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t . Hammen h . Stefan Tomandl, ”临床的作用在活的有机体内1 h-mr光谱学的评价癫痫病”,《光谱学, 卷。16, 文章的ID842843年, 10 页面, 2002年。 https://doi.org/10.1155/2002/842843
临床的作用在活的有机体内1 h-mr光谱学的评价癫痫病
文摘
1 h-mrs无创性方法检测各种脑代谢物含有N-acetylaspartat (NAA) cholin (Cho)、肌氨酸(Cr) GABA和glutamat已经成为一个诊断工具来评估疾病的中枢神经系统特别是包括癫痫和脑部肿瘤。1 h-mrs扮演越来越重要的角色在今天的癫痫病的评估和治疗计划。乙酰天冬氨酸被接受为一个标记的神经元轴突密度和生存能力。这是详细的生理作用是未知的。损失或减少的NAA看到疾病相关的神经元或轴突退化的损失。GABA,谷氨酸和glutamin (Glx)可能定义癫痫在生化方面的关注。1 h-mrs意味着高灵敏度和有效性焦点定位在颞叶癫痫患者(框架),而视频脑电图建立方法,MR-volumetry和SPECT。棘手的框架中间的病人安排患者手术乙酰天冬氨酸/ Cr或乙酰天冬氨酸/ Cr +曹不对称海马结构的索引创建和控制健康有好处。已经提到的相关结果建立本地化的技术。大多数作者调查这个话题同样发现1 h-mrs脑电图和高度整合MRI-Vol发现。 Recent studies show that 1H–MRS besides it's capability to lateralize the epileptic focus is able to distinguish between mesial and lateral TLE. In addition to it's sensitivity in focus lateralization 1H–MRS contains a predictability concerning the evaluation of postoperative outcome in patients with intractable TLE. Most studies reveal that changes contralateral to the epileptogenic focus or bilateral changes in metabolite spectra of 1H–MRS are associated with a poor whereas homolateral alterations to the focus reveal a good postoperative seizure outcome. The evaluation of anticonvulsive drugs by 1H–MRS is the topic of various recent studies in which human brain GABA levels are investigated by 1–HMRS under the influence of antiepileptic drugs mainly including vigabatrin and topiramat. The effect of antiepileptic drugs and their influence on seizure inhibitoring brain metabolites was investigated and the authors were able to create responder profiles by correlating the mentioned metabolites in a long–term study. They verified an increase of GABA within the beginning of antiepileptic treatment and an increase of homocarnosine, a GABA metabolite, in long term treatment (2–3 months) in the responder group.
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版权©2002 Hindawi出版公司。这是一个开放的分布式下文章知识共享归属许可,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。
