研究文章
毒性评估一种新的核磁共振成像标记,CoCl2-N-Acetylcysteine,老鼠
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| 注射后平均停留时间和治疗组 |
MCV, fL |
MCHC, g / dL |
中性粒细胞 |
单核细胞 |
淋巴细胞 |
| ×103/
l |
|
×103/
l |
|
×103/
l |
|
|
| 第二天 |
|
|
|
|
|
|
|
|
| 控制 |
61.7 (57.8 - -64.0) |
30.8 (29.1 - -32.6) |
2.3 (1.04 - -2.99) |
18.4 (10.4 - -24.9) |
0.27 (0.10 - -0.43) |
2.1 (1.0 - -2.7) |
9.63 (6.76 - -11.84) |
76.6 (68.7 - -87.2) |
| 低剂量 |
61.1 (57.1 - -63.3) |
30.9 (29.5 - -32.1) |
3.1 (1.67 - -4.63) |
21.6 (15.3 - -27.9) |
0.33 (0.25 - -0.56) |
2.3 (1.8 - -2.8) |
10.5 (8.43 - -15.38) |
72.5 (66.7 - -80.9) |
| Ref剂量 |
61.3 (57.8 - -62.9) |
30.1 (29.4 - -30.6) |
3.1 (0.9 - -5.27) |
20.1 (11.2 - -26.7) |
0.33 (0.09 - -0.54) |
2.1 (1.2 - -2.8) |
10.1 (6.84 - -15.13) |
74.7 (67.0 - -85.4) |
| 高剂量 |
58.5(56.8 - -60.0) |
30.9 (30.2 - -31.7) |
3.5 (2.15 - -4.64) |
26.6 (19.0 - -34.4) |
0.4 (0.27 - -0.87) |
2.9 (2.0 - -5.4) |
8.7 (6.75 - -10.15) |
66.7 (58 - 75.3) |
| 28天 |
|
|
|
|
|
|
|
|
| 控制 |
58.7 (58 - 59.6) |
30.5 (30.3 - -30.7) |
2.21 (1.03 - -2.87) |
22.1 (11.6 - -28.4) |
0.22 (0.16 - -0.3) |
2.2 (1.5 - -2.9) |
6.99 (6.31 - -7.39) |
71.7 (62.4 - -82.9) |
| 低剂量 |
59.3 (56.5 - -62.0) |
30.5 (30.1 - -30.9) |
2.5 (1.31 - -3.95) |
21.6 (15 - 34.4) |
0.27 (0.18 - -0.35) |
2.5 (1.5 - -4.0) |
8.3 (6.23 - -13.28) |
71.6 (55.6 -80) |
| Ref剂量 |
58.8 (57.3 - -59.8) |
31.1 (29.8 - -31.7) |
2.3 (1.08 - -3.57) |
24.2 (13.1 - -37.1) |
0.31 (0.16 - -0.56) |
31日。(1.9 - -5.9) |
6.8 (5.26 - -9.78) |
69.4 (54.8 - -81.5) |
| 高剂量 |
58.8 (56.5 - -60.1) |
30.6 (29.8 - -31.4) |
2.7 (2.07 - -3.20) |
23.1 (20.1 - -26.8) |
0.31 (0.20 - -0.53) |
2.7 (1.9 - -4.8) |
8.2 (7.05 - -10.87) |
70.4 (63.5 - -73.8) |
| 一天63 |
|
|
|
|
|
|
|
|
| 控制 |
58.8 (57.7 - -61.2) |
30.9 (30.6 - -31.4) |
1.65 (0.95 - -2.29) |
15 (8.9 - -20.3) |
0.22 (0.16 - -0.37) |
2 (1.3 - -3.3) |
8.83 (7.43 - -9.96) |
80.5 (73.2 - -87.0) |
| 低剂量 |
58.9 (57.0 - -60.5) |
31日。9(31.0 - -32.5) |
2.0 (1.16 - -2.52) |
16.2 (12.0 - -19.4) |
0.26 (0.19 - -0.35) |
2.2 (1.5 - -3.1) |
9.3 (8.03 - -10.75) |
78.5 (74.7 - -83.6 |
| Ref剂量 |
58.7 (57.2 - -60.7) |
32.2(32 - 32.5) |
1.8 (1.06 - -2.68) |
15.7 (10.1 - -24.2) |
0.23 (0.11 - -0.34) |
2.0 (1.3 - -3.2) |
8.8 (7.01 - -11.99) |
78.6 (69.6 - -85.3) |
| 高剂量 |
57.8 (55.8 - -61.1) |
31.4 (30.1 - -32.3) |
1.6 (1.0 - -2.38) |
12.6 (6.9 - -16.8) |
0.25 (0.09 - -0.38) |
1.9 (0.9 - -2.7) |
10.4 (9.13 - -12.91) |
82.8 (78.0 - -89.9) |
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数据显示为意味着(范围)。 显著不同于控制 P< 0.05。 控制,0% CoCl 2:南京;低剂量,CoCl 0.1% 2南京:2%;Ref CoCl (erence)剂量的1% 2南京:2%;高剂量,CoCl 10% 2:2% NAC。 ”,意思是微粒体积(在飞升);MCHC,意味着微粒血红蛋白浓度。
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