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no-repeat 6px;background-position:center;margin-top:10px;min-width:55px;display:none;} @media (min-width:768px){.bfymXb .floats-partial-section .floats-partial-footer .floats-partial-caption .expand_btn{display:none;}} .bfymXb .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{-webkit-flex:9;-ms-flex:9;flex:9;text-align:left;padding:21px 37px 10px 0px;font-size:16px;font-weight:700;} @media (min-width:768px){.bfymXb .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 18px 10px 18px;}} @media (min-width:992px){.bfymXb .floats-partial-section .floats-partial-footer .floats-partial-caption .caption-text{padding:19px 21px 10px 21px;}} .bfymXb .floats-partial-section .floats-partial-footer .floats-partial-caption 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height="24"><span class="text">提交</秒p一个n></span><span class="sc-htoDjs kNoiZu sc-dqBHgY cQgXqt fileArrow icon-colored undefined icon-themeable" title="" font-size="16"></span></a> <div class="sc-krDsej ewCAZX hide__submenu journalSubmenuCheck" id="journalnav__submenu"> <button class="sc-itybZL kdvWPs journalSubmenuCheck"><span class="sc-htoDjs gvAGTV sc-fzsDOv hAFFGk journalSubmenuCheck icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="9"></span></button> </div> <div class="sc-dTdPqK lkWWFY hide__submenu journal__nav__desktop" id="journalnav__submenudesktop"> <div order="0" class="sc-kUaPvJ ehYbwJ"> <div class="sc-gPWkxV legory"></div> <div class="sc-gPWkxV legory"></div> </div> <div class="sc-jVODtj epgILe"></div> <span class="sc-fONwsr kCfRMJ"></span> </div> </nav> </div> <div class="sc-nrwXf byflLi breadcrumb__wrapper journal_article__BreadCrumbStyle-sc-12fk6zy-2 bjwAQR article"> <a class="sc-htpNat bUhGXt link sc-eitiEO jXeALb breadCrumb" href="//www.newsama.com/journals/cmmm/" aria-label="Computational and Mathematical Methods in Medicine">计算和数学方法在医学</一个>/<gydF4y2Ba一个class="sc-htpNat bUhGXt link sc-eitiEO jXeALb breadCrumb" href="//www.newsama.com/journals/cmmm/contents/year/2011/" aria-label="2011">2011年</一个>/<gydF4y2Ba年代p一个n class="sc-bhlBdH UVThf">文章</秒p一个n> </div> <div class="threeColumn__ThreeColumnWrapper-sc-1bf4078-0 dDyxFF threeColumnWrapper"> <div class="threeColumn__LeftWrapper-sc-1bf4078-1 fkVFlF leftWrapper"> <button type="button" class="sc-eKZiaR dzZrgS section__button " id="sectionButton"><span class="sc-htoDjs diutvq icon__dots dots__detector icon-colored _3n-7Ho7DlfjMlZbrRr9Q4a icon-themeable" title="" font-size="22"></span>文章部分</gydF4y2Babutton> <div class="sc-bEjcJn jLUVhb static_contents__section_links links__hidden "> <div id="leftSectionMenu" class="sc-cbkKFq prcY sc-bGbJRg dVCLgr left_section_menu"> <p>在这一页上</p><年代p一个n class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#abstract" aria-label="">文摘</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#introduction" aria-label="">介绍</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#materials-and-methods" aria-label="">材料和方法</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#results" aria-label="">结果</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#discussion" aria-label="">讨论</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#acknowledgments" aria-label="">确认</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#supplementary-materials" aria-label="">补充材料</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#references" aria-label="">引用</一个></秒p一个n> <span class="sc-likbZx bBmZJZ grey" property="background-color" color="#D8D8D8"><a class="sc-htpNat bUhGXt link sc-ePZHVD ewHMLz" href="#copyright" aria-label="">版权</一个></秒p一个n> </div> </div> </div> <div class="threeColumn__ContentWrapper-sc-1bf4078-3 bbzREB contentWrapper"> <div class="threeColumn__Content-sc-1bf4078-4 jknsZc content"> <div class="articleContent__ArticleContentsWrapper-sc-2yl9jy-0 eSvjPB article_contents"> <div class="articleContent__ArticleContentsSectionsWrapper-sc-2yl9jy-1 jntdRu article_contents__sections_wrapper"> <div class="articleContent__ArticleWrapper-sc-2yl9jy-2 hAzjHP"> <div class="sc-chbbiW mBGSe article_header_class"> <p class="sc-kZmsYB bkiEfx article_type">研究文章|<gydF4y2Ba!-- -->开放获取</p><gydF4y2Badiv class="sc-RcBXQ ztvYg article_citation"> 体积<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- --> <span class="sc-fZwumE cUsFHx">|</秒p一个n>文章的ID<gydF4y2Ba!-- --> 843765年<gydF4y2Ba!-- --> <span class="sc-fZwumE cUsFHx">|</秒p一个n> <a class="sc-htpNat bUhGXt link sc-fQejPQ duuwge" href="https://doi.org/10.1155/2011/843765" aria-label="Doi-link">https://doi.org/10.1155/2011/843765</一个></div> <div class="sc-LKuAh lcOiDF article_full_citation"> <div class="sc-hzNEM gsmOCv isHide"> <p>科林·菲普斯,穆罕默德Kohandel<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> ”<年代p一个n class="adjust-article-svg-size">数学模型,孔隙流体压力的影响在实体肿瘤血管生成的行为</秒p一个n>”,<gydF4y2Ba!-- --><i>计算和数学方法在医学</我>,<ggydF4y2BaydF4y2Ba!-- --> 卷。<gydF4y2Ba!-- -->2011年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 文章的ID<gydF4y2Ba!-- -->843765年<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 9<gydF4y2Ba!-- -->   页面<gydF4y2Ba!-- -->,<gydF4y2Ba!-- --> 2011年<gydF4y2Ba!-- -->。<gydF4y2Ba!-- --> https://doi.org/10.1155/2011/843765</p></gydF4y2Badiv> <button class="sc-hSdWYo etauus sc-iBEsjs kPshFw" color="">显示引用</gydF4y2Babutton> </div> <h1 class="sc-iRbamj jZOxOO sc-iSDuPN gbcGIy article_title adjust-article-svg-size heading-title">数学模型,孔隙流体压力的影响在实体肿瘤血管生成的行为</gydF4y2Bah1> </div> <div class="sc-jrIrqw eHMFfo article_authors"> <hr class="sc-cEvuZC XkrFe hr__author"> <span class="">科林·菲普斯<年代up>1</秒up>和</秒p一个n> <span class=""><b>穆罕默德Kohandel</gydF4y2Bab><a class="sc-htpNat bUhGXt link" href="mailto:" aria-label="Mail Option"><span class="sc-htoDjs kNoiZu sc-hjRWVT irNWJI icon-colored _2zt-1j0LmaF8UjTQAM413G icon-themeable" title="" font-size="16"></span></a><sup>1<gydF4y2Ba!-- -->,<gydF4y2Ba!-- -->2</秒up></span> <div class="sc-fHxwqH dMuGGA isHide"> <p><sup>1</秒up><span>应用数学、滑铁卢大学、滑铁卢,加拿大</秒p一个n></p> <p><sup>2</秒up><span>数学中心医学领域数学科学研究所,多伦多,加拿大</秒p一个n></p> </div> <button class="sc-hSdWYo etauus sc-iQtOjA kfDwZY" color="">显示更多</gydF4y2Babutton> </div> <div class="articleContent__EditorWrapper-sc-2yl9jy-3 evMkvU"> <div class="articleContent__TextWrapper-sc-2yl9jy-8 fYrLtk"> <b>学术编辑器:</gydF4y2Bab>米歇尔·米利</gydF4y2Badiv> <div class="articleContent__PublicationTimeLineWrapper-sc-2yl9jy-4 fjviok"> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">收到了</秒p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">06年4月2011年</秒p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC notPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">接受</秒p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">2011年6月29日</秒p一个n> </div> <div class="articleContent__PublcationCol-sc-2yl9jy-5 hgKieC isPublished"> <span class="articleContent__PublicationField-sc-2yl9jy-6 cIribm">发表</秒p一个n> <span class="articleContent__PublicationValue-sc-2yl9jy-7 khHUcu">07年9月2011年</秒p一个n> </div> </div> </div> <article class="sc-jtRlXQ bfymXb article_body "> <div> <div class="xml-content"> <h4 class="header" id="abstract">文摘</gydF4y2Bah4> <p>我们提出一个数学模型proangiogenic和血管生长因子的浓度,及其产生的平衡/不平衡,在主机和肿瘤组织。除了生产、扩散和降解这些血管生成生长因子(AGFs),我们包括间质对流研究的局部不稳定影响孔隙流体压力(奖学金)这些因素的活动。代表AGFs的分子大小和孔隙流体的向外流动肿瘤表明,对流是一个重大的交通方式,这些分子。建模方法的结果表明,生理参数的变化,确定孔隙流体压力那样深刻影响肿瘤血管生成参数控制生产、扩散,AGFs退化。这个模型预测潜力确定实体肿瘤的血管生成行为和细胞毒性和抗血管新生疗法对肿瘤血管生成的影响。</p><年代p一个n class="end-abs"></span> <h4 id="introduction">1。介绍</gydF4y2Bah4> <p>血管生成的过程中,新血管从先前存在的脉管系统的发展,是由净proangiogenic和反血管增生生长因子之间的平衡(<一个href="#B3">1</一个>]。涉及多个监管因素在这一过程中,包括血管内皮生长因子(VEGF)家族及其受体的纤维母细胞生长因子(FGF)家庭,angiostatin,血管内皮抑制素(<一个href="#B3">1</一个>]。在肿瘤进展,这微妙的平衡是扭曲的血管生成,导致异常肿瘤脉管系统和微环境<一个href="#B14">2</一个>,<gydF4y2Ba一个href="#B9">3</一个>]。</p><p>gydF4y2Ba肿瘤血管网络时空上异构、缺氧、酸中毒、高孔隙流体压力(奖学金)是实体肿瘤的特征。而众所周知,所有这三个特征中扮演至关重要的角色的活动和upregulation血管生成生长因子(AGFs),这些特性和肿瘤血管生成之间的关系是复杂的,不能完全理解。最著名和广泛研究了AGF VEGF,有力proangiogenic代理是独立调节缺氧和酸中毒<一个href="#B8">4</一个>]。在血管生成通常由于缺氧引起的,这也是,酸性pH诱发等血管生成分子基本FGF [<一个href="#B5">5</一个>和一氧化氮<一个href="#B2">6</一个>]。虽然缺氧和酸中毒对血管生成的影响因素进行了研究实验,奖学金不太清楚升高的影响。在这里,我们试图探索proangiogenic奖学金渐变的效果,抗血管新生因子浓度,重点是诱导血管生成趋势的不平衡。</p><p>gydF4y2Ba两个复合因素导致高架奖学金在实体肿瘤血管通透性的增加和功能性淋巴管的缺失<一个href="#B9">3</一个>,<gydF4y2Ba一个href="#B11">7</一个>]。被假定肿瘤血管正常化,抗血管新生疗法的应用如抗体抑制VEGF或阻塞VEGFR-2,会导致降低肿瘤奖学金(<一个href="#B14">2</一个>,<gydF4y2Ba一个href="#B24">8</一个>]。巴克斯特和耆那教徒的<一个href="#B1">9</一个>)建立了一个数学模型来研究肿瘤的运输的液体和大分子。最近,耆那教等。<一个href="#B16">10</一个>)重新审视他们的模型来研究肿瘤血管正常化的作用,抗血管新生疗法奖学金,以及确定的参数可能导致减少奖学金。</p><p>gydF4y2Ba在其他工作中,Ramanujan et al。<一个href="#B20">11</一个>)使用一个数学框架研究专业的地方不平衡,抗血管新生的因素。他们的模型包含生产、扩散和降解这些因素,被用来解释肿瘤病灶坏死和休眠。这里,我们概括他们的模型,包括proangiogenic间隙对流的影响,抗血管新生因子浓度,这是由对流可以大大加剧交通的分子的典型AGFs大小(见表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab1/" target="_blank">1</一个>)。它也指出,对流起着重要的作用,不仅在确定当地的浓度,而且在AGFs的功能和活动,特别是VEGF (<一个href="#B12">12</一个>]。这种效应通过方程中对流项添加管理AGFs的浓度(请参见下一部分)。数学模型用于研究肿瘤血管生成的变化行为的结果改变组织或血管的属性(例如,渗透系数的组织,液压渗透率的船只)。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab1"> <div class="floats-partial-content fig-content-tab1"> <table class="table-group" id="tab1"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="3"> <hr></td> </tr> <tr class="thead"> <td align="left">分子</tgydF4y2Bad> <td align="center">血管生成的类别</tgydF4y2Bad> <td align="center">大小(kDa)</tgydF4y2Bad> </tr> <tr> <td class="thead-hr" colspan="3"> <hr></td> </tr> <tr> <td align="left">VEGF<年代ub>165年</秒ub>二聚体</tgydF4y2Bad> <td align="center">Proangiogenic</tgydF4y2Bad> <td align="center">45 (<一个href="#B7">13</一个>]</tggydF4y2BaydF4y2Bad> </tr> <tr> <td align="left">FGF家庭</tgydF4y2Bad> <td align="center">Proangiogenic</tgydF4y2Bad> <td align="center">华裔(<一个href="#B19">14</一个>]</tggydF4y2BaydF4y2Bad> </tr> <tr> <td align="left">TSP-1</tgydF4y2Bad> <td align="center">抗血管新生</tgydF4y2Bad> <td align="center">140年(<一个href="#B21">15</一个>]</tggydF4y2BaydF4y2Bad> </tr> <tr> <td align="left">Angiostatin</tgydF4y2Bad> <td align="center">抗血管新生</tgydF4y2Bad> <td align="center">38 [<一个href="#B18">16</一个>]</tggydF4y2BaydF4y2Bad> </tr> <tr> <td align="left">血管内皮抑制素</tgydF4y2Bad> <td align="center">抗血管新生</tgydF4y2Bad> <td align="center">20 [<一个href="#B17">17</一个>]</tggydF4y2BaydF4y2Bad> </tr> <tr class="table-tr"> <td colspan="3"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表1</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/tab1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 共同proangiogenic的分子量和反血管增生生长因子。</gydF4y2Badiv> </div> </div> <h4 id="materials-and-methods">2。材料和方法</gydF4y2Bah4> <h5 id="sec2.1">2.1。血管生成生长因子模型</gydF4y2Bah5> <p>后Hahnfeldt et al。<一个href="#B10">18</一个>],R一个manujan et al。<一个href="#B20">11</一个>),我们首先假设血管生成生长因子可以被认为是启动proangiogenic(刺激)或抗血管新生(抑制)的活动。尽管其中一些因素可能表现在proangiogenic或抗血管新生的方式取决于系统的状态,我们认为这种影响是可以忽略不计。而不同的细胞机制和信号级联激活特定的(可能有多个)因素对血管生成活动水平有更大的影响,我们只是认为赞成和抗血管新生因子浓度的代表通过这两类血管生成的影响。proangiogenic (<年代vgheight="9.875" id="M1" style="vertical-align:-2.29482pt;width:7.7624998px;" version="1.1" viewbox="0 0 7.7624998 9.875" width="7.7624998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.875)"> <g transform="translate(72,-64.1)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)和反血管增生(<年代vgheight="7.1750002" id="M2" style="vertical-align:-0.1254pt;width:7.9749999px;" version="1.1" viewbox="0 0 7.9749999 7.1750002" width="7.9749999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)因子浓度会用<年代vgheight="16.475" id="M3" style="vertical-align:-4.74141pt;width:14.775px;" version="1.1" viewbox="0 0 14.775 16.475" width="14.775" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.475)"> <g transform="translate(72,-58.82)"> <text transform="matrix(1,0,0,-1,-71.95,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.01,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="14.5875" id="M4" style="vertical-align:-3.22282pt;width:14.9125px;" version="1.1" viewbox="0 0 14.9125 14.5875" width="14.9125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.5875)"> <g transform="translate(72,-60.33)"> <text transform="matrix(1,0,0,-1,-71.95,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.01,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(<我>μ</gydF4y2Ba我>g/毫米<年代up>3</秒up>),分别。这些因素被认为分散在恒定的扩散系数<年代vgheight="16.2875" id="M5" style="vertical-align:-4.77652pt;width:18px;" version="1.1" viewbox="0 0 18 16.2875" width="18" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2875)"> <g transform="translate(72,-58.97)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.07,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米<年代up>2</秒up>/秒),<年代vgheight="12.675" id="M6" style="vertical-align:-2.34499pt;width:47.587502px;" version="1.1" viewbox="0 0 47.587502 12.675" width="47.587502" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.675)"> <g transform="translate(72,-61.86)"> <text transform="matrix(1,0,0,-1,-71.95,64.25)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.3269978" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.367388" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="26.481354" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.695105" y="0"> </t年代p一个n> </text> </g> </g> </svg>一阶动力学,降低下失活率<年代vgheight="16.512501" id="M7" style="vertical-align:-4.77652pt;width:14.125px;" version="1.1" viewbox="0 0 14.125 16.512501" width="14.125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.5125)"> <g transform="translate(72,-58.79)"> <text transform="matrix(1,0,0,-1,-71.95,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.17,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(年代<年代up>−1</秒up>)和独立生产与持续的生产速度<年代vgheight="12.975" id="M8" style="vertical-align:-4.77652pt;width:13.35px;" version="1.1" viewbox="0 0 13.35 12.975" width="13.35" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.975)"> <g transform="translate(72,-61.62)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.8,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(<我>μ</gydF4y2Ba我>g/毫米<年代up>3</秒up>/ s)。自上述扩散、失活和生产参数用来描述整个家庭因素与不同分子量和动能率,他们认为是代表各自的血管生成类。然而,这些参数可以在主机和肿瘤组织不同,这两个被认为是均匀和各向同性,所以在适当的时候,我们将区分这些值与标主机(<年代vgheight="10.95" id="M9" style="vertical-align:-0.1254pt;width:9.1374998px;" version="1.1" viewbox="0 0 9.1374998 10.95" width="9.1374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.95)"> <g transform="translate(72,-63.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.41)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ℎ</t年代p一个n> </text> </g> </g> </svg>)和肿瘤(<年代vgheight="9.125" id="M10" style="vertical-align:-0.11285pt;width:5.0124998px;" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.125)"> <g transform="translate(72,-64.7)"> <text transform="matrix(1,0,0,-1,-71.95,64.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)组织。正如前面指出的,我们也包括这些因素由于孔隙流体的对流速度(IFV)在肿瘤中扮演一个角色在决定高分子包括AGFs肿瘤的浓度。假设这些分子的速度等于孔隙流体的速度<年代vgheight="7.1624999" id="M11" style="vertical-align:-0.11285pt;width:7.5374999px;" version="1.1" viewbox="0 0 7.5374999 7.1624999" width="7.5374999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1625)"> <g transform="translate(72,-66.27)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米/秒)<一个href="#B23">19</一个>),我们到达方程<年代p一个n class="equation" id="EEq1"> <svg height="35.150002" id="M12" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 35.150002" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,35.15)"> <g transform="translate(72,-43.88)"> <text transform="matrix(1,0,0,-1,81.33,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,94.66,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 81.33,55.95 17.75,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,85.06,44.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="18.690001" y="-8.75"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.730389" y="-8.75"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,125.67,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,130.1,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ∇</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,139.24,57.82)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,144.11,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,151.05,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,158.26,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.327718" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,176.38,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,180.8,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,187.74,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,194.95,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,212.44,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,219.65,52.82)"> <tspan style="font-size: 12.50px; " x="29.620001" y="2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.255581" y="0"> ⋅</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.470001" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="41.396423" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,267.98,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,272.41,50.31)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="7.9400001" y="-2.51"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.106138" y="-2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.433138" y="-2.51"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="43.473526" y="-2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="49.587494" y="-2.51"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="54.801243" y="-2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="61.077751" y="-2.51"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="201.71001" y="-2.51"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="205.8735" y="-2.51"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="212.125" y="-2.51"> )</t年代p一个n> </text> </g> </g> </svg></span>步兵战车由达西定律给出的地方:<年代vgheight="13.325" id="M13" style="vertical-align:-2.29482pt;width:68.599998px;" version="1.1" viewbox="0 0 68.599998 13.325" width="68.599998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.325)"> <g transform="translate(72,-61.34)"> <text transform="matrix(1,0,0,-1,-71.95,63.67)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3897533" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.430141" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.994698" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="39.521984" y="0"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="48.661674" y="0"> </t年代p一个n> </text> </g> </g> </svg>,在那里<年代vgheight="10.325" id="M14" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米<年代up>2</秒up>/ s /毫米汞柱)的渗透系数是间质<年代vgheight="9.875" id="M15" style="vertical-align:-2.29482pt;width:7.7624998px;" version="1.1" viewbox="0 0 7.7624998 9.875" width="7.7624998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.875)"> <g transform="translate(72,-64.1)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米汞柱)是国际奖学金(<一个href="#B15">20.</一个>,<gydF4y2Ba一个href="#B25">21</一个>]。下面的方程管理奖学金推导,提出了(<一个href="#EEq5">5</一个>)。通过增加对流方程,我们可以研究更大的肿瘤,因为以前局限于那些对流模型不是一个因素(通常这些肿瘤与半径小于2毫米)。值得重新强调,间质对流也起着至关重要的作用的活动AGFs和肿瘤血管生成的过程<一个href="#B12">12</一个>]。对流效应已经被先前的模型药物分布和其他大分子在肿瘤(<一个href="#B1">9</一个>,<gydF4y2Ba一个href="#B15">20.</一个>),因此看起来自然包括它在这种情况下。扩散的参数、生产和退化AGFs主机和肿瘤组织内的那些假设基于条件规定Ramanujan et al。<一个href="#B20">11</一个>),这些都是展示在表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab2/" target="_blank">2</一个>。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab2"> <div class="floats-partial-content fig-content-tab2"> <table class="table-group" id="tab2"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr class="thead"> <td align="left">参数</tgydF4y2Bad> <td align="center">单位</tgydF4y2Bad> <td align="center">主机</tgydF4y2Bad> <td align="center">肿瘤</tgydF4y2Bad> <td align="center">归一化</tgydF4y2Bad> </tr> <tr> <td class="thead-hr" colspan="5"> <hr></td> </tr> <tr> <td align="left"><i>R</我></td> <td align="center">毫米</tgydF4y2Bad> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">4</tgydF4y2Bad> <td align="center">4</tgydF4y2Bad> </tr> <tr> <td align="left"><i>K</我></td> <td align="center">毫米<年代up>2</秒up>/ s /毫米汞柱</tgydF4y2Bad> <td align="center">2.5×10<年代up>−5</秒up></td> <td align="center">2.5×10<年代up>−5</秒up></td> <td align="center">2.5×10<年代up>−5</秒up></td> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="center" colspan="5">血管生成生长因子</tgydF4y2Bad> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="left"><i>D<年代ub>p</秒ub></i></td> <td align="center">毫米<年代up>2</秒up>/秒</tgydF4y2Bad> <td align="center">4.0×10<年代up>−5</秒up></td> <td align="center">5.5×10<年代up>−5</秒up></td> <td align="center">5.5×10<年代up>−5</秒up></td> </tr> <tr> <td align="left"><i>D<年代ub>一个</秒ub></i></td> <td align="center">毫米<年代up>2</秒up>/秒</tgydF4y2Bad> <td align="center">3.25×10<年代up>−5</秒up></td> <td align="center">4.0×10<年代up>−5</秒up></td> <td align="center">4.0×10<年代up>−5</秒up></td> </tr> <tr> <td align="left"><i>k<年代ub>p</秒ub></i></td> <td align="center">年代<年代up>−1</秒up></td> <td align="center">2.0×10<年代up>−4</秒up></td> <td align="center">1.99×10<年代up>−4</秒up></td> <td align="center">1.99×10<年代up>−4</秒up></td> </tr> <tr> <td align="left"><i>k<年代ub>一个</秒ub></i></td> <td align="center">年代<年代up>−1</秒up></td> <td align="center">1.5×10<年代up>−4</秒up></td> <td align="center">1.1×10<年代up>−4</秒up></td> <td align="center">1.1×10<年代up>−4</秒up></td> </tr> <tr> <td align="left"><span style="width: 13.7875px;"> <svg height="12.925" id="M16" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 13.7875 12.925" width="13.7875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.925)"> <g transform="translate(72,-61.66)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.8,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><i>μ</我>g/毫米<年代up>3</秒up>/秒</tgydF4y2Bad> <td align="center">2.0×10<年代up>−4</秒up></td> <td align="center">12.0×10<年代up>−4</秒up></td> <td align="center">12.0×10<年代up>−4</秒up></td> </tr> <tr> <td align="left"><span style="width: 13.925px;"> <svg height="11.0375" id="M17" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 13.925 11.0375" width="13.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.8,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"><i>μ</我>g/毫米<年代up>3</秒up>/秒</tgydF4y2Bad> <td align="center">1.5×10<年代up>−4</秒up></td> <td align="center">7.0×10<年代up>−4</秒up></td> <td align="center">7.0×10<年代up>−4</秒up></td> </tr> <tr> <td align="left"><span style="width: 14.5625px;"> <svg height="19.4125" id="M18" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 14.5625 19.4125" width="14.5625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,19.4125)"> <g transform="translate(72,-56.47)"> <text transform="matrix(1,0,0,-1,-66.15,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.8000002" y="2.72"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.17,58.12)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">80年</tgydF4y2Bad> <td align="center">57.9</tgydF4y2Bad> <td align="center">57.9</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 14.7125px;"> <svg height="17.525" id="M19" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 14.7125 17.525" width="14.7125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.525)"> <g transform="translate(72,-57.98)"> <text transform="matrix(1,0,0,-1,-66.15,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.8000002" y="2.72"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.17,58.12)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">73.8</tgydF4y2Bad> <td align="center">44</tgydF4y2Bad> <td align="center">44</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 14.4125px;"> <svg height="16" id="M20" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 14.4125 16" width="14.4125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16)"> <g transform="translate(72,-59.2)"> <text transform="matrix(1,0,0,-1,-65.75,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,60.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">80年</tgydF4y2Bad> <td align="center">349年</tgydF4y2Bad> <td align="center">349年</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 14.55px;"> <svg height="14.1125" id="M21" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 14.55 14.1125" width="14.55" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.1125)"> <g transform="translate(72,-60.71)"> <text transform="matrix(1,0,0,-1,-65.75,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,60.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">73.8</tgydF4y2Bad> <td align="center">280年</tgydF4y2Bad> <td align="center">280年</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 19.262501px;"> <svg height="20.924999" id="M22" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 19.262501 20.924999" width="19.262501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.925)"> <g transform="translate(72,-55.26)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">12.5</tgydF4y2Bad> <td align="center">9.1</tgydF4y2Bad> <td align="center">9.1</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 19.4px;"> <svg height="19.0375" id="M23" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 19.4 19.0375" width="19.4" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,19.0375)"> <g transform="translate(72,-56.77)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">15.4</tgydF4y2Bad> <td align="center">12.5</tgydF4y2Bad> <td align="center">12.5</tgydF4y2Bad> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="center" colspan="5">孔隙流体压力</tgydF4y2Bad> </tr> <tr> <td align="center" colspan="5"> <hr></td> </tr> <tr> <td align="left"><span style="width: 17.1625px;"> <svg height="16.237499" id="M24" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">mm / s /毫米汞柱</tgydF4y2Bad> <td align="center">3.6×10<年代up>−7</秒up></td> <td align="center">1.86×10<年代up>−5</秒up></td> <td align="center">3.7×10<年代up>−6</秒up></td> </tr> <tr> <td align="left"><i>年代</我>/<gydF4y2Ba我>V</gydF4y2Ba我></td> <td align="center">毫米<年代up>2</秒up>/毫米<年代up>3</秒up></td> <td align="center">17.4</tgydF4y2Bad> <td align="center">16.5</tgydF4y2Bad> <td align="center">15.2</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 13.925px;"> <svg height="11.025" id="M25" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 13.925 11.025" width="13.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">毫米汞柱</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> </tr> <tr> <td align="left"><i>σ</我></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">0.91</tgydF4y2Bad> <td align="center">8.7×10<年代up>−5</秒up></td> <td align="center">2.1×10<年代up>−3</秒up></td> </tr> <tr> <td align="left"><i><i>π</我><年代ub>v</秒ub></i></td> <td align="center">毫米汞柱</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> <td align="center">19.8</tgydF4y2Bad> <td align="center">19.2</tgydF4y2Bad> </tr> <tr> <td align="left"><i><i>π</我><年代ub>我</秒ub></i></td> <td align="center">毫米汞柱</tgydF4y2Bad> <td align="center">10</tgydF4y2Bad> <td align="center">17.3</tgydF4y2Bad> <td align="center">15.1</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 13.2625px;"> <svg height="11.05" id="M26" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">毫米汞柱</tgydF4y2Bad> <td align="center">10.9</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> <td align="center">20.</tgydF4y2Bad> </tr> <tr> <td align="left"><span style="width: 8.9375px;"> <svg height="7.1750002" id="M27" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center">- - - - - -</tgydF4y2Bad> <td align="center">2</tgydF4y2Bad> <td align="center">14</tgydF4y2Bad> <td align="center">6</tgydF4y2Bad> </tr> <tr class="table-tr"> <td colspan="5"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表2</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/tab2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 模型参数(<一个href="#B16">10</一个>,<gydF4y2Ba一个href="#B20">11</一个>]。</gydF4y2Badiv> </div> </div> <p>为了方便解决(<一个href="#EEq1">1</一个>),我们认为肿瘤是一个球体的半径<年代vgheight="10.325" id="M28" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米),由于生长因子的动态分布发生在比肿瘤生长更快的时间尺度,我们认为该系统在稳定状态。这导致方程<年代p一个n class="equation" id="EEq2"> <svg height="39.349998" id="M29" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 39.349998" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,39.35)"> <g transform="translate(72,-40.52)"> <text transform="matrix(1,0,0,-1,76.14,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,86.01,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 76.14,55.95 14.3,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,78.3,43.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,83.4,47.14)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,95.01,60.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 92.83,55.95 11.76,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,92.83,44.07)"> <tspan style="font-size: 12.50px; " x="15.04" y="-1.42"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.41" y="-8.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,122.34,57.82)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,128.41,63.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,142,60.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 128.41,55.95 18.02,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,131.55,44.07)"> <tspan style="font-size: 12.50px; " x="16.08" y="-1.42"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="28.23" y="-8.75"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="39.570221" y="-8.75"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,177.9,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,182.33,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,189.27,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,196.48,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,213.97,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,221.18,52.82)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.54" y="-7.25"> </t年代p一个n> </text> <g> <path d="m 233.72,55.95 10.52,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,233.99,43.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,239.09,47.14)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,248.81,60.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 246.64,55.95 11.75,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,246.64,44.07)"> <tspan style="font-size: 12.50px; " x="15.03" y="-1.42"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="24.41" y="-8.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,276.15,57.82)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,282.22,61.12)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <g> <path d="m 282.22,55.95 12.76,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,282.72,44.07)"> <tspan style="font-size: 12.50px; " x="13.46" y="-8.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,303.12,49.7)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,307.54,45.49)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.85" y="-7.3299999"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.890388" y="-7.3299999"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.14189" y="-7.3299999"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="166.58" y="-7.3299999"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="170.7435" y="-7.3299999"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="176.995" y="-7.3299999"> )</t年代p一个n> </text> </g> </g> </svg></span>方程(<一个href="#EEq2">2</一个>可以nondimensionalized)设置<年代vgheight="10.9125" id="M30" style="vertical-align:-0.17555pt;width:48.174999px;" version="1.1" viewbox="0 0 48.174999 10.9125" width="48.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-66.02,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.9264221" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="2.638133" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.678522" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="19.779745" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="23.255581" y="0"> </t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="21.950001" id="M31" style="vertical-align:-5.37082pt;width:70.137497px;" version="1.1" viewbox="0 0 70.137497 21.950001" width="70.137497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,21.95)"> <g transform="translate(72,-54.44)"> <text transform="matrix(1,0,0,-1,-71.23,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-0.72000003" y="2.72"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.51,56.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.61,59.85)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-36.63,56.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-32.2,59.85)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-20.29,64.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="-1.5" y="8.79"> </t年代p一个n> </text> </g> </g> </svg>在哪里<年代vgheight="20.700001" id="M32" style="vertical-align:-5.43091pt;width:70.5px;" version="1.1" viewbox="0 0 70.5 20.700001" width="70.5" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.7)"> <g transform="translate(72,-55.44)"> <text transform="matrix(1,0,0,-1,-71.95,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.51,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="-1.5" y="8.79"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.69,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-37,65.9)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> <tspan style="font-size: 8.75px; " x="-0.5" y="8.7799997"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-31.45,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-21.2,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.7799997"> </t年代p一个n> </text> </g> </g> </svg>在宿主组织稳态AGF浓度。除以<年代vgheight="16.2875" id="M33" style="vertical-align:-4.77652pt;width:18px;" version="1.1" viewbox="0 0 18 16.2875" width="18" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2875)"> <g transform="translate(72,-58.97)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.07,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>消除了扩散系数,无因次参数<年代vgheight="19.725" id="M34" style="vertical-align:-4.77652pt;width:87.412498px;" version="1.1" viewbox="0 0 87.412498 19.725" width="87.412498" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,19.725)"> <g transform="translate(72,-56.22)"> <text transform="matrix(1,0,0,-1,-66.15,63.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.8000002" y="2.73"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.17,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.27,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-38.46,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-34.03,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-24.78,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-19.9,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-6.55,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="20.4625" id="M35" style="vertical-align:-5.37082pt;width:112.8625px;" version="1.1" viewbox="0 0 112.8625 20.4625" width="112.8625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.4625)"> <g transform="translate(72,-55.63)"> <text transform="matrix(1,0,0,-1,-65.75,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.4,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.21,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-34.78,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-25.53,66.03)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-20.65,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.6393328" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-3.14,57.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,1.29,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,9.73,66.1)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="-1.5" y="8.79"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,14.08,61.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>而且,<年代vgheight="20.975" id="M36" style="vertical-align:-4.77652pt;width:85.474998px;" version="1.1" viewbox="0 0 85.474998 20.975" width="85.474998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.975)"> <g transform="translate(72,-55.22)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-53.52,60.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="21.555172" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-25.84,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-21.45,60.03)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-8.1,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>在哪里<年代vgheight="11.05" id="M37" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米汞柱)是用于nondimensionalize的有效压力的方程(定义的无量纲压力的压力<年代vgheight="14.7125" id="M38" style="vertical-align:-3.2316pt;width:52.275002px;" version="1.1" viewbox="0 0 52.275002 14.7125" width="52.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-65.07,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.8766499" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="2.7006481" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.741037" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="20.855003" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.330837" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-34.62,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,请参考(<一个href="#EEq6">6</一个>))。这nondimensionalization收益率方程<年代p一个n class="equation" id="EEq3"> <svg height="48.849998" id="M39" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 48.849998" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,48.85)"> <g transform="translate(72,-32.92)"> <text transform="matrix(1,0,0,-1,73.22,56.32)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> </text> <g> <path d="m 71.36,52.2 9.98,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,77.29,38.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.9264221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,76.46,43.39)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,86.28,56.32)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 83.73,52.2 12.5,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,83.73,40.32)"> <tspan style="font-size: 12.50px; " x="15.78" y="0.98000002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.315695" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4017758" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.809999" y="-8.75"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.883577" y="-8.75"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,114.71,54.07)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,120.78,59.85)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1300001" y="-2.72"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4099998" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,136.63,56.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 120.78,52.2 20.27,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,124.67,40.32)"> <tspan style="font-size: 12.50px; " x="17.58" y="0.98000002"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="30.459999" y="-8.75"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="47.599998" y="-11.48"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.799999" y="-8.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.315695" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4017758" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,173.25,45.94)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,178.4,51.8)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-0.72000003" y="2.73"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,186.12,45.94)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,193.32,49.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="17.54171" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.352724" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,211.32,45.94)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,218.52,49.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.31" y="-13.32"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.54" y="-10.78"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,241.59,56.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 231.06,52.2 14.96,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,239.48,38.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.9264221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,238.65,43.39)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,250.96,56.32)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 248.41,52.2 12.5,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,248.41,40.32)"> <tspan style="font-size: 12.50px; " x="15.78" y="-1.42"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.315695" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4017758" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.09" y="-8.75"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.163578" y="-8.75"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,278.67,54.07)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,284.74,57.37)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.278426" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.414279" y="0"> </t年代p一个n> </text> <g> <path d="m 284.74,52.2 13.52,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,285.25,40.32)"> <tspan style="font-size: 12.50px; " x="14.92" y="-11.48"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.2" y="-8.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.315695" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4017758" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,307.89,45.94)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,312.32,41.74)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.85" y="-7.3299999"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.877886" y="-7.3299999"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.129387" y="-7.3299999"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="161.8" y="-7.3299999"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="165.9635" y="-7.3299999"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="172.215" y="-7.3299999"> )</t年代p一个n> </text> </g> </g> </svg></span>这一步是至关重要的模型因为无量纲量用于定义衡量血管生成活动下面(<一个href="#EEq4">4</一个>)。</p><p>gydF4y2Ba没有对流项的,也就是说,消除了上学期(<一个href="#EEq3">3</一个>),一个可以用适当的边界条件获得解析解(<一个href="#B20">11</一个>]。然而,在这个工作中,我们还考虑到场景中扩散和对流运输可能发挥重要作用因素,因此我们依靠数值积分方案解决(<一个href="#EEq3">3</一个>)。</p><gydF4y2Bah5 id="sec2.2">2.2。血管生成活性</gydF4y2Bah5> <p>虽然我们感兴趣的定性影响奖学金AGF浓度,我们不是特别感兴趣的定量浓度两个因素组。proangiogenic和抗血管新生力量之间的关系是更重要的,因为这些因素之间的平衡是本地的行列式血管生成是否会抑制或启动。斯托尔后et al。<一个href="#B22">22</一个>),我们引入一个衡量血管生成活动<年代vgheight="7.1750002" id="M40" style="vertical-align:-0.1254pt;width:7.9749999px;" version="1.1" viewbox="0 0 7.9749999 7.1750002" width="7.9749999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>定义为<年代p一个n class="equation" id="EEq4"> <svg height="94.9375" id="M41" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 94.9375" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,94.9375)"> <g transform="translate(72,3.95)"> <text transform="matrix(1,0,0,-1,137.41,30.9)"> <tspan style="font-size: 12.50px; " x="21.790001" y="-25.99"> ⎧</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="-18.41"> ⎪</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="-7.6100001"> ⎪</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="3.1900001"> ⎨</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="13.99"> ⎪</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="24.780001"> ⎪</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.790001" y="32.310001"> ⎩</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.76" y="-31.67"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.040001" y="-28.950001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> =</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,176.89,56.72)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 168.39,52.23 13.34,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,169.11,39.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-0.72000003" y="2.73"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,176.83,34.11)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,185.7,49.11)"> <tspan style="font-size: 12.50px; " x="32.490002" y="-2.1600001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.77" y="0.56999999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="17.591721" y="0"> ,</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,225.91,45.42)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,234.16,48.54)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ≥</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.76" y="-2.73"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.04" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,254.64,45.42)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,262.52,49.11)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="-73.029999" y="24.459999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-73.75" y="27.190001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-95.32" y="36.41"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="-86.292831" y="36.41"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,197.21,18.8)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 188.77,15.82 13.33,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,189.54,3.56)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-0.72000003" y="2.73"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,197.26,-2.29)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,203.29,12.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.9" y="-2.1600001"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.18" y="0.56999999"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,225.91,9.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,234.16,12.13)"> <tspan style="font-size: 12.50px; " x="0" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.76" y="-2.73"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.04" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,254.64,9.01)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,262.52,12.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="211.60001" y="-18.200001"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="215.7635" y="-18.200001"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="222.015" y="-18.200001"> )</t年代p一个n> </text> </g> </g> </svg></span>在哪里<年代vgheight="11.0625" id="M42" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> ></t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>对应于血管生成启动,<年代vgheight="10.9125" id="M43" style="vertical-align:-0.17555pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 10.9125" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>表明一个稳定的血管网络,<年代vgheight="11.0625" id="M44" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>意味着没有发生血管生成,血管可能回归。而其他形式的这个函数<年代vgheight="7.1750002" id="M45" style="vertical-align:-0.1254pt;width:7.9749999px;" version="1.1" viewbox="0 0 7.9749999 7.1750002" width="7.9749999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>是可行的,我们选择这种形式由于其对称性和明显包含这些nondimensionalized因子之间的平衡浓度。</p><p>gydF4y2Ba在实体瘤典型的血管生成活动场景中保持血管生成抑制肿瘤的核心,高水平的血管生成抑制剂覆盖生产proangiogenic升高的影响因素。他们也显示出血管生成刺激肿瘤边界附近的血管生成平衡倾向于proangiogenic趋势。这通常会导致发展的一个核心组成的缺氧和缺氧坏死严重血管和细胞迅速增殖外缘(<一个href="#B13">23</一个>]。</p><p>gydF4y2Ba我们使用血管生成活动的措施<年代vgheight="7.1750002" id="M46" style="vertical-align:-0.1254pt;width:7.9749999px;" version="1.1" viewbox="0 0 7.9749999 7.1750002" width="7.9749999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>分类模型的输出为三种情况之一:焦抑制,抑制和全球血管生成<一个href="#B20">11</一个>]。上述典型的局部抑制的行为特征是一个过渡从消极到积极的价值观<年代vgheight="7.1750002" id="M47" style="vertical-align:-0.1254pt;width:7.9749999px;" version="1.1" viewbox="0 0 7.9749999 7.1750002" width="7.9749999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>我们从核心的边缘部分肿瘤。全球抑制血管生成定义<年代vgheight="11.0625" id="M48" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="11.0625" id="M49" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> ></t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>肿瘤(即处处都分别。,尽管<年代vgheight="13.125" id="M50" style="vertical-align:-1.95624pt;width:62.1875px;" version="1.1" viewbox="0 0 62.1875 13.125" width="62.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.125)"> <g transform="translate(72,-61.5)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.5645552" y="0"> ∈</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.604944" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.768442" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.019943" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.233692" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="45.485912" y="0"> ]</t年代p一个n> </text> </g> </g> </svg>)。</p><gydF4y2Bah5 id="sec2.3">2.3。孔隙流体压力</gydF4y2Bah5> <p>我们假设,如前所述,达西定律给出了孔隙流体速度之间的关系<年代vgheight="7.1624999" id="M51" style="vertical-align:-0.11285pt;width:7.5374999px;" version="1.1" viewbox="0 0 7.5374999 7.1624999" width="7.5374999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.1625)"> <g transform="translate(72,-66.27)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>和孔隙流体压力<年代vgheight="9.875" id="M52" style="vertical-align:-2.29482pt;width:7.7624998px;" version="1.1" viewbox="0 0 7.7624998 9.875" width="7.7624998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.875)"> <g transform="translate(72,-64.1)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>在一个各向同性和均匀的组织:<年代vgheight="13.55" id="M53" style="vertical-align:-2.29482pt;width:94.9375px;" version="1.1" viewbox="0 0 94.9375 13.55" width="94.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3897533" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.430141" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.994698" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="39.521984" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="43.685482" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="50.337078" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="56.451046" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="59.92688" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="66.578476" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="71.679703" y="0"> )</t年代p一个n> </text> </g> </g> </svg>,在那里<年代vgheight="10.325" id="M54" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>的渗透系数是间质(毫米<年代up>2</秒up>/ s /毫米汞柱)。稳态不可压缩流体的连续性方程<年代vgheight="13.55" id="M55" style="vertical-align:-2.29482pt;width:76.625px;" version="1.1" viewbox="0 0 76.625 13.55" width="76.625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ∇</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.915359" y="0"> ⋅</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.266884" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.66914" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="39.697025" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="47.761459" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="51.924957" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="57.026184" y="0"> )</t年代p一个n> </text> </g> </g> </svg>在哪里<年代vgheight="13.55" id="M56" style="vertical-align:-2.29482pt;width:26.987499px;" version="1.1" viewbox="0 0 26.987499 13.55" width="26.987499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.064435" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.227934" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="17.329159" y="0"> )</t年代p一个n> </text> </g> </g> </svg>是流体源项(s<年代up>−1</秒up>)。我们假设一个连续分布源在整个肿瘤由燕八哥定律:<年代vgheight="16.6" id="M57" style="vertical-align:-4.74141pt;width:230.89999px;" version="1.1" viewbox="0 0 230.89999 16.6" width="230.89999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.6)"> <g transform="translate(72,-58.72)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.064435" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.227934" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="17.329159" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.955988" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.996376" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.159878" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-21.93,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-17.15,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="18.792009" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.955507" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.119007" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,16.08,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,23.79,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.327718" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="20.229855" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.570074" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="38.909336" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="43.072834" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,74.47,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,82.17,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,101.12,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,104.34,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> )</t年代p一个n> </text> </g> </g> </svg>。在这里,参数液压微血管壁的渗透性<年代vgheight="16.237499" id="M58" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(mm / s /毫米汞柱),血管壁的表面面积单位体积的肿瘤<年代vgheight="10.9375" id="M59" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米<年代up>2</秒up>/毫米<年代up>3</秒up>),血管的压力<年代vgheight="11.025" id="M60" style="vertical-align:-3.21404pt;width:13.925px;" version="1.1" viewbox="0 0 13.925 11.025" width="13.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(毫米汞柱),血浆蛋白的平均渗透反射系数<年代vgheight="6.9875002" id="M61" style="vertical-align:-0.13794pt;width:9.3000002px;" version="1.1" viewbox="0 0 9.3000002 6.9875002" width="9.3000002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,6.9875)"> <g transform="translate(72,-66.41)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。用等离子体和间质渗透压力<年代vgheight="10.825" id="M62" style="vertical-align:-3.21404pt;width:15.7875px;" version="1.1" viewbox="0 0 15.7875 10.825" width="15.7875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.825)"> <g transform="translate(72,-63.34)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.35,63.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="10.8375" id="M63" style="vertical-align:-3.2316pt;width:13.65px;" version="1.1" viewbox="0 0 13.65 10.8375" width="13.65" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.8375)"> <g transform="translate(72,-63.33)"> <text transform="matrix(1,0,0,-1,-71.95,66.6)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.35,63.47)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>分别(毫米汞柱)。假设<年代vgheight="10.325" id="M64" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>也是恒定的,我们用达西定律和燕八哥定律到连续性方程获得奖学金在实体瘤模型方程(<一个href="#B1">9</一个>]<gydF4y2Ba年代p一个n class="equation" id="EEq5"> <svg height="34.950001" id="M65" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 34.950001" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,34.95)"> <g transform="translate(72,-44.04)"> <text transform="matrix(1,0,0,-1,110.57,53.04)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ∇</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,119.71,58.05)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,124.58,53.04)"> <tspan style="font-size: 12.50px; " x="31.389999" y="-10.75"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.5898008" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.617687" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,164.82,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 155.97,56.17 13.63,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,157.52,44.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.97" y="-16.01"> </t年代p一个n> </text> <g> <path d="m 171.99,56.17 10,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,171.99,44.29)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.28" y="-6.2399998"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="19.129999" y="-8.75"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,197.24,49.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,204.94,53.04)"> <tspan style="font-size: 12.50px; " x="20.77" y="2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="26.620001" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,239.16,49.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,246.87,53.04)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,265.81,49.92)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,269.03,50.53)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="26.09" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.6300001" y="-2.51"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.970221" y="-2.51"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="34.029999" y="-2.51"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="205.09" y="-2.51"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="209.25349" y="-2.51"> 5</t年代p一个n> <tspan style="font-size: 12.50px; " x="215.505" y="-2.51"> )</t年代p一个n> </text> </g> </g> </svg></span></p> <p>方程(<一个href="#EEq5">5</一个>可以nondimensionalized)设置<年代vgheight="14.7125" id="M66" style="vertical-align:-3.2316pt;width:52.275002px;" version="1.1" viewbox="0 0 52.275002 14.7125" width="52.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-65.07,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.8766499" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="2.7006481" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.741037" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="20.855003" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.330837" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-34.62,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>在哪里<年代vgheight="11.05" id="M67" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>是有效压力<年代vgheight="14.7125" id="M68" style="vertical-align:-3.2316pt;width:130.52499px;" version="1.1" viewbox="0 0 130.52499 14.7125" width="130.52499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.97,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-39.82,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-32.11,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.327718" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="18.666979" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.830479" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.67,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,6.04,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.340221" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,24.98,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,28.2,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>再次,重新调节径向距离<年代vgheight="7.0124998" id="M69" style="vertical-align:-0.0pt;width:6.5px;" version="1.1" viewbox="0 0 6.5 7.0124998" width="6.5" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.0125)"> <g transform="translate(72,-66.39)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>与肿瘤的半径<年代vgheight="10.325" id="M70" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,(在球坐标)<年代p一个n class="equation" id="EEq6"> <svg height="38.575001" id="M71" preserveaspectratio="xMaxYMin" style="vertical-align:-0pt;width:700.9375px;" version="1.1" viewbox="0 0 700.9375 38.575001" width="700.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,38.575)"> <g transform="translate(72,-41.14)"> <text transform="matrix(1,0,0,-1,135.39,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> </text> <g> <path d="m 133.53,56.57 9.97,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,139.45,43.07)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.913919" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,138.63,47.77)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,148.44,60.7)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <g> <path d="m 145.89,56.57 12.51,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,145.89,44.69)"> <tspan style="font-size: 12.50px; " x="15.78" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.328198" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.414279" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="31.09" y="-8.7600002"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.163578" y="-8.7600002"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,176.15,58.45)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,182.22,61.75)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="14.278426" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.414279" y="0"> </t年代p一个n> </text> <g> <path d="m 182.22,56.57 13.52,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,182.73,44.69)"> <tspan style="font-size: 12.50px; " x="14.2" y="-1.4299999"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="13.315695" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.4017758" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.049999" y="-8.7600002"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="39.090389" y="-8.7600002"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="47.654945" y="-8.7600002"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,237.44,58.45)"> <tspan style="font-size: 8.75px; " x="0" y="0"> 2</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,244.4,53.45)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="13.178162" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.407536" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.543388" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="30.657356" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.88385" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="229.72" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="233.8835" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="240.13499" y="0"> )</t年代p一个n> </text> </g> </g> </svg></span>在哪里<年代vgheight="20.4125" id="M72" style="vertical-align:-4.92886pt;width:117.2375px;" version="1.1" viewbox="0 0 117.2375 20.4125" width="117.2375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.4125)"> <g transform="translate(72,-55.67)"> <text transform="matrix(1,0,0,-1,-71.95,60.64)"> <tspan style="font-size: 12.50px; " x="31.809999" y="1.6799999"> √</t年代p一个n> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.515023" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="22.555412" y="0"> </t年代p一个n> </text> <g> <path d="m -28.53,70.71 50.27,0" style="fill:none;stroke:#000000;stroke-width:0.82499999;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:10;stroke-opacity:1;stroke-dasharray:none"></path> </g> <text transform="matrix(1,0,0,-1,-28.53,60.64)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-19.68,57.51)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.9,60.64)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.766283" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="25.29357" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="32.482796" y="0"> )</t年代p一个n> </text> </g> </g> </svg>。一般来说,无量纲参数<年代vgheight="7.1750002" id="M73" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>可能取决于生长因子的浓度;例如,实验研究[<一个href="#B26">24</一个>)表明,增加VEGF诱导约增加5倍<年代vgheight="16.237499" id="M74" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。在这里,我们假设<年代vgheight="7.1750002" id="M75" style="vertical-align:-0.1254pt;width:8.9375px;" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.175)"> <g transform="translate(72,-66.26)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>不会改变本地;然而,不同的值为正常(选择<年代vgheight="11.0375" id="M76" style="vertical-align:-3.22282pt;width:15.875px;" version="1.1" viewbox="0 0 15.875 11.0375" width="15.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> </g> </g> </svg>)、肿瘤(<年代vgheight="11.025" id="M77" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>),和标准化的情况下<一个href="#B16">10</一个>]。</p><p>gydF4y2Ba压力参数主机(下标<年代vgheight="10.95" id="M78" style="vertical-align:-0.1254pt;width:9.1374998px;" version="1.1" viewbox="0 0 9.1374998 10.95" width="9.1374998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.95)"> <g transform="translate(72,-63.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.41)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ℎ</t年代p一个n> </text> </g> </g> </svg>(下标)和肿瘤<年代vgheight="9.125" id="M79" style="vertical-align:-0.11285pt;width:5.0124998px;" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,9.125)"> <g transform="translate(72,-64.7)"> <text transform="matrix(1,0,0,-1,-71.95,64.86)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)组织与肿瘤的血管结构已经规范化使用抗血管新生药物是基于表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab3/" target="_blank">3</一个>耆那教等。<一个href="#B16">10</一个>];这些都是包括在表中<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab2/" target="_blank">2</一个>。在原来的表有一个范围的血管的压力<年代vgheight="11.025" id="M80" style="vertical-align:-3.21404pt;width:13.925px;" version="1.1" viewbox="0 0 13.925 11.025" width="13.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>我们有设置一个基本的价值<年代vgheight="14.7" id="M81" style="vertical-align:-3.21404pt;width:48.9375px;" version="1.1" viewbox="0 0 48.9375 14.7" width="48.9375" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.44,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.291889" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>毫米汞柱的所有组织。这个值接近的范围参数的平均值在正常和肿瘤组织。同样,的范围<年代vgheight="10.9375" id="M82" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>是替换值附近的意思。</p><gydF4y2Badiv class="floats-partial-section partial-other-wrapper" data-section="tab3"> <div class="floats-partial-content fig-content-tab3"> <table class="table-group" id="tab3"> <tbody> <tr> <td> <table class="table"> <tbody> <tr> <td class="thead-hr" colspan="3"> <hr></td> </tr> <tr class="thead"> <td align="left"><span style="width: 12.9875px;"> <svg height="11.025" id="M83" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg></span></td> <td align="center"> <svg height="18.487499" id="M84" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 57.237499 18.487499" width="57.237499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.05,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.530886" y="0"> 9</t年代p一个n> </text> </g> </g> </svg>(不处理)</tgydF4y2Bad> <td align="center"> <svg height="18.487499" id="M85" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 57.237499 18.487499" width="57.237499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.05,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.530886" y="0"> 9</t年代p一个n> </text> </g> </g> </svg>(细胞毒性治疗)</tgydF4y2Bad> </tr> <tr> <td class="thead-hr" colspan="3"> <hr></td> </tr> <tr> <td align="left">2</tgydF4y2Bad> <td align="center">全球血管生成</tgydF4y2Bad> <td align="center">全球抑制</tgydF4y2Bad> </tr> <tr> <td align="left">6</tgydF4y2Bad> <td align="center">全球血管生成</tgydF4y2Bad> <td align="center">焦抑制</tgydF4y2Bad> </tr> <tr> <td align="left">14</tgydF4y2Bad> <td align="center">焦抑制</tgydF4y2Bad> <td align="center">焦抑制</tgydF4y2Bad> </tr> <tr class="table-tr"> <td colspan="3"> <hr class="tbody-hr"></td> </tr> </tbody> </table></td> </tr> </tbody> </table> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">表3</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/tab3/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> 血管生成活动产生的细胞毒性治疗(见图S4)。</gydF4y2Badiv> </div> </div> <h5 id="sec2.4">2.4。解决方法</gydF4y2Bah5> <p>我们假设肿瘤嵌入正常宿主组织(例如,在一个器官),考虑下面的边界条件。我们通过实施确保球面对称的核心<年代vgheight="17.3375" id="M86" style="vertical-align:-5.33832pt;width:90.0625px;" version="1.1" viewbox="0 0 90.0625 17.3375" width="90.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,17.3375)"> <g transform="translate(72,-58.13)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.36,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-53.93,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.12743" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.228654" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-36.2,58.3)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-18.29,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="14.75" id="M87" style="vertical-align:-3.25793pt;width:83.5px;" version="1.1" viewbox="0 0 83.5 14.75" width="83.5" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.75)"> <g transform="translate(72,-60.2)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.6515961" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="12.765563" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="16.241398" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="22.892994" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.994217" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-41.46,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-23.54,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>和执行的连续性因素浓度和通量的肿瘤边界通过设置<年代vgheight="18.3125" id="M88" style="vertical-align:-4.77652pt;width:108.1125px;" version="1.1" viewbox="0 0 108.1125 18.3125" width="108.1125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.3125)"> <g transform="translate(72,-57.35)"> <text transform="matrix(1,0,0,-1,-71.95,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.01,59.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-60.58,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-47.17,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-40.67,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.6268301" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.667219" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.06,59.04)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-9.63,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,3.78,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> +</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,10.28,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="21.1625" id="M89" style="vertical-align:-5.86981pt;width:298.22501px;" version="1.1" viewbox="0 0 298.22501 21.1625" width="298.22501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,21.1625)"> <g transform="translate(72,-55.07)"> <text transform="matrix(1,0,0,-1,-71.95,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.5645552" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-53.32,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="-0.19" y="8.7700005"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-49.08,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-35.75,57.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-31.32,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.8523636" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="17.729254" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.081978" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="35.0084" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,10.63,57.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,15.06,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,17.56,55.13)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,33.6,58.5)"> <tspan style="font-size: 6.25px; " x="0" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,42.35,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.592442" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,73.02,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> <tspan style="font-size: 8.75px; " x="-0.19" y="8.7799997"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,78.57,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.3765302" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,91.9,57.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,96.32,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.8648672" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="17.741756" y="0"> +</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.081978" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="35.0084" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,138.28,57.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,142.71,60.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,145.21,55.12)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,161.25,58.49)"> <tspan style="font-size: 6.25px; " x="0" y="0"> +</t年代p一个n> </text> </g> </g> </svg>奖学金项目的连续性和IFV通过设置<年代vgheight="15.225" id="M90" style="vertical-align:-2.29482pt;width:94.974998px;" version="1.1" viewbox="0 0 94.974998 15.225" width="94.974998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.225)"> <g transform="translate(72,-59.82)"> <text transform="matrix(1,0,0,-1,-71.95,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.1139669" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.277466" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-52.42,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-45.93,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.6393328" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.667219" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="25.781185" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.944685" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-6.72,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> +</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-0.23,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="15.125" id="M91" style="vertical-align:-2.21957pt;width:94.512497px;" version="1.1" viewbox="0 0 94.512497 15.125" width="94.512497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.125)"> <g transform="translate(72,-59.9)"> <text transform="matrix(1,0,0,-1,-71.95,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="5.9264221" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.089921" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-52.61,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-46.11,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="7.6268301" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="19.667219" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="25.593641" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.757139" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-7.1,67.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> +</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-0.6,62.16)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>,也就是说,<年代vgheight="15.25" id="M92" style="vertical-align:-3.66173pt;width:227.60001px;" version="1.1" viewbox="0 0 227.60001 15.25" width="227.60001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,15.25)"> <g transform="translate(72,-59.8)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="8.5645552" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-53.86,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-48.31,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.815095" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="16.929062" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.404896" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.056492" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="32.157715" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.321217" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-9.49,59.85)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,6.55,63.22)"> <tspan style="font-size: 6.25px; " x="0" y="0"> −</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,15.31,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> −</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.592442" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,45.44,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,48.67,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="10.815095" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="16.929062" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.404896" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="27.056492" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="32.157715" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.321217" y="0"> |</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,87.5,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="3.570816" y="0"> =</t年代p一个n> <tspan style="font-size: 8.75px; " x="9.5659361" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="16.042416" y="0"> +</t年代p一个n> </text> </g> </g> </svg>通常,<年代vgheight="14.35" id="M93" style="vertical-align:-3.22282pt;width:54.3125px;" version="1.1" viewbox="0 0 54.3125 14.35" width="54.3125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.35)"> <g transform="translate(72,-60.52)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-62.42,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-53.4,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-31.84,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(基于表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab3/" target="_blank">3</一个>从[<一个href="#B16">10</一个>])。我们也要求因素浓度达到稳定状态,因为我们远离肿瘤实施<年代vgheight="22.0375" id="M94" style="vertical-align:-6.50204pt;width:137.3875px;" version="1.1" viewbox="0 0 137.3875 22.0375" width="137.3875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,22.0375)"> <g transform="translate(72,-54.37)"> <text transform="matrix(1,0,0,-1,-71.95,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.01,57.78)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-60.58,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.2647228" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.979553" y="0"> →</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.108665" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-17.81,65.9)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> <tspan style="font-size: 8.75px; " x="-0.5" y="8.7799997"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-12.26,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="3.4758339" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-2.01,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,0.91,55.59)"> <tspan style="font-size: 6.25px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,4.71,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="4.1634989" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="16.191385" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,29.35,65.97)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="-1.5" y="8.79"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,33.7,60.9)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>对于大型<年代vgheight="7.0124998" id="M95" style="vertical-align:-0.0pt;width:6.5px;" version="1.1" viewbox="0 0 6.5 7.0124998" width="6.5" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.0125)"> <g transform="translate(72,-66.39)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。最后,假设正常组织最终会耗尽所有多余的组织液<年代vgheight="13.55" id="M96" style="vertical-align:-2.29482pt;width:60.737499px;" version="1.1" viewbox="0 0 60.737499 13.55" width="60.737499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.55)"> <g transform="translate(72,-61.16)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="6.1139669" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="10.277466" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="15.37869" y="0"> )</t年代p一个n> <tspan style="font-size: 12.50px; " x="25.093521" y="0"> →</t年代p一个n> <tspan style="font-size: 12.50px; " x="42.22263" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>对于大型<年代vgheight="7.0124998" id="M97" style="vertical-align:-0.0pt;width:6.5px;" version="1.1" viewbox="0 0 6.5 7.0124998" width="6.5" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,7.0125)"> <g transform="translate(72,-66.39)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(<一个href="#B16">10</一个>]。</p><p>gydF4y2Banondimensionalized压力的解析解,<年代vgheight="12.95" id="M98" style="vertical-align:-2.29482pt;width:7.7624998px;" version="1.1" viewbox="0 0 7.7624998 12.95" width="7.7624998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.95)"> <g transform="translate(72,-61.64)"> <text transform="matrix(1,0,0,-1,-65.07,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.8766499" y="0"> </t年代p一个n> </text> </g> </g> </svg>,可以得到解决(<一个href="#EEq6">6</一个>)。这对无量纲IFV以及解决方案,<年代vgheight="14.7125" id="M99" style="vertical-align:-3.2316pt;width:89.737503px;" version="1.1" viewbox="0 0 89.737503 14.7125" width="89.737503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-65.61,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.3390212" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="3.0507319" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.091121" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="21.017544" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="30.269764" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.745598" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.909096" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-18.17,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.93,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-8.82,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-4.42,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg>,被Jain派生et al。<一个href="#B16">10</一个>)(见补充1在网上Supplementry材料doi: 10.1155 / 2011/843765)。径向剖面<年代vgheight="12.95" id="M100" style="vertical-align:-2.29482pt;width:7.7624998px;" version="1.1" viewbox="0 0 7.7624998 12.95" width="7.7624998" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,12.95)"> <g transform="translate(72,-61.64)"> <text transform="matrix(1,0,0,-1,-65.07,63.97)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.8766499" y="0"> </t年代p一个n> </text> </g> </g> </svg>然后使用数值求解因子浓度(<一个href="#EEq3">3</一个>)。相应的矩阵求逆问题是执行在Matlab中使用一个二阶有限差分格式。</p><gydF4y2Bah4 id="results">3所示。结果</gydF4y2Bah4> <p>间质压力和速度概要文件获得解决(<一个href="#EEq6">6</一个>);这些概要文件可以查看数据<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig1/" target="_blank">1(一)</一个>和<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig1/" target="_blank">1 (b)</一个>,分别。作为参数<年代vgheight="11.025" id="M101" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>增加,压力减少肿瘤边缘变得更加激烈,它也会导致更高的奖学金在肿瘤。同样,如<年代vgheight="11.025" id="M102" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>增加,孔隙流体速度达到一个更高的和尖锐的峰值在肿瘤的边缘。注意参数的选择<年代vgheight="11.025" id="M103" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>的肿瘤内2、6和14大致对应参数与正常组织,肿瘤组织正常化,nonnormalized肿瘤组织,分别;的选择<年代vgheight="11.0375" id="M104" style="vertical-align:-3.22282pt;width:15.875px;" version="1.1" viewbox="0 0 15.875 11.0375" width="15.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> </g> </g> </svg>外肿瘤仍然是一个恒定值2的数据<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig1/" target="_blank">1(一)</一个>和<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig1/" target="_blank">1 (b)</一个>(<gydF4y2Ba一个href="#B16">10</一个>]。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig1"> <div class="floats-partial-content fig-content-fig1"> <div class="partial-carousel--single-image"> <img alt="(一)”name="843765.fig.001a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.001a.jpg"> <br> <strong>(一)</秒trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”name="843765.fig.001b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.001b.jpg"> <br> <strong>(b)</秒trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig1"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”name="843765.fig.001a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.001a.jpg"><br><strong>(一)</秒trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”name="843765.fig.001b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.001b.jpg"><br><strong>(b)</秒trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig1"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图1</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/fig1/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <svg height="14.7125" id="M105" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 43.075001 14.7125" width="43.075001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.88,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 2</t年代p一个n> </text> </g> </g> </svg> <svg height="14.7125" id="M106" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 52.275002 14.7125" width="52.275002" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-65.07,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.8766499" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="2.7006481" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.741037" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="20.855003" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.330837" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-34.62,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <svg height="14.7125" id="M107" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 89.737503 14.7125" width="89.737503" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-65.61,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.3390212" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="3.0507319" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.091121" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="21.017544" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="30.269764" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="33.745598" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="37.909096" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-18.17,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-14.93,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-8.82,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-4.42,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> )</t年代p一个n> </text> </g> </g> </svg> <svg height="11.025" id="M108" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <svg height="10.6875" id="M109" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 33.700001 10.6875" width="33.700001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.6875)"> <g transform="translate(72,-63.45)"> <text transform="matrix(1,0,0,-1,-66.02,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-5.9264221" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="2.638133" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="14.678522" y="0"> 1</t年代p一个n> </text> </g> </g> </svg> <table> 相对压力和速度概要文件时gydF4y2Ba。相对奖学金项目gydF4y2Ba和相对IFV是gydF4y2Ba。传说条目对应于近似gydF4y2Ba归一化值正常组织,分别和nonnormalized肿瘤组织。肿瘤边界gydF4y2Ba。</t一个ble> </div> </div> </div> <p>我们解决(<一个href="#EEq3">3</一个>),在前一节中给出的边界条件和压力资料得到解决(<一个href="#EEq6">6</一个>),以确定AGF浓度和随后的失衡因素(<一个href="#EEq4">4</一个>)。首先,我们比较我们的结果没有对流模型与模型(<一个href="#B20">11</一个>];相对应的曲线的唯一区别没有对流图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" target="_blank">2(一个)</一个>和最初的结果<一个href="#B20">11</一个>)我们认为肿瘤半径4毫米(2.5毫米)为了保持一致的参数估计(<一个href="#B16">10</一个>用于压力模型。对于我们的模型和对流,肿瘤的血管生成活性仍然达到最大边界,以及肿瘤血管生成抑制持续的核心区域。然而,我们现在观察到一个更高的峰值的血管生成倾向rim和血管生成刺激更大的区域,见图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" target="_blank">2 (b)</一个>。这是由于较大的差异proangiogenic和反血管增生生长因子浓度在边界附近,由于这些因素被排挤出肿瘤核心到周围的正常组织,见图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" target="_blank">2(一个)</一个>。然而,正如我们将看到的,从一个系统的转变没有对流与对流系统并不简单。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig2"> <div class="floats-partial-content fig-content-fig2"> <div class="partial-carousel--single-image"> <img alt="(一)”name="843765.fig.002a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.002a.jpg"> <br> <strong>(一)</秒trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”name="843765.fig.002b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.002b.jpg"> <br> <strong>(b)</秒trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig2"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”name="843765.fig.002a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.002a.jpg"><br><strong>(一)</秒trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”name="843765.fig.002b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.002b.jpg"><br><strong>(b)</秒trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig2"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图2</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <a href="//www.newsama.com/journals/cmmm/2011/843765/fig2/">2(一个)</一个><一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/">2 (b)</一个><年代vgheight="10.9125" id="M110" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 34.737499 10.9125" width="34.737499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9125)"> <g transform="translate(72,-63.27)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3897533" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.430141" y="0"> 0</t年代p一个n> </text> </g> </g> </svg> <svg height="14.7" id="M111" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 48 14.7" width="48" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> </text> </g> </g> </svg> <svg height="14.7125" id="M112" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 43.075001 14.7125" width="43.075001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.88,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 2</t年代p一个n> </text> </g> </g> </svg> <table> 比较nondimensionalized proangiogenic(固体)和反血管增生(虚线)生长因子浓度(图(gydF4y2Ba图)和血管生成活动gydF4y2Ba模型没有对流)()gydF4y2Ba和对流(gydF4y2Ba,)gydF4y2Ba。的对流,血管生成刺激的面积更大、更明显。</t一个ble> </div> </div> </div> <p>通过改变的值<年代vgheight="11.025" id="M113" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,我们可以看到不同的效果只有压力分布图的贡献模型。这可以通过修改<年代vgheight="16.237499" id="M114" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="10.9375" id="M115" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>,或<年代vgheight="10.325" id="M116" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。然而,我们愿意考虑一个固定肿瘤半径和表面体积比,我们将考虑改变<年代vgheight="11.025" id="M117" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>对应的值的变化<年代vgheight="16.237499" id="M118" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>只有。请注意,我们不能单独分析的贡献奖学金通过修改<年代vgheight="10.325" id="M119" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>因为这也会改变无量纲对流参数的值(<一个href="#EEq3">3</一个>)。同样,我们可以看看无量纲对流参数的贡献仅通过修改<年代vgheight="11.05" id="M120" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。最后,我们将考虑改变导水率的影响<年代vgheight="10.325" id="M121" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>同时也减少<年代vgheight="11.025" id="M122" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>并增加<年代vgheight="20.975" id="M123" style="vertical-align:-4.77652pt;width:18.825001px;" version="1.1" viewbox="0 0 18.825001 20.975" width="18.825001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.975)"> <g transform="translate(72,-55.22)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>影响压力分布图和对流的速度。</p><p>gydF4y2Ba我们首先考虑只不同的压力参数的影响<年代vgheight="11.025" id="M124" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(固定<年代vgheight="14.7125" id="M125" style="vertical-align:-3.22282pt;width:43.075001px;" version="1.1" viewbox="0 0 43.075001 14.7125" width="43.075001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.88,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 2</t年代p一个n> </text> </g> </g> </svg>),如上所述,我们将假设是通过改变<年代vgheight="16.237499" id="M126" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,其余的参数固定如表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab2/" target="_blank">2</一个>。我们可以看到数据<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" target="_blank">3(一个)</一个>和<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" target="_blank">3 (b)</一个>,结果表明,改变压力参数会导致不同的肿瘤血管生成的行为。事实上,该地区的血管生成抑制(<年代vgheight="11.0625" id="M127" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>)的核心不是保守的价值观<年代vgheight="11.025" id="M128" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>之间可以忽略对流的情况下(<年代vgheight="14.7" id="M129" style="vertical-align:-3.21404pt;width:40.1875px;" version="1.1" viewbox="0 0 40.1875 14.7" width="40.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ≈</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>)和nonnormalized肿瘤组织(<年代vgheight="14.7" id="M130" style="vertical-align:-3.21404pt;width:48px;" version="1.1" viewbox="0 0 48 14.7" width="48" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>)。因此,这种行为是更复杂的比观察通过修改通过对流参数<年代vgheight="11.05" id="M131" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>或通过压力和对流参数<年代vgheight="10.325" id="M132" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(见图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig4/" target="_blank">4</一个>和<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig5/" target="_blank">5</一个>和下面的讨论)。的值<年代vgheight="11.025" id="M133" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>接近于零,有一个区域的血管生成抑制(<年代vgheight="11.0625" id="M134" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> <</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>核心和刺激<年代vgheight="11.0625" id="M135" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> ></t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>在边缘(类似于“对流”用例图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" target="_blank">2 (b)</一个>)。为中档的值<年代vgheight="11.025" id="M136" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>肿瘤可以体验全球血管生成(例如,<年代vgheight="11.0625" id="M137" style="vertical-align:-0.30096pt;width:35.174999px;" version="1.1" viewbox="0 0 35.174999 11.0625" width="35.174999" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0625)"> <g transform="translate(72,-63.15)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="9.7398367" y="0"> ></t年代p一个n> <tspan style="font-size: 12.50px; " x="21.780226" y="0"> 0</t年代p一个n> </text> </g> </g> </svg>对所有<年代vgheight="13.125" id="M138" style="vertical-align:-1.95624pt;width:62.1875px;" version="1.1" viewbox="0 0 62.1875 13.125" width="62.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,13.125)"> <g transform="translate(72,-61.5)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.5645552" y="0"> ∈</t年代p一个n> <tspan style="font-size: 12.50px; " x="20.604944" y="0"> (</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.768442" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="31.019943" y="0"> ,</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.233692" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="45.485912" y="0"> ]</t年代p一个n> </text> </g> </g> </svg>)。,而不是proangiogenic在肿瘤和抗血管新生的浓度平衡,抗血管新生因子浓度是完全低于proangiogenic因子的浓度。考虑<年代vgheight="14.7" id="M139" style="vertical-align:-3.21404pt;width:40.1875px;" version="1.1" viewbox="0 0 40.1875 14.7" width="40.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 2</t年代p一个n> </text> </g> </g> </svg>,这个假定的肿瘤组织也有同样的价值<年代vgheight="16.237499" id="M140" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>正常组织。事实上,在这种情况下保持不变在肿瘤血管生成活动由于浓度一致的区别这两个因素导致全球血管生成。参数对应的归一化肿瘤组织(<年代vgheight="14.825" id="M141" style="vertical-align:-3.21404pt;width:40.1875px;" version="1.1" viewbox="0 0 40.1875 14.825" width="40.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.825)"> <g transform="translate(72,-60.14)"> <text transform="matrix(1,0,0,-1,-71.95,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.27)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.4)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 6</t年代p一个n> </text> </g> </g> </svg>),我们看到一个中间行为全球发生血管生成,但活动的核心是远低于肿瘤边缘。高的值<年代vgheight="11.025" id="M142" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(例如,<年代vgheight="14.7" id="M143" style="vertical-align:-3.21404pt;width:48px;" version="1.1" viewbox="0 0 48 14.7" width="48" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>),再次成为核心地区镇压,但水平较高的肿瘤血管生成活动发生接近边缘如前所观察到的“对流”图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig2/" target="_blank">2 (b)</一个>。虽然不同的血管生成配置文件获得,事实仍然是肿瘤的血管生成活性随边缘<年代vgheight="11.025" id="M144" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。</p><gydF4y2Badiv class="floats-partial-section partial-carousel-wrapper" data-section="fig3"> <div class="floats-partial-content fig-content-fig3"> <div class="partial-carousel--single-image"> <img alt="(一)”name="843765.fig.003a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.003a.jpg"> <br> <strong>(一)</秒trong> </div> <div class="partial-carousel--single-image"> <img alt="(b)”name="843765.fig.003b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.003b.jpg"> <br> <strong>(b)</秒trong> </div> </div> <div class="floats-partial-middle"> <div class="floats-partial-middle--thumbs fig-thumbs-fig3"> <button class="partial-carousel-dot" aria-label="(a)"><img alt="(一)”name="843765.fig.003a" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.003a.jpg"><br><strong>(一)</秒trong></button> <button class="partial-carousel-dot" aria-label="(b)"><img alt="(b)”name="843765.fig.003b" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.003b.jpg"><br><strong>(b)</秒trong></button> </div> <div class="partial-carousel-next-prev fig-nav-fig3"> <button class="carousel-prev" aria-label="Previous"></button> <button class="carousel-next" aria-label="Next"></button> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图3</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <svg height="16.237499" id="M145" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <a href="//www.newsama.com/journals/cmmm/2011/843765/fig3/">3(一个)</一个><一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/">3 (b)</一个><年代vgheight="14.7" id="M146" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 40.1875 14.7" width="40.1875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 2</t年代p一个n> </text> </g> </g> </svg> <svg height="19.737499" id="M147" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 102.25 19.737499" width="102.25" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,19.7375)"> <g transform="translate(72,-56.21)"> <text transform="matrix(1,0,0,-1,-71.95,60.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,57.86)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-54.85,60.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.291889" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.417639" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="30.444805" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.222389" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="47.473892" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-1.12,66.16)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.99512" y="0"> 7</t年代p一个n> </text> </g> </g> </svg> <svg height="14.4625" id="M148" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 65.824997 14.4625" width="65.824997" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.4625)"> <g transform="translate(72,-60.43)"> <text transform="matrix(1,0,0,-1,-71.95,60.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.404415" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="29.182001" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.433502" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-30.26,65.96)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.99512" y="0"> 6</t年代p一个n> </text> </g> </g> </svg> <svg height="14.5" id="M149" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 73.637497 14.5" width="73.637497" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.5)"> <g transform="translate(72,-60.4)"> <text transform="matrix(1,0,0,-1,-71.95,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="6.2515001" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="9.3772497" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="15.62875" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.655916" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="35.433502" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="41.685001" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-24.01,65.93)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.99512" y="0"> 5</t年代p一个n> </text> </g> </g> </svg> <svg height="14.7125" id="M150" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 43.075001 14.7125" width="43.075001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-55.88,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 2</t年代p一个n> </text> </g> </g> </svg> <table> 不同血管液压渗透率的影响,(毫米/年代/毫米汞柱),在肿瘤组织AGF浓度(图(gydF4y2Ba图)和血管生成活动)gydF4y2Ba。的值614gydF4y2Ba对应gydF4y2Ba,gydF4y2Ba,毫米/年代/毫米汞柱。宿主组织的参数是固定的gydF4y2Ba。这个变化产生的压力曲线的形状,因此孔隙流体的速度。</t一个ble> </div> </div> </div> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig4"> <div class="floats-partial-content fig-content-fig4"> <div class="partial-carousel--single-image"> <img alt="" name="843765.fig.004" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.004.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图4</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/fig4/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <svg height="11.05" id="M151" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <svg height="20.025" id="M152" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 110.0625 20.025" width="110.0625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.025)"> <g transform="translate(72,-55.98)"> <text transform="matrix(1,0,0,-1,-71.95,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,57.63)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-54.85,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.291889" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.417639" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.66914" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="36.696304" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="47.473892" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="53.725391" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,5.13,65.93)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.99512" y="0"> 5</t年代p一个n> </text> </g> </g> </svg> <svg height="20.975" id="M153" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 18.825001 20.975" width="18.825001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.975)"> <g transform="translate(72,-55.22)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <table> 不同的影响(gydF4y2Ba毫米汞柱)AGF浓度(嵌入)和血管生成活动固定毫米/年代/毫米汞柱,这改变对流参数的值gydF4y2Ba。</t一个ble> </div> </div> </div> <div class="floats-partial-section partial-carousel-wrapper" data-section="fig5"> <div class="floats-partial-content fig-content-fig5"> <div class="partial-carousel--single-image"> <img alt="" name="843765.fig.005" src="https://static-01.hindawi.com/articles/cmmm/volume-2011/843765/figures/843765.fig.005.jpg"> <br> <strong></strong> </div> </div> <div class="floats-partial-footer"> <div class="floats-partial-caption"> <span class="caption-text">图5</秒p一个n> <a aria-label="full view" class="caption-partial-url" href="//www.newsama.com/journals/cmmm/2011/843765/fig5/" title="" target="_blank"></a> </div> <div class="floats-partial-caption-text"> <svg height="10.325" id="M154" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <sup>2</秒up> <svg height="20.025" id="M155" style="vertical-align:-4.74141pt" version="1.1" viewbox="0 0 120.4875 20.025" width="120.4875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.025)"> <g transform="translate(72,-55.98)"> <text transform="matrix(1,0,0,-1,-71.95,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,57.63)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-54.85,60.76)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.040389" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.291889" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="21.417639" y="0"> 8</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.66914" y="0"> 6</t年代p一个n> <tspan style="font-size: 12.50px; " x="40.859802" y="0"> ×</t年代p一个n> <tspan style="font-size: 12.50px; " x="55.813393" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="62.064892" y="0"> 0</t年代p一个n> </text> <text transform="matrix(1,0,0,-1,13.47,65.93)"> <tspan style="font-size: 8.75px; " x="0" y="0"> −</t年代p一个n> <tspan style="font-size: 8.75px; " x="5.99512" y="0"> 5</t年代p一个n> </text> </g> </g> </svg> <svg height="14.7125" id="M156" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 60 14.7125" width="60" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7125)"> <g transform="translate(72,-60.23)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.97,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 0</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.530886" y="0"> 。</t年代p一个n> <tspan style="font-size: 12.50px; " x="27.656635" y="0"> 9</t年代p一个n> </text> </g> </g> </svg> <svg height="11.025" id="M157" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <svg height="20.975" id="M158" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 18.825001 20.975" width="18.825001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.975)"> <g transform="translate(72,-55.22)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg> <table> 增加的影响(gydF4y2Ba毫米/gydF4y2Bas /毫米汞柱)AGF浓度(嵌入)和血管生成活动固定毫米/年代/毫米汞柱gydF4y2Ba毫米汞柱,这同时减少gydF4y2Ba并增加gydF4y2Ba导致改变奖学金和高架对流运输。</t一个ble> </div> </div> </div> <p>正如所料,修复<年代vgheight="14.7" id="M159" style="vertical-align:-3.21404pt;width:48px;" version="1.1" viewbox="0 0 48 14.7" width="48" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,14.7)"> <g transform="translate(72,-60.24)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,60.37)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-58.19,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 1</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> </text> </g> </g> </svg>和增加<年代vgheight="11.05" id="M160" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,从而增加对流因素导致更高的浓度外肿瘤(见图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig4/" target="_blank">4</一个>rim)和更大的浓度差异。这正值一个增加肿瘤血管生成活动的边缘。参数被认为是和一个合理的范围<年代vgheight="11.05" id="M161" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,只有焦抑制肿瘤的展品。其他活动可以实现,但需要修改AGF参数(见S1-S3灵敏度分析的数据)。</p><p>gydF4y2Ba最后,我们考虑不同<年代vgheight="10.325" id="M162" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,这个参数值的增加导致下降<年代vgheight="11.025" id="M163" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="11.0375" id="M164" style="vertical-align:-3.22282pt;width:15.875px;" version="1.1" viewbox="0 0 15.875 11.0375" width="15.875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.0375)"> <g transform="translate(72,-63.17)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> ℎ</t年代p一个n> </text> </g> </g> </svg>随着增加对流参数的值<年代vgheight="20.975" id="M165" style="vertical-align:-4.77652pt;width:18.825001px;" version="1.1" viewbox="0 0 18.825001 20.975" width="18.825001" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,20.975)"> <g transform="translate(72,-55.22)"> <text transform="matrix(1,0,0,-1,-70.19,62.57)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="-1.76" y="2.54"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.42,56.91)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。这实质上化合物中观察到的数据的影响<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" target="_blank">3(一个)</一个>,<gydF4y2Ba一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" target="_blank">3 (b)</一个>和<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig4/" target="_blank">4</一个>导致高浓度的血管生成在肿瘤(从减少<年代vgheight="11.025" id="M166" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)和肿瘤边缘(增加<年代vgheight="11.05" id="M167" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>);参见图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig5/" target="_blank">5</一个>。</p><p>gydF4y2Ba后Ramanujan et al。<一个href="#B20">11</一个>AGF生产),我们进行了敏感性分析;看到S1-S3补充数据。我们通过修复概括他们的结果感兴趣的参数之一(<年代vgheight="11.025" id="M168" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="11.05" id="M169" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="10.325" id="M170" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)和分析结果在一个大范围的肿瘤产品价值(<年代vgheight="18.487499" id="M171" style="vertical-align:-4.74141pt;width:14.4125px;" version="1.1" viewbox="0 0 14.4125 18.487499" width="14.4125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="16.6" id="M172" style="vertical-align:-3.22282pt;width:14.55px;" version="1.1" viewbox="0 0 14.55 16.6" width="14.55" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.6)"> <g transform="translate(72,-58.72)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg><b>)</gydF4y2Bab>。焦抑制线之间发生相同的颜色,全球抑制发生高于本地区(高<年代vgheight="16.6" id="M173" style="vertical-align:-3.22282pt;width:14.55px;" version="1.1" viewbox="0 0 14.55 16.6" width="14.55" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.6)"> <g transform="translate(72,-58.72)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>低<年代vgheight="18.487499" id="M174" style="vertical-align:-4.74141pt;width:14.4125px;" version="1.1" viewbox="0 0 14.4125 18.487499" width="14.4125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>),和全球发生血管生成(低<年代vgheight="16.6" id="M175" style="vertical-align:-3.22282pt;width:14.55px;" version="1.1" viewbox="0 0 14.55 16.6" width="14.55" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.6)"> <g transform="translate(72,-58.72)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>、高<年代vgheight="18.487499" id="M176" style="vertical-align:-4.74141pt;width:19.625px;" version="1.1" viewbox="0 0 19.625 18.487499" width="19.625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-61.58,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.201488" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.13,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>)。结果表明,焦抑制观察到只有一个狭长的参数空间。这是现实,因为人会认为行为是敏感的平衡这些因素的生产速度。正如预期的那样,这种行为并不敏感,不同的主机生产参数肿瘤生产(结果未显示)。</p><p>gydF4y2Ba图S1显示这种变化时不同的敏感性<年代vgheight="11.025" id="M177" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。作为<年代vgheight="11.025" id="M178" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>焦抑制的增加,该地区从一个非常狭窄的地区扩大到涵盖更多的参数空间上方和下方。为不同的值<年代vgheight="11.05" id="M179" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>焦之间的边界,我们注意到小运动抑制和全球全球抑制血管生成而焦抑制之间的边界和增加<年代vgheight="11.05" id="M180" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(见图S2)。最后,对于<年代vgheight="10.325" id="M181" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,我们看到这些影响的结合;焦抑制和外围刺激发生的区域不断扩大,飘向图S3(高的左上角<年代vgheight="16.6" id="M182" style="vertical-align:-3.22282pt;width:19.762501px;" version="1.1" viewbox="0 0 19.762501 16.6" width="19.762501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.6)"> <g transform="translate(72,-58.72)"> <text transform="matrix(1,0,0,-1,-61.58,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.201488" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-61.13,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>、低<年代vgheight="18.487499" id="M183" style="vertical-align:-4.74141pt;width:14.4125px;" version="1.1" viewbox="0 0 14.4125 18.487499" width="14.4125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>)。参数值对应于焦抑制开关值对应于在全球范围内血管生成行为对流项时补充道。也这些图所示参数空间中的精确点对应于肿瘤的生产价值<年代vgheight="18.487499" id="M184" style="vertical-align:-4.74141pt;width:57.237499px;" version="1.1" viewbox="0 0 57.237499 18.487499" width="57.237499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.05,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 3</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 4</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.530886" y="0"> 9</t年代p一个n> </text> </g> </g> </svg>和<年代vgheight="18.487499" id="M185" style="vertical-align:-4.74141pt;width:57.237499px;" version="1.1" viewbox="0 0 57.237499 18.487499" width="57.237499" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-57.05,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> =</t年代p一个n> <tspan style="font-size: 12.50px; " x="12.027886" y="0"> 2</t年代p一个n> <tspan style="font-size: 12.50px; " x="18.279387" y="0"> 7</t年代p一个n> <tspan style="font-size: 12.50px; " x="24.530886" y="0"> 9</t年代p一个n> </text> </g> </g> </svg>(见部分<一个href="#sec4">4</一个>)。</p><gydF4y2Bah4 id="discussion">4所示。讨论</gydF4y2Bah4> <p>我们提出了一个数学模型来研究proangiogenic间隙对流的影响,抗血管新生因子在肿瘤和周围宿主组织浓度,并从这个决定整个肿瘤的血管生成活动。结果AGF浓度资料定性同意实验观测表明浓度最高的肿瘤的核心,作为一个方法减少肿瘤边缘(<一个href="#B8">4</一个>]。由此产生的血管生成行为,包括抑制肿瘤核心和最大刺激血管生成在肿瘤边缘附近,与实验观测,如肿瘤灌注(<一个href="#B6">25</一个>]。proangiogenic之间的不平衡和抗血管新生因子提供了一个实证解释观察到的血管生成活动,可以产生与肿瘤坏死或增长。奖学金和因子的精确影响对流在肿瘤的血管生成活动尚未证实,我们的结果表明,一个奖学金梯度可以显著影响血管生成在肿瘤的抑制和刺激。</p><p>gydF4y2Ba虽然没有明确包括,抗血管新生疗法的效果可以确定在这个模型,因为它已被证明的价值<年代vgheight="11.025" id="M186" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>减少血管正常化时的应用,例如,anti-VEGFR-2 [<一个href="#B16">10</一个>]。的价值<年代vgheight="11.025" id="M187" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>通过减少的任意组合可以减少吗<年代vgheight="10.9375" id="M188" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="16.237499" id="M189" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,或<年代vgheight="10.325" id="M190" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,所有这些可能发生的抗血管新生疗法。<年代vgheight="10.9375" id="M191" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>减少血管破坏和/或改造由于政府的抗血管新生药物(在这种情况下,有更少的单位面积血管壁的肿瘤体积)。半径<年代vgheight="10.325" id="M192" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>减少间接;肿瘤血管倒退,肿瘤细胞缺氧,因此成为缺氧或坏死。此外,血管渗透性<年代vgheight="16.237499" id="M193" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>可以减少由于明智地应用抗血管新生药物(血管正常化,<一个href="#B14">2</一个>])。压力参数<年代vgheight="11.025" id="M194" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>也可以通过增加水力传导率降低<年代vgheight="10.325" id="M195" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,效果有些相应的增加抵消了对流参数(参考图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig5/" target="_blank">5</一个>)。然而,<年代vgheight="10.325" id="M196" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>可以增加了管理的酶降解细胞外基质(ECM),随后降低流阻的间质(<一个href="#B25">21</一个>]。总的来说,策略,导致参数的降低<年代vgheight="11.025" id="M197" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>导致减少奖学金项目,影响肿瘤血管生成活动。如图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig3/" target="_blank">3 (b)</一个>和讨论的部分<一个href="#sec3">3</一个>,从减少interstitlal流体速度的变化<年代vgheight="11.025" id="M198" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>降低了血管生成活性rim和产生更恒定的水平的血管生成在肿瘤的活动。另一方面,也可以考虑抗血管新生药物管理通过减少proangiogenic因素的浓度增加的退化(或失活)常数(参见图S5)。失活的增加应该考虑大多数抗血管新生治疗只影响单个因素或一个家庭的增长因素。</p><p>gydF4y2Ba一个可以考虑的影响细胞毒性治疗,化疗或放疗的应用减少了肿瘤细胞的数量少导致proangiogenic因素生产(图S4);这是通过降低参数<年代vgheight="18.487499" id="M199" style="vertical-align:-4.74141pt;width:14.4125px;" version="1.1" viewbox="0 0 14.4125 18.487499" width="14.4125" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,18.4875)"> <g transform="translate(72,-57.21)"> <text transform="matrix(1,0,0,-1,-65.75,61.99)"> <tspan style="font-size: 12.50px; " x="0" y="0"> ̃</t年代p一个n> <tspan style="font-size: 12.50px; " x="-6.1889849" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.3,66.99)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 8.75px; " x="0" y="8.1300001"> </t年代p一个n> </text> </g> </g> </svg>。我们认为这个产量的减少和运动参数空间灵敏度图所示(图S1-S3)。在图S4,我们可以观察到结果的值取决于血管生成的行为<年代vgheight="11.025" id="M200" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>总结如表<一个href="//www.newsama.com/journals/cmmm/2011/843765/tab3/" target="_blank">3</一个>。细胞毒性治疗的效果在肿瘤细胞或血管也可以减少压力由于间隙的增加空间;这可能是包含在我们的模型,例如,增加<年代vgheight="10.325" id="M201" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>(图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig5/" target="_blank">5</一个>)。细胞毒性治疗的效果也可以包括通过减少肿瘤的半径<年代vgheight="10.325" id="M202" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>。抗血管新生疗法和化疗的组合可以同时被执行上述参数的变化;这些改变化合物的影响导致进一步减少血管生成趋势。</p><p>gydF4y2Ba减少奖学金之前或同时与其他治疗方法是一个重要的问题在癌症治疗,因为组织液的流动的肿瘤可以防止药物穿透肿瘤体积。而各种抗血管新生疗法的影响(减少<年代vgheight="10.9375" id="M203" style="vertical-align:-0.20064pt;width:27.137501px;" version="1.1" viewbox="0 0 27.137501 10.9375" width="27.137501" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.9375)"> <g transform="translate(72,-63.25)"> <text transform="matrix(1,0,0,-1,-71.95,63.5)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> <tspan style="font-size: 12.50px; " x="8.1269503" y="0"> /</t年代p一个n> <tspan style="font-size: 12.50px; " x="11.602784" y="0"> </t年代p一个n> </text> </g> </g> </svg>,<年代vgheight="16.237499" id="M204" style="vertical-align:-4.74141pt;width:17.1625px;" version="1.1" viewbox="0 0 17.1625 16.237499" width="17.1625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,16.2375)"> <g transform="translate(72,-59.01)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-63.1,60.66)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,或<年代vgheight="10.325" id="M205" style="vertical-align:-0.0pt;width:11.6875px;" version="1.1" viewbox="0 0 11.6875 10.325" width="11.6875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)或ECM-degrading酶(增加<年代vgheight="10.325" id="M206" style="vertical-align:-0.0pt;width:13.2875px;" version="1.1" viewbox="0 0 13.2875 10.325" width="13.2875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,10.325)"> <g transform="translate(72,-63.74)"> <text transform="matrix(1,0,0,-1,-71.95,63.79)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>)减少<年代vgheight="11.025" id="M207" style="vertical-align:-3.21404pt;width:12.9875px;" version="1.1" viewbox="0 0 12.9875 11.025" width="12.9875" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-64.9,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>因此压力,还有其他独立的机制,也可以引起减少压力。例如,减少<年代vgheight="11.05" id="M208" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>将减少奖学金。这可能是通过降低血管的压力<年代vgheight="11.025" id="M209" style="vertical-align:-3.21404pt;width:13.925px;" version="1.1" viewbox="0 0 13.925 11.025" width="13.925" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.025)"> <g transform="translate(72,-63.18)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>,可以随时通过降低血液的阻力。临床上,降低血液的粘度或肿瘤血管正常化将完成的目标少阻力(<一个href="#B25">21</一个>]。变化的影响<年代vgheight="11.05" id="M210" style="vertical-align:-3.2316pt;width:13.2625px;" version="1.1" viewbox="0 0 13.2625 11.05" width="13.2625" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(1.25,0,0,-1.25,0,11.05)"> <g transform="translate(72,-63.16)"> <text transform="matrix(1,0,0,-1,-71.95,66.44)"> <tspan style="font-size: 12.50px; " x="0" y="0"> </t年代p一个n> </text> <text transform="matrix(1,0,0,-1,-65.84,63.31)"> <tspan style="font-size: 8.75px; " x="0" y="0"> </t年代p一个n> </text> </g> </g> </svg>如图<一个href="//www.newsama.com/journals/cmmm/2011/843765/fig4/" target="_blank">4</一个>为减少血管生成活动的有效压力导致递减水平边缘。</p><p>gydF4y2Ba通过考虑不同的血管生成修改任何行为所涉及的关键参数的压力模型,我们可以建立一个替代(或更有可能的是,互补)这些变化的机制。而之前假设[<一个href="#B20">11</一个>)生产、退化和扩散的AGFs主要是负责整个血管生成行为,我们已经展出,肿瘤组织生理的变化也可能引起这些变化。两组之间的相互作用参数,AGF有关的属性,确定肿瘤AGF浓度和相应的生理决定孔隙流体压力,应该进一步研究更详细的建模和实验工作。我们强调,这是从来没有这个工作定量预测的目标浓度的特定AGFs或模型血管生成的过程,而是强调肿瘤组织属性的重要性和高分子对流对血管生成的行为。</p><p>gydF4y2Ba我们应该注意到有限制一个数学模型,其中许多已经提到了在模型开发。这些包括AGFs的两个截然不同的群体的存在,我们的血管生成活动的具体函数形式测量和流体分布源项。各种假设中最为突出的是球面对称和同质性的组织和环境(<一个href="#B20">11</一个>]。的另一个主要的限制是常数的假设参数值在肿瘤和宿主组织,甚至常量值假设在这个边界。这些假设使得建模和计算驯良的尤其是生理参数的函数径向距离在文献中并不常见。然而,我们的计算方法可以很容易地进行扩展,以包括异构肿瘤微环境在可用性方面的相关实验数据。最后,我们建议一个实验研究测量孔隙流体压力和数量与AGF浓度或血管生成相关活动(如血管密度或灌注)将有助于验证我们的定性模型预测。</p><gydF4y2Bah4 id="acknowledgments">确认</gydF4y2Bah4> <p>作者要感谢l·穆恩和美国Sivaloganathan关于论文有用的建议。这项工作是财务支持的加拿大自然科学和工程研究理事会(NSERC、发现格兰特)以及一个NSERC / CIHR合作医疗研究基金会资助。</p><gydF4y2Bah4 id="supplementary-materials">补充材料</gydF4y2Bah4> <div class="sup-content"> <p>敏感性分析在数据S1、S2和S3显示肿瘤的区域在参数空间生产的代表值<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msub> <mrow> <mi> α</gydF4y2Bami> </mrow> <mrow> <mi> l</gydF4y2Bami> </mrow> </msub> </math> </inline-formula>,<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msub> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> e</gydF4y2Bami> </mrow> </msub> </math> </inline-formula>,<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mi> K</gydF4y2Bami> </math> </inline-formula>分别。焦抑制线之间发生相同的颜色,全球抑制发生高于本地区(高<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> 一个</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> </math> </inline-formula>低<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> </math> </inline-formula>)和全球发生血管生成(低<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> 一个</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> </math> </inline-formula>高<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> </math> </inline-formula>)。黑方块表示参数用于肿瘤血管生成因子生产的基本情况<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mo> (</gydF4y2Bamo> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> <mo> =</gydF4y2Bamo> <mn fontstyle="italic"> 349年</gydF4y2Bamn> <mo> )</gydF4y2Bamo> </math> </inline-formula>而黑圆圈表示降低proangiogenic因素生产用于化疗<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mo> (</gydF4y2Bamo> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> g</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> <mo> =</gydF4y2Bamo> <mn fontstyle="italic"> 279年</gydF4y2Bamn> <mo> )</gydF4y2Bamo> </math> </inline-formula>。</p><p>gydF4y2Ba应用化疗导致细胞死亡和减少肿瘤proangiogenic生产;结果血管生成活动概要文件如图S5。应用抗血管新生疗法可以灭活proangiogenic因素导致增加肿瘤proangiogenic失活;我们考虑增加<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> k</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> <mo> =</gydF4y2Bamo> <mn fontstyle="italic"> 58</gydF4y2Bamn> </math> </inline-formula>来<我nline-formula> <math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <msubsup> <mrow> <mover accent="true"> <mrow> <mi> k</gydF4y2Bami> </mrow> <mo> ̃</gydF4y2Bamo> </mover> </mrow> <mrow> <mi> p</gydF4y2Bami> </mrow> <mrow> <mi> t</gydF4y2Bami> </mrow> </msubsup> <mo> =</gydF4y2Bamo> <mn fontstyle="italic"> 70年</gydF4y2Bamn> </math> </inline-formula>图S5。</p><gydF4y2Baol class="supplementary--docs"> <li><a href="//www.newsama.com/downloads/journals/cmmm/2011/843765.f1.pdf">补充数据</一个></l我></ol> </div> </div> <div class="xml-content"> <h4 class="references" id="references">引用</gydF4y2Bah4> <ol> <li id="B3">p . 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Intaglietta&publication_year=1979" target="_blank">谷歌学术搜索</一个></秒p一个n></li> </ol> </div> <div class="xml-content"> <h4 class="copyright" id="copyright">版权</gydF4y2Bah4> <p>版权©2011科林·菲普斯和默罕默德·Kohandel。这是一个开放的分布式下文章<一个rel="license" href="http://creativecommons.org/licenses/by/3.0/">知识共享归属许可</一个>,它允许无限制的使用、分配和复制在任何媒介,提供最初的工作是正确引用。</p></gydF4y2Badiv> </div> </article> </div> </div> </div> <div class="biblio__Wrapper-sc-1nou1lz-0 eyHfWh journal_article__BiblioIntegratorWidget-sc-12fk6zy-5 dbAANp article_widget biblioWrapper hide"> <hr> <h4 class="biblio__H4-sc-1nou1lz-2 becpDt hrTitleRef">更多相关文章</gydF4y2Bah4> <div id="biblio_widget" class="biblio__BiblioWrapper-sc-1nou1lz-1 bvnCfh"></div> </div> </div> </div> <div class="threeColumn__RightWrapper-sc-1bf4078-2 jzTMLK rightWrapper" id="rightSectionMenu"> <div> <div class="journal_article__ArticleStickyTopToolbar-sc-12fk6zy-0 gbrQxi article_sticky_top_toolbar"> <div class="sc-cBdUnI hRnXob article_top_toolbar"> <a class="sc-htpNat bUhGXt link 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height="24"><span class="text">下载引用</秒p一个n></span><span class="sc-htoDjs bqeMOy sc-dqBHgY cQgXqt fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> <a class="sc-htpNat bUhGXt link sc-jtRfpW dIjoCg sc-BngTV hmDWcT ref_desktop" href="//www.newsama.com/journals/cmmm/2011/843765.ris" aria-label="" target="" id="toolbar__dcNavSmall"><span><img alt="" class="sc-EHOje jOLhQl sc-kTUwUJ eujois" title="" role="presentation" src="data:image/svg+xml;base64,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" height="24"><span class="text">引用</秒p一个n></span><span class="sc-htoDjs bqeMOy sc-dqBHgY cQgXqt fileArrow icon-colored _3P4iUn1NDM5G77nWCamJ4l icon-themeable" title="" font-size="20"></span></a> </div> </div> <div class="journal_article__ArticleStickyBottomToolbar-sc-12fk6zy-1 isgRZA article_sticky_bottom_toolbar"> <div class="sc-cTjmhe ihmyEq article_bottom_toolbar"> <div class="sc-cugefK itFKcQ accordion" property="background-color" color="#D8D8D8" id="toolbar__dofNav"> <span><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" src="data:image/svg+xml;base64,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" height="24"><span class="sc-dRFtgE jrsDZP">下载其他格式</秒p一个n><span class="sc-gkFcWv gWTCXQ">更多的</秒p一个n></span> <span class="sc-htoDjs bMdQcY sc-gbOuXE jGPvPL icon-colored _1CwL9R82TPl2HxDleeYGDR icon-themeable" title="" font-size="11"></span> </div> <div class="sc-fnwBNb etzuBr"> <a class="sc-htpNat bUhGXt link sc-iNhVCk gWgCNb open_panel" href="//www.newsama.com/downloads/journals/cmmm/2011/843765.epub" aria-label="ePub" property="background-color" color="#D8D8D8"> <div class="sc-eAKXzc WHkfb"> ePub</gydF4y2Badiv><img alt="" class="sc-EHOje jOLhQl sc-bfYoXt cGuwDn" title="" role="presentation" src="data:image/svg+xml;base64,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" 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height="24"><span class="sc-dRFtgE jrsDZP">订单打印副本</秒p一个n><span class="sc-gkFcWv gWTCXQ">订单</秒p一个n></span><span class="sc-htoDjs kNoiZu sc-gbOuXE jGPvPL right__icon icon-colored _32KP5uexH-Bgs7Kj8Gk1Tz icon-themeable" title="" font-size="16"></span></a> <div class="sc-hBbWxd kdRRST"> <div class="sc-dyGzUR cHatnS"> <div> 的观点<年代p一个n>1583年</秒p一个n> </div> <div> 下载<年代p一个n>1004年</秒p一个n> </div> </div> <div> <div class="sc-drKuOJ kxdGAZ"> <span class="__dimensions_badge_embed__" data-doi="10.1155/2011/843765" data-style="small_circle"></span>引用</gydF4y2Badiv> </div> </div> <nav class="sc-bRBYWo fXBKFa sc-hUfwpO jHPgUP" id="toolbar__iconNav"> <h3 class="sc-Rmtcm hNPrIr">分享文章</gydF4y2Bah3> <ul class="sc-hzDkRC bnbfTS"> <li class="iconBorder"><a class="sc-htpNat bUhGXt link" href="https://twitter.com/share?url=https://doi.org/10.1155/2011/843765&via=Hindawi" aria-label="Sharing on Twitter" rel="noopener noreferrer" target="_blank"><img alt="" class="sc-EHOje jOLhQl socialTwitter" title="" 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