研究文章
新易感性位点心肌梗塞、高血压、2型糖尿病、血脂异常12号染色体上抓起
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|
|
S.E. |
瓦尔德 |
价值 |
Exp () |
95% C.I. Exp () |
| 较低的 |
上 |
|
| 心肌梗死 |
|
|
|
|
|
|
|
| rs2259820_CC |
0.178 |
0.087 |
4.20 |
0.041 |
1.19 |
1.01 |
1.42 |
| rs2464196_TT |
0.171 |
0.086 |
4.01 |
0.045 |
1.19 |
1.00 |
1.40 |
| rs2259816_T |
0.123 |
0.057 |
4.67 |
0.031 |
1.13 |
1.01 |
1.26 |
| 2型糖尿病 |
|
|
|
|
|
|
|
| rs2259820_T |
0.129 |
0.051 |
6.40 |
0.011 * |
1.14 |
1.03 |
1.26 |
| rs2259820_CT + TT |
0.178 |
0.085 |
4.39 |
0.036 |
1.20 |
1.01 |
1.41 |
| rs2464196_C |
0.114 |
0.051 |
5.06 |
0.024 |
1.12 |
1.02 |
1.24 |
| rs1169310_G |
−0.104 |
0.051 |
4.17 |
0.041 |
0.90 |
0.82 |
1.00 |
| 高血压 |
|
|
|
|
|
|
|
| rs2393791_T |
0.127 |
0.059 |
4.58 |
0.032 |
1.14 |
1.01 |
1.28 |
| rs7310409_G |
0.148 |
0.059 |
6.16 |
0.013 * |
1.16 |
1.03 |
1.30 |
| rs2259820_T |
−0.149 |
0.059 |
6.46 |
0.011 * |
0.86 |
0.77 |
0.97 |
| rs2464196_AG + GG |
0.223 |
0.088 |
6.39 |
0.012 * |
1.25 |
1.05 |
1.49 |
| 高甘油三酯血症 |
|
|
|
|
|
|
|
| rs2393791_T |
0.129 |
0.054 |
5.59 |
0.018 * |
1.14 |
1.02 |
1.27 |
| rs7310409_G |
0.117 |
0.054 |
4.64 |
0.031 |
1.12 |
1.01 |
1.25 |
| rs2259820_C |
−0.130 |
0.054 |
5.82 |
0.016 * |
0.88 |
0.79 |
0.98 |
| rs2464196_T |
−0.108 |
0.054 |
4.04 |
0.044 |
0.90 |
0.81 |
1.00 |
| rs2259816_T |
−0.117 |
0.055 |
4.52 |
0.034 |
0.90 |
0.80 |
0.99 |
| rs1169310_G |
0.140 |
0.054 |
6.71 |
0.010 * |
1.15 |
1.04 |
1.28 |
| rs1169313_ (CT + TT) |
0.215 |
0.080 |
7.14 |
0.008 * |
1.24 |
1.06 |
1.45 |
| 低密度脂蛋白胆固醇水平高 |
|
|
|
|
|
|
|
| rs2259820_T |
0.203 |
0.070 |
8.44 |
0.004 * * |
1.23 |
1.07 |
1.41 |
| rs2464196_T |
0.198 |
0.069 |
8.16 |
0.004 * * |
1.22 |
1.06 |
1.39 |
| rs2259816_T |
0.164 |
0.072 |
5.19 |
0.023 |
1.18 |
1.02 |
1.36 |
| rs1169310_G |
−0.175 |
0.071 |
6.13 |
0.013 * |
0.84 |
0.73 |
0.96 |
| rs1169313_T |
−0.160 |
0.071 |
5.10 |
0.024 |
0.85 |
0.74 |
0.98 |
|
|
表列出了变异与心肌梗死(MI);3044例和1587控制),2型糖尿病(2550和2081),高血压(3528和1103),高甘油三酯血症(1160和3156),(631和3681)和低密度脂蛋白胆固醇水平在4631个人学习之前和之后的调整影响的其他风险因素,Bonferroni调整,调整后干扰共存的疾病和协变量(见补充数据)。:β系数;C.I.:置信区间;经验:指数;价值观:调整调整混杂因素后的价值意义。;。
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