文摘

因为环境暴露于创伤的必要条件是创伤后应激障碍(PTSD)的发展,最近关注基因研究一直是引人注目的。此类研究的主要催化剂是流行病学研究的观察,不是所有创伤幸存者开发这个障碍。此外,神经内分泌发现已存在的荷尔蒙改变产生创伤后应激障碍的风险。提出的基本原理研究遗传因素在创伤后应激障碍和创伤暴露,但研究表明,基因型可能只存在有限的图片这种疾病的分子生物学。我们描述的信息的类型可以从候选基因和基因组研究获得纳入环境因素在设计(即。,gene – environment interaction and gene-environment correlation studies) and studies that capitalize on the idea that environment modifies gene expression, via epigenetic or other molecular mechanisms. The examination of epigenetic mechanisms in tandem with gene expression will help refine models that explain how PTSD risk, pathophysiology, and recovery is mediated by the environment. Since inherited genetic variation may also influence the extent of epigenetic or gene expression changes resulting from the environment, such studies should optimally be followed up by studies of genotype.