研究文章
模拟研究比较不同统计方法预测生物标志物的鉴定
表1
估计错误概率与精确
置信区间(在括号中)为所有研究方法场景1和2。
|
|
n= 250 |
n= 500 |
n= 1000 |
| 低岑。 |
高岑。 |
低岑。 |
高岑。 |
低岑。 |
高岑。 |
|
| 场景1 |
平均分割 |
4.7% |
5.3% |
4.9% |
4.4% |
5.0% |
6.4% |
| (3.5 - -6.2%) |
(4.0 - -6.9%) |
(3.6 - -6.4%) |
(3.2 - -5.9%) |
(3.7 - -6.5%) |
(5.0 - -8.1%) |
| 四分位数分裂 |
6.3% |
5.3% |
4.2% |
5.1% |
3.5% |
5.7% |
| (4.9 - -8.0%) |
(4.0 - -6.9%) |
(3.0 - -5.6%) |
(3.8 - -6.7%) |
(2.4 - -4.8%) |
(4.3 - -7.3%) |
| 最优分割 |
43.6% |
39.9% |
45.8% |
40.9% |
45.5% |
46.6% |
| (40.5 - -46.7%) |
(36.8 - -43.0%) |
(42.7 - -48.9%) |
(37.8 - -44.0%) |
(42.4 - -48.6%) |
(43.5 - -49.7%) |
| STEPP |
4.8% |
5.9% |
5.1% |
4.2% |
4.0% |
6.3% |
| (3.6 - -6.3%) |
(4.5 - -7.5%) |
(3.8 - -6.7%) |
(3.0 - -5.6%) |
(2.9 - -5.4%) |
(4.9 - -8.0%) |
| 考克斯(线性int)。 |
4.9% |
5.2% |
4.8% |
4.4% |
4.8% |
5.8% |
| (3.6 - -6.4%) |
(3.9 - -6.8%) |
(3.6 - -6.3%) |
(3.2 - -5.9%) |
(3.6 - -6.3%) |
(4.4 - -7.4%) |
| MFPI (FP1-flex3) |
10.1% |
10.6% |
10.4% |
12.0% |
10.3% |
13.5% |
| (8.3 - -12.1%) |
(8.8 - -12.7%) |
(8.6 - -12.5%) |
(10.1 - -14.2%) |
(8.5 - -12.4%) |
(11.4 - -15.8%) |
| MFPI (FP2-flex1) |
4.9% |
5.6% |
4.9% |
4.7% |
6.0% |
7.0% |
| (3.6 - -6.4%) |
(4.3 - -7.2%) |
(3.6 - -6.4%) |
(3.5 - -6.2%) |
(4.6 - -7.7%) |
(5.5 - -8.8%) |
| LPLB |
4.6% |
4.5% |
4.2% |
4.4% |
3.9% |
5.8% |
| (3.4 - -6.1%) |
(3.3 - -6.0%) |
(3.0 - -5.6%) |
(3.2 - -5.9%) |
(2.8 - -5.3%) |
(4.4 - -7.4%) |
|
| 场景2 |
平均分割 |
4.2% |
6.0% |
5.7% |
4.2% |
5.7% |
4.3% |
| (3.0 - -5.6%) |
(4.6 - -7.7%) |
(4.3 - -7.3%) |
(3.0 - -5.6%) |
(4.3 - -7.3%) |
(3.1 - -5.7%) |
| 四分位数分裂 |
5.3% |
6.7% |
5.1% |
4.5% |
5.0% |
5.4% |
| (4.0 - -6.9%) |
(5.2 - -8.4%) |
(3.8 - -6.7%) |
(3.3 - -6.0%) |
(3.7 - -6.5%) |
(4.1 - -7.0%) |
| 最优分割 |
50.8% |
42.8% |
53.9% |
45.9% |
52.0% |
47.4% |
| (47.7 - -53.9%) |
(39.7 - -45.9%) |
(50.8 - -57.0%) |
(42.8 - -49.0%) |
(48.9 - -55.1%) |
(44.3 - -50.5%) |
| STEPP |
5.4% |
8.2% |
6.8% |
6.8% |
7.8% |
6.9% |
| (4.1 - -7.0%) |
(6.6 - -10.1%) |
(5.3 - -8.5%) |
(5.3 - -8.5%) |
(6.2 - -9.6%) |
(5.4 - -8.7%) |
| 考克斯(线性int)。 |
4.5% |
8.2% |
4.8% |
6.4% |
5.0% |
5.2% |
| (3.3 - -6.0%) |
(6.6 - -10.1%) |
(3.6 - -6.3%) |
(5.0 - -8.1%) |
(3.7 - -6.5%) |
(3.9 - -6.8%) |
| MFPI (FP1-flex3) |
8.1% |
12.6% |
9.1% |
10.3% |
8.1% |
7.8% |
| (6.5 - -10.0%) |
(10.6 - -14.8%) |
(7.4 - -11.1%) |
(8.5 - -12.4%) |
(6.5 - -10.0%) |
(6.2 - -9.6%) |
| MFPI (FP2-flex1) |
5.5% |
6.5% |
6.5% |
5.6% |
4.1% |
5.9% |
| (4.2 - -7.1%) |
(5.1 - -8.2%) |
(5.1 - -8.2%) |
(4.3 - -7.2%) |
(3.0 - -5.5%) |
(4.5 - -7.5%) |
| LPLB |
6.2% |
5.8% |
7.3% |
4.8% |
7.7% |
6.1% |
| (4.8 - -7.9%) |
(4.4 - -7.4%) |
(5.8 - -9.1%) |
(3.6 - -6.3%) |
(6.1 - -9.5%) |
(4.7 - -7.8%) |
|
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