疾病标记

研究文章

揭示了Affymetrix DMET +平台独特ADME-Related变体在阿拉伯民族的分布

表2

non-CYP450变体的分布水平DMET +平台。


集团	类型	所有	加器分布
集团	类型	所有	未被发现	< 0.01	> 0.01

转运蛋白	ABC转运蛋白	242年	108 (0.44)	33 (0.14)	101 (0.42)
	溶质转运蛋白	322年	137 (0.42)	47 (0.15)	138 (0.43)
	atp酶、铜^{2 +}转运蛋白α肽	17	7 (0.41)	1 (0.06)	9 (0.53)

转移酶	Glucuronosyltransferases (ugt)	116年	58 (0.50)	11 (0.10)	47 (0.40)
	Sulfotransferases	138年	45 (0.33)	18 (0.13)	75 (0.54)
	谷胱甘肽S-transferase	88年	42 (0.48)	4 (0.04)	42 (0.48)
	n -乙酰氨基葡萄糖转移酶	37	20 (0.54)	5 (0.13)	12 (0.32)
	NNMT HNMT,其他人(COMT的垫子,硫代嘌呤甲基转移酶,QPRT, PNMT)	40	19日(0.48)	5 (0.12)	16 (0.40)

脱氢酶	抗利尿激素;aldh、XDHs G6PD	104年	54 (0.52)	7 (0.07)	43 (0.41)

单氧酶	AOX fmo,人物形象	92年	38 (0.41)	10 (0.11)	44 (0.48)

还原酶	VKORC1 HMGCRs,穷,CBR	43	16 (0.37)	7 (0.16)	20 (0.47)

受体	NR1,成员2和3	21	11 (0.52)	3 (0.14)	7 (0.33)
	PPARγ、δ	53	13 (0.25)	2 (0.03)	38 (0.72)
	核受体亚科3	12	5 (0.42)	5 (0.42)	2 (0.16)
	其他(RALBP1 SPN, APOA RXRA, AHR, ARNT)	25	11 (0.44)	4 (0.16)	10 (0.40)

杂项	铝青铜、ARSA CA5P AKAP CDA, CES上,PTGIS, CCDC, CROT,抢断,FAAH, EPHX, DCK,彩球,TBXAS, TPSG, ORM, PGAP3,阿通,PPP1R9, PRSS53, RPL, TYMS	144年	71 (0.49)	21日(0.15)	52 (0.36)

ABC,腺苷结合盒转运蛋白;ALDH醛脱氢酶;抗利尿激素、酒精脱氢酶3班;铝青铜,白蛋白;ARSA arylsulfatase;AHR,芳基碳氢化合物受体;AKAP锚蛋白激酶;APOA、载脂蛋白受体亚型;AOX,替代氧化酶;CA5P碳酸酐酶; CBR, carbonyl reductase; CCDC, coiled-coil domain-containing protein; CDA, cytidine deaminase; CES, carboxylesterase; COMT, catechol-O-methyl transferase; CROT, peroxisomal carnitine O-octanoyltransferase; DCK, deoxycytidine kinase; EPHX, microsomal epoxide hydrolase; FAAH, fatty acid amide hydrolase; FMO, flavin-containing monooxygenase; G6PD, glucose 6-phosphate dehydrogenase; HNMT, histamine N-methyltransferase; MAO, monoamine oxidase; MAT, methionine adenosyl transferases; NNMT, nicotinamide N-methyltransferase; NR1, nucleic acid receptor, group 1; ORM, orosomucoid; PGAP3, post-GPI attachment to proteins 3; PON, serum paraoxonase/arylesterase; POR, cytochrome P450 reductase; PPAR, peroxisome proliferator-activated receptors; PNMT, phenylethanolamine N-methyltransferase; PTGIS, prostaglandin-I synthase; QPRT, quinolinate phosphoribosyltransferase; PPP1R9, protein phosphatase 1, regulatory subunit 9B; PRSS53; serine protease, 53; RALBP1, ralA binding protein 1; RPL, ribosomal protein-binding receptor; RXRA, retinoic acid receptor; SERPINA, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin); SPG, spastic paraplegia; SPN, sialophorin receptor; TBXAS, thromboxane A synthase 1 (platelet); TYMS, thymidylate synthetase; TPMT, thiopurine S-methyltransferase; TPSG, tryptase; XDH, xanthine dehydrogenases.