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no-repeat 6px;background-position:center;margin-top:10px;min-width:55px;display:none;} @media (min-width:768px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .expand_btn{display:none;}} .gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{-webkit-flex:9;-ms-flex:9;flex:9;text-align:left;padding:21px 37px 10px 0px;font-size:16px;font-weight:700;} @media (min-width:768px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 18px 10px 18px;}} @media (min-width:992px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 21px 10px 21px;}} .gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption 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no-repeat 6px;background-position:center;padding:16px 0 16px 0;min-width:62px;max-width:62px;} @media (min-width:768px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:16px 0 17px 0;min-width:52px;max-width:52px;}} @media (min-width:992px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url{padding:15px 0 17px 0;min-width:60px;max-width:60px;}} .gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-partial-url:hover{-webkit-text-decoration:none;text-decoration:none;} .gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption-text{font-size:14px;padding:0px 18px 17px 22px;} @media (min-width:768px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 15px 15px 18px;}} @media (min-width:992px){.gvEcCq .floats-partial-section .floats-partial-footer .floats-partial-caption-text{padding:0px 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href="//www.newsama.com/journals/jsc/" aria-label="Journal of Skin Cancer">杂志的皮肤癌</一个>/<一个cl一个年代年代=”年代c-htpNat bUhGXt link sc-eitiEO jXeALb breadCrumb" href="//www.newsama.com/journals/jsc/contents/year/2012/" aria-label="2012">2012年</一个>/<年代p一个ncl一个年代年代=”年代c-bhlBdH UVThf">文章</年代p一个n> </div> <div class="threeColumn__ThreeColumnWrapper-sc-1bf4078-0 dDyxFF threeColumnWrapper"> <div class="threeColumn__LeftWrapper-sc-1bf4078-1 fkVFlF leftWrapper"> <button type="button" class="sc-eKZiaR dzZrgS section__button " id="sectionButton"><span class="sc-htoDjs diutvq icon__dots dots__detector icon-colored _3n-7Ho7DlfjMlZbrRr9Q4a icon-themeable" title="" font-size="22"></span>文章部分</button> <div class="sc-bEjcJn jLUVhb static_contents__section_links links__hidden "> <div id="leftSectionMenu" class="sc-cbkKFq prcY sc-bGbJRg dVCLgr left_section_menu"> <p>在这一页上</p> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" 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cUsFHx">|</年代p一个n> <a class="sc-htpNat bUhGXt link sc-fQejPQ duuwge" href="https://doi.org/10.1155/2012/393681" aria-label="Doi-link">https://doi.org/10.1155/2012/393681</一个> </div> <div class="sc-LKuAh lcOiDF article_full_citation"> <div class="sc-hzNEM gsmOCv isHide"> <p>t . Magcwebeba里德尔,s . Swanevelder p . Bouic p .黑黝黝的w . Gelderblom, ”<年代p一个ncl一个年代年代=”一个djust-article-svg-size">Interleukin-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi mathvariant="bold"> α</mml:mi> </mml:math>感应人类角质细胞(HaCaT):一个<我>在体外</我>模型的化学预防皮肤</年代p一个n>”,<i>杂志的皮肤癌</我>, 卷。2012年, 文章的ID393681年, 10   页面, 2012年。 https://doi.org/10.1155/2012/393681</p> </div> <button class="sc-hSdWYo etauus sc-iBEsjs kPshFw" color="">显示引用</button> </div> <h1 class="sc-iRbamj jZOxOO sc-iSDuPN kEVvRd article_title adjust-article-svg-size heading-title">Interleukin-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi mathvariant="bold"> α</mml:mi> </mml:math>感应人类角质细胞(HaCaT):一个<我>在体外</我>模型的化学预防皮肤</h1> </div> <div class="sc-jrIrqw eHMFfo article_authors"> <hr class="sc-cEvuZC XkrFe hr__author"> <span class="">t . Magcwebeba,<年代up>1,2</年代up></span> <span class="">美国里德尔,<年代up>1</年代up></span> <span class="">美国Swanevelder,<年代up>3</年代up></span> <span class="">p . Bouic,<年代up>4</年代up></span> <span class="">p .黑黝黝的,<年代up>2</年代up> 和</年代p一个n> <span class=""><b>w . Gelderblom</b><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-hjRWVT irNWJI icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a><sup>1,2</年代up></span> <div class="sc-fHxwqH dMuGGA isHide"> <p><sup>1</年代up><span>真菌毒素和实验规划致癌作用(PROMEC)单位,医学研究委员会,邮政信箱19070,Tygerberg 7505年,南非</年代p一个n></p> <p><sup>2</年代up><span>Stellenbosch大学生物化学系私人包X1,南非Stellenbosch 7602</年代p一个n></p> <p><sup>3</年代up><span>Biostatistic单位,医学研究委员会,邮政信箱19070,Tygerberg 7505年,南非</年代p一个n></p> <p><sup>4</年代up><span>Synexa生命科学,邮政信箱1573,Bellville 7535年,南非</年代p一个n></p> </div> <button class="sc-hSdWYo etauus sc-iQtOjA kfDwZY" color="">显示更多</button> </div> <div class="articleContent__EditorWrapper-sc-2yl9jy-3 evMkvU"> <div class="articleContent__TextWrapper-sc-2yl9jy-8 fYrLtk"> <b>学术编辑器:</b>朱塞佩Argenziano</d我v> <div class="articleContent__PublicationTimeLineWrapper-sc-2yl9jy-4 fjviok"> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年2月06</年代p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">修改后的</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年4月16日</年代p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年4月16日</年代p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC isPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</年代p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2012年6月25日</年代p一个n> </div> </div> </div> <article class="sc-jtRlXQ gvEcCq article_body "> <div> <div class="xml-content"> <h4 class="header" id="abstract">文摘</h4> <p>长期暴露于紫外线辐射和有毒化学物质与慢性炎症,导致皮肤癌症发展interleukin-1α(il - 1<我>α</我>),结构上所产生的角化细胞,扮演一个关键作用在皮肤炎症。本研究的目的是探讨il - 1的调制<我>α</我>生产HaCaT角化细胞细胞系。佛波醇12-myristate 13-acetate未能诱导il - 1<我>α</我>HaCaT细胞,这可能是与特定的缺乏会影响下游MEK / ERK信号通路在这些细胞。钙离子载体、ionomycin稍有增强细胞内(icIL-1的生产<我>α</我>),但这导致坏死释放浓度更高。uv - b照射显著增加icIL-1的生产<我>α</我>与最大剂量依赖性的方式诱导展出24小时以最小的坏死和凋亡的影响。HaCaT细胞模型的验证表明,非甾体类抗炎药(非甾体抗炎药),布洛芬,和糖皮质激素地塞米松抑制icIL-1<我>α</我>相关的生产,这是一个轻微的抑制细胞的可行性。角质化细胞是UV-B-induced模型提供了一个<我>在体外</我>系统,除了佛波醇ester-like化合物,作为筛查试验确定利用皮肤刺激和/或治疗局部代理通过il - 1的调制<我>α</我>生产。</p> <span class="end-abs"></span> <h4 id="introduction">1。介绍</h4> <p>炎症是一种生理反应,保护身体免受各种侮辱,如人身伤害、病原体、接触有毒化学物质,紫外线照射。急性炎症反应当治疗结果体现了很短的一段时间;然而,长期的炎症可以导致癌症发展(<一个href="#B1">1</一个>- - - - - -<一个href="#B3">3</一个>]。各种炎症介质被认为是发展的关键角色球员的急性和慢性反应与il - 1、TNF -<我>α</我>这个过程的主要细胞因子传播(<一个href="#B4">4</一个>- - - - - -<一个href="#B6">6</一个>]。il - 1、TNF -<我>α</我>启动信号级联,导致的基因表达和生产辅助介质,包括细胞因子和趋化因子、生长因子、粘附分子,环氧酶2型(cox - 2),诱导一氧化氮合酶(间接宾语),和其他促炎的因素。这有助于chemoattraction活性氧(ROS)的第免疫细胞在修复受损组织的援助<一个href="#B7">7</一个>,<一个href="#B8">8</一个>]。研究表明il - 1、TNF -的作用<我>α</我>不同阶段的肿瘤发生与免疫细胞产生的活性氧主要功能化学感受器恶性转变(<一个href="#B9">9</一个>,<一个href="#B10">10</一个>]。的慢性激活其他继发性炎症介质功能在促进恶性肿瘤细胞的增殖和生存,也有助于他们的进展为浸润性肿瘤细胞。慢性炎症和致癌作用之间的联系表明,机遇存在调制的主要细胞因子的生产可用于开发新的抗炎药物,可以尽可能的利用化学预防剂(<一个href="#B9">9</一个>,<一个href="#B11">11</一个>]。</p> <p>角质细胞,表皮细胞,细胞因子的生产函数作为主要因素(<一个href="#B12">12</一个>]。的主要细胞因子,il - 1<我>α</我>主导,因为它是既定的合成生物活性前体蛋白(proIL-1<我>α</我>),而il - 1<我>β</我>在不活跃的前体形式存在(<一个href="#B13">13</一个>]。相比之下,TNF -<我>α</我>在接触刺激诱导,在培养的角质细胞发生在非常低的水平,对炎症似乎扮演一个小角色<我>在活的有机体内</我>il - 1相比,<我>α</我>(<一个href="#B14">14</一个>,<一个href="#B15">15</一个>]。il - 1<我>α</我>仍在角化细胞及其生物活性细胞相关,包括伤口愈合和白细胞招募,通过其cell-expressed表面受体调节。1型受体负责转导炎性信号,而2型抵销这些影响,常常被视为“诱饵”受体(<一个href="#B16">16</一个>- - - - - -<一个href="#B19">19</一个>]。il - 1<我>α</我>生产的角化细胞增加了各种刺激包括佛波醇酯、uv - b照射,ionomycin [<一个href="#B20">20.</一个>- - - - - -<一个href="#B23">23</一个>]。由于预制il - 1<我>α</我>只是被动地在细胞损伤时释放(<一个href="#B19">19</一个>),各种研究利用细胞因子在炎症和致癌模型来研究分子机制参与炎症性皮肤疾病和癌症的发展推广(<一个href="#B21">21</一个>,<一个href="#B24">24</一个>- - - - - -<一个href="#B26">26</一个>]。il - 1的调制<我>α</我>也已被确认为一个有用的细胞刺激物筛查工具,和越来越多的利息这个发展的细胞因子的使用抗炎药,也可以作为chemopreventative代理(<一个href="#B27">27</一个>- - - - - -<一个href="#B31">31日</一个>]。</p> <p>虽然il - 1的使用<我>α</我>在<我>在活的有机体内</我>模型更生理相关的人类,伦理问题和艰苦的过程参与使用动物看到培养角质细胞成为皮肤毒性的原型模型和化学预防研究[<一个href="#B32">32</一个>- - - - - -<一个href="#B35">35</一个>]。在这方面,改变了角质细胞的使用,特别是HaCaT细胞系盛行不衰,被认为是一个有效的和操作方便的替代品主要文化(<一个href="#B36">36</一个>]。HaCaT细胞系已广泛应用于各种研究相关的皮肤刺激和药物开发(<一个href="#B28">28</一个>,<一个href="#B29">29日</一个>,<一个href="#B36">36</一个>,<一个href="#B37">37</一个>]。然而,最近的研究警告称,他们在药理和/或适当性毒性筛选化验,尤其是当考虑到佛波醇ester-like化合物。有人建议,这些细胞的详细描述他们的应用程序作为一个前应该进行<我>在体外</我>模型(<一个href="#B38">38</一个>,<一个href="#B39">39</一个>]。</p> <p>当前的研究寻求不同兴奋剂的适用性,包括PMA、ionomycin,钙离子载体,uv - b, il - 1<我>α</我>归纳利用使之改变了keratinocytic HaCaT细胞系。的诱导il - 1<我>α</我>验证了通过使用已知的抗炎药为了验证<我>在体外</我>细胞模型利用作为一个筛选试验确定皮肤刺激和/或治疗局部代理。</p> <h4 id="materials-and-methods">2。材料和方法</h4> <h5 id="sec2.1">2.1。化学药品和试剂</h5> <p>佛波醇12-myristate 13-acetate (PMA)、地塞米松、布洛芬、二甲亚砜(DMSO),牛血清白蛋白(BSA)(美国Sigma-Aldrich)。胎牛血清(的边后卫)(美国表达载体)。rpmi - 1640, Dulbeco的磷酸缓冲盐(DPBS)、谷酰胺,heat-inactivated胎牛血清,trypsin-versene,汉克的缓冲盐溶液(hbs) (Lonza、比利时)。重组人il - 1<我>α</我>酶联免疫试剂盒(研发系统、美国)CytoTox 96非放射性细胞毒性试验,CellTiter-Glo发光细胞生存能力,Caspase-3/7化验(美国Promega)。Triton-x100 (BDH化工有限公司,普尔英格兰),Tween-20 (ICN生物医药公司、美国),ionomycin钙盐(Synexa、南非)。</p> <h5 id="sec2.2">2.2。角化细胞细胞培养</h5> <p>自发地在家乡的角化细胞(HaCaT)是美国人类生物学的礼物在开普敦大学,南非。rpmi - 1640细胞培养的补充与heat-inactivated胎牛血清(10%)、谷酰胺(2毫米)在湿润的气氛中5%的有限公司<年代ub>2</年代ub>/ 95%空气在37°C。细胞通过每3天1:3分流比。</p> <h5 id="sec2.3">2.3。PMA对诱导il - 1的影响<我>α</我></h5> <h6 id="sec2.3.1">2.3.1。确定最佳的细胞密度和孵化时间</h6> <p>HaCaT细胞被播种rpmi - 1640年媒体含有10%的边后卫(100<我>μ</我>L)的密度<年代vg height="14.375" id="M2" style="vertical-align:-0.3135pt;width:54.424999px;" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>在96 -微量滴定板(美国康宁合演)和孵化在37°C 24 h confluency达到70 - 80%。新鲜的rpmi - 1640中包含0.5%的边后卫媒体包含不同PMA浓度(0.31 -100 ng / mL)使用。PMA是溶解在DMSO溶液给最终的浓度< 0.1%,板块孵化6,12日和24小时提供上层清液,和细胞被洗PBS(3倍)。细胞细胞溶解的0.5%在PBS triton和一个周期的冻结解冻(−80°C)。细胞溶解产物被储存在细胞内il - 1−20°C<我>α</我>的决心。</p> <h6 id="sec2.3.2">2.3.2。细胞外(exIL-1<我>α</我>)和胞内il - 1<我>α</我>(icIL -<我>α</我>PMA和Ionomycin)感应</h6> <p>细胞被播种在更高的密度(<年代vg height="14.375" id="M3" style="vertical-align:-0.3135pt;width:54.424999px;" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>)加强il - 1<我>α</我>信号。细胞治疗与更高浓度的PMA (6.25 -100 ng / mL)或ionomycin (0.2 -10<我>μ</我>g / mL)和孵化6 h。孵化后,上层清液被收集并存储在−exIL-1 20°C<我>α</我>的决心。这些细胞被洗与PBS (3 x)和细胞溶解0.5% triton结合冻融循环。细胞溶解产物resuspended和保持在−20°C icIL-1的决心<我>α</我>生产。</p> <h6 id="sec2.3.3">2.3.3。il - 1<我>α</我>的决心</h6> <p>两个icIL-1<我>α</我>和exIL-1<我>α</我>分别在细胞溶解产物和上层清液,测定il - 1<我>α</我>酶联免疫试剂盒根据制造商的指示。标准准备和化验在重复五个复制每个样本的准备。吸光度测量在450 nm丹尼克斯板读者(丹尼克斯技术,美国),和数据分析使用标准曲线产生GraphPad棱镜(Windows版本5)(GraphPad软件公司,拉霍亚,CA,美国)。值表示为pg / mL的上层清液或细胞溶解产物。</p> <h6 id="sec2.3.4">2.3.4。细胞毒性和可行性分析(LDH释放和ATP生产)</h6> <p>细胞毒性测试化学品的评估通过监测LDH释放或LDH释放和ATP生产在确定PMA和ionomycin的影响,分别。LDH释放,样本分析利用比色CytoTox 96包,和吸光度测量490海里(丹尼克斯标)。LDH释放被表示为一个百分比总数的LDH释放(由一个冻融循环细胞细胞溶解)根据以下计算:<年代p一个ncl一个年代年代=”equation" id="eq1"> <svg height="41.825001" id="M4" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 41.825001" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,41.825)"> <g transform="translate(72,-38.54)"> <text transform="matrix(1,0,0,-1,71.9,52.37)"> <tspan style="font-size: 12.50px; " x="0" y="0"> %</t年代p一个n> <tspan style="font-size: 12.50px; " x="13.490737" y="0"> C</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.830238" y="0"> y</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.081738" y="0"> t</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.545069" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.696545" y="0"> t</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.147373" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="47.123806" y="0"> x</t年代p一个n> <tspan style="font-size: 12.50px; " x="53.375305" y="0"> 我</t年代p一个n> <tspan style="font-size: 12.50px; " x="56.851143" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="62.402473" y="0"> 我</t年代p一个n> <tspan style="font-size: 12.50px; " x="65.878304" y="0"> t</t年代p一个n> <tspan style="font-size: 12.50px; " x="69.354141" y="0"> y</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,155.15,52.37)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,185.06,63.41)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.8521242" y="0"> b</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.103624" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.967291" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.21879" y="0"> r</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.38229" y="0"> b</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.633789" y="0"> 一个</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.185123" y="0"> n</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.436623" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="53.987953" y="0"> e</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,244.6,60.28)"> <tspan style="font-size: 8.75px; " x="0" y="0"> (</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,247.51,60.28)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 年代</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.4045279" y="0"> u</t年代p一个n> <tspan style="font-size: 8.75px; " x="7.7805281" y="0"> p</t年代p一个n> <tspan style="font-size: 8.75px; " x="12.156528" y="0"> e</t年代p一个n> <tspan style="font-size: 8.75px; " x="16.042416" y="0"> r</t年代p一个n> <tspan style="font-size: 8.75px; " x="19.140623" y="0"> n</t年代p一个n> <tspan style="font-size: 8.75px; " x="23.516624" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="27.402512" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="29.923088" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="33.808975" y="0"> n</t年代p一个n> <tspan style="font-size: 8.75px; " x="38.184975" y="0"> t</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,288.13,60.28)"> <tspan style="font-size: 8.75px; " x="0" y="0"> )</t年代p一个n> </text> <g> <path d="m 172.55,55.5 131.5,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,172.55,43.62)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.8521242" y="0"> b</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.103624" y="0"> 年代</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.967291" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.21879" y="0"> r</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.38229" y="0"> b</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.633789" y="0"> 一个</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.185123" y="0"> n</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.436623" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="53.987953" y="0"> e</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,232.09,40.49)"> <tspan style="font-size: 8.75px; " x="0" y="0"> (</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,235,40.49)"> <tspan style="font-size: 8.75px; " x="0" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="2.424304" y="0"> o</t年代p一个n> <tspan style="font-size: 8.75px; " x="6.730288" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.2421122" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.128" y="0"> l</t年代p一个n> <tspan style="font-size: 8.75px; " x="18.475471" y="0"> l</t年代p一个n> <tspan style="font-size: 8.75px; " x="23.822945" y="0"> D</t年代p一个n> <tspan style="font-size: 8.75px; " x="30.141888" y="0"> H</t年代p一个n> <tspan style="font-size: 8.75px; " x="39.375248" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="43.261135" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="47.147022" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="49.580078" y="0"> 我</t年代p一个n> <tspan style="font-size: 8.75px; " x="52.013138" y="0"> v</t年代p一个n> <tspan style="font-size: 8.75px; " x="56.389137" y="0"> 我</t年代p一个n> <tspan style="font-size: 8.75px; " x="58.822193" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="61.255249" y="0"> y</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,300.64,40.49)"> <tspan style="font-size: 8.75px; " x="0" y="0"> )</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,312.19,52.37)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.777586" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="17.029085" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.280586" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.532085" y="0"> 。</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,474.12,52.37)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.414999" y="0"> )</t年代p一个n> </text> </g> </g> </svg></span>决定细胞生存能力,CellTiter-Glo发光生存工具包用于监测细胞内ATP生产利用白色固体板(Porvair科学,谢伯顿,英国)。监控ATP生产、荧光素酶试剂添加和盘子旋转2分钟和孵化在黑暗中在室温下10分钟。ATP生产监控与Veritas微型板块光度计(美国Promega)。相对光的发光信号测量单元(RLU)和数据表示为一个百分比(%)控制细胞的如下:<年代p一个ncl一个年代年代=”equation" id="eq2"> <svg height="36.962502" id="M5" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 36.962502" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,36.9625)"> <g transform="translate(72,-42.43)"> <text transform="matrix(1,0,0,-1,96.15,54.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> %</t年代p一个n> <tspan style="font-size: 12.50px; " x="13.50324" y="0"> 一个</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.867746" y="0"> T</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.50708" y="0"> P</t年代p一个n> <tspan style="font-size: 12.50px; " x="40.622246" y="0"> p</t年代p一个n> <tspan style="font-size: 12.50px; " x="46.873749" y="0"> r</t年代p一个n> <tspan style="font-size: 12.50px; " x="50.974731" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.226231" y="0"> d</t年代p一个n> <tspan style="font-size: 12.50px; " x="63.47773" y="0"> u</t年代p一个n> <tspan style="font-size: 12.50px; " x="69.729233" y="0"> c</t年代p一个n> <tspan style="font-size: 12.50px; " x="75.280563" y="0"> t</t年代p一个n> <tspan style="font-size: 12.50px; " x="78.756393" y="0"> 我</t年代p一个n> <tspan style="font-size: 12.50px; " x="82.232231" y="0"> o</t年代p一个n> <tspan style="font-size: 12.50px; " x="88.483734" y="0"> n</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,198.53,54.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,220.77,63.67)"> <tspan style="font-size: 12.50px; " x="0" y="0"> R</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.3395014" y="0"> l</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.75378" y="0"> U</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,245.55,60.55)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> o</t年代p一个n> <tspan style="font-size: 8.75px; " x="8.2618876" y="0"> n</t年代p一个n> <tspan style="font-size: 8.75px; " x="12.637888" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="15.070944" y="0"> r</t年代p一个n> <tspan style="font-size: 8.75px; " x="17.932848" y="0"> o</t年代p一个n> <tspan style="font-size: 8.75px; " x="22.308847" y="0"> l</t年代p一个n> </text> <g> <path d="m 211.76,57.57 68.04,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,211.76,45.69)"> <tspan style="font-size: 12.50px; " x="0" y="0"> R</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.3395014" y="0"> l</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.75378" y="0"> U</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,236.54,42.57)"> <tspan style="font-size: 8.75px; " x="0" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="2.4330561" y="0"> r</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3387198" y="0"> e</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.2246084" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="13.110496" y="0"> t</t年代p一个n> <tspan style="font-size: 8.75px; " x="15.543552" y="0"> e</t年代p一个n> <tspan style="font-size: 8.75px; " x="19.42944" y="0"> d</t年代p一个n> <tspan style="font-size: 8.75px; " x="26.711103" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="30.596992" y="0"> e</t年代p一个n> <tspan style="font-size: 8.75px; " x="34.48288" y="0"> l</t年代p一个n> <tspan style="font-size: 8.75px; " x="36.915936" y="0"> l</t年代p一个n> <tspan style="font-size: 8.75px; " x="39.348991" y="0"> 年代</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,287.94,54.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.765083" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="17.029085" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.280586" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.532085" y="0"> 。</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,474.12,54.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.414999" y="0"> )</t年代p一个n> </text> </g> </g> </svg></span></p> <h5 id="sec2.4">2.4。UV-B-Induced il - 1<我>α</我>生产、细胞毒性和细胞凋亡</h5> <p>细胞被播种在96孔细胞培养板的密度<年代vg height="14.375" id="M6" style="vertical-align:-0.3135pt;width:54.424999px;" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>在媒体(100<我>μ</我>L)含有10%的边后卫和孵化24 h。删除培养媒体后,细胞暴露于不同剂量(20、40、80、160、240 mJ /厘米<年代up>2</年代up>)DPBS uv - b光(100<我>μ</我>L)没有塑料盖子。UVIlink紫外线交联剂(UVitek有限,英国)配备6 8瓦紫外线管波长为302 nm (Vilber Lourmat,法国)。辐照后,立即治疗细胞补充新鲜rpmi - 1640中含有0.5%的边后卫和孵化为不同时期(6、12和24 h)。</p> <p>细胞毒性、细胞凋亡和il - 1<我>α</我>确定后6、12和24小时。细胞毒性监测通过确定LDH释放如上所述。细胞凋亡,细胞与细胞裂解细胞溶解缓冲区(20<我>μ</我>L)结合一个冻融循环。细胞溶解产物被转移(25<我>μ</我>L)变成了一片白色的固体板和孵化与半胱天冬酶试剂(25 3/7<我>μ</我>L)在室温下1 h在黑暗中。孵化后,盘子Veritas光度计板机进行分析,计算和caspase-3活动褶皱增加比控制。</p> <h5 id="sec2.5">2.5。炎症模型验证利用抗炎药物</h5> <p>细胞被播种密度<年代vg height="14.375" id="M7" style="vertical-align:-0.3135pt;width:54.424999px;" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>孵化24小时的rpmi - 1640中含有10%的边后卫。细胞首先接触到uv - b光(80 mj /厘米<年代up>2</年代up>)在DPBS (100<我>μ</我>L)如上所述,然后用不同的孵化地塞米松和布洛芬浓度(0.31到1.25毫米)24 h rpmi - 1640年媒体含有0.5%的边后卫。删除后上层清液,细胞被洗DPBS和细胞溶解0.5% triton结合冻融循环之一。细胞溶解产物icIL-1准备在不同的板块进行分析<我>α</我>、ATP生产和LDH释放如上所述。</p> <h5 id="sec2.6">2.6。统计分析</h5> <p>所有参数都使用Kolmogorov-Smirnof测试测试正常。集团对所有参数方差参数的均匀性进行了测试使用列文的测试。组差异对这些参数参数测试用单向方差分析在SAS (GLM)和事后图基测试,这是事后多个成对比较的所有不同的组。那些对两个或两个以上的固定参数的影响,交互条款也被调查,看看他们改进的模型适合表明主要影响的交互影响的结果。最小二乘方法(LS)被用来估计组差异,包括95%置信区间的影响和差异。Tukey-Kramer调整了自动如果数据是不平衡的。</p> <p>对于非参数参数,显著组差异研究利用克鲁斯卡尔-沃利斯检验,以及事后Tukey-type测试来确定不同的组。当涉及到只有两组参数比较,<年代vg height="9.125" id="M8" style="vertical-align:-0.11285pt;width:5.0124998px;" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.125)"> <g transform="translate(72,-64.7)"> <text transform="matrix(1,0,0,-1,-71.95,64.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>测试。</p> <p>用SAS v9.2进行了统计分析,统计显著性被认为是5% (<年代vg height="11.25" id="M9" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)。</p> <h4 id="results">3所示。结果</h4> <h5 id="sec3.1">3.1。il - 1<我>α</我>由PMA诱导</h5> <p>PMA增加<我>在体外</我>生产的细胞内il - 1<我>α</我>在角化细胞noncytotoxic浓度(<一个href="#B21">21</一个>),然而,最近的研究报道PMA-specific HaCaT缺陷细胞,但对il - 1效应还没有被证明<我>α</我>生产(<一个href="#B39">39</一个>,<一个href="#B40">40</一个>]。目前的研究调查了调制PMA对il - 1的影响<我>α</我>感应和释放,不同浓度和时间的孵化的函数。在icIL-1显著减少<我>α</我>生产注意到作为时间的函数,在24小时(表记录的最低水平<一个href="//www.newsama.com/journals/jsc/2012/393681/tab1/" target="_blank">1</一个>)。然而,PMA没有显著增加细胞内il - 1<我>α</我>(icIL-1<我>α</我>)生产的浓度和不同的时间点。PMA也不诱导细胞外il - 1<我>α</我>(exIL-1<我>α</我>)发布也没有表现出任何细胞毒性的影响(表<一个href="//www.newsama.com/journals/jsc/2012/393681/tab2/" target="_blank">2</一个>)。</p> <div class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-content fig-content-tab1"> <table class="table-group" id="tab1"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="7"> <hr></td> </tr> <tr> <td align="left">PMA浓缩的。(ng / mL)</td> <td align="center">Ctrl。</td> <td align="center">6.25</td> <td align="center">12.5</td> <td align="center">25</td> <td align="center">50</td> <td align="center">One hundred.</td> </tr> <tr> <td align="left">暴露(h)</td> <td align="center" colspan="6">il - 1<我>α</我>浓度(pg / mL)</td> </tr> <tr> <td align="left" colspan="7"> <hr></td> </tr> <tr> <td align="left">6</td> <td align="center"><span style="width: 109.925px;"> <svg height="15.7125" id="M10" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.7125" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 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style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 102.1125 15.65" width="102.1125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 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style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.525" id="M13" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.525" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M14" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M15" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">12</td> <td align="center"><span style="width: 101.5125px;"> <svg height="15.525" id="M16" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 101.5125 15.525" width="101.5125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 3</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 102.125px;"> <svg height="17.9625" id="M17" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 102.125 17.9625" width="102.125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.162498px;"> <svg height="17.9625" id="M18" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 99.162498 17.9625" width="99.162498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.29"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 106.975px;"> <svg height="17.9625" id="M19" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 106.975 17.9625" width="106.975" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.29"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.162498px;"> <svg height="17.9625" id="M20" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 99.162498 17.9625" width="99.162498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.29"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.162498px;"> <svg height="17.9625" id="M21" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 99.162498 17.9625" width="99.162498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.29"> B</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">24</td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.8625" id="M22" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 93.6875 15.8625" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.8625)"> <g transform="translate(72,-59.31)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> C</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.675" id="M23" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 85.875 15.675" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.675)"> <g transform="translate(72,-59.46)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> C</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.8" id="M24" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 93.6875 15.8" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.8)"> <g transform="translate(72,-59.36)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> C</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.675" id="M25" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 85.875 15.675" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.675)"> <g transform="translate(72,-59.46)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> C</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.675" id="M26" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 85.875 15.675" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.675)"> <g transform="translate(72,-59.46)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> C</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.675" id="M27" style="vertical-align:-3.25792pt" version="1.1" viewbox="0 0 85.875 15.675" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.675)"> <g transform="translate(72,-59.46)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> C</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="7"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>细胞被播种密度的15 000个细胞/。价值观代表四个复制的平均值±标准偏差。字母上标(行)表明显著不同控制和PMA浓度;在下标字母(列)表明潜伏期显著区别。值被认为是重要的时候<年代vg height="11.25" id="M28" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>。<br></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/jsc/2012/393681/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 不同培养时间的影响和PMA浓度在细胞内il - 1的生产<我>α</我>。</d我v> </div> </div> <div class="floats-partial-section partial-other-wrapper" data-section="tab2"> <div class="floats-partial-content fig-content-tab2"> <table class="table-group" id="tab2"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="7"> <hr></td> </tr> <tr> <td align="left" rowspan="2">PMA浓缩的。(ng / mL)</td> <td align="center">Ctrl。</td> <td align="center">6.25</td> <td align="center">12.5</td> <td align="center">25</td> <td align="center">50</td> <td align="center">One hundred.</td> </tr> <tr> <td align="center" colspan="6">il - 1<我>α</我>浓度(pg / mL)</td> </tr> <tr> <td align="left" colspan="7"> <hr></td> </tr> <tr> <td align="left">细胞内的</td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M29" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.7125" id="M30" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.7125" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 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109.925px;"> <svg height="15.525" id="M31" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.525" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M32" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M33" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 109.925px;"> <svg height="15.65" id="M34" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 109.925 15.65" width="109.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">细胞外</td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M35" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M36" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.65" id="M37" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.65" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M38" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.7125" id="M39" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.7125" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M40" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left"><b>% LDH释放</b></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M41" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M42" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M43" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M44" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M45" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="13.3125" id="M46" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 13.3125" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.3125)"> <g transform="translate(72,-61.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="7"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>细胞被播种密度<年代vg height="14.375" id="M47" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>/好,孵化6 h。值表示为6次重复的平均值±标准偏差。细胞毒性代表LDH释放总量的百分比。字母上标表示控制和PMA浓度之间的显著差异;在下标字母表示显著差异在细胞内和细胞外的il - 1之间<我>α</我>生产。<年代vg height="11.25" id="M48" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>被认为是显著的。PMA:佛波醇12-myristate 13-acetate;LDH:乳酸脱氢酶。<br></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表2</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/jsc/2012/393681/tab2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> PMA对细胞内和细胞外的il - 1的影响<我>α</我>生产和测定细胞毒性的影响。</d我v> </div> </div> <h5 id="sec3.2">3.2。Ionomycin对il - 1的影响<我>α</我>生产和细胞毒性</h5> <p>ionomycin诱导的能力<我>新创</我>合成和释放il - 1<我>α</我>已经证明了在subcytotoxic浓度正常角化细胞(<一个href="#B15">15</一个>]。钙离子载体促进成熟的加工和分泌il - 1<我>α</我>单核细胞和巨噬细胞(<一个href="#B41">41</一个>,<一个href="#B42">42</一个>]。当前的研究试图描述其影响icIL-1的感应和释放<我>α</我>在HaCaT细胞作为细胞生存能力的函数。Ionomycin (0.2 -10<我>μ</我>增加icIL-1 g / mL)治疗<我>α</我>剂量依赖性的方式增加了双重的为1.25<我>μ</我>克/毫升(图<一个href="//www.newsama.com/journals/jsc/2012/393681/fig1/" target="_blank">1(一)</一个>)。ionomycin更高浓度(5和10<我>μ</我>g / mL), exIL-1水平<我>α</我>显著增加,但这是与显著相关(<年代vg height="11.25" id="M49" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)细胞毒性效应与减少细胞生存能力(ATP生产)和增加细胞毒性(LDH释放(图)<一个href="//www.newsama.com/journals/jsc/2012/393681/fig1/" target="_blank">1 (b)</一个>)。</p> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig1"> <div class="floats-partial-content fig-content-fig1"> <div class="partial-carousel--single-image"> <img alt="(一)”n一个me="393681.fig.001a" src="https://static-01.hindawi.com/articles/jsc/volume-2012/393681/figures/393681.fig.001a.jpg"> <br> <strong>(一)</年代trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”n一个me="393681.fig.001b" src="https://static-01.hindawi.com/articles/jsc/volume-2012/393681/figures/393681.fig.001b.jpg"> <br> <strong>(b)</年代trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig1"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”n一个me="393681.fig.001a" src="https://static-01.hindawi.com/articles/jsc/volume-2012/393681/figures/393681.fig.001a.jpg"><br><strong>(一)</年代trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”n一个me="393681.fig.001b" src="https://static-01.hindawi.com/articles/jsc/volume-2012/393681/figures/393681.fig.001b.jpg"><br><strong>(b)</年代trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig1"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/jsc/2012/393681/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <i>α</我> <i>α</我> <svg height="11.25" id="M50" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg> <svg height="10.8125" id="M51" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 35.099998 10.8125" width="35.099998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.8125)"> <g transform="translate(72,-63.35)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.6773224" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.71771" y="0"> 4</t年代p一个n> </text> </g> </g> </svg> <table> ionomycin效应在细胞内(icIL-1 interleukin-1α浓度)和细胞外(exIL-1)环境中利用HaCaT (a)对细胞毒性的影响和细胞生存能力监控% LDH释放和% ATP生产,分别不同字母或(b)。(*)酒吧显示显著差异(从控制)。值意味着±SD ()。</t一个ble> </div> </div> </div> <h5 id="sec3.3">3.3。uv - b照射在角化细胞的影响</h5> <h6 id="sec3.3.1">3.3.1。剂量和时间紫外线照射对il - 1的影响<我>α</我>生产不同的细胞生存能力的函数参数</h6> <p>细胞内il - 1<我>α</我>生产显著不同(<年代vg height="11.25" id="M52" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)之间的潜伏期,获得的最高水平后6 h后虽然减少了12和24 h(表<一个href="//www.newsama.com/journals/jsc/2012/393681/tab3/" target="_blank">3</一个>)。细胞外的il - 1<我>α</我>(exIL-1<我>α</我>)遵循相同的趋势虽然很低水平相比icIL-1<我>α</我>。</p> <div class="floats-partial-section partial-other-wrapper" data-section="tab3"> <div class="floats-partial-content fig-content-tab3"> <table class="table-group" id="tab3"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="8"> <hr></td> </tr> <tr> <td align="left" rowspan="2">潜伏期</td> <td align="left" rowspan="2">测量单位</td> <td align="center" colspan="6">紫外线剂量(mJ /厘米<年代up>2</年代up>)</td> </tr> <tr> <td align="center">Ctrl</td> <td align="center">20.</td> <td align="center">40</td> <td align="center">80年</td> <td align="center">160年</td> <td align="center">240年</td> </tr> <tr> <td align="left" colspan="8"> <hr></td> </tr> <tr> <td align="left" rowspan="5">6小时</td> <td align="left">icIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 99.112503px;"> <svg height="15.825" id="M53" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.112503 15.825" width="99.112503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.673936" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 106.925px;"> <svg height="15.825" id="M54" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 106.925 15.825" width="106.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.663936" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 115.35px;"> <svg height="18.075001" id="M55" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 115.35 18.075001" width="115.35" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.162688" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 114.7375px;"> <svg height="15.6375" id="M56" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 114.7375 15.6375" width="114.7375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.672688" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 115.35px;"> <svg height="18.075001" id="M57" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 115.35 18.075001" width="115.35" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.162688" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 115.35px;"> <svg height="18.200001" id="M58" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 115.35 18.200001" width="115.35" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.3900003"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.162688" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left"><b>icIL-1<我>α</我>成倍增加</b></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M59" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M60" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.275002px;"> <svg height="18.225" id="M61" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.275002 18.225" width="85.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="16.012501" id="M62" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.050003 16.012501" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.275002px;"> <svg height="18.225" id="M63" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.275002 18.225" width="85.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.275002px;"> <svg height="18.225" id="M64" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.275002 18.225" width="85.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">exIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M65" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.525" id="M66" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.525" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.7125" id="M67" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.7125" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.65" id="M68" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.65" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.525" id="M69" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.525" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.7125" id="M70" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.7125" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> B</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">% LDH释放</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.7625" id="M71" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.7625" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M72" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.6375" id="M73" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.6375" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.7625" id="M74" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.7625" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.825" id="M75" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.825" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.825" id="M76" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.825" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">Caspase-3(成倍增加)</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.7625" id="M77" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.7625" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 88.912498px;"> <svg height="15.6375" id="M78" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 88.912498 15.6375" width="88.912498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="8.7659998" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 89.525002px;"> <svg height="18.075001" id="M79" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 89.525002 18.075001" width="89.525002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="8.7658882" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M80" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.825" id="M81" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.825" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M82" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left" colspan="8"> <hr></td> </tr> <tr> <td align="left" rowspan="5">12小时</td> <td align="left">icIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 106.925px;"> <svg height="15.825" id="M83" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 106.925 15.825" width="106.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.663936" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 106.925px;"> <svg height="15.7625" id="M84" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 106.925 15.7625" width="106.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.3900003"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.663936" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 107.425px;"> <svg height="15.6375" id="M85" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 107.425 15.6375" width="107.425" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.576416" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 115.35px;"> <svg height="18.200001" id="M86" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 115.35 18.200001" width="115.35" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.3900003"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.162688" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 114.7375px;"> <svg height="15.6375" id="M87" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 114.7375 15.6375" width="114.7375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="61.002136" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="70.379387" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.69,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.672688" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 107.425px;"> <svg height="15.6375" id="M88" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 107.425 15.6375" width="107.425" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.576416" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left"><b>icIL-1<我>α</我>成倍增加</b></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M89" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M90" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M91" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.887497px;"> <svg height="18.225" id="M92" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.887497 18.225" width="85.887497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M93" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.275002px;"> <svg height="18.225" id="M94" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.275002 18.225" width="85.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">exIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 85.875px;"> <svg height="15.65" id="M95" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.65" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.65)"> <g transform="translate(72,-59.48)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.7125" id="M96" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.7125" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7125)"> <g transform="translate(72,-59.43)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 93.6875px;"> <svg height="15.525" id="M97" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 93.6875 15.525" width="93.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M98" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 86.487503px;"> <svg height="17.9625" id="M99" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 86.487503 17.9625" width="86.487503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 94.300003px;"> <svg height="18.15" id="M100" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 94.300003 18.15" width="94.300003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.15)"> <g transform="translate(72,-57.48)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4399996"> B</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">% LDH释放</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.825" id="M101" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.825" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M102" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M103" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 3</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.262501" id="M104" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.262501" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2625)"> <g transform="translate(72,-57.39)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.200001" id="M105" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.200001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M106" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">Caspase-3(成倍增加)</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.825" id="M107" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.825" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M108" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 78.574997px;"> <svg height="15.55" id="M109" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 78.574997 15.55" width="78.574997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.55)"> <g transform="translate(72,-59.56)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="15.7625" id="M110" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 15.7625" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 92.474998px;"> <svg height="18.075001" id="M111" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 92.474998 18.075001" width="92.474998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 86.387497px;"> <svg height="15.55" id="M112" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 86.387497 15.55" width="86.387497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.55)"> <g transform="translate(72,-59.56)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> d</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left" colspan="8"> <hr></td> </tr> <tr> <td align="left" rowspan="5">24小时</td> <td align="left">icIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 99.612503px;"> <svg height="15.825" id="M113" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.612503 15.825" width="99.612503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.586416" y="8.4399996"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.612503px;"> <svg height="15.6375" id="M114" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.612503 15.6375" width="99.612503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.586416" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 81.387497px;"> <svg height="15.825" id="M115" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 81.387497 15.825" width="81.387497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="34.383251" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.508999" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="43.760502" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-21.94,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.621424" y="8.4399996"> c</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 108.0375px;"> <svg height="18.200001" id="M116" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 108.0375 18.200001" width="108.0375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.3900003"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.066416" y="8.3900003"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 100.225px;"> <svg height="18.262501" id="M117" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 100.225 18.262501" width="100.225" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2625)"> <g transform="translate(72,-57.39)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="11.076416" y="8.4399996"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.612503px;"> <svg height="15.825" id="M118" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.612503 15.825" width="99.612503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="10.586416" y="8.4399996"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left"><b>icIL-1<我>α</我>成倍增加</b></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M119" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M120" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.275002px;"> <svg height="18.225" id="M121" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 85.275002 18.225" width="85.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="18.225" id="M122" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 18.225" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="18.225" id="M123" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 18.225" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.225)"> <g transform="translate(72,-57.42)"> <text transform="matrix(1,0,0,-1,-71.95,60.71)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="5.3699999" y="8.4399996"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.662498px;"> <svg height="16.012501" id="M124" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 84.662498 16.012501" width="84.662498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.0125)"> <g transform="translate(72,-59.19)"> <text transform="matrix(1,0,0,-1,-71.95,62.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.81)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4499998"> </t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">exIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M125" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M126" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M127" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 85.875px;"> <svg height="15.525" id="M128" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 85.875 15.525" width="85.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.525)"> <g transform="translate(72,-59.58)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 94.300003px;"> <svg height="17.9625" id="M129" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 94.300003 17.9625" width="94.300003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 94.300003px;"> <svg height="17.9625" id="M130" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 94.300003 17.9625" width="94.300003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.9625)"> <g transform="translate(72,-57.63)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> B</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">% LDH释放</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.825" id="M131" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.825" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M132" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.6375" id="M133" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.6375" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M134" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="15.7625" id="M135" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 15.7625" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="15.825" id="M136" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 15.825" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">Caspase-3(成倍增加)</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M137" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.075001" id="M138" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.075001" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.075001" id="M139" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.075001" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.825" id="M140" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.825" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.7625" id="M141" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.7625" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="15.6375" id="M142" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 15.6375" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="8"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>细胞被播种密度<年代vg height="14.375" id="M143" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 54.424999 14.375" width="54.424999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.375)"> <g transform="translate(72,-60.5)"> <text transform="matrix(1,0,0,-1,-71.95,60.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.278666" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="26.056252" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-33.38,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>/好;值代表平均值±标准偏差的一式四份;在上标小写字母表示差异控制和紫外线剂量(mj /厘米<年代up>2</年代up>);大写字母,下标表示细胞内il - 1之间的显著差异<我>α</我>和细胞外il - 1<我>α</我>(pg / mL);小写字母在下标表示潜伏期显著区别(小时)icIL-1<我>α</我>(pg / mL), icIL-1成倍增加,毒性,capsase-3;值被认为是重要的如果<年代vg height="11.25" id="M144" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>。icIL-1<我>α</我>:细胞内白介素1<我>α</我>;exIL-1<我>α</我>:细胞外白介素1<我>α</我>;LDH:乳酸脱氢酶。<br></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表3</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/jsc/2012/393681/tab3/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> UV-induced il - 1<我>α</我>生产、细胞毒性和凋亡的影响。</d我v> </div> </div> <p>当考虑到不同的紫外线治疗6 h, icIL-1<我>α</我>水平影响最低的剂量(20 mJ /厘米<年代up>2</年代up>),而感应从40 mJ /厘米<年代up>2</年代up>以来最高水平观察细胞暴露于80 mJ /厘米<年代up>2</年代up>。的icIL-1<我>α</我>在两个最高剂量水平显著下降,但仍明显高于未经处理的控制水平。细胞外的il - 1<我>α</我>水平并未表现出对uv - b相比,未暴露的细胞。12小时后,最低的两个紫外线剂量对icIL-1没有显著影响<我>α</我>水平,而细胞暴露于80 mJ /厘米<年代up>2</年代up>影响icIL-1产量最高。然而,在两个最高紫外线剂量,感应显著(<年代vg height="11.25" id="M145" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)减少dose-dependant的方式达到类似于未经处理的控制细胞的水平。总的来说,icIL-1<我>α</我>水平显著下降相比,6 h水平。关于exIL-1<我>α</我>,有一个显著的增加水平从40到240 mJ /厘米<年代up>2</年代up>成为重要的(<年代vg height="11.25" id="M146" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)在两个最高剂量。24小时后,细胞表现出类似的模式,观察到12 h在考虑icIL-1的感应<我>α</我>。在更早的时间点相比,160 mJ /厘米<年代up>2</年代up>80 mj / cm剂量产生了类似的结果<年代up>2</年代up>照射治疗。然而,在240 mJ /厘米<年代up>2</年代up>,icIL-1<我>α</我>显著降低了类似于未经处理的控制细胞的水平。这恰逢显著减少(<年代vg height="11.25" id="M147" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>exIL-1)增加<我>α</我>类似于12 h时间点的水平。感兴趣的是icIL-1的成倍增加<我>α</我>在细胞暴露于80 mJ /厘米<年代up>2</年代up>和160 mJ /厘米<年代up>2</年代up>这是明显高(三倍)24小时相比,6 - 12 h时间点(2倍)。</p> <p>当你考虑% LDH释放细胞毒性的函数,没有注意到6 h后的效果。然而,在12 h,存在剂量依赖的相关性影响变得明显在LDH释放略有增加UV-B-treated中可观察到细胞。在24 h, LDH释放的增加是影响80 mj /厘米<年代up>2</年代up>观察到的最大活动两个最高剂量(160 mJ /厘米<年代up>2</年代up>和240 mJ /厘米<年代up>2</年代up>)。比较不同的潜伏期之间的细胞毒性效应表明6 - 12 h之间没有显著性差异而显示的最高剂量显著增加细胞毒性在24 h。</p> <p>的UV-B-induced caspase-3活动也不同在考虑不同的潜伏期和剂量的照射。当考虑caspase-3活动6 h,观察从80年增加了2倍mJ /厘米<年代up>2</年代up>及以上。12小时后,一个重要的褶皱增加(2 x)注意到从40 mj /厘米<年代up>2</年代up>15倍的剂量反应增加了剂量最高的240 mJ /厘米<年代up>2</年代up>。的icIL-1<我>α</我>凋亡率,考虑到成倍增加,在80年乔丹1:3 /厘米<年代up>2</年代up>剂量的照射。24小时后凋亡成倍增加只是观察到从80 mJ /厘米<年代up>2</年代up>及以上。褶皱增加细胞凋亡显著(<年代vg height="11.25" id="M148" style="vertical-align:-0.30096pt;width:56.150002px;" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.25)"> <g transform="translate(72,-63)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.890113" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.930502" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="32.307751" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="38.559254" y="0"> 5</t年代p一个n> </text> </g> </g> </svg>)相比下降到12 h icIL-1时间点<我>α</我>凋亡的比例约为1:1类似6 h后获得的。</p> <h6 id="sec3.3.2">3.3.2。抗炎活性(地塞米松和布洛芬)</h6> <p>调查的调制UV-induced icIL-1<我>α</我>生产HaCaT细胞,已知的抗炎化合物的抑制效应被用来验证细胞模型作为筛查工具识别化合物作为chemopreventive利用代理。地塞米松抑制UV-induced icIL-1<我>α</我>生产24 h后剂量依赖性的方式,而布洛芬只表现出抑制作用最强的最高浓度(表使用<一个href="//www.newsama.com/journals/jsc/2012/393681/tab4/" target="_blank">4</一个>)。布洛芬(1.25毫米)相比表现出最强的抑制与icIL-1地塞米松<我>α</我>级别的控制。然而,在低浓度的情况却恰恰相反。icIL-1的抑制<我>α</我>地塞米松没有显著减少在ATP生产相比UV-B-treated细胞LDH释放显著降低时,与未经处理的控制角化细胞。然而,布洛芬的抑制作用显著降低ATP生产相比,角化细胞治疗。LDH释放明显低于UV-B-treated细胞表现出类似于未经处理的细胞水平。</p> <div class="floats-partial-section partial-other-wrapper" data-section="tab4"> <div class="floats-partial-content fig-content-tab4"> <table class="table-group" id="tab4"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="6"> <hr></td> </tr> <tr class="thead"> <td align="left">地塞米松浓缩的(毫米)</td> <td align="center">Ctrl</td> <td align="center">积极的控制</td> <td align="center">1.25</td> <td align="center">0.63</td> <td align="center">0.31</td> </tr> <tr> <td class="thead-hr" colspan="6"> <hr></td> </tr> <tr> <td align="left">icIL-1<我>α</我>(pg / mL)</td> <td align="center"><span style="width: 80.287498px;"> <svg height="12.2375" id="M149" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2375)"> <g transform="translate(72,-62.21)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> </g> </g> </svg><sup>一个</年代up></span></td> <td align="center"><span style="width: 80.287498px;"> <svg height="12.175" id="M150" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.175" width="80.287498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.175)"> <g transform="translate(72,-62.26)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> </g> </g> </svg><sup>b</年代up></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.6375" id="M151" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.6375" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.675003px;"> <svg height="18.075001" id="M152" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.675003 18.075001" width="99.675003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M153" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">抑制(%)</td> <td align="center">- - - - - -</td> <td align="center">- - - - - -</td> <td align="center"><span style="width: 80.287498px;"> <svg height="12.2375" id="M154" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2375)"> <g transform="translate(72,-62.21)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 80.287498px;"> <svg height="12.2375" id="M155" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2375)"> <g transform="translate(72,-62.21)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 88.112503px;"> <svg height="12.2375" id="M156" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 88.112503 12.2375" width="88.112503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2375)"> <g transform="translate(72,-62.21)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 2</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">% ATP生产</td> <td align="center"><span style="width: 99.0625px;"> <svg height="15.825" id="M157" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.0625 15.825" width="99.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.825)"> <g transform="translate(72,-59.34)"> <text transform="matrix(1,0,0,-1,-71.95,62.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.200001" id="M158" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.200001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.200001" id="M159" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.200001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.200001" id="M160" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.200001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2)"> <g transform="translate(72,-57.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 3</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.862503px;"> <svg height="18.075001" id="M161" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 18.075001" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">%铲运机释放</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M162" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.7625" id="M163" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.7625" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.075001" id="M164" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.075001" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.075001" id="M165" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.075001" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.075001" id="M166" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.075001" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left" colspan="6"> <hr></td> </tr> <tr> <td align="left">布洛芬浓缩的(毫米)</td> <td align="center">Ctrl *</td> <td align="center">积极的Ctrl *</td> <td align="center">1.25</td> <td align="center">0.63</td> <td align="center">0.31</td> </tr> <tr> <td align="left" colspan="6"> <hr></td> </tr> <tr> <td align="left">icIL-1<我>α</我>(pg / mL)</td> <td align="center">- - - - - -</td> <td align="center">- - - - - -</td> <td align="center"><span style="width: 91.862503px;"> <svg height="15.7625" id="M167" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.862503 15.7625" width="91.862503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.7625)"> <g transform="translate(72,-59.39)"> <text transform="matrix(1,0,0,-1,-71.95,62.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.3900003"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 100.2875px;"> <svg height="18.075001" id="M168" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 100.2875 18.075001" width="100.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 100.2875px;"> <svg height="18.075001" id="M169" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 100.2875 18.075001" width="100.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 7</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">抑制(%)</td> <td align="center">- - - - - -</td> <td align="center">- - - - - -</td> <td align="center"><span style="width: 80.287498px;"> <svg height="12.2375" id="M170" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.2375)"> <g transform="translate(72,-62.21)"> <text transform="matrix(1,0,0,-1,-71.95,63.35)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">(-)</td> <td align="center">(-)</td> </tr> <tr> <td align="left">% ATP生产</td> <td align="center"><span style="width: 99.0625px;"> <svg height="15.6375" id="M171" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.0625 15.6375" width="99.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.754499" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="28.13175" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.158916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.6375" id="M172" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.6375" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 8</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 92.474998px;"> <svg height="18.262501" id="M173" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 92.474998 18.262501" width="92.474998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2625)"> <g transform="translate(72,-57.39)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4399996"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.675003px;"> <svg height="18.075001" id="M174" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.675003 18.075001" width="99.675003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8699999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 99.0625px;"> <svg height="15.6375" id="M175" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 99.0625 15.6375" width="99.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 9</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.750637" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="64.127884" y="0"> 1</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.56,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3800001" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr> <td align="left">% LDH释放</td> <td align="center"><span style="width: 83.4375px;"> <svg height="15.6375" id="M176" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 83.4375 15.6375" width="83.4375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 91.25px;"> <svg height="15.6375" id="M177" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 91.25 15.6375" width="91.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.6375)"> <g transform="translate(72,-59.49)"> <text transform="matrix(1,0,0,-1,-71.95,62.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.503" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.880251" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.907415" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.499138" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="57.876389" y="0"> 4</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.82,67.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> c</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.3899999" y="8.29"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 84.050003px;"> <svg height="18.262501" id="M178" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 84.050003 18.262501" width="84.050003" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2625)"> <g transform="translate(72,-57.39)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 9</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> b</t年代p一个n> <tspan style="font-size: 8.75px; " x="4.8800001" y="8.4399996"> 一个</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 88.912498px;"> <svg height="18.262501" id="M179" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 88.912498 18.262501" width="88.912498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.2625)"> <g transform="translate(72,-57.39)"> <text transform="matrix(1,0,0,-1,-71.95,60.65)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 5</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.4399996"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><span style="width: 88.912498px;"> <svg height="18.075001" id="M180" style="vertical-align:-3.22281pt" version="1.1" viewbox="0 0 88.912498 18.075001" width="88.912498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.075)"> <g transform="translate(72,-57.54)"> <text transform="matrix(1,0,0,-1,-71.95,60.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ±</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.996136" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.247639" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="45.373386" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.624886" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.07,65.97)"> <tspan style="font-size: 8.75px; " x="8.7600002" y="8.29"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="0"> 一个</t年代p一个n> <tspan style="font-size: 8.75px; " x="3.8858881" y="0"> b</t年代p一个n> </text> </g> </g> </svg></span></td> </tr> <tr class="table-tr"> <td colspan="6"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> <tr class="table-fn"> <td>Ctrl-control代表细胞没有暴露于紫外线光。值提出了均值±标准差。在下标字母表示显著区别治疗浓度dexamethesone和布洛芬;值在斜体代表% icIL-1抑制<我>α</我>地塞米松和布洛芬(-)表示没有抑制;%抑制从积极的控制计算。地塞米松和布洛芬是在相同的实验进行因此,类似的控制和pos控制。* Pos Ctrl -积极控制代表细胞暴露于80 mj /厘米<年代up>2</年代up>的紫外线光。icIL-1<我>α</我>细胞内interleukin-1alpha。<br></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表4</年代p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/jsc/2012/393681/tab4/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> icIL-1地塞米松和布洛芬<我>α</我>生产、细胞生存能力和细胞毒性。</d我v> </div> </div> <h4 id="discussion">4所示。讨论</h4> <p>由角化细胞细胞因子的生产已经调查<我>在体外</我>利用初级和各种各样的角化细胞细胞系(<一个href="#B12">12</一个>,<一个href="#B13">13</一个>,<一个href="#B15">15</一个>,<一个href="#B28">28</一个>,<一个href="#B43">43</一个>]。这些研究已经证实il - 1<我>α</我>产生生物活性前体蛋白在小鼠和人类的角化细胞和受伤的人类角质细胞释放的il - 1<我>α</我>可以用来预测的外部刺激的影响<我>在活的有机体内</我>炎症过程和皮肤致癌作用[<一个href="#B15">15</一个>,<一个href="#B27">27</一个>,<一个href="#B34">34</一个>,<一个href="#B43">43</一个>]。<我>在体外</我>模型表明,il - 1的生物活性<我>α</我>由佛波醇酯和uv - b诱导,可以调制各种代理包括合成和天然化合物(<一个href="#B28">28</一个>,<一个href="#B29">29日</一个>,<一个href="#B44">44</一个>),从而表明il - 1<我>α</我>,或者调制,可以发挥重要作用的治疗炎性疾病和化学预防皮肤。然而,从这些数据<我>在体外</我>角化细胞模型应该被小心的差异之间存在正常角化细胞和转化细胞系(<一个href="#B38">38</一个>,<一个href="#B39">39</一个>]。特别重要的是被广泛使用的HaCaT细胞系作为筛查工具在刺激和化学预防研究。这使自发转化细胞系已报道有致癌分子机制相关的特异表达/化学预防(<一个href="#B38">38</一个>,<一个href="#B39">39</一个>]。因此有人建议,HaCaT细胞的特性和其他转化细胞系在应用程序作为前应该批判性的评估<我>体外</我>皮肤毒性和化学预防研究模型。因此,本研究旨在描述il - 1的感应<我>α</我>和由此产生的影响细胞完整性后接触PMA, ionomycin, uv - b照射。</p> <p>虽然皮肤癌发起人PMA诱导的基因表达和il - 1<我>α</我>生产在正常角化细胞(<一个href="#B20">20.</一个>,<一个href="#B21">21</一个>],HaCaT细胞已被证明有一个PMA-specific缺陷与受损增殖蛋白激酶(MAPKs)开凿MEK / ERK信号通路(<一个href="#B39">39</一个>,<一个href="#B42">42</一个>]。然而,PMA信号参与诱导IL -<我>α</我>在鼠标角质细胞基因表达建议通过蛋白激酶C和不发生MAPK [<一个href="#B20">20.</一个>]。在目前的研究PMA诱导il - 1<我>α</我>生产,这表明PMA信号HaCaT细胞特异表达不仅是特定于MAPK但还涉及其他信号通路。因此,HaCaT细胞可能不是一个有用的模型来调查的影响佛波醇ester-like皮肤毒性化学物质和/或细胞因子诱导。然而,众所周知,通常HaCaT细胞分化[<一个href="#B45">45</一个>),提供皮肤敏化的微环境相关,例如,对表皮生长因子、转化生长因子(TGF)<我>β</我>1、TGF -<我>α</我>,白介素、干扰素γ和TNF -<我>α</我>,促进il - 1的生产<我>α</我>(<一个href="#B36">36</一个>,<一个href="#B46">46</一个>]。HaCaT细胞也发现一个合适的模型<我>在体外</我>模型来调查期和二期表皮代谢的化学物质和药物(<一个href="#B36">36</一个>]。</p> <p>钙离子载体,ionomycin,据报道启动前体il - 1的处理<我>α</我>到活跃的细胞因子通过calpain的作用在许多细胞类型,calcium-dependent膜相关蛋白酶(<一个href="#B41">41</一个>,<一个href="#B42">42</一个>]。Ionomycin增强预制il - 1的蛋白水解处理<我>α</我>和释放il - 1的成熟<我>α</我>在脂多糖(LPS)激活人类il - 1细胞系constituively产生<我>α</我>(<一个href="#B41">41</一个>]。然而,在角化细胞,本构icIL-1<我>α</我>很少在全身的前体形式分泌,但subcytotoxic ionomycin浓度已被证明增加icIL-1<我>α</我>水平相关<我>新创</我>合成(<一个href="#B15">15</一个>]。另一方面,il - 1的存在<我>α</我>在低水平的细胞外环境涉及17 kDa成熟蛋白质的分泌,处理由ionomycin通过促进calcium-dependent calpain蛋白酶(<一个href="#B47">47</一个>]。在目前的研究中,ionomycin增加了细胞内il - 1<我>α</我>在低浓度水平,这是伴随着轻微的释放到上清液;然而,在更高的浓度有细胞毒性。这是在协议与其他研究表明il - 1<我>α</我>只是释放某些严重的病理条件下与细胞死亡(<一个href="#B48">48</一个>]。不受控制的和/或坏死释放il - 1<我>α</我>可能不适合化学预防研究关心的“控制”前加剧炎症反应。与成熟的il - 1进行处理<我>α</我>,icIL-1<我>α</我>蛋白质是nonsecretable,但在坏死“泄漏”到细胞外环境中,它可以增加炎症活动的细胞通过受体信号(<一个href="#B49">49</一个>]。</p> <p>uv - b照射HaCaT细胞导致剂量依赖性增加icIL-1水平<我>α</我>释放到外部环境与轻微的细胞毒性效应在高剂量水平。这是同意类似的研究,进行了主要角质细胞中il - 1<我>α</我>据报道,增加细胞内不致命的剂量时逐步释放致命剂量(> 100 mJ /厘米吗<年代up>2</年代up>)由于膜损伤<一个href="#B50">50</一个>]。最佳折叠icIL-1的感应<我>α</我>实现24小时后紫外线剂量的80 mJ /厘米吗<年代up>2</年代up>以最小的细胞毒性和低水平的细胞凋亡相比12 h时间点。HaCaT细胞诱导凋亡的uv - b光与另一项研究提供证据表明UV-induced凋亡通过内在收益(线粒体)和外在途径(<一个href="#B51">51</一个>]。细胞凋亡的程度将取决于紫外线引起的DNA损伤的数量,和后者的调制主要影响皮肤致癌的感应。</p> <p>il - 1<我>α</我>建议具有双重功能,即细胞内激活转录机械及其相关影响炎症的恶化和胞外受体介导的信号转导<一个href="#B49">49</一个>,<一个href="#B52">52</一个>]。在UV-B-exposed角质细胞,表明il - 1<我>α</我>不仅调节自己的生产,但也会增加肿瘤坏死因子等促炎细胞因子的生产<我>α</我>、il - 6和引发(<一个href="#B53">53</一个>]。调制的胞内il - 1的函数<我>α</我>因此,似乎是一个有用的目标在某些炎症条件(<一个href="#B52">52</一个>]。失活的生物活性il - 1<我>α</我>,比如通过诱导细胞凋亡可以防止炎症由于它是保留在染色质分数与胞质内容(没有公布<一个href="#B49">49</一个>]。这表明UV-induced il - 1<我>α</我>生产可能是一个有用的模型来调节炎症从而破坏机制通过调制炎性疾病相关的细胞凋亡。</p> <p>uv - b照射也是诱发自然的释放il - 1抑制剂,表皮细胞contra-IL-1和内源性il - 1受体拮抗剂(IL-1ra)角化细胞(<一个href="#B54">54</一个>,<一个href="#B55">55</一个>]。这些分子的释放与调节免疫和增生性反应通过阻断il - 1的活动。IL-1ra也已经有了很广泛的研究(<一个href="#B47">47</一个>),其拮抗剂活动归因于特定比率IL-1ra / il - 1<我>α</我>可被其他细胞因子和各种代理包括uv - b辐射调制(<一个href="#B46">46</一个>,<一个href="#B56">56</一个>,<一个href="#B57">57</一个>]。调制的IL-1ra / il - 1<我>α</我>比通过uv - b依赖于剂量低剂量与高水平的IL-1ra虽然高剂量的平衡转向il - 1<我>α</我>(<一个href="#B57">57</一个>,<一个href="#B58">58</一个>]。这种不平衡对il - 1<我>α</我>与炎症相关疾病包括皮肤致癌作用[<一个href="#B56">56</一个>]表明IL-1ra / il - 1<我>α</我>致癌作用的不同阶段之间的比率不同。IL-1ra被发现在细胞的最高水平代表的早期阶段皮肤致癌作用与抗肿瘤活性的地方(<一个href="#B59">59</一个>]。调制IL-1ra / il - 1之间的比率<我>α</我>提供了一种替代机制,可以探索和纳入发展化学预防细胞模型<我>在体外</我>。</p> <p>糖皮质激素的抑制作用(GR)、地塞米松、和抗炎药布洛芬,il - 1<我>α</我>生产表明,该模型也可以用于测试抗炎作用,除了诱导细胞凋亡。地塞米松能激活胞质GR转录因子的受体,使敌对活动如激活蛋白1 (AP-1),核因子kappaβ(NF -<我>κ</我>B),这些是所需的促炎细胞因子的基因表达和生产<一个href="#B60">60</一个>]。据报道,布洛芬也被下调促炎细胞因子的生产在高剂量,除了影响下游环氧酶(<一个href="#B61">61年</一个>]。抑制il - 1<我>α</我>在当前的研究中有关降低无细胞毒性,细胞代谢活动的调制凋亡细胞死亡应该进一步调查。</p> <p>目前uv - b / HaCaT<我>在体外</我>模型提供了充足的机会调节il - 1的生产<我>α</我>相关的信号转导途径,要么通过扰乱它的感应和/或通过增强细胞凋亡从而间接消除细胞含有超标的主要细胞因子。除了佛波醇的活性ester-like化合物,HaCaT细胞行为类似于正常皮肤角质细胞,特别是在应对紫外线照射,因此可以被用来监控il - 1的调制<我>α</我>内容由潜在的抗炎和或proapoptotic化合物。然而,利用不同的后续验证<我>在活的有机体内</我>系统在小鼠和人类皮肤之前应该用于验证他们的调制特性调制il - 1的开发可能的治疗产品<我>α</我>生产。</p> <h4 id="acknowledgments">确认</h4> <p>作者感谢南非洛依柏丝理事会和南非的癌症协会(CANSA)资助的研究。</p> </div> <div class="xml-content"> <h4 class="references" id="references">引用</h4> <ol> <li id="B1">m·m·穆勒”在皮肤上皮肿瘤炎症:老故事和新的想法,”<我>欧洲癌症杂志</我>,42卷,不。6,735 - 744年,2006页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://doi.org/10.1016/j.ejca.2006.01.014">出版商的网站</一个><span class="sep">|</年代p一个n><a href="https://scholar.google.com/scholar_lookup?title=Inflammation%20in%20epithelial%20skin%20tumours:%20old%20stories%20and%20new%20ideas&author=M. 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Rubartelli&publication_year=1995" target="_blank">谷歌学术搜索</一个></span></li> <li id="B57">w·卢h·李,和y . k .公园”,反对紫外线B辐射对受体拮抗剂及interleukin-1<我>α</我>信使RNA表达人类表皮样癌细胞系,”<我>Photodermatology Photoimmunology,光医学</我>,11卷,不。3、91 - 94年,1995页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Opposing%20effects%20of%20ultraviolet%20B%20irradiation%20on%20interleukin-1%20receptor%20antagonist%20and%20interleukin-1a%20messenger%20RNA%20expression%20in%20a%20human%20epidermoid%20carcinoma%20cell%20line&author=W. Lew&author=S. H. Lee&author=&author=Y. K. Park&publication_year=1995" target="_blank">谷歌学术搜索</一个></span></li> <li id="B58">t . Muhlberg w .小张,c . Spitzweg h·d·Schworm h . j . Heberling和a . e . Heufelder受体拮抗剂核糖核酸及蛋白质表达培养坟墓的和正常的轨道成纤维细胞不同调制地塞米松和辐照,”<我>临床内分泌和代谢杂志》上</我>,卷85,不。2、734 - 742年,2000页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://doi.org/10.1210/jc.85.2.734">出版商的网站</一个><span class="sep">|</年代p一个n><a href="https://scholar.google.com/scholar_lookup?title=Interleukin-1%20receptor%20antagonist%20ribonucleic%20acid%20and%20protein%20expression%20by%20cultured%20Graves'%20and%20normal%20orbital%20fibroblasts%20is%20differentially%20modulated%20by%20dexamethasone%20and%20irradiation&author=T. Mühlberg&author=W. Joba&author=C. Spitzweg&author=H. D. Schworm&author=H. J. Heberling&author=&author=A. E. Heufelder&publication_year=2000" target="_blank">谷歌学术搜索</一个></span></li> <li id="B59">美国洛杉矶,j .蒙加m . f . Locniskar和s·m·费舍尔,“改变的表达interleukin-1受体拮抗剂在小鼠皮肤致癌作用的不同阶段,“<我>分子致癌作用</我>,24卷,不。4、276 - 286年,1999页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Altered%20expression%20of%20interleukin-1%20receptor%20antagonist%20in%20different%20stages%20of%20mouse%20skin%20carcinogenesis&author=E. La&author=S. J. Muga&author=M. F. Locniskar&author=&author=S. M. Fischer&publication_year=1999" target="_blank">谷歌学术搜索</一个></span></li> <li id="B60">w . y . Almawi和o . k . Melemedjian“糖皮质激素抗增殖作用的分子机制:拮抗糖皮质激素受体转录因子的活动,“<我>《白细胞生物学</我>,卷71,不。1、9 - 15,2002页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://scholar.google.com/scholar_lookup?title=Molecular%20mechanisms%20of%20glucocorticoid%20antiproliferative%20effects:%20antagonism%20of%20transcription%20factor%20activity%20by%20glucocorticoid%20receptor&author=W. Y. Almawi &author=O. K. Melemedjian&publication_year=2002" target="_blank">谷歌学术搜索</一个></span></li> <li id="B61">m . s .焦虑中,j·d·克拉克,卡瓦略,m .刺痛,m . Schmelz华盛顿美国约曼公司,”在人类皮肤细胞因子反应实验炎症,有害刺激,和管理COX-inhibitor:研究中,一个微量透析可把时程延长”<我>疼痛</我>,卷139,不。1、15 -,2008页。<年代p一个ncl一个年代年代=”reflinks">视图:<一个href="https://doi.org/10.1016/j.pain.2008.02.028">出版商的网站</一个><span class="sep">|</年代p一个n><a href="https://scholar.google.com/scholar_lookup?title=Cytokine%20profile%20in%20human%20skin%20in%20response%20to%20experimental%20inflammation,%20noxious%20stimulation,%20and%20administration%20of%20a%20COX-inhibitor:%20a%20microdialysis%20study&author=M. S. Angst&author=J. D. Clark&author=B. Carvalho&author=M. Tingle&author=M. Schmelz&author=&author=D. C. Yeomans&publication_year=2008" target="_blank">谷歌学术搜索</一个></span></li> </ol> </div> <div class="xml-content"> <h4 class="copyright" id="copyright">版权</h4> <p>版权©2012 t Magcwebeba等。这是一个开放的分布式下文章<一个rel=”l我cen年代e”href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</一个>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</p> </div> </div> </article> </div> </div> </div> <div class="biblio__Wrapper-sc-1nou1lz-0 eyHfWh journal_article__BiblioIntegratorWidget-sc-12fk6zy-5 dbAANp article_widget biblioWrapper hide"> <hr> <h4 class="biblio__H4-sc-1nou1lz-2 becpDt hrTitleRef">更多相关文章</h4> <div id="biblio_widget" class="biblio__BiblioWrapper-sc-1nou1lz-1 hFGNjP"></div> </div> </div> </div> <div class="threeColumn__RightWrapper-sc-1bf4078-2 jzTMLK rightWrapper" id="rightSectionMenu"> <div> <div class="journal_article__ArticleStickyTopToolbar-sc-12fk6zy-0 gbrQxi article_sticky_top_toolbar"> <div class="sc-cBdUnI hRnXob article_top_toolbar"> <a class="sc-htpNat bUhGXt link sc-jtRfpW dIjoCg sc-exkUMo hymroZ 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src="data:image/svg+xml;base64,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" height="24"><span class="sc-dRFtgE jrsDZP">下载其他格式</年代p一个n><span class="sc-gkFcWv gWTCXQ">更多的</年代p一个n></span> <span class="sc-htoDjs bMdQcY sc-gbOuXE jGPvPL icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="11"></span> </div> <div class="sc-fnwBNb etzuBr"> <a class="sc-htpNat bUhGXt link sc-iNhVCk gWgCNb open_panel" href="//www.newsama.com/downloads/journals/jsc/2012/393681.epub" aria-label="ePub" property="background-color" color="#D8D8D8"> <div class="sc-eAKXzc WHkfb"> ePub</d我v><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" src="data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHN2ZyB3aWR0aD0iMjBweCIgaGVpZ2h0PSIyMnB4IiB2aWV3Qm94PSIwIDAgMjAgMjIiIHZlcnNpb249IjEuMSIgeG1sbnM9Imh0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnIiB4bWxuczp4bGluaz0iaHR0cDovL3d3dy53My5vcmcvMTk5OS94bGluayI+CiAgICA8IS0tIEdlbmVyYXRvcjogU2tldGNoIDUzLjIgKDcyNjQzKSAtIGh0dHBzOi8vc2tldGNoYXBwLmNvbSAtLT4KICAgIDx0aXRsZT5jaGV2cm9uLWRvd24gY29weSAzPC90aXRsZT4KICAgIDxkZXNjPkNyZWF0ZWQgd2l0aCBTa2V0Y2guPC9kZXNjPgogICAgPGRlZnM+CiAgICAgICAgPHBhdGggZD0iTTExLDEzLjU4NTc4NjQgTDExLDIgQzExLDEuNDQ3NzE1MjUgMTEuNDQ3NzE1MywxIDEyLDEgQzEyLjU1MjI4NDcsMSAxMywxLjQ0NzcxNTI1IDEzLDIgTDEzLDEzLjU4NTc4NjQgTDE1LjI5Mjg5MzIsMTEuMjkyODkzMiBDMTUuNjgzNDE3NSwxMC45MDIzNjg5IDE2LjMxNjU4MjUsMTAuOTAyMzY4OSAxNi43MDcxMDY4LDExLjI5Mjg5MzIgQzE3LjA5NzYzMTEsMTEuNjgzNDE3NSAxNy4wOTc2MzExLDEyLjMxNjU4MjUgMTYuNzA3MTA2OCwxMi43MDcxMDY4IEwxMi43MDcxMDY4LDE2LjcwNzEwNjggQzEyLjMxNjU4MjUsMTcuMDk3NjMxMSAxMS42ODM0MTc1LDE3LjA5NzYzMTEgMTEuMjkyODkzMiwxNi43MDcxMDY4IEw3LjI5Mjg5MzIyLDEyLjcwNzEwNjggQzYuOTAyMzY4OTMsMTIuMzE2NTgyNSA2LjkwMjM2ODkzLDExLjY4MzQxNzUgNy4yOTI4OTMyMiwxMS4yOTI4OTMyIEM3LjY4MzQxNzUxLDEwLjkwMjM2ODkgOC4zMTY1ODI0OSwxMC45MDIzNjg5IDguNzA3MTA2NzgsMTEuMjkyODkzMiBMMTEsMTMuNTg1Nzg2NCBaIE0yLDE3IEMyLDE2LjQ0NzcxNTMgMi40NDc3MTUyNSwxNiAzLDE2IEMzLjU1MjI4NDc1LDE2IDQsMTYuNDQ3NzE1MyA0LDE3IEw0LDIwIEM0LDIwLjU1MjI4NDcgNC40NDc3MTUyNSwyMSA1LDIxIEwxOSwyMSBDMTkuNTUyMjg0NywyMSAyMCwyMC41NTIyODQ3IDIwLDIwIEwyMCwxNyBDMjAsMTYuNDQ3NzE1MyAyMC40NDc3MTUzLDE2IDIxLDE2IEMyMS41NTIyODQ3LDE2IDIyLDE2LjQ0NzcxNTMgMjIsMTcgTDIyLDIwIEMyMiwyMS42NTY4NTQyIDIwLjY1Njg1NDIsMjMgMTksMjMgTDUsMjMgQzMuMzQzMTQ1NzUsMjMgMiwyMS42NTY4NTQyIDIsMjAgTDIsMTcgWiIgaWQ9InBhdGgtMSI+PC9wYXRoPgogICAgPC9kZWZzPgogICAgPGcgaWQ9IlN5bWJvbHMiIHN0cm9rZT0ibm9uZSIgc3Ryb2tlLXdpZHRoPSIxIiBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiPgogICAgICAgIDxnIGlkPSJTaWRlYmFycy9EZXNrdG9wL0FydGljbGUtU2lkZWJhciIgdHJhbnNmb3JtPSJ0cmFuc2xhdGUoLTI5MS4wMDAwMDAsIC0xMzQuMDAwMDAwKSI+CiAgICAgICAgICAgIDxnIGlkPSJEb3dubG9hZC1yZWZlcmVuY2UiIHRyYW5zZm9ybT0idHJhbnNsYXRlKDAuMDAwMDAwLCAxMTIuMDAwMDAwKSI+CiAgICAgICAgICAgICAgICA8ZyBpZD0iVHlwZS1hbmQtaWNvbnMiIHRyYW5zZm9ybT0idHJhbnNsYXRlKDIwLjAwMDAwMCwgMjEuMDAwMDAwKSI+CiAgICAgICAgICAgICAgICAgICAgPGcgaWQ9Ikljb25zL0Rvd25sb2FkIiB0cmFuc2Zvcm09InRyYW5zbGF0ZSgyNjkuMDAwMDAwLCAwLjAwMDAwMCkiPgogICAgICAgICAgICAgICAgICAgICAgICA8ZyBpZD0iZG93bmxvYWQiPgogICAgICAgICAgICAgICAgICAgICAgICAgICAgPG1hc2sgaWQ9Im1hc2stMiIgZmlsbD0id2hpdGUiPgogICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIDx1c2UgeGxpbms6aHJlZj0iI3BhdGgtMSI+PC91c2U+CiAgICAgICAgICAgICAgICAgICAgICAgICAgICA8L21hc2s+CiAgICAgICAgICAgICAgICAgICAgICAgICAgICA8dXNlIGlkPSJDb21iaW5lZC1TaGFwZSIgZmlsbD0iIzAwMDAwMCIgZmlsbC1ydWxlPSJub256ZXJvIiB4bGluazpocmVmPSIjcGF0aC0xIj48L3VzZT4KICAgICAgICAgICAgICAgICAgICAgICAgICAgIDxnIGlkPSJDT0xPUi8tUHJpbWFyeS1HcmVlbiIgbWFzaz0idXJsKCNtYXNrLTIpIiBmaWxsPSIjNkJBNDM5IiBmaWxsLXJ1bGU9ImV2ZW5vZGQiPgogICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIDxyZWN0IGlkPSJSZWN0YW5nbGUiIHg9IjAiIHk9IjAiIHdpZHRoPSIyNCIgaGVpZ2h0PSIyNCI+PC9yZWN0PgogICAgICAgICAgICAgICAgICAgICAgICAgICAgPC9nPgogICAgICAgICAgICAgICAgICAgICAgICA8L2c+CiAgICAgICAgICAgICAgICAgICAgPC9nPgogICAgICAgICAgICAgICAgPC9nPgogICAgICAgICAgICA8L2c+CiAgICAgICAgPC9nPgogICAgPC9nPgo8L3N2Zz4=" height="24"></a> <a class="sc-htpNat bUhGXt link sc-iNhVCk gWgCNb open_panel" href="//www.newsama.com/downloads/journals/jsc/2012/393681.xml" aria-label="XML" property="background-color" color="#D8D8D8"> <div class="sc-eAKXzc WHkfb"> XML</d我v><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" src="data:image/svg+xml;base64,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" 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height="24"><span class="sc-dRFtgE jrsDZP">订单打印副本</年代p一个n><span class="sc-gkFcWv gWTCXQ">订单</年代p一个n></span><span class="sc-htoDjs kNoiZu sc-gbOuXE jGPvPL right__icon icon-colored _32KP5uexH-Bgs7Kj8Gk1Tz icon-themeable" title="" font-size="16"></span></a> <div class="sc-hBbWxd kdRRST"> <div class="sc-dyGzUR cHatnS"> <div> 的观点<年代p一个n>7798年</年代p一个n> </div> <div> 下载<年代p一个n>2293年</年代p一个n> </div> </div> <div> <div class="sc-drKuOJ kxdGAZ"> <span class="__dimensions_badge_embed__" data-doi="10.1155/2012/393681" data-style="small_circle"></span>引用</d我v> </div> </div> <nav class="sc-bRBYWo fXBKFa sc-hUfwpO jHPgUP" id="toolbar__iconNav"> <h3 class="sc-Rmtcm hNPrIr">分享文章</h3> <ul class="sc-hzDkRC bnbfTS"> <li class="iconBorder"><a class="sc-htpNat bUhGXt link" href="https://twitter.com/share?url=https://doi.org/10.1155/2012/393681&via=Hindawi" aria-label="Sharing on Twitter" rel="noopener noreferrer" target="_blank"><img alt="" class="sc-EHOje jOLhQl socialTwitter" title="" role="presentation" 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