i>μ</我></i>)和剪切速率(<年代vg height="12.7625" id="M6" style="vertical-align:-2.34499pt;width:8.0625px;" version="1.1" viewbox="0 0 8.0625 12.7625" width="8.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.7625)"> <g transform="translate(72,-61.79)"> <text transform="matrix(1,0,0,-1,-65.9,64.17)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̇</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.038949" y="0"> </t年代p一个n> </text> </g> </g> </svg>)。剪切速率,在二维空间中定义的根据:<年代p一个nclass="equation" id="EEq3"> <svg height="53.150002" id="M7" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 53.150002" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,53.15)"> <g transform="translate(72,-29.48)"> <text transform="matrix(1,0,0,-1,90.85,45.62)"> <tspan style="font-size: 12.50px; " x="15.81" y="-17.68"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.81" y="-11.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.81" y="-5.3299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.81" y="16.09"> ⎷</t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> ̇</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.038949" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="3.7634029" y="0"> =</t年代p一个n> </text> <g> <path d="m 121.47,70.71 207.36,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,121.47,35.89)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.1" y="-9.7299995"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="16.35" y="-2.4100001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.4" y="-16.99"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="40.528149" y="-16.99"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.789032" y="-16.99"> </t年代p一个n> </text> <g> <path d="m 148.39,48.75 13.27,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,148.39,36.87)"> <tspan style="font-size: 12.50px; " x="14.46" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3890328" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,172.23,60.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,179.88,45.62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.35" y="7.3200002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="22.059999" y="-7.2600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="35.188148" y="-7.2600002"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.449034" y="-7.2600002"> </t年代p一个n> </text> <g> <path d="m 201.8,48.75 12.59,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,201.8,36.87)"> <tspan style="font-size: 12.50px; " x="16.559999" y="-8.75"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.379999" y="-16.01"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="43.040001" y="-16.110001"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.77" y="-16.01"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </t年代p一个n> </text> <g> <path d="m 230.9,48.75 13.27,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,230.9,36.87)"> <tspan style="font-size: 12.50px; " x="14.46" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3890328" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,254.74,60.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,262.39,45.62)"> <tspan style="font-size: 12.50px; " x="17.6" y="7.3200002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="28.17" y="-7.2600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="41.84" y="-7.3600001"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="34.560001" y="-7.2600002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> 2</t年代p一个n> </text> <g> <path d="m 290.56,48.75 12.72,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,290.62,36.87)"> <tspan style="font-size: 12.50px; " x="13.85" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3890328" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,313.85,60.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,318.72,35.89)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.11" y="-9.7299995"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="155.39999" y="-9.7299995"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="159.56349" y="-9.7299995"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="165.815" y="-9.7299995"> )</t年代p一个n> </text> </g> </g> </svg></span>在哪里<年代vg height="12.1375" id="M8" style="vertical-align:-0.11285pt;width:7.5374999px;" version="1.1" viewbox="0 0 7.5374999 12.1375" width="7.5374999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.1375)"> <g transform="translate(72,-62.29)"> <text transform="matrix(1,0,0,-1,-65.2,62.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.7391171" y="0"> </t年代p一个n> </text> </g> </g> </svg>和<年代vg height="12.2625" id="M9" style="vertical-align:-0.11285pt;width:8.0375004px;" version="1.1" viewbox="0 0 8.0375004 12.2625" width="8.0375004" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2625)"> <g transform="translate(72,-62.19)"> <text transform="matrix(1,0,0,-1,-64.67,62.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ⃗</t年代p一个n> <tspan style="font-size: 12.50px; " x="-7.2800002" y="0.1"> </t年代p一个n> </text> </g> </g> </svg>速度组件(<一个href="#B32">32</一个>]。</p> <p>求解控制方程,边界条件是必需的。在目前的研究中,我们假定血管床保持恒流在健康和狭窄的动脉。</p> <p>层流流动被认为是不稳定的,和充分发展研究部分;因此,进口速度分布是将抛物线作为表达的(<一个href="#EEq4">3</一个>):<年代p一个nclass="equation" id="EEq4"> <svg height="48.1875" id="M10" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 48.1875" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,48.1875)"> <g transform="translate(72,-33.45)"> <text transform="matrix(1,0,0,-1,144,49.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3897533" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.430141" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,171.36,46.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="6.8090558" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.694944" y="0"> x</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,190.48,39.87)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="28.629999" y="-2.4000001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="41.650002" y="-16.98"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.2600002" y="-9.7299995"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="17.287167" y="-9.7299995"> −</t年代p一个n> </text> <g> <path d="m 229.69,52.73 14.14,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,229.69,40.85)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,238.94,37.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,245.03,42.27)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,254.4,64.82)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,259.28,39.87)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.35" y="-9.7299995"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="214.84" y="-9.7299995"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="219.00349" y="-9.7299995"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="225.255" y="-9.7299995"> )</t年代p一个n> </text> </g> </g> </svg></span>在哪里<年代vg height="10.325" id="M11" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>径向位置和吗<年代vg height="14.35" id="M12" style="vertical-align:-3.22282pt;width:17.799999px;" version="1.1" viewbox="0 0 17.799999 14.35" width="17.799999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.35)"> <g transform="translate(72,-60.52)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.7,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>内半径的动脉。</p> <p>依赖时间的速度是取自左冠状动脉的文学在心动周期(<一个href="#B33">33</一个>]。波形的时期<年代vg height="10.9125" id="M13" style="vertical-align:-0.17555pt;width:56.325001px;" version="1.1" viewbox="0 0 56.325001 10.9125" width="56.325001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.339981" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.380369" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.63187" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.75762" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="40.097122" y="0"> 年代</t年代p一个n> </text> </g> </g> </svg>,在那里<年代vg height="13.45" id="M14" style="vertical-align:-2.21957pt;width:106.725px;" version="1.1" viewbox="0 0 106.725 13.45" width="106.725" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7148314" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.75522" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="29.832157" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.995659" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.859325" y="0"> e</t年代p一个n> <tspan style="font-size: 12.50px; " x="44.410656" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="49.961987" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.601322" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="69.641708" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="75.893211" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="79.018959" y="0"> 2</t年代p一个n> </text> </g> </g> </svg>收缩,<年代vg height="13.45" id="M15" style="vertical-align:-2.21957pt;width:118.4375px;" version="1.1" viewbox="0 0 118.4375 13.45" width="118.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.45)"> <g transform="translate(72,-61.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.092081" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.132469" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="39.209408" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="43.372906" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.236572" y="0"> e</t年代p一个n> <tspan style="font-size: 12.50px; " x="53.787907" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="59.339237" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="66.978569" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="79.018959" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="85.270462" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="88.39621" y="0"> 7</t年代p一个n> </text> </g> </g> </svg>舒张期阶段。之间的最大速度级休息条件变化0.15 m / s, 0.25 m / s的冠状动脉直径4毫米。动脉流在心脏舒张期峰值MBP 102.2毫升<我>/</我>分钟(<一个href="#B34">34</一个>,<一个href="#B35">35</一个>]。出口的船只,traction-free边界条件是实施(<一个href="#B36">36</一个>]。牛顿血属性在这个模型是血粘度<年代vg height="13.7375" id="M16" style="vertical-align:-2.29482pt;width:72.012497px;" version="1.1" viewbox="0 0 72.012497 13.7375" width="72.012497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.7375)"> <g transform="translate(72,-61.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="11.077658" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.118048" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.369547" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.495296" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.746796" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="44.998299" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.249798" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>Pa。年代,和blood density<年代vg height="13.675" id="M17" style="vertical-align:-2.29482pt;width:58.612499px;" version="1.1" viewbox="0 0 58.612499 13.675" width="58.612499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.675)"> <g transform="translate(72,-61.06)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.031727" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="34.283226" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="40.534725" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>公斤/米<年代up>3</年代up>分别为(<一个href="#B37">37</一个>]。</p> <h4 id="results-and-discussions">3所示。结果和讨论</h4> <p>搏动性血流动力学分析进行了健康和狭窄的分支,研究的影响流条件和WSS分布上的收缩位置。</p> <h5 id="sec3.1">3.1。流模拟相应的健康的冠状动脉分叉</h5> <p>健康的冠状动脉分叉的模型开发和相应的速度场和WSS分布进行调查。心脏舒张期峰值的计算速度场是呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig2/" target="_blank">2</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig2"> <div class="floats-partial-content fig-content-fig2"> <div class="partial-carousel--single-image"> <img alt="" name="419087.fig.002" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.002.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图2</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 速度场在峰值舒张冠状动脉分叉。</t一个ble> </div> </div> </div> <p>速度概要文件在正常冠状动脉分叉倾向于船底座,导致更高的速度沿着内墙壁和低速度沿外墙。</p> <p>牛顿流动,WSS是切向剪切力的大小在墙上的流体和是由墙剪切速率(速度梯度的墙)乘以液体的粘度<年代vg height="13.6125" id="M18" style="vertical-align:-2.34499pt;width:55.387501px;" version="1.1" viewbox="0 0 55.387501 13.6125" width="55.387501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.6125)"> <g transform="translate(72,-61.11)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.028366" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.068754" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="39.734535" y="0"> ̇</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.695583" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="40.034607" y="0"> )</t年代p一个n> </text> </g> </g> </svg>。可以看出,速度的梯度产生显著变化在WSS内外MBD的墙壁和某人WSS分布在健康的动脉心脏舒张期峰值图所示<一个href="//www.newsama.com/journals/mse/2012/419087/fig3/" target="_blank">3</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig3"> <div class="floats-partial-content fig-content-fig3"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.003a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.003a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.003b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.003b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig3"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.003a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.003a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.003b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.003b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig3"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图3</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig3/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 分布健康WSS的冠状动脉分叉(a)和WSS的内外壁某人(b)。</t一个ble> </div> </div> </div> <p>WSS图的分布<一个href="//www.newsama.com/journals/mse/2012/419087/fig3/" target="_blank">3(一个)</一个>显示了高的区域剪切应力在船底座大大大于WSS整个大部分血管壁。</p> <p>内皮细胞(衬动脉壁)受到剪切应力的变化是由于周期性的血液流动的性质。生理WSS的大小范围从1到7 Pa在正常动脉(<一个href="#B38">38</一个>]。壁剪切应力超过此范围可能生成机制,导致血管病理。低WSS的值可能导致动脉粥样硬化过程,因此被认为是“athero-prone”,而WSS高于这个范围可能激活血小板,因此“高剪切诱导血栓形成(<一个href="#B38">38</一个>]。之前<我>在体外</我>和<我>在活的有机体内</我>研究定位区域内动脉粥样硬化主要是干扰血液流动,在WSS低于< 0.5 Pa (<一个href="#B39">39</一个>]。WSS值沿着内部和外墙描绘在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig3/" target="_blank">3</一个>表明的一小部分支架表面暴露在如此低的WSS在心脏舒张期峰值十几分叉模型。WSS的大的值在心脏舒张期峰值发生在某人内壁下游船底座。结果表明,某人,低WSS值发生在外墙。低WSS分布在外墙按照这些领域的动脉粥样硬化病变的定位。的确,有强有力的证据表明,低WSS值可能相关病变定位(<一个href="#B39">39</一个>- - - - - -<一个href="#B41">41</一个>]。</p> <h5 id="sec3.2">3.2。流模拟分叉病变(1,1,1),(0,1,1)和(1,0,- 1)</h5> <p>讨论了水流条件和WSS分布健康的分岔,我们接下来继续检查流条件和WSS麦地那病灶分布三种病变类型分类(图<一个href="//www.newsama.com/journals/mse/2012/419087/fig1/" target="_blank">1</一个>)。在临床医学中,狭窄的严重程度通常被定义为使用直径测量闭塞的百分比:<年代vg height="15.0625" id="M19" style="vertical-align:-3.13504pt;width:216.85001px;" version="1.1" viewbox="0 0 216.85001 15.0625" width="216.85001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.0625)"> <g transform="translate(72,-59.95)"> <text transform="matrix(1,0,0,-1,-71.95,63.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> %</t年代p一个n> <tspan style="font-size: 12.50px; " x="13.50324" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> t</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.75522" y="0"> e</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.306553" y="0"> n</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.558052" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="39.809551" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="44.673218" y="0"> 我</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.149052" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="56.476051" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="72.679939" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="76.843437" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,11.55,60)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,19.2,63.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,37.2,60)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,42.07,63.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.6393328" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,56.36,60)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,64.01,63.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ∗</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3147354" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.566235" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.817736" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.069235" y="0"> %</t年代p一个n> </text> </g> </g> </svg>,在那里<年代vg height="14.475" id="M20" style="vertical-align:-3.13504pt;width:14.5375px;" version="1.1" viewbox="0 0 14.5375 14.475" width="14.5375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.475)"> <g transform="translate(72,-60.42)"> <text transform="matrix(1,0,0,-1,-71.95,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 1</t年代p一个n> </text> </g> </g> </svg>动脉直径和吗<年代vg height="14.475" id="M21" style="vertical-align:-3.13504pt;width:14.5375px;" version="1.1" viewbox="0 0 14.5375 14.475" width="14.5375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.475)"> <g transform="translate(72,-60.42)"> <text transform="matrix(1,0,0,-1,-71.95,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> </g> </g> </svg>是狭隘的直径。随着疾病的进展,狭窄的比例也增加。狭窄的几何本模拟中使用相同的几何艾哈迈德和吉登斯用于他们的实验工作<一个href="#B42">42</一个>]。对称的中度(50%),重度狭窄(75%)与高斯对称的表面形态对MBP, MBD,和某人。</p> <p>计算模型和力学性能是建立基于冠状动脉分叉详细的一节。障碍物在MBP, MBD,某人还远未出口,这样流可以返回到接近充分发展状态,出口边界条件不影响上游活动发生。</p> <p>流建模,网格敏感性分析进行分叉病变(1,1,1),(0,1,1),和(1 0 1)三种不同网格密度和速度场,和WSS值比较不同数量的元素。进行了非定常模拟使用粗,中,细网格的几何估计网格敏感性动脉分叉几何在整个心动周期。在分叉病变(1 1 1)与50%的狭窄,我们使用一个粗网格元素(8665);一个中等网格元素(13097);一个细孔(19625个元素)。结果分析的速度剖面和沿着MBD WSS和某人的速度概要文件和WSS粗网格密度与介质网格显示最大8%的区别。结果表明,速度场和WSS值最大1%差异中、细网格密度。考虑介质的微不足道的区别和细网格密度和计算时间,13097个元素的介质网格和网格密度。插图,分岔类型(1,1,1),我们提出在收缩峰值和峰值速度场在某人舒张了三网密度图<一个href="//www.newsama.com/journals/mse/2012/419087/fig4/" target="_blank">4</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig4"> <div class="floats-partial-content fig-content-fig4"> <div class="partial-carousel--single-image"> <img alt="" name="419087.fig.004" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.004.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图4</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig4/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 速度场在顶峰收缩和舒张峰值某人三网密度。</t一个ble> </div> </div> </div> <p>瞬态模拟进行了狭窄的冠状动脉分支,和相应的速度场和剪切应力的分布进行调查。在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig5/" target="_blank">5</一个>三个代表的快照的速度场的大小在心脏舒张期峰值显示狭窄(50%和75%<年代vg height="10.9125" id="M22" style="vertical-align:-0.17555pt;width:51.75px;" version="1.1" viewbox="0 0 51.75 10.9125" width="51.75" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="7.37677" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.417158" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.668659" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.794409" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.04591" y="0"> 7</t年代p一个n> </text> </g> </g> </svg>s)分叉病变类型(1,1,1),(0,1,1)和(1 0 1)麦地那病变分类。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig5"> <div class="floats-partial-content fig-content-fig5"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.005a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.005a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.005b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.005b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig5"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.005a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.005a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.005b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.005b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig5"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图5</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig5/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 地图速度场的大小和相应的流率在50% (a)和(b)狭窄的分岔的75%。</t一个ble> </div> </div> </div> <p>仿真结果呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig5/" target="_blank">5</一个>显示了一个截然不同的血液流动的速度分布狭窄的分岔的下游,展示了分叉病变类型对血流的影响模式,如流动分离和再循环区。分叉病变最大速度的50%和75%狭窄大约是0.42 m / s, 0.84 m / s,分别与收缩与狭窄的分岔的MBP。下游的病变,墙壁附近的流动减慢和逆转由于粘性的影响。分叉病变类型更狭窄(75%),体验更多的流动分离,更大的再循环区下游分叉病变的狭窄比较狭窄的50%。结果呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig5/" target="_blank">5</一个>还表明,分岔与收缩MBD和某人(1 0 1)最低级的血液流到某人我们计算的比值的大小某人流总MBP流在高峰舒张分叉病变。流值测定聚合仿真结果和速度概要2.4厘米(8 d<年代ub>MBD</年代ub>),1.62厘米(6 d<年代ub>某人</年代ub>)远端MBD的病变和某人。结果病变的存在与否MBD MBP,各种血液动力学条件发生在某人具有相同比例的狭窄(图<一个href="//www.newsama.com/journals/mse/2012/419087/fig5/" target="_blank">5</一个>)。最大血流量的比值可以实现在一个狭窄的某人最大血流在MBP各种中间分叉病变类型和严重狭窄时总结在表<一个href="//www.newsama.com/journals/mse/2012/419087/tab1/" target="_blank">1</一个>。</p> <div class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-content fig-content-tab1"> <table class="table-group" id="tab1"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="4"> <hr></td> </tr> <tr class="thead"> <td align="left">直径减少</td> <td align="center">(1,1,1)</td> <td align="center">(0,1,1)</td> <td align="center">(1,0,- 1)</td> </tr> <tr> <td class="thead-hr" colspan="4"> <hr></td> </tr> <tr> <td align="left">50%</td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.75" id="M23" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.75" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 4</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.9375" id="M24" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.9375" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.9375)"> <g transform="translate(72,-60.05)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.22)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.22)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 5</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.75" id="M25" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.75" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 1</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left" colspan="4"> <hr></td> </tr> <tr> <td align="left">75%</td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.75" id="M26" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.75" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 7</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.75" id="M27" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.75" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 2</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 111.5125px;"> <svg height="14.875" id="M28" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 111.5125 14.875" width="111.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.875)"> <g transform="translate(72,-60.1)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.92,60.27)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8661122" y="0"> B</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-51.72,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> 问</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.22,60.27)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 米</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.618112" y="0"> P</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-16.75,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.405136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 6</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="4"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 某人的比例流向MBP流。</div> </div> </div> <p>因为它是描述在表<一个href="//www.newsama.com/journals/mse/2012/419087/tab1/" target="_blank">1</一个>在分叉病变(1,0,- 1),最大舒张某人流中间和严重狭窄时总数的31%和16% MBP流。结果支持,降低血液流动在某人创建一个至关重要的条件这个分支在分叉病变(1 0 1)相比,分叉病变(1,1,1),和(0,1,1)。</p> <h5 id="sec3.3">3.3。壁剪切应力(WSS)分叉病变类型</h5> <p>WSS是最重要的因素之一,在发展中动脉粥样硬化,动脉分支和发现更容易在动脉斑块形成<一个href="#B20">20.</一个>- - - - - -<一个href="#B23">23</一个>]。虽然动脉粥样硬化是一种疾病影响血管系统作为一个整体,它不均匀分布在某人和MBD相当大的差异不同的分叉病变类型。因此,WSS分布研究了某人的内外壁和MBD真正分岔(1,1,1),(0,1,1)和(1,0,- 1)与麦地那相关病变的分类。</p> <p>在舒张期峰值点的一个心动周期,WSS字段是真实分叉病变50%狭窄的呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig6/" target="_blank">6</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig6"> <div class="floats-partial-content fig-content-fig6"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.006a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.006a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.006b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.006b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig6"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.006a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.006a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.006b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.006b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig6"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图6</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig6/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 壁剪切应力在高峰收缩(a)和心脏舒张期峰值(b)在真正的分叉病变。</t一个ble> </div> </div> </div> <p>的分布规律表明,MBP,上游流量分配器,WSS是统一的。WSS的高峰值在船底座狭窄的中心和分岔。WSS值在内部和外部墙壁山峰狭窄的中心和post-stenosis地区达到最小值,然后逐渐复苏的下游狭窄动脉壁,直到水平。如前所述,低WSS地区与动脉粥样硬化的进展发生在紊流区下游内外墙壁上的狭窄。</p> <p>墙的内外壁剪切应力分布某人下游的狭窄研究分岔类型(1,1,1),(0,1,1)和(1,0,- 1)。WSS下游病变的变化在某人的高墙内外心脏舒张期峰值呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig7/" target="_blank">7</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig7"> <div class="floats-partial-content fig-content-fig7"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.007a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.007b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007b.jpg"> <br> <strong>(b)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(c)”n一个米e=”419087。fig.007c" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007c.jpg"> <br> <strong>(c)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig7"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.007a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.007b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007b.jpg"><br><strong>(b)</年代trong></button> <button class="partial-carousel-dot" aria-label="(c)"><img alt="(c)”n一个米e=”419087。fig.007c" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.007c.jpg"><br><strong>(c)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig7"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图7</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig7/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 高墙内外壁剪应力的某人和心脏舒张期峰值。</t一个ble> </div> </div> </div> <p>比较WSS值沿着内部和外墙之间正常(图<一个href="//www.newsama.com/journals/mse/2012/419087/fig3/" target="_blank">3</一个>并且推测(图)和动脉粥样硬化<一个href="//www.newsama.com/journals/mse/2012/419087/fig7/" target="_blank">7</一个>)显示,动脉硬化的墙壁含有更多的地区暴露在低WSS值。在动脉硬化的分岔,WSS的大小分岔类型的内外壁(1,0,- 1)在狭窄的地区和沿动脉壁小于相应的大小在分岔类型(1 1 1)和(0,1,1)。</p> <p>低WSS地区与动脉粥样硬化的进展发生在狭窄的紊流区下游。某人在分叉病变狭窄,低WSS地区观察poststenosis地区是…我们现在检查的荷载分配行为WSS poststenosis地区的外墙…为此,连续三分(A、B和C)被认为是下游外墙的狭窄。点位于狭窄下游0.1毫米。a - b和c的距离是1.5毫米。WSS下游病变的时间变化,在三个连续点某人的外墙真正提出了分岔图<一个href="//www.newsama.com/journals/mse/2012/419087/fig8/" target="_blank">8</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig8"> <div class="floats-partial-content fig-content-fig8"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.008a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.008b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008b.jpg"> <br> <strong>(b)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(c)”n一个米e=”419087。fig.008c" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008c.jpg"> <br> <strong>(c)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(d)”n一个米e=”419087。fig.008d" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008d.jpg"> <br> <strong>(d)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig8"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.008a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.008b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008b.jpg"><br><strong>(b)</年代trong></button> <button class="partial-carousel-dot" aria-label="(c)"><img alt="(c)”n一个米e=”419087。fig.008c" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008c.jpg"><br><strong>(c)</年代trong></button> <button class="partial-carousel-dot" aria-label="(d)"><img alt="(d)”n一个米e=”419087。fig.008d" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.008d.jpg"><br><strong>(d)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig8"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图8</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig8/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 颞WSS在三分真分叉病变的外墙某人。</t一个ble> </div> </div> </div> <p>WSS整个心动周期的变化是高度相关的流动速度。WSS的力量的特征,纵向作用于血管壁。在高峰收缩和峰值舒张,血液流动平行于墙时快,这些力量会更高。某人墙上,每个点WSS的最大价值在所有分岔类型与心动周期的峰值收缩期和舒张期峰值。WSS分叉病变类型的最大值(1 1 1)和(0,1,1)收缩期和舒张期峰值点是0.65 Pa和0.9 Pa。相应的WSS病变类型(1,0,- 1)是0.58 Pa和0.75 Pa透露WSS的最小大小与损伤类型(1,0,- 1)。WSS的低价值大多是在减速阶段具有两个心动周期时间的三分之一。</p> <p>评估WSS模式变化MBD沿整个墙在心动周期的所有时间步,意味着WSS值沿着内部和外墙下游68个节点的损伤计算分叉病变类型(1,1,1)和(0,1,1)和78个节点的分叉病变类型(1,0,- 1)。意思是WSS值决定在每个时间步长和平均WSS值沿着MBD的内外壁在心动周期呈现在图<一个href="//www.newsama.com/journals/mse/2012/419087/fig9/" target="_blank">9</一个>。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig9"> <div class="floats-partial-content fig-content-fig9"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个米e=”419087。fig.009a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.009a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个米e=”419087。fig.009b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.009b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig9"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个米e=”419087。fig.009a" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.009a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个米e=”419087。fig.009b" src="https://static-01.hindawi.com/articles/mse/volume-2012/419087/figures/419087.fig.009b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig9"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图9</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/mse/2012/419087/fig9/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <table> 意思是WSS值沿着MBD的内外壁在一个心动周期。</t一个ble> </div> </div> </div> <p>WSS的MBD的分布模式显示,大部分地区的支架表面暴露于WSS在生理范围内。比较WSS分布的分叉病变类型(1,1,1),(0,1,1),和(1,0,- 1)表明,在舒张期期间,动脉区域下游分叉病变类型(1,1,1),(0,1,1)暴露降低WSS的大小。</p> <p>作为另一个重要的血流动力学参数,研究了WSS在真正的分叉病变。WSS分布预测下游的狭窄是非常有用的理解的影响干扰流内皮细胞和血液元素附近的墙上,可以用于支持医疗决定。</p> <p>本研究的结果应该被限制内的某些局限性。首先,这项工作中所使用的几何图形是一系列理想化的二维轴对称狭窄动脉分叉理想化。在我们的问题中,狭窄的配置和百分比是固定的而实际上他们可能不同,沿着船出现在不同的地方。本研究的另一个几何限制的事实是我们不合规的船只的构成;所有的船只都视为刚性墙边界。模拟不考虑血液的非牛顿特性。事实上,虽然血表现通常像牛顿流体在高剪切率、非牛顿性质可能影响血液流动模式在低剪切速率和剪切应力的结果。此外,我们的几何模型是基于直血管的表示,虽然他们可能会弯曲的现实中。船舶曲率可以有显著影响的偏态速度剖面和流的一般行为。</p> <h4 id="conclusion">4所示。结论</h4> <p>大多数的实验和数值研究脉动的流过狭窄的动脉执行假设一个简单的容器,没有血流动力学变化与各种分叉病变类型相关的研究到目前为止特别是在麦地那的背景下病变分类。目前的研究是出于需要了解流条件和各分岔WSS分布在冠状动脉分叉病变类型。我们已经调查了WSS的流率和时间依赖性模式产生的脉动血流动力学数值模拟的流在健康和狭窄的冠状动脉分支。各种狭窄配置被认为是根据麦地那病变分类和详细的数值结果时间WSS分布可能参与损伤起始和进展突出显示。本研究的主要结果是,不同的分岔类型决定了不同的流动比率和WSS分布在某人,某人流比MBP流少了50%和75%(1 0 1)分叉病变类型相比(0,1,1)和(1 1 1)。考试WSS分布在真正的分叉病变显示某人,athero-prone地区而言,损伤类型(1,1,1)不太可能最坏的情况下,因为研究结果支持,损伤类型(1 0 1)导致更低的值WSS内部和外墙尤其是在心动周期的减速阶段。在分叉病变类型,结果表明,水流条件和WSS分布在某人受到损伤形态不能完全由定量评估冠状动脉血管造影参数。</p> </div> <div class="xml-content"> <h4 class="references" id="references">引用</h4> 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Giddens&publication_year=1983" target="_blank">谷歌学术搜索</一个></span></li> </ol> </div> <div class="xml-content"> <h4 class="copyright" id="copyright">版权</h4> <p>版权©2012 Marjan Molavi Zarandi等。这是一个开放的分布式下文章<一个rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</一个>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</p> </div> </div> </article> </div> </div> </div> <div id="related-articles" class="biblio__Wrapper-sc-1nou1lz-0 eyHfWh journal_article__BiblioIntegratorWidget-sc-12fk6zy-5 dbAANp article_widget biblioWrapper hide"> <hr> <h4 class="biblio__H4-sc-1nou1lz-2 becpDt hrTitleRef">更多相关文章</h4>对本文没有相关内容可用。<div id="biblio_widget" class="biblio__BiblioWrapper-sc-1nou1lz-1 kaaUfC"></div> </div> </div> </div> <div class="threeColumn__RightWrapper-sc-1bf4078-2 jzTMLK rightWrapper" id="rightSectionMenu"> <div> <div class="journal_article__ArticleStickyTopToolbar-sc-12fk6zy-0 gbrQxi article_sticky_top_toolbar"> <div class="sc-cBdUnI hRnXob article_top_toolbar"> <a class="sc-htpNat bUhGXt 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src="data:image/svg+xml;base64,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" height="24"><span class="text">下载引用</年代p一个n></span><span class="sc-htoDjs bqeMOy sc-dqBHgY cQgXqt fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> <a class="sc-htpNat bUhGXt link sc-jtRfpW dUABlg sc-BngTV hmDWcT ref_desktop" href="//www.newsama.com/journals/mse/2012/419087.ris" aria-label="" target="" id="toolbar__dcNavSmall"><span><img alt="" class="sc-EHOje jOLhQl sc-kTUwUJ eujois" title="" role="presentation" src="data:image/svg+xml;base64,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" height="24"><span class="text">引用</年代p一个n></span><span class="sc-htoDjs bqeMOy sc-dqBHgY cQgXqt fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> </div> </div> <div class="journal_article__ArticleStickyBottomToolbar-sc-12fk6zy-1 isgRZA article_sticky_bottom_toolbar"> <div class="sc-cTjmhe ihmyEq article_bottom_toolbar"> <div class="sc-cugefK itFKcQ accordion" property="background-color" color="#D8D8D8" id="toolbar__dofNav"> <span><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" 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height="24"><span class="sc-dRFtgE jrsDZP">下载其他格式</年代p一个n><span class="sc-gkFcWv gWTCXQ">更多的</年代p一个n></span> <span class="sc-htoDjs bMdQcY sc-gbOuXE jGPvPL icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="11"></span> </div> <div class="sc-fnwBNb etzuBr"> <a class="sc-htpNat bUhGXt link sc-iNhVCk gWgCNb open_panel" href="//www.newsama.com/downloads/journals/mse/2012/419087.epub" aria-label="ePub" property="background-color" color="#D8D8D8"> <div class="sc-eAKXzc WHkfb"> ePub</div><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" 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height="24"><span class="sc-dRFtgE jrsDZP">订单打印副本</年代p一个n><span class="sc-gkFcWv gWTCXQ">订单</年代p一个n></span><span class="sc-htoDjs kNoiZu sc-gbOuXE jGPvPL right__icon icon-colored _32KP5uexH-Bgs7Kj8Gk1Tz icon-themeable" title="" font-size="16"></span></a> <div class="sc-hBbWxd kdRRST"> <div class="sc-dyGzUR cHatnS"> <div> 的观点<年代p一个n>2965年</年代p一个n> </div> <div> 下载<年代p一个n>1442年</年代p一个n> </div> </div> <div> <div class="sc-drKuOJ kxdGAZ"> <span class="__dimensions_badge_embed__" data-doi="10.1155/2012/419087" data-style="small_circle"></span>引用</div> </div> </div> <nav class="sc-bRBYWo fXBKFa sc-hUfwpO jHPgUP" id="toolbar__iconNav"> <h3 class="sc-Rmtcm hNPrIr">分享文章</h3> <ul class="sc-hzDkRC bnbfTS"> <li class="iconBorder"><a class="sc-htpNat bUhGXt link" href="https://twitter.com/share?url=https://doi.org/10.1155/2012/419087&via=Hindawi" aria-label="Sharing on Twitter" rel="noopener noreferrer" target="_blank"><img alt="" class="sc-EHOje jOLhQl socialTwitter" title="" role="presentation" 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