PDF
开放获取
向仲民，Vahram Haroutunian, Lap Ho, Dushant Purohit, Giulio Maria Pasinetti， ＂小胶质细胞在大脑中的激活作为阿尔茨海默病神经病理学和临床痴呆的炎症生物标志物"，疾病标记， 卷。22， 文章的ID276239， 8 页面， 2006． https://doi.org/10.1155/2006/276239
小胶质细胞在大脑中的激活作为阿尔茨海默病神经病理学和临床痴呆的炎症生物标志物
摘要
小胶质细胞介导的炎症在阿尔茨海默病(AD)神经病理学进展中的作用尚不清楚。在这项研究中,后期大脑部分来自广告和控制情况下受到人类白细胞抗原(HLA)是免疫组织化学检查小胶质细胞激活广告评估的进展pre-mortem临床痴呆评定(CDR)和尸检病理表现神经炎的斑块(NP)和神经原纤维缠结(NT)根据Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). In both gray and white matter of the entorhinal cortex (EC) and HLA-DR immunostaining increased with the progression of CDR or CERAD NP, and to a lesser degree with CERAD NT. Between CDR stages HLA-DR significance was found in moderate (CDR 2) to severe dementia (CDR 5) where as between CERAD NP stages staining increased significantly from NP 0 (no plaque) to NP 1 (sparse plaques), suggesting increased microglia activation begins with amyloid NP deposition. In the hippocampus, a significant increase in microglia immunostaining was found in the pyramidal cell layer of CA1 as early as CDR 1, and in the upper molecular layer of the dentate gyrus in CDR 0.5. This increase continues with the progression of CDR and reaches maximum in CDR 5. When assessed by CERAD NP stages however, a significant increase in microglia immunostaining was found only in mid-to-late stages (NP 3) and reduced staining was seen in NP 5. These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on the involved brain region.
版权
版权所有©2006 Hindawi出版公司。这是一篇发布在知识共享署名许可协议，允许在任何媒介上不受限制地使用、传播和复制，但必须正确引用原作。
